- Bridging the gap between systems biology and medicine
Department of Critical Care Medicine and CRISMA laboratory, University of Pittsburgh School of Medicine, Scaife 602, 3550 Terrace, Pittsburgh, PA 15261, USA
Genome Med 1:88. 2009
- Staging of biliary atresia at diagnosis by molecular profiling of the liver
Division of Pediatric Gastroenterology, Hepatology and Nutrition of Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Genome Med 2:33. 2010
..CONCLUSIONS : Molecular profiling at diagnosis of biliary atresia uncovers a signature of inflammation or fibrosis in most livers. This signature may relate to staging of disease at diagnosis and has implications to clinical outcomes...
- Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer
Biomedical Informatics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Genome Biol 8:R131. 2007
- Temporal gene expression profiling reveals CEBPD as a candidate regulator of brain disease in prosaposin deficient mice
Division of Human Genetics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MLC 4006, Cincinnati, OH, USA
BMC Neurosci 9:76. 2008
..Extensive GSL storage occurs in various central nervous system regions in mammalian prosaposin deficiencies...
- Multiple interactions between the alpha 2C- and beta1-adrenergic receptors influence heart failure survival
Sharon L R Kardia
Department of Epidemiology, School of Public Health, University of Michigan, 109 Observatory St, Ann Arbor, MI 48109 2029, USA
BMC Med Genet 9:93. 2008
..The purpose of this study was to investigate possible synergistic effects of polymorphisms of these two intronless genes (ADRB1 and ADRA2C, respectively) on the risk of death/transplant in heart failure patients...
- Global gene expression profile progression in Gaucher disease mouse models
You Hai Xu
The Division of Human Genetics, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229 3039, USA
BMC Genomics 12:20. 2011
..The pathogenic pathways resulting from lipid laden macrophages (Gaucher cells) in visceral organs and their abnormal functions are obscure...
- Microarray and comparative genomics-based identification of genes and gene regulatory regions of the mouse immune system
John J Hutton
Department of Pediatrics and Biomedical Informatics, University of Cincinnati and Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
BMC Genomics 5:82. 2004
..Using expression pattern criteria, we identified 360 genes with preferential expression in thymus, spleen, peripheral blood mononuclear cells, lymph nodes (unstimulated or stimulated), or in vitro activated T-cells...
- Wnt/beta-catenin signaling is required for development of the exocrine pancreas
James M Wells
Department of Developmental Biology, Cincinnati Children s Hospital Research 45267, Cincinnati, OH 45267, USA
BMC Dev Biol 7:4. 2007
..A Pdx1-cre mouse line was used to delete a floxed beta-catenin allele specifically in the developing pancreas, and embryonic pancreata were studied by immunohistochemistry and microarray analysis...
- High-throughput detection of mutations responsible for childhood hearing loss using resequencing microarrays
1Biomedical Informatics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
BMC Biotechnol 10:10. 2010
..We present results from hearing loss arrays developed in two different research facilities and highlight some of the approaches we adopted to enhance the applicability of resequencing arrays in a clinical setting...
- Bayesian hierarchical model for transcriptional module discovery by jointly modeling gene expression and ChIP-chip data
Department of Environmental Health, University of Cincinnati, 3223 Eden Ave, ML 56, Cincinnati, Ohio 45267, USA
BMC Bioinformatics 8:283. 2007
..The optimal approach to joint modeling of data generated by these two complementary biological assays, with the goal of identifying and characterizing TMs, is an important open problem in computational biomedicine...
- Inferring novel disease indications for known drugs by semantically linking drug action and disease mechanism relationships
Xiaoyan A Qu
Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, USA
BMC Bioinformatics 10:S4. 2009
- Improved human disease candidate gene prioritization using mouse phenotype
Division of Biomedical Informatics, Cincinnati Children s Hospital Medical Center, Cincinnati, USA
BMC Bioinformatics 8:392. 2007
- Disease candidate gene identification and prioritization using protein interaction networks
Division of Biomedical Informatics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
BMC Bioinformatics 10:73. 2009
..In the current study, we describe a candidate gene prioritization method that is entirely based on protein-protein interaction network (PPIN) analyses...
- Immature cell populations and an erythropoiesis gene-expression signature in systemic juvenile idiopathic arthritis: implications for pathogenesis
Claas H Hinze
Division of Rheumatology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Arthritis Res Ther 12:R123. 2010
..The aim of this study was to determine the association of this signature with peripheral blood mononuclear cell (PBMC) subpopulations and its specificity for sJIA as compared with related conditions...