Research Topics
| David BernsteinSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
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Publications
Epidemiology, clinical presentation, and antibody response to primary infection with herpes simplex virus type 1 and type 2 in young womenDavid I Bernstein
Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
Clin Infect Dis 56:344-51. 2013..Herpes simplex virus infections type 1 (HSV-1) and type 2 (HSV-2) are common, but the epidemiology of HSV disease is changing...
Vaccines for cytomegalovirusD I Bernstein
Infect Disord Drug Targets 11:514-25. 2011..The optimal composition for a CMV vaccine remains to be defined but trials continue with the gB vaccine and others...- Amphipathic DNA polymers exhibit antiviral activity against systemic murine Cytomegalovirus infectionRhonda D Cardin
Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
Virol J 6:214. 2009..The activity of these agents against animal cytomegalovirus (CMV) infections in vitro and in vivo was therefore investigated... - The adjuvant CLDC increases protection of a herpes simplex type 2 glycoprotein D vaccine in guinea pigsDavid I Bernstein
Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
Vaccine 28:3748-53. 2010..CLDC enhanced protection compared to MPL/Alum and is the first vaccine to reduce recurrent virus shedding, a key to decreasing the spread of HSV-2... - A live attenuated human rotavirus vaccineDavid I Bernstein
Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Division of Infectious Diseases, Department of Pediatrics, Cincinnati, Ohio 45229, USA
Drugs Today (Barc) 43:281-91. 2007..The vaccine is administered as two oral doses with at least four weeks between doses. The first dose may be administered from the age of 6 weeks, and both doses should be completed by 24 weeks of age... - Amphipathic DNA polymers exhibit antiherpetic activity in vitro and in vivoDavid I Bernstein
Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
Antimicrob Agents Chemother 52:2727-33. 2008..001) and 60 min (50%, P = 0.07) against disease. These observations suggest that APs may have microbicidal activity and potential as broad-spectrum antiherpetic agents and represent a novel class of agents that should be studied further... 
Rotavirus overviewDavid I Bernstein
Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
Pediatr Infect Dis J 28:S50-3. 2009..Rotavirus vaccination is now included as part of the routine vaccination schedule for all infants in the United States...- Evaluations of unformulated and formulated dendrimer-based microbicide candidates in mouse and guinea pig models of genital herpesD I Bernstein
Division of Infectious Diseases, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Antimicrob Agents Chemother 47:3784-8. 2003..From these studies a lead compound and formulation (2V of SPL7013) was chosen for ongoing evaluations in primate models of simian immunodeficiency virus and Chlamydia trachomatis infection... - Potent adjuvant activity of cationic liposome-DNA complexes for genital herpes vaccinesDavid I Bernstein
Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
Clin Vaccine Immunol 16:699-705. 2009..CLDC appears to be a potent adjuvant for HSV vaccines and should be evaluated further... - Safety and immunogenicity of glycoprotein D-adjuvant genital herpes vaccineDavid I Bernstein
Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
Clin Infect Dis 40:1271-81. 2005.... - Live attenuated human rotavirus vaccine, RotarixDavid I Bernstein
Division of Infectious Diseases, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, OH 45229, USA
Semin Pediatr Infect Dis 17:188-94. 2006..Efficacy against severe rotavirus gastroenteritis and hospitalization have ranged from 85 to 100 percent... - Evaluation of imiquimod 5% cream to modify the natural history of herpes labialis: a pilot studyDavid I Bernstein
Children s Hospital Medical Center Division of Infectious Diseases, Cincinnati, OH 45229, USA
Clin Infect Dis 41:808-14. 2005..Therefore, we evaluated the safety and potential of topical imiquimod to decrease the rate of recurrence in humans with a history of recurrent herpes labialis... - N-Methanocarbathymidine is more effective than acyclovir for treating neonatal herpes simplex virus infection in guinea pigsDavid I Bernstein
Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, United States
Antiviral Res 92:386-8. 2011..In fact, (N)-MCT improved survival up to 3 dpi, the last time point evaluated. (N)-MCT was highly effective and superior to high dose ACV therapy for the treatment of neonatal herpes in the guinea pig model... - Safety and immunogenicity of a candidate parvovirus B19 vaccineDavid I Bernstein
Cincinnati Chidren s Hospital Medical Center, University of Cincinnati, 3333 Burnet Ave, ML 6014, Cincinnati, OH 45229, United States
Vaccine 29:7357-63. 2011..Given the possible severe consequences of parvovirus B19 infection, further development of a safe and effective vaccine continues to be important... - A randomized, double-blind, placebo-controlled, phase 1/2a study of the safety and immunogenicity of a live, attenuated human parainfluenza virus type 3 vaccine in healthy infantsDavid I Bernstein
Cincinnati Children s Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Vaccine 29:7042-8. 2011.... - Randomized, double-blind, Phase 1 trial of an alphavirus replicon vaccine for cytomegalovirus in CMV seronegative adult volunteersDavid I Bernstein
Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 44259, USA
Vaccine 28:484-93. 2009..This alphavirus replicon particle vaccine was safe and induced neutralizing antibody and multifunctional T cell responses against three CMV antigens that are important targets for protective immunity... - Second-year follow-up evaluation of live, attenuated human rotavirus vaccine 89-12 in healthy infantsDavid I Bernstein
Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
J Infect Dis 186:1487-9. 2002..001 for each). These encouraging results have led to continued evaluation, in several countries, of a vaccine candidate derived from strain 89-12... - Effects of herpes simplex virus type 2 glycoprotein vaccines and CLDC adjuvant on genital herpes infection in the guinea pigDavid I Bernstein
Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
Vaccine 29:2071-8. 2011..Improvements in HSV-2 vaccines may require inclusion of more T cell targets, more potent adjuvants or live virus vaccines... - Glycoprotein D adjuvant herpes simplex virus vaccineDavid Bernstein
Cincinnati Children s Hospital Medical Center, Division of Infectious Diseases, University of Cincinnati, Cincinnati, OH 45229, USA
Expert Rev Vaccines 4:615-27. 2005..A large ongoing trial in HSV seronegative females will provide additional data on protection from HSV disease and infection... - Effect of previous or simultaneous immunization with canarypox expressing cytomegalovirus (CMV) glycoprotein B (gB) on response to subunit gB vaccine plus MF59 in healthy CMV-seronegative adultsDavid I Bernstein
Division of Infectious Diseases, Children s Hospital Medical Center, CH 1, 3333 Burnet Ave Rm 1345, Cincinnati, Ohio 45229 3039, USA
J Infect Dis 185:686-90. 2002..All 3 vaccine regimens induced high-titer antibody and lymphoproliferative responses, but no benefit for priming or simultaneous vaccination was detected... - Protection against congenital cytomegalovirus infection and disease in guinea pigs, conferred by a purified recombinant glycoprotein B vaccineMark R Schleiss
Division of Infectious Diseases, Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
J Infect Dis 189:1374-81. 2004..These are the first data indicating that a recombinant gB vaccine protects against congenital CMV infection and disease... - Herpes simplex virus (HSV) type 2 glycoprotein D subunit vaccines and protection against genital HSV-1 or HSV-2 disease in guinea pigsNigel Bourne
Division of Infectious Diseases, Children s Hospital Medical Center, Cincinnati, Ohio, USA
J Infect Dis 187:542-9. 2003.... - Recurrent vaginal shedding of herpes simplex type 2 virus in the mouse and effects of antiviral therapyNicholas Farley
Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
Antiviral Res 86:188-95. 2010..Thus, this model provides an inexpensive model for evaluating therapeutic strategies and immune control of persistent HSV... - Preconception vaccination with a glycoprotein B (gB) DNA vaccine protects against cytomegalovirus (CMV) transmission in the guinea pig model of congenital CMV infectionMark R Schleiss
Division of Infectious Diseases, Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
J Infect Dis 188:1868-74. 2003..These data support the concept that subunit gB vaccination may be useful in protecting against CMV-induced disease... - A phase 1 study of 4 live, recombinant human cytomegalovirus Towne/Toledo chimeric vaccinesThomas C Heineman
Division of Infectious Diseases and Immunology, Saint Louis University School of Medicine, St Louis, Missouri 63110, and Division of Pediatric Infectious Diseases, Children s Hospital Medical Center, University of Cincinnati, OH, USA
J Infect Dis 193:1350-60. 2006..Although not evaluated for this indication, live attenuated HCMV vaccines based on the Towne strain are well-tolerated and have demonstrated moderate efficacy in other clinical settings... - Modification of primary and recurrent genital herpes in guinea pigs by passive immunizationNigel Bourne
Children s Hospital Medical Center, Division of Infectious Diseases, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
J Gen Virol 83:2797-801. 2002..The amount of DNA in the ganglia of As+72-treated animals was not significantly lower than that of controls. These observations have implications for both the dynamics of latency establishment and desirable vaccine characteristics... - Human papillomavirus vaccinesJessica A Kahn
Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
Pediatr Infect Dis J 22:443-5. 2003 - Longitudinal risk of herpes simplex virus (HSV) type 1, HSV type 2, and cytomegalovirus infections among young adolescent girlsLawrence R Stanberry
Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio, USA
Clin Infect Dis 39:1433-8. 2004..Cross-sectional seroprevalence studies indicate that infections with herpes simplex virus (HSV) types 1 (HSV-1) and 2 (HSV-2) and cytomegalovirus (CMV) are common. However, data on the rates of acquisition of these infections are limited... - An animal model of neonatal cytomegalovirus infectionFernando J Bravo
Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA
Antiviral Res 60:41-9. 2003..001) and viral replication but did not improve weight gain. This model should be useful for further evaluations of the pathogenesis of CMV infections and for evaluation of antiviral drugs and vaccines... - Viral sexually transmitted disease vaccine acceptability among college studentsConstance W Boehner
Department of Psychology, University of Cincinnati, Cincinnati, Ohio, USA
Sex Transm Dis 30:774-8. 2003..The object of this study was to examine factors that could affect vaccine acceptance among college students for 2 sexually transmitted diseases (STDs)... - Atopy as a risk factor for habitual snoring at age 1 yearManinder Kalra
Division of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
Chest 129:942-6. 2006..To determine the prevalence of habitual snoring (HS) in 1-year-old children, and to assess the relationship between HS and atopic status in these children... - Effect of asthma on the risk of obstructive sleep apnea syndrome in atopic womenManinder Kalra
Division of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, Ohio 45229, USA
Ann Allergy Asthma Immunol 97:231-5. 2006..Obstructive sleep apnea syndrome is associated with significant morbidity and remains underdiagnosed in women. Identification of high-risk groups among women is important for early detection and treatment... - Factors influencing pediatricians' intention to recommend human papillomavirus vaccinesJessica A Kahn
Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Ambul Pediatr 7:367-73. 2007.... - Rotarix: development of a live attenuated monovalent human rotavirus vaccineDavid I Bernstein
Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, OH 45229, USA
Pediatr Ann 35:38-43. 2006 - Estimating the rotavirus hospitalization disease burden and trends, using capture-recapture methodsMary Allen Staat
Division of Infectious Diseases, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Pediatr Infect Dis J 29:1083-6. 2010..Our objective was to use capture-recapture methods to estimate rotavirus hospitalization rates and to examine trends over time... - Age-related changes in magnitude and diversity of cross-reactive CD4+ T-cell responses to the novel pandemic H1N1 influenza hemagglutininRamu A Subbramanian
Cincinnati Children s Hospital Medical Center, Division of Infectious Diseases, Department of Pediatrics, Cincinnati, Ohio, USA
Hum Immunol 71:957-63. 2010..These results have important ramifications for our understanding of influenza immunity in humans and development of vaccine strategies against this important pathogen... - Adherence to the HPV vaccine dosing intervals and factors associated with completion of 3 dosesLea E Widdice
Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, MLC 4000, Cincinnati, OH 45229 3039, USA
Pediatrics 127:77-84. 2011..The objectives of this study were to determine (1) adherence to the immunization schedule for the human papillomavirus quadrivalent vaccine and (2) factors associated with completion of the 3-dose series... - Effects of adjuvants on the safety and immunogenicity of an avian influenza H5N1 vaccine in adultsDavid I Bernstein
Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
J Infect Dis 197:667-75. 2008..Influenza A H5N1 viruses pose a significant threat to human health... - Rhesus rotavirus vaccine effectiveness and factors associated with receipt of vaccineMary Allen Staat
Cincinnati Children s Hospital Medical Center, Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Pediatr Infect Dis J 25:1013-8. 2006..The objective of this study was to determine the effectiveness of the RotaShield vaccine against rotavirus gastroenteritis requiring hospitalization and to evaluate factors associated with vaccine receipt... - Reductions in cross-neutralizing antibody responses in infants after attenuation of the human rotavirus vaccine candidate 89-12Richard L Ward
Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Infect Dis 194:1729-36. 2006..Even so, the Rotarix vaccine developed from attenuated 89-12 was found to elicit excellent protection against non-G1 rotaviruses... - Rotarix: a rotavirus vaccine for the worldRichard L Ward
Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
Clin Infect Dis 48:222-8. 2009..This article describes the history of the development of the RIX4414 vaccine... - Personal meaning of human papillomavirus and Pap test results in adolescent and young adult womenJessica A Kahn
Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Health Psychol 26:192-200. 2007..The objective of this study was to explore personal meaning of HPV and Pap test results in adolescent and young adult women... - Oral hexadecyloxypropyl-cidofovir therapy in pregnant guinea pigs improves outcome in the congenital model of cytomegalovirus infectionFernando J Bravo
Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
Antimicrob Agents Chemother 55:35-41. 2011..Taken together, HDP-CDV shows potential as a well-tolerated antiviral candidate for treatment of congenital human CMV (HCMV) infection... - Effect of maternal treatment with cyclic HPMPC in the guinea pig model of congenital cytomegalovirus infectionFernando J Bravo
Cincinnati Children's Hospital Medical Center, OH 45229, USA
J Infect Dis 193:591-7. 2006..12 log(10) genome copies/ mu g of DNA (P < .0001). CONCLUSIONS: Treatment of the GPCMV-infected pregnant dam with 1 dose of cHPMPC improves the outcome of congenital infection and decreases viral replication in a guinea pig model... - The non-nucleoside antiviral, BAY 38-4766, protects against cytomegalovirus (CMV) disease and mortality in immunocompromised guinea pigsMark R Schleiss
Division of Infectious Diseases, Children s Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Antiviral Res 65:35-43. 2005..Mortality differences were accompanied by reduction in DNAemia in Hartley guinea pigs. Based upon its favorable safety, pharmacokinetic, and therapeutic profiles, BAY 38-4766 warrants further investigation in the GPCMV model... - Prevalence of diarrheagenic Escherichia coli in acute childhood enteritis: a prospective controlled studyMitchell B Cohen
Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Pediatr 146:54-61. 2005..Since diarrheagenic E. coli are not identified by common clinical laboratory techniques, we hypothesized that these organisms might be an unrecognized cause of enteritis in children in the U.S... - Attitudes about human papillomavirus vaccine in young womenJessica A Kahn
Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Int J STD AIDS 14:300-6. 2003..005), and higher number of sexual partners (P=0.028). Information on attitudes about HPV vaccination and predictors of intention to receive a vaccine may guide immunization initiatives for young adults... - A case-control study to determine risk factors for hospitalization for rotavirus gastroenteritis in U.S. childrenPenelope H Dennehy
Hasbro Children s Hospital and Brown Medical School, Department of Pediatrics, Division of Infectious Diseases, Providence, RI 02903
Pediatr Infect Dis J 25:1123-31. 2006.... - Lack of induction of autoantibody responses following immunization with cytomegalovirus (CMV) glycoprotein B (gB) in healthy CMV-seronegative subjectsMark R Schleiss
Division of Infectious Diseases, 3333 Burnet Avenue, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
Vaccine 23:687-92. 2004..These data reinforce the favorable safety profile of CMV gB vaccines... - Human papillomavirus vaccines and adolescentsJessica A Kahn
Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Curr Opin Obstet Gynecol 17:476-82. 2005..This review will describe human papillomavirus (HPV) vaccines in development, summarize data regarding safety and efficacy of these vaccines, and discuss key issues related to HPV vaccine implementation... - Treatment of herpes simplex virus infectionsRebecca C Brady
Cincinnati Children s Hospital Medical Center, Division of Infectious Diseases, 3333 Burnet Avenue, Mail Location 6014, Cincinnati, OH 45229 3039, USA
Antiviral Res 61:73-81. 2004..This article will review the common presentations for HSV disease and the current recommendations for the treatment of these infections. A detailed summary of the antiviral drugs used to treat HSV infections is also presented... - Factors predicting the acceptance of herpes simplex virus type 2 antibody testing among adolescents and young adultsGregory D Zimet
Department of Pediatrics, Indiana University School of Medicine, Indianapolis, USA
Sex Transm Dis 31:665-9. 2004..The rates and determinants of acceptance of herpes simplex virus type 2 (HSV-2) testing have not been adequately studied... - Comparison of adolescent and young adult self-collected and clinician-collected samples for human papillomavirusJessica A Kahn
Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Obstet Gynecol 103:952-9. 2004..To examine the concordance between self-collected and clinician-collected samples for human papillomavirus (HPV) DNA... - Psychological, behavioral, and interpersonal impact of human papillomavirus and Pap test resultsJessica A Kahn
Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
J Womens Health (Larchmt) 14:650-9. 2005..The purpose of this study was to explore the short-term psychological, behavioral, and interpersonal impact of human papillomavirus (HPV) and Pap results in adolescent and young adult women... - Rotavirus immunoglobulin a responses stimulated by each of 3 doses of a quadrivalent human/bovine reassortant rotavirus vaccineRichard L Ward
Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Infect Dis 189:2290-3. 2004..In total, 16, 19, and 15 vaccine recipients had increases after 1, 2, and 3 doses, respectively, indicating that a 3-dose regimen increased the immune response elicited by this vaccine... - Pediatricians' intention to administer human papillomavirus vaccine: the role of practice characteristics, knowledge, and attitudesJessica A Kahn
Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Adolesc Health 37:502-10. 2005..The objective of this study was to examine pediatrician characteristics and attitudes associated with intention to recommend two hypothetical human papillomavirus (HPV) vaccines... - Pandemic and seasonal H1N1 influenza hemagglutinin-specific T cell responses elicited by seasonal influenza vaccinationRamu A Subbramanian
Cincinnati Children s Hospital Medical Center, Division of Infectious Diseases, Department of Pediatrics, Cincinnati, OH, USA
Vaccine 28:8258-67. 2010..Cross reactive T cell responses to the pandemic H1N1 HA existed among the cohort before the circulation of the virus to varying degrees and these responses were boosted by seasonal vaccination... - Clinical presentations of rotavirus infection among hospitalized childrenMary Allen Staat
Division of Infectious Disease, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Pediatr Infect Dis J 21:221-7. 2002..Although rotaviruses (RVs) are the most common cause of severe gastroenteritis in children, there is a lack of information detailing the spectrum of clinical manifestations of RV disease resulting in hospitalization... - Effect of yearly vaccinations with live, attenuated, cold-adapted, trivalent, intranasal influenza vaccines on antibody responses in childrenDavid I Bernstein
Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, OH, USA
Pediatr Infect Dis J 22:28-34. 2003..The cold-adapted, trivalent influenza vaccine (CAIV-T) may become an option for annual vaccination. However, there is little information regarding the immune response to repeated immunization with CAIV-T... - Exposure to traffic exhaust and night cough during early childhood: the CCAAPS birth cohortHeidi Sucharew
Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
Pediatr Allergy Immunol 21:253-9. 2010..73, 95% CI: 0.53, 1.01). No other factors were significant. These results suggest that traffic exhaust exposure may be a risk factor for night cough in young children... - A model of human cytomegalovirus infection in severe combined immunodeficient miceFernando J Bravo
Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, ML 6014, Cincinnati, OH 45229 3039, USA
Antiviral Res 76:104-10. 2007..0001). These results indicate that the Gelfoam-HCMV SCID mouse model is suitable for the in vivo evaluation of new antivirals against HCMV and is simpler and more convenient than previous models... - Effective strategies for HPV vaccine delivery: the views of pediatriciansAbbigail M Tissot
Division of Adolescent Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
J Adolesc Health 41:119-25. 2007..The objectives of this research were to examine pediatricians' views about key issues related to HPV vaccine delivery and identify their strategies for effective vaccine delivery... - Quantitative-competitive PCR monitoring of viral load following experimental guinea pig cytomegalovirus infectionMark R Schleiss
Cincinnati Children s Hospital Medical Center, Division of Infectious Diseases, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
J Virol Methods 108:103-10. 2003..Viral load determination should be useful for monitoring outcomes following vaccine studies, as well as responses to experimental antiviral agents... - Acellular pertussis vaccines and complement killing of Bordetella pertussisAlison A Weiss
Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267 0524, USA
Infect Immun 72:7346-51. 2004..The responses of the other individuals were complex, with evidence of both beneficial and antagonistic responses occurring, sometimes in the same individual... - House dust bioactivities predict skin prick test reactivity for children with high risk of allergyHaejin Kim
Department of Medicine, University of Cincinnati, Cincinnati, Ohio, USA
J Allergy Clin Immunol 129:1529-37.e2. 2012.... - Evaluation of the clinical efficacy and safety of grapeseed extract in the treatment of fall seasonal allergic rhinitis: a pilot studyDavid I Bernstein
Division of Immunology, University of Cincinnati College of Medicine, Ohio 45267, USA
Ann Allergy Asthma Immunol 88:272-8. 2002..No significant laboratory abnormalities were detected. CONCLUSIONS: This study did not show trends supporting the efficacy of GSE in the treatment of SAR... - Antibody-mediated neutralization of pertussis toxin-induced mitogenicity of human peripheral blood mononuclear cellsScott H Millen
Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, Cincinnati, Ohio 45267, USA
Infect Immun 72:615-20. 2004..the convalescent group had higher titers in the PBMC assay. Results for pertussis toxin neutralization with the CHO assay appear to be distinct from those with the PBMC assay... - Rotavirus meningoencephalitis in a previously healthy child and a review of the literatureMichelle Dickey
Division of Infectious Disease, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
Pediatr Infect Dis J 28:318-21. 2009..A review of the literature describes 23 cases of central nervous system disease attributed to rotavirus... - The underrecognized burden of influenza in young childrenKatherine A Poehling
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, USA
N Engl J Med 355:31-40. 2006..CONCLUSIONS: Among young children, outpatient visits associated with influenza were 10 to 250 times as common as hospitalizations. Few influenza infections were recognized clinically... - Diisocyanate antigen-stimulated monocyte chemoattractant protein-1 synthesis has greater test efficiency than specific antibodies for identification of diisocyanate asthmaDavid I Bernstein
Department of Internal Medicine, Division of Immunology, College of Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267 0563, USA
Am J Respir Crit Care Med 166:445-50. 2002..This study indicates that the MCP-1 stimulation assay has greater sensitivity and specificity than the specific antibody assays in correctly identifying DA... - The potential impact of a prophylactic herpes simplex vaccineRichard Rupp
Division of Adolescent and Behavioral Health, Department of Pediatrics, 301 University Blvd, Galveston, TX 77555 1119, USA
Expert Opin Emerg Drugs 13:41-52. 2008..HSV infection acquired perinatally may result in severe sequelae or even death despite appropriate therapy. Furthermore, it is becoming increasingly clear that genital HSV infections significantly raise the risk of HIV transmission... - Rotavirus deaths: rare or unrecognized?Mary Allen Staat
University of Cincinnati, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, Division of Infectious Diseases, Ohio 45229, USA
Clin Pediatr (Phila) 44:535-7. 2005 - Influence of dog ownership and high endotoxin on wheezing and atopy during infancyPaloma Campo
Department of Internal Medicine, Immunology Division, University of Cincinnati, Cincinnati, OH 45267-0563, USA
J Allergy Clin Immunol 118:1271-8. 2006..CLINICAL IMPLICATIONS: A home environment with many dogs and high levels of endotoxin may be conducive to reduced wheezing in infancy... - Mold damage in homes and wheezing in infantsSeung-Hyun Cho
Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio 45267-0056, USA
Ann Allergy Asthma Immunol 97:539-45. 2006..CONCLUSIONS: Visible mold was shown to be a significant risk factor for recurrent wheezing in infants at high risk of developing atopic disorders, whereas HDM exposure did not significantly increase the risk... - Is it traffic type, volume, or distance? Wheezing in infants living near truck and bus trafficPatrick H Ryan
Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267 0056, USA
J Allergy Clin Immunol 116:279-84. 2005..Previous studies of air pollution have not examined the association between exposure to varying types, distance, and amounts of traffic and wheezing in very young infants... - Environmental risk factors of rhinitis in early infancyJocelyn M Biagini
Department of Environmental Health, University of Cincinnati, and Division of Allergy and Immunology, Department of Pediatrics, Cincinati Children s Hospital Medical Center, OH 45267 0056, USA
Pediatr Allergy Immunol 17:278-84. 2006..This study suggests that ETS exposure, rather than visible mold, is associated with rhinitis and allergic rhinitis in infants. The analysis also suggests that mold may be a stronger risk factor for URI that ETS... - Allergy diagnostic testing: an updated practice parameterI Leonard Bernstein
University of Cincinnati College of Medicine, Ohio, USA
Ann Allergy Asthma Immunol 100:S1-148. 2008 - Vaccination success rate and reaction profile with diluted and undiluted smallpox vaccine: a randomized controlled trialThomas R Talbot
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.S
JAMA 292:1205-12. 2004..However, reactogenicity was not reduced with dilution of the vaccine and, as with other smallpox vaccines, may impair daily activities... - Nonmedical costs associated with rotavirus disease requiring hospitalizationBrian P Lee
Children s Hospital and Research Center at Oakland, Oakland, CA, USA
Pediatr Infect Dis J 24:984-8. 2005..Herein, we report the results from the largest prospective study in the United States determining the nonmedical costs of severe rotavirus infections... - Development of candidate rotavirus vaccines derived from neonatal strains in IndiaRoger I Glass
Respiratory and Enteric Viruses Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Infect Dis 192:S30-5. 2005..This unique project, which is developing a new rotavirus vaccine in India with the use of Indian strains, an Indian manufacturer, and an Indian clinical development program, aims to expedite introduction of rotavirus vaccines in India... - Transmissibility, infectivity and immunogenicity of a live human parainfluenza type 3 virus vaccine (HPIV3cp45) among susceptible infants and toddlersShabir A Madhi
University of the Witwatersrand Medical Research Council Respiratory and Meningeal Pathogens Research Unit, South Africa
Vaccine 24:2432-9. 2006..This study examined the transmissibility between young children of an intranasally administered live attenuated human parainfluenza virus type 3 (HPIV3)-cp45 vaccine candidate... - Glycoprotein-D-adjuvant vaccine to prevent genital herpesLawrence R Stanberry
Department of Pediatrics and Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston 77555 0351, USA
N Engl J Med 347:1652-61. 2002..An effective prophylactic vaccine would help control the spread of genital herpes... - RIX4414 (Rotarix): a live attenuated human rotavirus vaccineDavid I Bernstein
J Pediatr (Rio J) 83:193-5. 2007 - Use of active surveillance to validate international classification of diseases code estimates of rotavirus hospitalizations in childrenVincent P Hsu
Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Pediatrics 115:78-82. 2005..Our study evaluated the sensitivity of the rotavirus ICD code among children hospitalized for AGE by using active surveillance for rotavirus at a tertiary children's hospital... - Safety and immunogenicity of concurrent administration of live attenuated influenza vaccine with measles-mumps-rubella and varicella vaccines to infants 12 to 15 months of ageTerry Nolan
School of Population Health, University of Melbourne and Murdoch Children s Research Institute, Carlton, Melbourne, Victoria 3010, Australia
Pediatrics 121:508-16. 2008..This study evaluated the safety, tolerability, and immunogenicity of live attenuated influenza vaccine administered concurrently with measles-mumps-rubella vaccine and varicella vaccine to healthy children 12 to 15 months of age... - Predictors of herpes simplex virus type 2 antibody positivity among persons with no history of genital herpesKenneth H Fife
Department of Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
Sex Transm Dis 31:676-81. 2004..The demographic, historical, and behavioral factors that predict a positive herpes simplex virus type 2 (HSV-2) antibody test in persons without a history of genital herpes have not been well-defined... - Safety, efficacy, and immunogenicity of a live, quadrivalent human-bovine reassortant rotavirus vaccine in healthy infantsH Fred Clark
University of Pennsylvania School of Medicine, Philadelphia, and Merck and Co, Inc, West Point, Pennsylvania 19486, USA
J Pediatr 144:184-90. 2004..CONCLUSIONS: QRV was generally well tolerated, immungenic, and highly effective against rotavirus gastroenteritis... - Optimum diagnostic assay and clinical specimen for routine rotavirus surveillanceLauren J Stockman
National Center for Immunization and Respiratory Diseases, Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Clin Microbiol 46:1842-3. 2008..Testing of bulk stools by EIA appears to be optimum for rotavirus surveillance... - Safety of the trivalent, cold-adapted influenza vaccine in preschool-aged childrenPedro A Piedra
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
Pediatrics 110:662-72. 2002..To provide additional information on the safety of trivalent, cold-adapted influenza vaccine (CAIV-T) in children... - Bordetella Pertussis infections in vaccinated and unvaccinated adolescents and adults, as assessed in a national prospective randomized Acellular Pertussis Vaccine Trial (APERT)Joel I Ward
University of California Los Angeles UCLA Center for Vaccine Research, Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, David Geffen School of Medicine UCLA, Torrance, California 90502 2502, USA
Clin Infect Dis 43:151-7. 2006..Acellular pertussis (aP) booster immunizations have been recommended for adolescents and older persons to enhance long-term protection and to possibly reduce community transmission of infections... - Return for results after herpes simplex virus type 2 screeningJ Dennis Fortenberry
Indiana University School of Medicine, Indianapolis, USA
Sex Transm Dis 31:655-8. 2004..The objective of this study was to evaluate factors associated with return for results of type-specific herpes simplex virus (HSV) screening...