Research Topics
| Hermine BrunnerSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Pediatric SLE--towards a comprehensive management planHermine I Brunner
William S Rowe Division of Rheumatology and Lupus Center, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Nat Rev Rheumatol 7:225-33. 2011....- Validation of the Pediatric Automated Neuropsychological Assessment Metrics in childhood-onset systemic lupus erythematosusHermine I Brunner
Cincinnati Children s Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio
Arthritis Care Res (Hoboken) 65:372-81. 2013..To evaluate the reproducibility and validity of the Pediatric Automated Neuropsychological Assessment Metrics (Ped-ANAM) when used in childhood-onset systemic lupus erythematosus (cSLE)... 
Association of noninvasively measured renal protein biomarkers with histologic features of lupus nephritisHermine I Brunner
Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Arthritis Rheum 64:2687-97. 2012....- Identification of urinary metabolites that distinguish membranous lupus nephritis from proliferative lupus nephritis and focal segmental glomerulosclerosisLindsey E Romick-Rosendale
Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA
Arthritis Res Ther 13:R199. 2011.... - Developing outcome measures for paediatric rheumatic diseasesHermine I Brunner
Cincinnati Children s Hospital Medical Center, University of Cincinnati, William Rowe Division of Rheumatology, Cincinnati, OH 45229 3039, USA
Best Pract Res Clin Rheumatol 23:609-24. 2009.... 
Differences in disease outcomes between medicaid and privately insured children: possible health disparities in juvenile rheumatoid arthritisHermine I Brunner
William Rowe Division of Rheumatology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Arthritis Rheum 55:378-84. 2006..To determine the relationship between health insurance status and disease outcome in children with juvenile rheumatoid arthritis (JRA)...- Urinary neutrophil gelatinase-associated lipocalin as a biomarker of nephritis in childhood-onset systemic lupus erythematosusHermine I Brunner
Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Arthritis Rheum 54:2577-84. 2006..We undertook this study to determine the relationship between urinary NGAL excretion and SLE disease activity or damage, with a focus on nephritis... - Initial validation of the Pediatric Automated Neuropsychological Assessment Metrics for childhood-onset systemic lupus erythematosusHermine I Brunner
Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Arthritis Rheum 57:1174-82. 2007..To evaluate the concurrent validity and diagnostic accuracy of the pediatric Automated Neuropsychological Assessment Metrics (Ped-ANAM) when used in childhood-onset systemic lupus erythematosus (SLE)... - Corticosteroid use in childhood-onset systemic lupus erythematosus-practice patterns at four pediatric rheumatology centersH I Brunner
Cincinnati Children s Hospital Medical Center, University of Cincinnati, USA
Clin Exp Rheumatol 27:155-62. 2009..To evaluate corticosteroid prescribing patterns in childhood-onset systemic lupus erythematosus (SLE), comparing four academic pediatric rheumatology practices... - Health-related quality of life and its relationship to patient disease course in childhood-onset systemic lupus erythematosusHermine I Brunner
Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
J Rheumatol 36:1536-45. 2009.... - Prospective validation of the provisional criteria for the evaluation of response to therapy in childhood-onset systemic lupus erythematosusHermine I Brunner
Cincinnati Children s Hospital Medical Center, University of Cincinnati, William Rowe Division of Rheumatology, E 4010, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Arthritis Care Res (Hoboken) 62:335-44. 2010..To prospectively validate the provisional criteria for the evaluation of response to therapy in children with systemic lupus erythematosus (SLE)... - Toward the development of criteria for global flares in juvenile systemic lupus erythematosusHermine I Brunner
Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Arthritis Care Res (Hoboken) 62:811-20. 2010..To develop a definition of global flare in juvenile systemic lupus erythematosus (SLE) and derive candidate criteria for measuring juvenile SLE flares... - Minimal clinically important differences of disease activity indices in childhood-onset systemic lupus erythematosusHermine I Brunner
Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Arthritis Care Res (Hoboken) 62:950-9. 2010..To determine the minimal clinically important differences (MCIDs) of validated measures of systemic lupus erythematosus (SLE) disease activity in childhood-onset SLE... - Preliminary criteria for global flares in childhood-onset systemic lupus erythematosusHermine I Brunner
Cincinnati Children s Hospital Medical Center, Ohio, USA
Arthritis Care Res (Hoboken) 63:1213-23. 2011..To develop widely acceptable preliminary criteria of global flare for childhood-onset systemic lupus erythematosus (cSLE)... - Disease outcomes and ovarian function of childhood-onset systemic lupus erythematosusH I Brunner
Cincinnati Children s Hospital Medical Center, University of Cincinnati, William Rowe Division of Rheumatology, OH 45229, USA
Lupus 15:198-206. 2006..8; 95% CI: 1.7-4.8; P = 0.026). Patient mortality and disease damage with cSLE continue to be high. Although overt POF with cyclophosphamide exposure is rare, it is a risk factor for significantly decreased ovarian reserve cSLE... - Cost of treatment of childhood-onset systemic lupus erythematosusHermine I Brunner
Cincinnati Children s Hospital Medical Center, William Rowe Division of Rheumatology E 4010, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Arthritis Rheum 55:184-8. 2006..To determine the direct cost of care of children with childhood-onset systemic lupus erythematosus (cSLE), and to determine the direct cost per quality-adjusted life year (QALY) with cSLE... - European Consensus Lupus Activity Measurement is sensitive to change in disease activity in childhood-onset systemic lupus erythematosusHermine I Brunner
Cincinnati Children s Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio, USA
Arthritis Rheum 49:335-41. 2003..To confirm the construct validity and to characterize the measurement properties of the ECLAM by assessing its ability to predict damage and steroid requirements... - Lupus headaches in childhood-onset systemic lupus erythematosus: relationship to disease activity as measured by the systemic lupus erythematosus disease activity index (SLEDAI) and disease damageH I Brunner
William Rowe Division of Rheumatology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati 45229 3039, USA
Lupus 12:600-6. 2003..When used in children, the insensitivity of the SLEDAI to capture LHA did not seem to decrease the responsiveness of the SLEDAI to detect clinically important worsening of disease, or negatively impact on its ability to predict damage... - Health-related quality of life in children with rheumatic diseasesHermine I Brunner
Cincinnati Children s Hospital Medical Center, OH 45229 3039, USA
Curr Opin Rheumatol 15:602-12. 2003..For the interpretation of the values of the physical function and health-related quality of life measures, their measurement properties have to be studied... - Health of children with chronic arthritis: relationship of different measures and the quality of parent proxy reportingHermine I Brunner
Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229 3039, USA
Arthritis Rheum 51:763-73. 2004..To evaluate whether HRQOL scores vary as a function of disability status beyond chance. To assess the quality of the parent proxy report for HRQOL as compared with disability, pain, and well-being... - Minimal clinically important differences of the childhood health assessment questionnaireHermine I Brunner
Division of Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
J Rheumatol 32:150-61. 2005..125. We estimated minimal clinically important differences (MCID) of the CHAQ for worsening and improvement that were actually experienced by children with JRA using patient, parent, and clinical perspectives... - Gastrointestinal symptoms and their association with health-related quality of life of children with juvenile rheumatoid arthritis: validation of a gastrointestinal symptom questionnaireHermine I Brunner
Division of Rheumatology E 4010, Cincinnati Children s Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
J Clin Rheumatol 11:194-204. 2005.... - Neutrophil gelatinase-associated lipocalin is a predictor of the course of global and renal childhood-onset systemic lupus erythematosus disease activityClaas H Hinze
Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio
Arthritis Rheum 60:2772-81. 2009..To determine whether neutrophil gelatinase-associated lipocalin (NGAL) can predict worsening of global and renal disease activity in childhood-onset systemic lupus erythematosus (SLE)... - Initial validation of a novel protein biomarker panel for active pediatric lupus nephritisMichiko Suzuki
Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Pediatr Res 65:530-6. 2009..0001), and L-PGDS (p < 0.01) occurred, indicating that these PS proteins are biomarkers of LN activity and may help anticipate the future course of LN... - Disease control and health-related quality of life in juvenile idiopathic arthritisMichael Seid
Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Arthritis Rheum 61:393-9. 2009.... - Specialized neuromuscular training to improve neuromuscular function and biomechanics in a patient with quiescent juvenile rheumatoid arthritisGregory D Myer
Sports Medicine Biodynamics Center and Human Performance Laboratory, Cincinnati Children s Hospital Medical Center, MLC 10001, Cincinnati, OH 45229, USA
Phys Ther 85:791-802. 2005..The purpose of this case report is to describe a novel multidisciplinary approach for evaluating and preparing a patient with quiescent juvenile rheumatoid arthritis (JRA) for safe sports participation... - Difference in disease features between childhood-onset and adult-onset systemic lupus erythematosusHermine I Brunner
Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
Arthritis Rheum 58:556-62. 2008..To investigate potential differences between childhood-onset and adult-onset systemic lupus erythematosus (SLE)... - Risk factors for damage in childhood-onset systemic lupus erythematosus: cumulative disease activity and medication use predict disease damageHermine I Brunner
Division of Rheumatology, Children s Hospital Medical Center, University of Cincinnati, PAV2 129, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Arthritis Rheum 46:436-44. 2002.... - Identification of a urinary proteomic signature for lupus nephritis in childrenMichiko Suzuki
Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
Pediatr Nephrol 22:2047-57. 2007..90 for 22, 23, 44, 79, and 100 kDa biomarkers. Thus, SELDI-TOF-MS has identified a urine proteomic signature strongly associated with SLE renal involvement and active SLE nephritis... - Neutrophil gelatinase-associated lipocalin as a biomarker of disease activity in pediatric lupus nephritisMichiko Suzuki
Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
Pediatr Nephrol 23:403-12. 2008..3 +/- 6.2 or 21%; renal disease activity: 20.2 +/- 6.0 or 51%; both p = not significant]. In conclusion, NGAL in urine but not in plasma represents a novel biomarker for renal disease activity in pSLE... - Effectively measuring adherence to medications for systemic lupus erythematosus in a clinical settingSri Koneru
University of Cincinnati Medical Center, Cincinnati, Ohio, USA
Arthritis Rheum 57:1000-6. 2007.... - Preliminary definition of disease flare in juvenile rheumatoid arthritisHermine I Brunner
William S Rowe Division of Rheumatology, Cincinnati Children s Hospital Medical Center, OH 45229, USA
J Rheumatol 29:1058-64. 2002..To develop preliminary criteria for defining disease flare in patients with polyarticular-course juvenile rheumatoid arthritis (JRA)... - Item weightings for the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Disease Damage Index using Rasch analysis do not lead to an important improvementHermine I Brunner
William Rowe Division of Rheumatology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
J Rheumatol 30:292-7. 2003.... - Adherence to medications in systemic lupus erythematosusSri Koneru
Division of Immunology, University of Cincinnati Medical Center, Cincinnati, OH, USA
J Clin Rheumatol 14:195-201. 2008..Lack of adherence is a ubiquitous problem which can be a hindrance in the treatment of chronic conditions like systemic lupus erythematosus (SLE)... - Monitoring methotrexate toxicity in juvenile idiopathic arthritisLakshmi Kocharla
Division of Rheumatology, University of Cincinnati Medical Center, Cincinnati, OH 45229 3039, USA
J Rheumatol 36:2813-8. 2009.... - Pediatric lupus--are there differences in presentation, genetics, response to therapy, and damage accrual compared with adult lupus?Rina Mina
Division of Rheumatology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MC 4010, Cincinnati, OH 45229, USA
Rheum Dis Clin North Am 36:53-80, vii-viii. 2010..Mortality rates remain higher with pediatric SLE. Children and adolescents accrue more damage, especially in the renal, ocular and musculoskeletal organ systems. Conversely, cardiovascular mortality is more prevalent in adults with SLE... - Functional magnetic resonance imaging assessment of cognitive function in childhood-onset systemic lupus erythematosus: a pilot studyMark W DiFrancesco
Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Arthritis Rheum 56:4151-63. 2007.... - Feasibility and construct validity of the parent willingness-to-pay technique for children with juvenile idiopathic arthritisAndrea C Barron
Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229-3039, USA
Arthritis Rheum 51:899-908. 2004..Relatively large WTP estimates support a possible important negative impact of the disease on families of children with JIA... - Association between lack of angiogenic response in muscle tissue and high expression of angiostatic ELR-negative CXC chemokines in patients with juvenile dermatomyositis: possible link to vasculopathyNdate Fall
Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Arthritis Rheum 52:3175-80. 2005..To investigate the relationship between the vasculopathy of juvenile dermatomyositis (juvenile DM) and the balance between the angiostatic ELR- and angiogenic ELR+ CXC chemokines in the muscle of patients with the disease... - An ACE inhibitor reduces Th2 cytokines and TGF-beta1 and TGF-beta2 isoforms in murine lupus nephritisDeijanira Alves De Albuquerque
Department of Internal Medicine, University of Cincinnati College of Medicine, Veterans Administration Medical Center and Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45267-0563, USA
Kidney Int 65:846-59. 2004..We argue here that ACE inhibitors not only act as selective TGF-beta inhibitors, but also as selective immunomodulators, to improve lupus nephritis... - The diagnostic significance of soluble CD163 and soluble interleukin-2 receptor alpha-chain in macrophage activation syndrome and untreated new-onset systemic juvenile idiopathic arthritisJack Bleesing
Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Arthritis Rheum 56:965-71. 2007..This study was undertaken to assess the value of serum sIL-2Ralpha and sCD163 in diagnosing acute macrophage activation syndrome complicating systemic juvenile idiopathic arthritis (JIA)... - Interferon-gamma:interleukin 4 ratios and associated type 1 cytokine expression in juvenile rheumatoid arthritis synovial tissueMichael P Scola
Department of Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA
J Rheumatol 29:369-78. 2002..The strong correlation between IFN-gamma and IL-12 in JRA suggests a prominent role for IL-12 in promoting the type I bias, while IL-15 and IL-18 may also indirectly increase IFN-gamma expression and further bias the immune response... - Pediatric rheumatology--its own specialtyClaas Hinze
Nat Clin Pract Rheumatol 4:279. 2008 - Targeting B cells in the treatment of childhood-onset systemic lupus erythematosusJennifer L Huggins
J Pediatr 148:571-3. 2006
Research Grants
- TRIPTORELIN FOR OVARY PROTECTION IN CHILDHOOD LIPUSHermine Brunner; Fiscal Year: 2007..Abstract Not Provided ..