David Bernstein

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc Epidemiology, clinical presentation, and antibody response to primary infection with herpes simplex virus type 1 and type 2 in young women
    David I Bernstein
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    Clin Infect Dis 56:344-51. 2013
  2. ncbi request reprint Vaccines for cytomegalovirus
    D I Bernstein
    Infect Disord Drug Targets 11:514-25. 2011
  3. pmc Amphipathic DNA polymers exhibit antiviral activity against systemic murine Cytomegalovirus infection
    Rhonda D Cardin
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Virol J 6:214. 2009
  4. ncbi request reprint A live attenuated human rotavirus vaccine
    David I Bernstein
    Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Division of Infectious Diseases, Department of Pediatrics, Cincinnati, Ohio 45229, USA
    Drugs Today (Barc) 43:281-91. 2007
  5. pmc Amphipathic DNA polymers exhibit antiherpetic activity in vitro and in vivo
    David I Bernstein
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Antimicrob Agents Chemother 52:2727-33. 2008
  6. ncbi request reprint Glycoprotein D adjuvant herpes simplex virus vaccine
    David Bernstein
    Cincinnati Children s Hospital Medical Center, Division of Infectious Diseases, University of Cincinnati, Cincinnati, OH 45229, USA
    Expert Rev Vaccines 4:615-27. 2005
  7. ncbi request reprint Evaluation of imiquimod 5% cream to modify the natural history of herpes labialis: a pilot study
    David I Bernstein
    Children s Hospital Medical Center Division of Infectious Diseases, Cincinnati, OH 45229, USA
    Clin Infect Dis 41:808-14. 2005
  8. doi request reprint Rotavirus overview
    David I Bernstein
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    Pediatr Infect Dis J 28:S50-3. 2009
  9. doi request reprint A randomized, double-blind, placebo-controlled, phase 1/2a study of the safety and immunogenicity of a live, attenuated human parainfluenza virus type 3 vaccine in healthy infants
    David I Bernstein
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Vaccine 29:7042-8. 2011
  10. pmc Potent adjuvant activity of cationic liposome-DNA complexes for genital herpes vaccines
    David I Bernstein
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Clin Vaccine Immunol 16:699-705. 2009

Detail Information

Publications92

  1. pmc Epidemiology, clinical presentation, and antibody response to primary infection with herpes simplex virus type 1 and type 2 in young women
    David I Bernstein
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    Clin Infect Dis 56:344-51. 2013
    ..Herpes simplex virus infections type 1 (HSV-1) and type 2 (HSV-2) are common, but the epidemiology of HSV disease is changing...
  2. ncbi request reprint Vaccines for cytomegalovirus
    D I Bernstein
    Infect Disord Drug Targets 11:514-25. 2011
    ..The optimal composition for a CMV vaccine remains to be defined but trials continue with the gB vaccine and others...
  3. pmc Amphipathic DNA polymers exhibit antiviral activity against systemic murine Cytomegalovirus infection
    Rhonda D Cardin
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Virol J 6:214. 2009
    ..The activity of these agents against animal cytomegalovirus (CMV) infections in vitro and in vivo was therefore investigated...
  4. ncbi request reprint A live attenuated human rotavirus vaccine
    David I Bernstein
    Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Division of Infectious Diseases, Department of Pediatrics, Cincinnati, Ohio 45229, USA
    Drugs Today (Barc) 43:281-91. 2007
    ..The vaccine is administered as two oral doses with at least four weeks between doses. The first dose may be administered from the age of 6 weeks, and both doses should be completed by 24 weeks of age...
  5. pmc Amphipathic DNA polymers exhibit antiherpetic activity in vitro and in vivo
    David I Bernstein
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Antimicrob Agents Chemother 52:2727-33. 2008
    ..001) and 60 min (50%, P = 0.07) against disease. These observations suggest that APs may have microbicidal activity and potential as broad-spectrum antiherpetic agents and represent a novel class of agents that should be studied further...
  6. ncbi request reprint Glycoprotein D adjuvant herpes simplex virus vaccine
    David Bernstein
    Cincinnati Children s Hospital Medical Center, Division of Infectious Diseases, University of Cincinnati, Cincinnati, OH 45229, USA
    Expert Rev Vaccines 4:615-27. 2005
    ..A large ongoing trial in HSV seronegative females will provide additional data on protection from HSV disease and infection...
  7. ncbi request reprint Evaluation of imiquimod 5% cream to modify the natural history of herpes labialis: a pilot study
    David I Bernstein
    Children s Hospital Medical Center Division of Infectious Diseases, Cincinnati, OH 45229, USA
    Clin Infect Dis 41:808-14. 2005
    ..Therefore, we evaluated the safety and potential of topical imiquimod to decrease the rate of recurrence in humans with a history of recurrent herpes labialis...
  8. doi request reprint Rotavirus overview
    David I Bernstein
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    Pediatr Infect Dis J 28:S50-3. 2009
    ..Rotavirus vaccination is now included as part of the routine vaccination schedule for all infants in the United States...
  9. doi request reprint A randomized, double-blind, placebo-controlled, phase 1/2a study of the safety and immunogenicity of a live, attenuated human parainfluenza virus type 3 vaccine in healthy infants
    David I Bernstein
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Vaccine 29:7042-8. 2011
    ....
  10. pmc Potent adjuvant activity of cationic liposome-DNA complexes for genital herpes vaccines
    David I Bernstein
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Clin Vaccine Immunol 16:699-705. 2009
    ..CLDC appears to be a potent adjuvant for HSV vaccines and should be evaluated further...
  11. ncbi request reprint Safety and immunogenicity of glycoprotein D-adjuvant genital herpes vaccine
    David I Bernstein
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Clin Infect Dis 40:1271-81. 2005
    ....
  12. pmc The adjuvant CLDC increases protection of a herpes simplex type 2 glycoprotein D vaccine in guinea pigs
    David I Bernstein
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
    Vaccine 28:3748-53. 2010
    ..CLDC enhanced protection compared to MPL/Alum and is the first vaccine to reduce recurrent virus shedding, a key to decreasing the spread of HSV-2...
  13. pmc Evaluations of unformulated and formulated dendrimer-based microbicide candidates in mouse and guinea pig models of genital herpes
    D I Bernstein
    Division of Infectious Diseases, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Antimicrob Agents Chemother 47:3784-8. 2003
    ..From these studies a lead compound and formulation (2V of SPL7013) was chosen for ongoing evaluations in primate models of simian immunodeficiency virus and Chlamydia trachomatis infection...
  14. doi request reprint Randomized, double-blind, Phase 1 trial of an alphavirus replicon vaccine for cytomegalovirus in CMV seronegative adult volunteers
    David I Bernstein
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 44259, USA
    Vaccine 28:484-93. 2009
    ..This alphavirus replicon particle vaccine was safe and induced neutralizing antibody and multifunctional T cell responses against three CMV antigens that are important targets for protective immunity...
  15. pmc N-Methanocarbathymidine is more effective than acyclovir for treating neonatal herpes simplex virus infection in guinea pigs
    David I Bernstein
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, United States
    Antiviral Res 92:386-8. 2011
    ..In fact, (N)-MCT improved survival up to 3 dpi, the last time point evaluated. (N)-MCT was highly effective and superior to high dose ACV therapy for the treatment of neonatal herpes in the guinea pig model...
  16. pmc Safety and immunogenicity of a candidate parvovirus B19 vaccine
    David I Bernstein
    Cincinnati Chidren s Hospital Medical Center, University of Cincinnati, 3333 Burnet Ave, ML 6014, Cincinnati, OH 45229, United States
    Vaccine 29:7357-63. 2011
    ..Given the possible severe consequences of parvovirus B19 infection, further development of a safe and effective vaccine continues to be important...
  17. ncbi request reprint Second-year follow-up evaluation of live, attenuated human rotavirus vaccine 89-12 in healthy infants
    David I Bernstein
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Infect Dis 186:1487-9. 2002
    ..001 for each). These encouraging results have led to continued evaluation, in several countries, of a vaccine candidate derived from strain 89-12...
  18. pmc Effects of herpes simplex virus type 2 glycoprotein vaccines and CLDC adjuvant on genital herpes infection in the guinea pig
    David I Bernstein
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    Vaccine 29:2071-8. 2011
    ..Improvements in HSV-2 vaccines may require inclusion of more T cell targets, more potent adjuvants or live virus vaccines...
  19. ncbi request reprint Live attenuated human rotavirus vaccine, Rotarix
    David I Bernstein
    Division of Infectious Diseases, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, OH 45229, USA
    Semin Pediatr Infect Dis 17:188-94. 2006
    ..Efficacy against severe rotavirus gastroenteritis and hospitalization have ranged from 85 to 100 percent...
  20. ncbi request reprint Effect of previous or simultaneous immunization with canarypox expressing cytomegalovirus (CMV) glycoprotein B (gB) on response to subunit gB vaccine plus MF59 in healthy CMV-seronegative adults
    David I Bernstein
    Division of Infectious Diseases, Children s Hospital Medical Center, CH 1, 3333 Burnet Ave Rm 1345, Cincinnati, Ohio 45229 3039, USA
    J Infect Dis 185:686-90. 2002
    ..All 3 vaccine regimens induced high-titer antibody and lymphoproliferative responses, but no benefit for priming or simultaneous vaccination was detected...
  21. ncbi request reprint Protection against congenital cytomegalovirus infection and disease in guinea pigs, conferred by a purified recombinant glycoprotein B vaccine
    Mark R Schleiss
    Division of Infectious Diseases, Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    J Infect Dis 189:1374-81. 2004
    ..These are the first data indicating that a recombinant gB vaccine protects against congenital CMV infection and disease...
  22. ncbi request reprint Herpes simplex virus (HSV) type 2 glycoprotein D subunit vaccines and protection against genital HSV-1 or HSV-2 disease in guinea pigs
    Nigel Bourne
    Division of Infectious Diseases, Children s Hospital Medical Center, Cincinnati, Ohio, USA
    J Infect Dis 187:542-9. 2003
    ....
  23. ncbi request reprint Preconception vaccination with a glycoprotein B (gB) DNA vaccine protects against cytomegalovirus (CMV) transmission in the guinea pig model of congenital CMV infection
    Mark R Schleiss
    Division of Infectious Diseases, Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    J Infect Dis 188:1868-74. 2003
    ..These data support the concept that subunit gB vaccination may be useful in protecting against CMV-induced disease...
  24. pmc Recurrent vaginal shedding of herpes simplex type 2 virus in the mouse and effects of antiviral therapy
    Nicholas Farley
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
    Antiviral Res 86:188-95. 2010
    ..Thus, this model provides an inexpensive model for evaluating therapeutic strategies and immune control of persistent HSV...
  25. ncbi request reprint A phase 1 study of 4 live, recombinant human cytomegalovirus Towne/Toledo chimeric vaccines
    Thomas C Heineman
    Division of Infectious Diseases and Immunology, Saint Louis University School of Medicine, St Louis, Missouri 63110, and Division of Pediatric Infectious Diseases, Children s Hospital Medical Center, University of Cincinnati, OH, USA
    J Infect Dis 193:1350-60. 2006
    ..Although not evaluated for this indication, live attenuated HCMV vaccines based on the Towne strain are well-tolerated and have demonstrated moderate efficacy in other clinical settings...
  26. ncbi request reprint Longitudinal risk of herpes simplex virus (HSV) type 1, HSV type 2, and cytomegalovirus infections among young adolescent girls
    Lawrence R Stanberry
    Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Clin Infect Dis 39:1433-8. 2004
    ..Cross-sectional seroprevalence studies indicate that infections with herpes simplex virus (HSV) types 1 (HSV-1) and 2 (HSV-2) and cytomegalovirus (CMV) are common. However, data on the rates of acquisition of these infections are limited...
  27. ncbi request reprint Human papillomavirus vaccines
    Jessica A Kahn
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Pediatr Infect Dis J 22:443-5. 2003
  28. ncbi request reprint Modification of primary and recurrent genital herpes in guinea pigs by passive immunization
    Nigel Bourne
    Children s Hospital Medical Center, Division of Infectious Diseases, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    J Gen Virol 83:2797-801. 2002
    ..The amount of DNA in the ganglia of As+72-treated animals was not significantly lower than that of controls. These observations have implications for both the dynamics of latency establishment and desirable vaccine characteristics...
  29. ncbi request reprint Viral sexually transmitted disease vaccine acceptability among college students
    Constance W Boehner
    Department of Psychology, University of Cincinnati, Cincinnati, Ohio, USA
    Sex Transm Dis 30:774-8. 2003
    ..The object of this study was to examine factors that could affect vaccine acceptance among college students for 2 sexually transmitted diseases (STDs)...
  30. ncbi request reprint An animal model of neonatal cytomegalovirus infection
    Fernando J Bravo
    Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Antiviral Res 60:41-9. 2003
    ..001) and viral replication but did not improve weight gain. This model should be useful for further evaluations of the pathogenesis of CMV infections and for evaluation of antiviral drugs and vaccines...
  31. pmc Effect of asthma on the risk of obstructive sleep apnea syndrome in atopic women
    Maninder Kalra
    Division of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, Ohio 45229, USA
    Ann Allergy Asthma Immunol 97:231-5. 2006
    ..Obstructive sleep apnea syndrome is associated with significant morbidity and remains underdiagnosed in women. Identification of high-risk groups among women is important for early detection and treatment...
  32. pmc Atopy as a risk factor for habitual snoring at age 1 year
    Maninder Kalra
    Division of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Chest 129:942-6. 2006
    ..To determine the prevalence of habitual snoring (HS) in 1-year-old children, and to assess the relationship between HS and atopic status in these children...
  33. ncbi request reprint Prevalence of diarrheagenic Escherichia coli in acute childhood enteritis: a prospective controlled study
    Mitchell B Cohen
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Pediatr 146:54-61. 2005
    ..Since diarrheagenic E. coli are not identified by common clinical laboratory techniques, we hypothesized that these organisms might be an unrecognized cause of enteritis in children in the U.S...
  34. ncbi request reprint Rotarix: development of a live attenuated monovalent human rotavirus vaccine
    David I Bernstein
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, OH 45229, USA
    Pediatr Ann 35:38-43. 2006
  35. doi request reprint Effects of adjuvants on the safety and immunogenicity of an avian influenza H5N1 vaccine in adults
    David I Bernstein
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    J Infect Dis 197:667-75. 2008
    ..Influenza A H5N1 viruses pose a significant threat to human health...
  36. pmc Adherence to the HPV vaccine dosing intervals and factors associated with completion of 3 doses
    Lea E Widdice
    Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, MLC 4000, Cincinnati, OH 45229 3039, USA
    Pediatrics 127:77-84. 2011
    ..The objectives of this study were to determine (1) adherence to the immunization schedule for the human papillomavirus quadrivalent vaccine and (2) factors associated with completion of the 3-dose series...
  37. ncbi request reprint Factors influencing pediatricians' intention to recommend human papillomavirus vaccines
    Jessica A Kahn
    Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Ambul Pediatr 7:367-73. 2007
    ....
  38. ncbi request reprint Treatment of herpes simplex virus infections
    Rebecca C Brady
    Cincinnati Children s Hospital Medical Center, Division of Infectious Diseases, 3333 Burnet Avenue, Mail Location 6014, Cincinnati, OH 45229 3039, USA
    Antiviral Res 61:73-81. 2004
    ..This article will review the common presentations for HSV disease and the current recommendations for the treatment of these infections. A detailed summary of the antiviral drugs used to treat HSV infections is also presented...
  39. ncbi request reprint Personal meaning of human papillomavirus and Pap test results in adolescent and young adult women
    Jessica A Kahn
    Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Health Psychol 26:192-200. 2007
    ..The objective of this study was to explore personal meaning of HPV and Pap test results in adolescent and young adult women...
  40. ncbi request reprint Attitudes about human papillomavirus vaccine in young women
    Jessica A Kahn
    Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Int J STD AIDS 14:300-6. 2003
    ..005), and higher number of sexual partners (P=0.028). Information on attitudes about HPV vaccination and predictors of intention to receive a vaccine may guide immunization initiatives for young adults...
  41. ncbi request reprint Estimating the rotavirus hospitalization disease burden and trends, using capture-recapture methods
    Mary Allen Staat
    Division of Infectious Diseases, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Pediatr Infect Dis J 29:1083-6. 2010
    ..Our objective was to use capture-recapture methods to estimate rotavirus hospitalization rates and to examine trends over time...
  42. ncbi request reprint A case-control study to determine risk factors for hospitalization for rotavirus gastroenteritis in U.S. children
    Penelope H Dennehy
    Hasbro Children s Hospital and Brown Medical School, Department of Pediatrics, Division of Infectious Diseases, Providence, RI 02903
    Pediatr Infect Dis J 25:1123-31. 2006
    ....
  43. ncbi request reprint Rhesus rotavirus vaccine effectiveness and factors associated with receipt of vaccine
    Mary Allen Staat
    Cincinnati Children s Hospital Medical Center, Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Pediatr Infect Dis J 25:1013-8. 2006
    ..The objective of this study was to determine the effectiveness of the RotaShield vaccine against rotavirus gastroenteritis requiring hospitalization and to evaluate factors associated with vaccine receipt...
  44. ncbi request reprint Effect of maternal treatment with cyclic HPMPC in the guinea pig model of congenital cytomegalovirus infection
    Fernando J Bravo
    Cincinnati Children s Hospital Medical Center, OH 45229, USA
    J Infect Dis 193:591-7. 2006
    ..Using the guinea pig model of congenital CMV infection, we sought to determine whether antiviral treatment of a CMV-infected dam could improve the outcome of offspring...
  45. pmc Oral hexadecyloxypropyl-cidofovir therapy in pregnant guinea pigs improves outcome in the congenital model of cytomegalovirus infection
    Fernando J Bravo
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    Antimicrob Agents Chemother 55:35-41. 2011
    ..Taken together, HDP-CDV shows potential as a well-tolerated antiviral candidate for treatment of congenital human CMV (HCMV) infection...
  46. pmc The non-nucleoside antiviral, BAY 38-4766, protects against cytomegalovirus (CMV) disease and mortality in immunocompromised guinea pigs
    Mark R Schleiss
    Division of Infectious Diseases, Children s Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Antiviral Res 65:35-43. 2005
    ..Mortality differences were accompanied by reduction in DNAemia in Hartley guinea pigs. Based upon its favorable safety, pharmacokinetic, and therapeutic profiles, BAY 38-4766 warrants further investigation in the GPCMV model...
  47. ncbi request reprint Lack of induction of autoantibody responses following immunization with cytomegalovirus (CMV) glycoprotein B (gB) in healthy CMV-seronegative subjects
    Mark R Schleiss
    Division of Infectious Diseases, 3333 Burnet Avenue, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Vaccine 23:687-92. 2004
    ..These data reinforce the favorable safety profile of CMV gB vaccines...
  48. ncbi request reprint Comparison of adolescent and young adult self-collected and clinician-collected samples for human papillomavirus
    Jessica A Kahn
    Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Obstet Gynecol 103:952-9. 2004
    ..To examine the concordance between self-collected and clinician-collected samples for human papillomavirus (HPV) DNA...
  49. ncbi request reprint Factors predicting the acceptance of herpes simplex virus type 2 antibody testing among adolescents and young adults
    Gregory D Zimet
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, USA
    Sex Transm Dis 31:665-9. 2004
    ..The rates and determinants of acceptance of herpes simplex virus type 2 (HSV-2) testing have not been adequately studied...
  50. doi request reprint Age-related changes in magnitude and diversity of cross-reactive CD4+ T-cell responses to the novel pandemic H1N1 influenza hemagglutinin
    Ramu A Subbramanian
    Cincinnati Children s Hospital Medical Center, Division of Infectious Diseases, Department of Pediatrics, Cincinnati, Ohio, USA
    Hum Immunol 71:957-63. 2010
    ..These results have important ramifications for our understanding of influenza immunity in humans and development of vaccine strategies against this important pathogen...
  51. ncbi request reprint Human papillomavirus vaccines and adolescents
    Jessica A Kahn
    Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Curr Opin Obstet Gynecol 17:476-82. 2005
    ..This review will describe human papillomavirus (HPV) vaccines in development, summarize data regarding safety and efficacy of these vaccines, and discuss key issues related to HPV vaccine implementation...
  52. ncbi request reprint Psychological, behavioral, and interpersonal impact of human papillomavirus and Pap test results
    Jessica A Kahn
    Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Womens Health (Larchmt) 14:650-9. 2005
    ..The purpose of this study was to explore the short-term psychological, behavioral, and interpersonal impact of human papillomavirus (HPV) and Pap results in adolescent and young adult women...
  53. ncbi request reprint Rotavirus immunoglobulin a responses stimulated by each of 3 doses of a quadrivalent human/bovine reassortant rotavirus vaccine
    Richard L Ward
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Infect Dis 189:2290-3. 2004
    ..In total, 16, 19, and 15 vaccine recipients had increases after 1, 2, and 3 doses, respectively, indicating that a 3-dose regimen increased the immune response elicited by this vaccine...
  54. doi request reprint Rotarix: a rotavirus vaccine for the world
    Richard L Ward
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Clin Infect Dis 48:222-8. 2009
    ..This article describes the history of the development of the RIX4414 vaccine...
  55. ncbi request reprint Pediatricians' intention to administer human papillomavirus vaccine: the role of practice characteristics, knowledge, and attitudes
    Jessica A Kahn
    Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Adolesc Health 37:502-10. 2005
    ..The objective of this study was to examine pediatrician characteristics and attitudes associated with intention to recommend two hypothetical human papillomavirus (HPV) vaccines...
  56. ncbi request reprint Reductions in cross-neutralizing antibody responses in infants after attenuation of the human rotavirus vaccine candidate 89-12
    Richard L Ward
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Infect Dis 194:1729-36. 2006
    ..Even so, the Rotarix vaccine developed from attenuated 89-12 was found to elicit excellent protection against non-G1 rotaviruses...
  57. doi request reprint Pandemic and seasonal H1N1 influenza hemagglutinin-specific T cell responses elicited by seasonal influenza vaccination
    Ramu A Subbramanian
    Cincinnati Children s Hospital Medical Center, Division of Infectious Diseases, Department of Pediatrics, Cincinnati, OH, USA
    Vaccine 28:8258-67. 2010
    ..Cross reactive T cell responses to the pandemic H1N1 HA existed among the cohort before the circulation of the virus to varying degrees and these responses were boosted by seasonal vaccination...
  58. pmc Traffic-related air pollution exposure in the first year of life and behavioral scores at 7 years of age
    Nicholas C Newman
    Division of General and Community Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Environ Health Perspect 121:731-6. 2013
    ..There is increasing concern about the potential effects of traffic-related air pollution (TRAP) on the developing brain. The impact of TRAP exposure on childhood behavior is not fully understood because of limited epidemiologic studies...
  59. ncbi request reprint Clinical presentations of rotavirus infection among hospitalized children
    Mary Allen Staat
    Division of Infectious Disease, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Pediatr Infect Dis J 21:221-7. 2002
    ..Although rotaviruses (RVs) are the most common cause of severe gastroenteritis in children, there is a lack of information detailing the spectrum of clinical manifestations of RV disease resulting in hospitalization...
  60. ncbi request reprint Effect of yearly vaccinations with live, attenuated, cold-adapted, trivalent, intranasal influenza vaccines on antibody responses in children
    David I Bernstein
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, OH, USA
    Pediatr Infect Dis J 22:28-34. 2003
    ..The cold-adapted, trivalent influenza vaccine (CAIV-T) may become an option for annual vaccination. However, there is little information regarding the immune response to repeated immunization with CAIV-T...
  61. doi request reprint Exposure to traffic exhaust and night cough during early childhood: the CCAAPS birth cohort
    Heidi Sucharew
    Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Pediatr Allergy Immunol 21:253-9. 2010
    ..73, 95% CI: 0.53, 1.01). No other factors were significant. These results suggest that traffic exhaust exposure may be a risk factor for night cough in young children...
  62. pmc Effective strategies for HPV vaccine delivery: the views of pediatricians
    Abbigail M Tissot
    Division of Adolescent Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Adolesc Health 41:119-25. 2007
    ..The objectives of this research were to examine pediatricians' views about key issues related to HPV vaccine delivery and identify their strategies for effective vaccine delivery...
  63. ncbi request reprint Quantitative-competitive PCR monitoring of viral load following experimental guinea pig cytomegalovirus infection
    Mark R Schleiss
    Cincinnati Children s Hospital Medical Center, Division of Infectious Diseases, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Virol Methods 108:103-10. 2003
    ..Viral load determination should be useful for monitoring outcomes following vaccine studies, as well as responses to experimental antiviral agents...
  64. pmc Acellular pertussis vaccines and complement killing of Bordetella pertussis
    Alison A Weiss
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267 0524, USA
    Infect Immun 72:7346-51. 2004
    ..The responses of the other individuals were complex, with evidence of both beneficial and antagonistic responses occurring, sometimes in the same individual...
  65. pmc A model of human cytomegalovirus infection in severe combined immunodeficient mice
    Fernando J Bravo
    Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, ML 6014, Cincinnati, OH 45229 3039, USA
    Antiviral Res 76:104-10. 2007
    ..0001). These results indicate that the Gelfoam-HCMV SCID mouse model is suitable for the in vivo evaluation of new antivirals against HCMV and is simpler and more convenient than previous models...
  66. pmc House dust bioactivities predict skin prick test reactivity for children with high risk of allergy
    Haejin Kim
    Department of Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    J Allergy Clin Immunol 129:1529-37.e2. 2012
    ....
  67. pmc Influence of dog ownership and high endotoxin on wheezing and atopy during infancy
    Paloma Campo
    Department of Internal Medicine, Immunology Division, University of Cincinnati, Cincinnati, OH 45267 0563, USA
    J Allergy Clin Immunol 118:1271-8. 2006
    ..Increased exposure to microbial products early in life may protect from development of atopic disorders in childhood. Few studies have examined the relationship of endotoxin exposure and pet ownership on atopy and wheezing during infancy...
  68. pmc Antibody-mediated neutralization of pertussis toxin-induced mitogenicity of human peripheral blood mononuclear cells
    Scott H Millen
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Infect Immun 72:615-20. 2004
    ..the convalescent group had higher titers in the PBMC assay. Results for pertussis toxin neutralization with the CHO assay appear to be distinct from those with the PBMC assay...
  69. ncbi request reprint The underrecognized burden of influenza in young children
    Katherine A Poehling
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, USA
    N Engl J Med 355:31-40. 2006
    ..The disease burden of influenza infection among children is not well established. We conducted a population-based surveillance of medical visits associated with laboratory-confirmed influenza...
  70. ncbi request reprint Rotavirus deaths: rare or unrecognized?
    Mary Allen Staat
    University of Cincinnati, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, Division of Infectious Diseases, Ohio 45229, USA
    Clin Pediatr (Phila) 44:535-7. 2005
  71. doi request reprint Rotavirus meningoencephalitis in a previously healthy child and a review of the literature
    Michelle Dickey
    Division of Infectious Disease, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Pediatr Infect Dis J 28:318-21. 2009
    ..A review of the literature describes 23 cases of central nervous system disease attributed to rotavirus...
  72. ncbi request reprint Diisocyanate antigen-stimulated monocyte chemoattractant protein-1 synthesis has greater test efficiency than specific antibodies for identification of diisocyanate asthma
    David I Bernstein
    Department of Internal Medicine, Division of Immunology, College of Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267 0563, USA
    Am J Respir Crit Care Med 166:445-50. 2002
    ..This study indicates that the MCP-1 stimulation assay has greater sensitivity and specificity than the specific antibody assays in correctly identifying DA...
  73. ncbi request reprint Evaluation of the clinical efficacy and safety of grapeseed extract in the treatment of fall seasonal allergic rhinitis: a pilot study
    David I Bernstein
    Division of Immunology, University of Cincinnati College of Medicine, Ohio 45267, USA
    Ann Allergy Asthma Immunol 88:272-8. 2002
    ..Although grapeseed extract (GSE) is an herbal that is marketed for treating allergic rhinitis, its efficacy is unproven...
  74. ncbi request reprint The potential impact of a prophylactic herpes simplex vaccine
    Richard Rupp
    Division of Adolescent and Behavioral Health, Department of Pediatrics, 301 University Blvd, Galveston, TX 77555 1119, USA
    Expert Opin Emerg Drugs 13:41-52. 2008
    ..HSV infection acquired perinatally may result in severe sequelae or even death despite appropriate therapy. Furthermore, it is becoming increasingly clear that genital HSV infections significantly raise the risk of HIV transmission...
  75. ncbi request reprint Is it traffic type, volume, or distance? Wheezing in infants living near truck and bus traffic
    Patrick H Ryan
    Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267 0056, USA
    J Allergy Clin Immunol 116:279-84. 2005
    ..Previous studies of air pollution have not examined the association between exposure to varying types, distance, and amounts of traffic and wheezing in very young infants...
  76. pmc Mold damage in homes and wheezing in infants
    Seung Hyun Cho
    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio 45267 0056, USA
    Ann Allergy Asthma Immunol 97:539-45. 2006
    ..In most studies that investigate the association of mold or water damage and respiratory disorders in infants, the analysis is not adjusted for exposure to house dust mite (HDM), which is also a known cause of respiratory illnesses...
  77. ncbi request reprint Allergy diagnostic testing: an updated practice parameter
    I Leonard Bernstein
    University of Cincinnati College of Medicine, Ohio, USA
    Ann Allergy Asthma Immunol 100:S1-148. 2008
  78. pmc Environmental risk factors of rhinitis in early infancy
    Jocelyn M Biagini
    Department of Environmental Health, University of Cincinnati, and Division of Allergy and Immunology, Department of Pediatrics, Cincinati Children s Hospital Medical Center, OH 45267 0056, USA
    Pediatr Allergy Immunol 17:278-84. 2006
    ..This study suggests that ETS exposure, rather than visible mold, is associated with rhinitis and allergic rhinitis in infants. The analysis also suggests that mold may be a stronger risk factor for URI that ETS...
  79. ncbi request reprint Safety of the trivalent, cold-adapted influenza vaccine in preschool-aged children
    Pedro A Piedra
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Pediatrics 110:662-72. 2002
    ..To provide additional information on the safety of trivalent, cold-adapted influenza vaccine (CAIV-T) in children...
  80. ncbi request reprint Glycoprotein-D-adjuvant vaccine to prevent genital herpes
    Lawrence R Stanberry
    Department of Pediatrics and Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston 77555 0351, USA
    N Engl J Med 347:1652-61. 2002
    ..An effective prophylactic vaccine would help control the spread of genital herpes...
  81. ncbi request reprint Safety, efficacy, and immunogenicity of a live, quadrivalent human-bovine reassortant rotavirus vaccine in healthy infants
    H Fred Clark
    University of Pennsylvania School of Medicine, Philadelphia, and Merck and Co, Inc, West Point, Pennsylvania 19486, USA
    J Pediatr 144:184-90. 2004
    ..To investigate safety, efficacy, and immunogenicity of live quadrivalent rotavirus vaccine (QRV) containing human-bovine (WC3) reassortant rotavirus serotypes G1, G2, G3, and P1a...
  82. ncbi request reprint Vaccination success rate and reaction profile with diluted and undiluted smallpox vaccine: a randomized controlled trial
    Thomas R Talbot
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA s
    JAMA 292:1205-12. 2004
    ....
  83. pmc Optimum diagnostic assay and clinical specimen for routine rotavirus surveillance
    Lauren J Stockman
    National Center for Immunization and Respiratory Diseases, Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Clin Microbiol 46:1842-3. 2008
    ..Testing of bulk stools by EIA appears to be optimum for rotavirus surveillance...
  84. ncbi request reprint Transmissibility, infectivity and immunogenicity of a live human parainfluenza type 3 virus vaccine (HPIV3cp45) among susceptible infants and toddlers
    Shabir A Madhi
    University of the Witwatersrand Medical Research Council Respiratory and Meningeal Pathogens Research Unit, South Africa
    Vaccine 24:2432-9. 2006
    ..This study examined the transmissibility between young children of an intranasally administered live attenuated human parainfluenza virus type 3 (HPIV3)-cp45 vaccine candidate...
  85. ncbi request reprint Nonmedical costs associated with rotavirus disease requiring hospitalization
    Brian P Lee
    Children s Hospital and Research Center at Oakland, Oakland, CA, USA
    Pediatr Infect Dis J 24:984-8. 2005
    ..Herein, we report the results from the largest prospective study in the United States determining the nonmedical costs of severe rotavirus infections...
  86. ncbi request reprint Development of candidate rotavirus vaccines derived from neonatal strains in India
    Roger I Glass
    Respiratory and Enteric Viruses Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 192:S30-5. 2005
    ..This unique project, which is developing a new rotavirus vaccine in India with the use of Indian strains, an Indian manufacturer, and an Indian clinical development program, aims to expedite introduction of rotavirus vaccines in India...
  87. ncbi request reprint RIX4414 (Rotarix): a live attenuated human rotavirus vaccine
    David I Bernstein
    J Pediatr (Rio J) 83:193-5. 2007
  88. ncbi request reprint Use of active surveillance to validate international classification of diseases code estimates of rotavirus hospitalizations in children
    Vincent P Hsu
    Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Pediatrics 115:78-82. 2005
    ..Our study evaluated the sensitivity of the rotavirus ICD code among children hospitalized for AGE by using active surveillance for rotavirus at a tertiary children's hospital...
  89. ncbi request reprint Predictors of herpes simplex virus type 2 antibody positivity among persons with no history of genital herpes
    Kenneth H Fife
    Department of Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
    Sex Transm Dis 31:676-81. 2004
    ..The demographic, historical, and behavioral factors that predict a positive herpes simplex virus type 2 (HSV-2) antibody test in persons without a history of genital herpes have not been well-defined...
  90. doi request reprint Safety and immunogenicity of concurrent administration of live attenuated influenza vaccine with measles-mumps-rubella and varicella vaccines to infants 12 to 15 months of age
    Terry Nolan
    School of Population Health, University of Melbourne and Murdoch Children s Research Institute, Carlton, Melbourne, Victoria 3010, Australia
    Pediatrics 121:508-16. 2008
    ..This study evaluated the safety, tolerability, and immunogenicity of live attenuated influenza vaccine administered concurrently with measles-mumps-rubella vaccine and varicella vaccine to healthy children 12 to 15 months of age...
  91. ncbi request reprint Bordetella Pertussis infections in vaccinated and unvaccinated adolescents and adults, as assessed in a national prospective randomized Acellular Pertussis Vaccine Trial (APERT)
    Joel I Ward
    University of California Los Angeles UCLA Center for Vaccine Research, Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, David Geffen School of Medicine UCLA, Torrance, California 90502 2502, USA
    Clin Infect Dis 43:151-7. 2006
    ..Acellular pertussis (aP) booster immunizations have been recommended for adolescents and older persons to enhance long-term protection and to possibly reduce community transmission of infections...
  92. ncbi request reprint Return for results after herpes simplex virus type 2 screening
    J Dennis Fortenberry
    Indiana University School of Medicine, Indianapolis, USA
    Sex Transm Dis 31:655-8. 2004
    ..The objective of this study was to evaluate factors associated with return for results of type-specific herpes simplex virus (HSV) screening...