Kim M Cecil

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi request reprint Proton magnetic resonance spectroscopy of the frontal lobe and cerebellar vermis in children with a mood disorder and a familial risk for bipolar disorders
    Kim M Cecil
    Imaging Research Center, Department of Radiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Child Adolesc Psychopharmacol 13:545-55. 2003
  2. pmc Proton magnetic resonance spectroscopy in adults with childhood lead exposure
    Kim M Cecil
    Cincinnati Children s Environmental Health Center at Cincinnati Children s Hospital Medical Center, Ohio 45229, USA
    Environ Health Perspect 119:403-8. 2011
  3. pmc Altered myelination and axonal integrity in adults with childhood lead exposure: a diffusion tensor imaging study
    Christopher J Brubaker
    Cincinnati Children s Environmental Health Center at the Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Neurotoxicology 30:867-75. 2009
  4. pmc Lithium treatment effects on Myo-inositol in adolescents with bipolar depression
    Nick C Patel
    Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0004, USA
    Biol Psychiatry 60:998-1004. 2006
  5. ncbi request reprint Neurochemical effects of olanzapine in first-hospitalization manic adolescents: a proton magnetic resonance spectroscopy study
    Melissa P DelBello
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Neuropsychopharmacology 31:1264-73. 2006
  6. pmc The influence of age of lead exposure on adult gray matter volume
    Christopher J Brubaker
    Cincinnati Children s Environmental Health Center, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Neurotoxicology 31:259-66. 2010
  7. ncbi request reprint Frontal lobe differences in bipolar disorder as determined by proton MR spectroscopy
    Kim M Cecil
    Imaging Research Center, Department of Radiology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Bipolar Disord 4:357-65. 2002
  8. pmc Long term antipsychotic treatment does not alter metabolite concentrations in rat striatum: an in vivo magnetic resonance spectroscopy study
    Diana M Lindquist
    Imaging Research Center, Dept of Radiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Schizophr Res 128:83-90. 2011
  9. pmc Decreased brain volume in adults with childhood lead exposure
    Kim M Cecil
    Cincinnati Children s Environmental Health Center, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS Med 5:e112. 2008
  10. ncbi request reprint Elevated lactate as an early marker of brain injury in inflicted traumatic brain injury
    Kathi L Makoroff
    Department of Pediatrics, Mayerson Center for Safe and Healthy Children, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Pediatr Radiol 35:668-76. 2005

Detail Information

Publications27

  1. ncbi request reprint Proton magnetic resonance spectroscopy of the frontal lobe and cerebellar vermis in children with a mood disorder and a familial risk for bipolar disorders
    Kim M Cecil
    Imaging Research Center, Department of Radiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Child Adolesc Psychopharmacol 13:545-55. 2003
    ....
  2. pmc Proton magnetic resonance spectroscopy in adults with childhood lead exposure
    Kim M Cecil
    Cincinnati Children s Environmental Health Center at Cincinnati Children s Hospital Medical Center, Ohio 45229, USA
    Environ Health Perspect 119:403-8. 2011
    ..Childhood lead exposure adversely affects neurodevelopment. However, few studies have examined changes in human brain metabolism that may underlie known adverse cognitive and behavioral outcomes...
  3. pmc Altered myelination and axonal integrity in adults with childhood lead exposure: a diffusion tensor imaging study
    Christopher J Brubaker
    Cincinnati Children s Environmental Health Center at the Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Neurotoxicology 30:867-75. 2009
    ..This study indicates that childhood lead exposure is associated with a significant and persistent impact on white matter microstructure as quantified with diffusivity changes suggestive of altered myelination and axonal integrity...
  4. pmc Lithium treatment effects on Myo-inositol in adolescents with bipolar depression
    Nick C Patel
    Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0004, USA
    Biol Psychiatry 60:998-1004. 2006
    ..This study used proton magnetic resonance spectroscopy (1H MRS) to identify the in vivo effects of lithium on myo-inositol (mI) concentrations in adolescent bipolar depression...
  5. ncbi request reprint Neurochemical effects of olanzapine in first-hospitalization manic adolescents: a proton magnetic resonance spectroscopy study
    Melissa P DelBello
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Neuropsychopharmacology 31:1264-73. 2006
    ..Additionally, olanzapine-induced increases in choline may lead to alteration of abnormalities in cell membrane metabolism or second messenger pathways that are thought to be involved in the pathophysiology of bipolar disorder...
  6. pmc The influence of age of lead exposure on adult gray matter volume
    Christopher J Brubaker
    Cincinnati Children s Environmental Health Center, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Neurotoxicology 31:259-66. 2010
    ..This study demonstrates that maximum blood lead levels do not fully account for gray matter changes associated with childhood lead exposure, particularly in the frontal lobes of young men...
  7. ncbi request reprint Frontal lobe differences in bipolar disorder as determined by proton MR spectroscopy
    Kim M Cecil
    Imaging Research Center, Department of Radiology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Bipolar Disord 4:357-65. 2002
    ..Patients with bipolar disorder having a manic or mixed episode were hypothesized to demonstrate metabolic abnormalities within the frontal lobe...
  8. pmc Long term antipsychotic treatment does not alter metabolite concentrations in rat striatum: an in vivo magnetic resonance spectroscopy study
    Diana M Lindquist
    Imaging Research Center, Dept of Radiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Schizophr Res 128:83-90. 2011
    ..Only the Cho/Cr ratio showed a significant time-by-treatment effect (p=0.0285). These results are in agreement with previous studies of the striatum. However, regional and disease-specific effects remain unresolved...
  9. pmc Decreased brain volume in adults with childhood lead exposure
    Kim M Cecil
    Cincinnati Children s Environmental Health Center, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS Med 5:e112. 2008
    ..In this study, we examined the relationship between childhood lead exposure and adult brain volume using magnetic resonance imaging (MRI). We also explored how volume changes correlate with historic neuropsychological assessments...
  10. ncbi request reprint Elevated lactate as an early marker of brain injury in inflicted traumatic brain injury
    Kathi L Makoroff
    Department of Pediatrics, Mayerson Center for Safe and Healthy Children, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Pediatr Radiol 35:668-76. 2005
    ..The metabolic and neurochemical abnormalities that underlie traumatic brain injury remain poorly understood, but hypoxia-ischemic injury might play an important role...
  11. ncbi request reprint Incidence of brain creatine transporter deficiency in males with developmental delay referred for brain magnetic resonance imaging
    Amy Newmeyer
    Division of Developmental Disabilities, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Dev Behav Pediatr 26:276-82. 2005
    ..This study suggests that brain creatine deficiency is an important consideration in the differential diagnosis of males with global developmental delay referred for brain MRI; brain MRS should be considered in such cases...
  12. doi request reprint Late proton magnetic resonance spectroscopy following traumatic brain injury during early childhood: relationship with neurobehavioral outcomes
    Nicolay Chertkoff Walz
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Neurotrauma 25:94-103. 2008
    ..Some neurometabolite levels differed between the TBI and OI groups more than 1 year post-injury and were related to injury severity, as well as some neurobehavioral outcomes following TBI during early childhood...
  13. ncbi request reprint MR imaging and spectroscopy in juvenile Huntington disease
    Mark Schapiro
    Division of Neurology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Pediatr Radiol 34:640-3. 2004
    ..Imaging findings of caudate atrophy and abnormal T2 prolongation in the putamina with MR spectroscopy findings consistent with dense gliosis can be helpful indicators of juvenile Huntington disease...
  14. ncbi request reprint Presence of normal creatine in the muscle of a patient with a mutation in the creatine transporter: a case study
    Gail J Pyne-Geithman
    Department of Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Mol Cell Biochem 262:35-9. 2004
    ..Identifying this alternative creatine-transport mechanism may be useful in treating the neurologic and cognitive impairments of patients with creatine-transporter deficiency...
  15. pmc Proton magnetic resonance spectroscopy: technique for the neuroradiologist
    Kim M Cecil
    Department of Radiology, Pediatrics, Neuroscience and Environmental Health, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Neuroimaging Clin N Am 23:381-92. 2013
    ..When appropriately incorporating MRS into the neuroradiologic evaluation, this technique produces relevant information to radiologists and clinicians for their understanding of adult and pediatric neurologically based disease processes...
  16. doi request reprint 1H NMR analysis of choline metabolites in fine-needle-aspirate biopsies of breast cancer
    John M Pearce
    Center for Imaging Research, University of Cincinnati College of Medicine, and Department of Radiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45267 0583, USA
    MAGMA 26:337-43. 2013
    ....
  17. pmc Pediatric sports-related concussion produces cerebral blood flow alterations
    Todd A Maugans
    Division of Neurosurgery, Department of Surgery, Cincinnati Children s Hospital Medical Center, MLC 2016, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Pediatrics 129:28-37. 2012
    ..The authors of this investigation explore these possibilities after pediatric SRC...
  18. doi request reprint Megalencephalic leukoencephalopathy with subcortical cysts: a third confirmed case with literature review
    Lili Miles
    Division of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Pediatr Dev Pathol 12:180-6. 2009
    ..Fine uniform vacuolation of white matter with wide separation of myelinated axons is the hallmark of MLC in early childhood...
  19. pmc Correlation of diffusion tensor imaging with executive function measures after early childhood traumatic brain injury
    Brad Kurowski
    Department of Pediatric Rehabilitation Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    J Pediatr Rehabil Med 2:273-83. 2009
    ..Examine relationships of diffusion tensor imaging (DTI) fractional anisotropy (FA) to executive function (EF) and attention measures following early childhood (3-7 years) traumatic brain injury (TBI)...
  20. ncbi request reprint Magnetic resonance spectroscopy and metabolic imaging in white matter diseases and pediatric disorders
    Kim M Cecil
    Department of Radiology and Pediatrics, Cincinnati Children s Hospital Medical Center and the College of Medicine of the University of Cincinnati, Cincinnati, OH 45229, USA
    Top Magn Reson Imaging 17:275-93. 2006
    ..With this composite summary, the reader should find it easier to implement and interpret spectroscopy in the clinical setting for the diagnosis and monitoring of patients with white matter disorders...
  21. ncbi request reprint Reversible MR imaging and MR spectroscopy abnormalities in association with metronidazole therapy
    Kim M Cecil
    Department of Radiology MLC 5031, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    J Comput Assist Tomogr 26:948-51. 2002
    ..Proton MRS examination demonstrated a persistent lactate elevation during metronidazole treatment. Clinical, spectroscopic, and imaging abnormalities resolved with discontinuation of metronidazole...
  22. ncbi request reprint The clinical syndrome of creatine transporter deficiency
    Ton J DeGrauw
    Division of Neurology, Childrens Hospital Medical Center, Cincinnati, OH 45229, USA
    Mol Cell Biochem 244:45-8. 2003
    ..MR Spectroscopy is a non-invasive method for obtaining a preliminary diagnosis of this disorder. Muscle creatine uptake may be normal in this disorder...
  23. ncbi request reprint MR spectroscopy of metabolic disorders
    Kim M Cecil
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Neuroimaging Clin N Am 16:87-116, viii. 2006
    ..Although many conditions have a similar presentation, MRS offers valuable information for the individual patient in diagnosis and therapy when integrated fully into the clinical setting...
  24. ncbi request reprint The impact of early childhood lead exposure on brain organization: a functional magnetic resonance imaging study of language function
    Weihong Yuan
    Department of Radiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Pediatrics 118:971-7. 2006
    ..The purpose of this work was to assess the long-term impact of childhood lead exposure on the neurosubstrate of language function and brain organization...
  25. ncbi request reprint Methylsulfonylmethane observed by in vivo proton magnetic resonance spectroscopy in a 5-year-old child with developmental disorder: effects of dietary supplementation
    Kim M Cecil
    Department of Radiology MC 5031, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    J Comput Assist Tomogr 26:818-20. 2002
    ..Recognition of this chemical on brain proton MRS as an exogenous compound is necessary to avoid confusion as a pathologic metabolite of pediatric metabolic disease...
  26. ncbi request reprint Magnetic resonance spectroscopy in a 9-day-old heterozygous female child with creatine transporter deficiency
    Kim M Cecil
    Division of Radiology, Children s Hospital Medical Center, University of Cincinnati Medical Center, OH 45229, USA
    J Comput Assist Tomogr 27:44-7. 2003
    ..A 9-day-old heterozygous female child with this syndrome demonstrated a significant reduction of creatine on proton MRS. She is a carrier of the R514X nonsense mutation...
  27. doi request reprint Temporal change in N-acetyl-aspartate concentrations in adolescents with bipolar depression treated with lithium
    Nick C Patel
    College of Pharmacy, University of Georgia, Medical College of Georgia, Augusta, Georgia 30912 2450, USA
    J Child Adolesc Psychopharmacol 18:132-9. 2008
    ..This proton magnetic resonance spectroscopy (1H MRS) study identified the in vivo effects of lithium on N-acetyl-aspartate (NAA) concentrations in adolescent bipolar depression...