John Bissler

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi request reprint Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial
    John J Bissler
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Lancet 381:817-24. 2013
  2. pmc Human TSC-associated renal angiomyolipoma cells are hypersensitive to ER stress
    Brian J Siroky
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, OH 45229 3039, USA
    Am J Physiol Renal Physiol 303:F831-44. 2012
  3. pmc Glomerulocystic kidney disease
    John J Bissler
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, MLC 7022, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Pediatr Nephrol 25:2049-56; quiz 2056-9. 2010
  4. pmc Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis
    John J Bissler
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    N Engl J Med 358:140-51. 2008
  5. ncbi request reprint Triplex DNA and human disease
    John J Bissler
    Department of Pediatrics, Division of Nephrology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Front Biosci 12:4536-46. 2007
  6. ncbi request reprint A mechanistic approach to inherited polycystic kidney disease
    John J Bissler
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Pediatr Nephrol 20:558-66. 2005
  7. ncbi request reprint Renal angiomyolipomata
    John J Bissler
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Kidney Int 66:924-34. 2004
  8. doi request reprint Characterization of Fabry disease in 352 pediatric patients in the Fabry Registry
    Robert J Hopkin
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Pediatr Res 64:550-5. 2008
  9. ncbi request reprint Stathmin-deficient mice develop fibrosis and show delayed recovery from ischemic-reperfusion injury
    Kamyar Zahedi
    Division of Nephrology and Hypertension, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Am J Physiol Renal Physiol 290:F1559-67. 2006
  10. ncbi request reprint Tuberous sclerosis complex: renal imaging findings
    Keith A Casper
    Department of Radiology, Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Radiology 225:451-6. 2002

Research Grants

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial
    John J Bissler
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Lancet 381:817-24. 2013
    ..We compared the angiomyolipoma response rate on everolimus with placebo in patients with tuberous sclerosis or sporadic lymphanioleiomyomatosis-associated angiomyolipomata...
  2. pmc Human TSC-associated renal angiomyolipoma cells are hypersensitive to ER stress
    Brian J Siroky
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, OH 45229 3039, USA
    Am J Physiol Renal Physiol 303:F831-44. 2012
    ..These results suggest that human angiomyolipoma cells are uniquely susceptible to agents that exacerbate ER stress and that additional synergy may be achievable with targeted combination therapy...
  3. pmc Glomerulocystic kidney disease
    John J Bissler
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, MLC 7022, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Pediatr Nephrol 25:2049-56; quiz 2056-9. 2010
    ....
  4. pmc Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis
    John J Bissler
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    N Engl J Med 358:140-51. 2008
    ..The drug sirolimus suppresses mTOR signaling...
  5. ncbi request reprint Triplex DNA and human disease
    John J Bissler
    Department of Pediatrics, Division of Nephrology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Front Biosci 12:4536-46. 2007
    ..Some alternative DNA structures are associated with human diseases, and this review focuses on disease-associated polypurine polypyrimidine mirror repeat sequences...
  6. ncbi request reprint A mechanistic approach to inherited polycystic kidney disease
    John J Bissler
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Pediatr Nephrol 20:558-66. 2005
    ..Renal cystogenesis may be the result of a disruption of a critical feedback loop that regulates tissue morphology based on the epithelial cell environment...
  7. ncbi request reprint Renal angiomyolipomata
    John J Bissler
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Kidney Int 66:924-34. 2004
    ..The purpose of this article is to update the nephrologist on the molecular understanding of renal angiomyolipomata and for the possibilities of pharmacologic therapy in the future...
  8. doi request reprint Characterization of Fabry disease in 352 pediatric patients in the Fabry Registry
    Robert J Hopkin
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Pediatr Res 64:550-5. 2008
    ..Thus, many pediatric Fabry patients report early symptoms, particularly pain, gastrointestinal symptoms, and impaired quality of life. Some children experience major complications during the pediatric years...
  9. ncbi request reprint Stathmin-deficient mice develop fibrosis and show delayed recovery from ischemic-reperfusion injury
    Kamyar Zahedi
    Division of Nephrology and Hypertension, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Am J Physiol Renal Physiol 290:F1559-67. 2006
    ....
  10. ncbi request reprint Tuberous sclerosis complex: renal imaging findings
    Keith A Casper
    Department of Radiology, Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Radiology 225:451-6. 2002
    ..To review the renal imaging findings and changes over time in a large series of young patients with tuberous sclerosis complex (TSC)...
  11. ncbi request reprint Reduction of postembolization syndrome after ablation of renal angiomyolipoma
    John J Bissler
    Division of Nephrology and Department of Radiology, Children s Hospital Medical Center, Cincinnati, OH, USA
    Am J Kidney Dis 39:966-71. 2002
    ..The use of a short-term tapering dose of prednisone appeared to reduce PES compared with the reported literature and improved patient comfort...
  12. doi request reprint Automated algorithm for quantifying the extent of cystic change on volumetric chest CT: initial results in Lymphangioleiomyomatosis
    Vincent J Schmithorst
    Department of Radiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    AJR Am J Roentgenol 192:1037-44. 2009
    ..The purpose of our study was to develop a new method for quantifying the severity of cystic lung disease using chest CT and to evaluate this method in patients with lymphangioleiomyomatosis (LAM)...
  13. doi request reprint Renal involvement in tuberous sclerosis complex and von Hippel-Lindau disease: shared disease mechanisms?
    Brian J Siroky
    Division of Nephrology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Nat Clin Pract Nephrol 5:143-56. 2009
    ..This Review summarizes the pathophysiologic and therapeutic overlap between tuberous sclerosis complex and von Hippel-Lindau disease and highlights the results of recent drug trials in these settings...
  14. ncbi request reprint Embolization of renal angiomyolipomata in patients with tuberous sclerosis complex
    Jarrod M Williams
    Division of Radiology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Am J Kidney Dis 47:95-102. 2006
    ..Our study examines the efficacy of selective embolization in decreasing tumor burden, preventing hemorrhage, and preserving renal function...
  15. ncbi request reprint Comparative evaluation of alpha-galactosidase A infusions for treatment of Fabry disease
    Robert J Hopkin
    Division and Program in Human Genetics, Cincinnati Children s Research Foundation, Cincinnati, Ohio 45229 3039, USA
    Genet Med 5:144-53. 2003
    ..In addition, the need for additional long-term data is emphasized because this is not attainable in short-term trials for a chronic disease...
  16. pmc RecQ and RecG helicases have distinct roles in maintaining the stability of polypurine.polypyrimidine sequences
    Bradley P Dixon
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, MLC 7022, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, United States
    Mutat Res 643:20-8. 2008
    ..5 kb Pu.Py tract containing multiple mirror repeats. These results support a two-tiered model where RecQ facilitates fork progression through triplex-forming tracts and, failing processivity, RecG is critical for replication fork restart...
  17. ncbi request reprint Frequency and imaging appearance of hepatic angiomyolipomas in pediatric and adult patients with tuberous sclerosis
    Bradley L Fricke
    Department of Radiology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    AJR Am J Roentgenol 182:1027-30. 2004
    ..This study evaluates the frequency and imaging appearance of hepatic angiomyolipomas in pediatric and adult patients with tuberous sclerosis...
  18. ncbi request reprint Spermidine/spermine N1-acetyltransferase overexpression in kidney epithelial cells disrupts polyamine homeostasis, leads to DNA damage, and causes G2 arrest
    Kamyar Zahedi
    Division of Nephrology and Hypertension, Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Am J Physiol Cell Physiol 292:C1204-15. 2007
    ..We propose that in kidneys subjected to IRI, one mechanism through which increased expression of SSAT may cause cellular injury and organ damage is through induction of DNA damage and the disruption of cell cycle...
  19. ncbi request reprint DNA lesion-specific co-localization of the Mre11/Rad50/Nbs1 (MRN) complex and replication protein A (RPA) to repair foci
    Jacob G Robison
    Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Biol Chem 280:12927-34. 2005
    ....
  20. pmc PKD1 intron 21: triplex DNA formation and effect on replication
    Hiren P Patel
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Nucleic Acids Res 32:1460-8. 2004
    ..During DNA replication, the G-rich template of the PKD1 Pu.Py tracts may form a triplex structure with the nascent strand, thereby blocking replication and potentially leading to recombination and mutation...
  21. ncbi request reprint Cell cycle-and proteasome-dependent formation of etoposide-induced replication protein A (RPA) or Mre11/Rad50/Nbs1 (MRN) complex repair foci
    Jacob G Robison
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Cell Cycle 6:2399-407. 2007
    ..These data suggest that in response to DNA DSBs, cell cycle-preferred repair pathways differentially engage RPA and the MRN complex in repair foci...
  22. pmc Serum vascular endothelial growth factor-D prospectively distinguishes lymphangioleiomyomatosis from other diseases
    Lisa R Young
    Division of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Chest 138:674-81. 2010
    ..The purpose of this study was to determine the prospective diagnostic usefulness of a serologic test for vascular endothelial growth factor-D (VEGF-D), a lymphangiogenic growth factor...
  23. ncbi request reprint Renal, hepatic, and marrow dysfunction in a patient with chronic renal insufficiency
    Rebecca C Brady
    Department of Pediatrics, Division of Nephrology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Pediatr Nephrol 18:293-6. 2003
    ..Doxycycline therapy and aggressive supportive care led to complete recovery...
  24. pmc Increased cancer risk of augmentation cystoplasty: possible role for hyperosmolal microenvironment on DNA damage recognition
    Bradley P Dixon
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Mutat Res 670:88-95. 2009
    ..Failure of such protective adaptations in the tissues used for augmentation cystoplasties may place these tissues at increased risk for malignancy...
  25. ncbi request reprint Replication protein A is required for etoposide-induced assembly of MRE11/RAD50/NBS1 complex repair foci
    Jacob G Robison
    Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Cell Cycle 6:2408-16. 2007
    ..These data support a role for RPA as an initial signal/sensor for DNA damage that facilitates recruitment of MRN and ATM/ATR to sites of damage, where they then work together to fully activate the DNA damage response...
  26. ncbi request reprint Unpaired structures in SCA10 (ATTCT)n.(AGAAT)n repeats
    Vladimir N Potaman
    Laboratory of DNA Structure and Function, Center for Genome Research, Institute of Biosciences and Technology, Texas A and M University System Health Sciences Center, Houston, TX 77030 3303, USA
    J Mol Biol 326:1095-111. 2003
    ..A model is proposed in which unscheduled or aberrant DNA replication is a critical step in the expansion mutation...
  27. pmc Unstable spinocerebellar ataxia type 10 (ATTCT*(AGAAT) repeats are associated with aberrant replication at the ATX10 locus and replication origin-dependent expansion at an ectopic site in human cells
    Guoqi Liu
    Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio 45435, USA
    Mol Cell Biol 27:7828-38. 2007
    ..These results implicate replication origin activity as one molecular mechanism associated with the instability of (ATTCT)n tracts that are longer than normal length...
  28. pmc Apolipoprotein J/clusterin prevents a progressive glomerulopathy of aging
    Mark E Rosenberg
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Minnesota, UMHC 736, 516 Delaware Street SE, Minneapolis, MN 55455, USA
    Mol Cell Biol 22:1893-902. 2002
    ..These results establish a protective role of apoJ/clusterin against chronic glomerular kidney disease and support the hypothesis that apoJ/clusterin modifies immune complex metabolism and disposal...

Research Grants6

  1. Utility of Rapamycin for the Treatment of Renal Angiomy*
    John Bissler; Fiscal Year: 2004
    ..Successful completion of the aim of this study will help to establish tuberous sclerosis as a valuable model for targeted molecular therapy for neoplasia. ..
  2. DNA Replication Fork: Pausing, Recombination and Disease
    John Bissler; Fiscal Year: 2007
    ..By understanding the effects of these sequences on the fidelity of DNA replication, therapeutic inroads into delaying disease onset can be made. ..