Bruce J Aronow

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc Bridging the gap between systems biology and medicine
    Gilles Clermont
    Department of Critical Care Medicine and CRISMA laboratory, University of Pittsburgh School of Medicine, Scaife 602, 3550 Terrace, Pittsburgh, PA 15261, USA
    Genome Med 1:88. 2009
  2. pmc Staging of biliary atresia at diagnosis by molecular profiling of the liver
    Katie Moyer
    Division of Pediatric Gastroenterology, Hepatology and Nutrition of Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Genome Med 2:33. 2010
  3. pmc Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer
    Sergio Kaiser
    Biomedical Informatics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Genome Biol 8:R131. 2007
  4. pmc Multiple interactions between the alpha 2C- and beta1-adrenergic receptors influence heart failure survival
    Sharon L R Kardia
    Department of Epidemiology, School of Public Health, University of Michigan, 109 Observatory St, Ann Arbor, MI 48109 2029, USA
    BMC Med Genet 9:93. 2008
  5. pmc Global gene expression profile progression in Gaucher disease mouse models
    You Hai Xu
    The Division of Human Genetics, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229 3039, USA
    BMC Genomics 12:20. 2011
  6. pmc Inferring novel disease indications for known drugs by semantically linking drug action and disease mechanism relationships
    Xiaoyan A Qu
    Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, USA
    BMC Bioinformatics 10:S4. 2009
  7. ncbi request reprint Differential regulation of activator protein-1 and heat shock factor-1 in myocardial ischemia and reperfusion injury: role of poly(ADP-ribose) polymerase-1
    Basilia Zingarelli
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Am J Physiol Heart Circ Physiol 286:H1408-15. 2004
  8. pmc Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling
    Toru Oka
    Department of Pediatrics, University of Cincinnati, Division of Molecular Cardiovascular Biology, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Circ Res 101:313-21. 2007
  9. pmc Targeted ablation of miR-21 decreases murine eosinophil progenitor cell growth
    Thomas X Lu
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 8:e59397. 2013
  10. pmc ToppCluster: a multiple gene list feature analyzer for comparative enrichment clustering and network-based dissection of biological systems
    Vivek Kaimal
    Division of Biomedical Informatics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Nucleic Acids Res 38:W96-102. 2010

Collaborators

Detail Information

Publications67

  1. pmc Bridging the gap between systems biology and medicine
    Gilles Clermont
    Department of Critical Care Medicine and CRISMA laboratory, University of Pittsburgh School of Medicine, Scaife 602, 3550 Terrace, Pittsburgh, PA 15261, USA
    Genome Med 1:88. 2009
    ....
  2. pmc Staging of biliary atresia at diagnosis by molecular profiling of the liver
    Katie Moyer
    Division of Pediatric Gastroenterology, Hepatology and Nutrition of Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Genome Med 2:33. 2010
    ..CONCLUSIONS : Molecular profiling at diagnosis of biliary atresia uncovers a signature of inflammation or fibrosis in most livers. This signature may relate to staging of disease at diagnosis and has implications to clinical outcomes...
  3. pmc Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer
    Sergio Kaiser
    Biomedical Informatics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Genome Biol 8:R131. 2007
    ..5-18.5...
  4. pmc Multiple interactions between the alpha 2C- and beta1-adrenergic receptors influence heart failure survival
    Sharon L R Kardia
    Department of Epidemiology, School of Public Health, University of Michigan, 109 Observatory St, Ann Arbor, MI 48109 2029, USA
    BMC Med Genet 9:93. 2008
    ..The purpose of this study was to investigate possible synergistic effects of polymorphisms of these two intronless genes (ADRB1 and ADRA2C, respectively) on the risk of death/transplant in heart failure patients...
  5. pmc Global gene expression profile progression in Gaucher disease mouse models
    You Hai Xu
    The Division of Human Genetics, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229 3039, USA
    BMC Genomics 12:20. 2011
    ..The pathogenic pathways resulting from lipid laden macrophages (Gaucher cells) in visceral organs and their abnormal functions are obscure...
  6. pmc Inferring novel disease indications for known drugs by semantically linking drug action and disease mechanism relationships
    Xiaoyan A Qu
    Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, USA
    BMC Bioinformatics 10:S4. 2009
    ....
  7. ncbi request reprint Differential regulation of activator protein-1 and heat shock factor-1 in myocardial ischemia and reperfusion injury: role of poly(ADP-ribose) polymerase-1
    Basilia Zingarelli
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Am J Physiol Heart Circ Physiol 286:H1408-15. 2004
    ..The data indicate that PARP-1 may exert a pathological role in reperfusion injury by functioning as an enhancing factor of AP-1 activation and as a repressing factor of HSF-1 activation and HSP70 expression...
  8. pmc Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling
    Toru Oka
    Department of Pediatrics, University of Cincinnati, Division of Molecular Cardiovascular Biology, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Circ Res 101:313-21. 2007
    ..These are the first genetic data detailing the function of Pn in the adult heart as a regulator of cardiac remodeling and hypertrophy...
  9. pmc Targeted ablation of miR-21 decreases murine eosinophil progenitor cell growth
    Thomas X Lu
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 8:e59397. 2013
    ..These results demonstrate that miR-21 can regulate the development of eosinophils by influencing eosinophil progenitor cell growth. Our findings have identified one of the first miRNAs with a role in regulating eosinophil development...
  10. pmc ToppCluster: a multiple gene list feature analyzer for comparative enrichment clustering and network-based dissection of biological systems
    Vivek Kaimal
    Division of Biomedical Informatics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Nucleic Acids Res 38:W96-102. 2010
    ..ToppCluster can be accessed freely at http://toppcluster.cchmc.org...
  11. doi request reprint Identifying disease-causal genes using Semantic Web-based representation of integrated genomic and phenomic knowledge
    Ranga Chandra Gudivada
    Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH 45229 3039, USA
    J Biomed Inform 41:717-29. 2008
    ....
  12. pmc Temporal gene expression profiling reveals CEBPD as a candidate regulator of brain disease in prosaposin deficient mice
    Ying Sun
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MLC 4006, Cincinnati, OH, USA
    BMC Neurosci 9:76. 2008
    ..Extensive GSL storage occurs in various central nervous system regions in mammalian prosaposin deficiencies...
  13. ncbi request reprint Comprehensive microarray analysis of Hoxa11/Hoxd11 mutant kidney development
    Kristopher Schwab
    Division of Developmental Biology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Dev Biol 293:540-54. 2006
    ..These results identify the multiple molecular pathways downstream of Hox11 function in the developing kidney...
  14. pmc Immature cell populations and an erythropoiesis gene-expression signature in systemic juvenile idiopathic arthritis: implications for pathogenesis
    Claas H Hinze
    Division of Rheumatology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Arthritis Res Ther 12:R123. 2010
    ..The aim of this study was to determine the association of this signature with peripheral blood mononuclear cell (PBMC) subpopulations and its specificity for sJIA as compared with related conditions...
  15. pmc GenomeTrafac: a whole genome resource for the detection of transcription factor binding site clusters associated with conventional and microRNA encoding genes conserved between mouse and human gene orthologs
    Anil G Jegga
    Division of Biomedical Informatics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Nucleic Acids Res 35:D116-21. 2007
    ....
  16. pmc Gene expression profiles of Mst1r-deficient mice during nickel-induced acute lung injury
    Ali Mallakin
    Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0558, USA
    Am J Respir Cell Mol Biol 34:15-27. 2006
    ..This assessment of gene expression indicates the importance of genetic factors in contributing to lung injury, and points to strategies for intervention in the progression of inflammatory diseases...
  17. pmc Subtype-specific peripheral blood gene expression profiles in recent-onset juvenile idiopathic arthritis
    Michael G Barnes
    Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 60:2102-12. 2009
    ....
  18. pmc MiR-223 deficiency increases eosinophil progenitor proliferation
    Thomas X Lu
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Immunol 190:1576-82. 2013
    ..Our results demonstrate that microRNAs regulate the development of eosinophils by influencing eosinophil progenitor growth and differentiation and identify a contributory role for miR-223 in this process...
  19. pmc PhenoHM: human-mouse comparative phenome-genome server
    Divya Sardana
    Department of Computer Science, University of Cincinnati, Cincinnati, OH, USA
    Nucleic Acids Res 38:W165-74. 2010
    ..The PhenoHM server can be accessed freely at http://phenome.cchmc.org...
  20. ncbi request reprint Microarray analysis of focal segmental glomerulosclerosis
    Kristopher Schwab
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Am J Nephrol 24:438-47. 2004
    ..Here we use oligonucleotide microarrays to obtain a global gene expression profile of kidney biopsy specimens from patients with FSGS in order to better understand the pathogenesis of this disease...
  21. pmc MicroRNA-21 limits in vivo immune response-mediated activation of the IL-12/IFN-gamma pathway, Th1 polarization, and the severity of delayed-type hypersensitivity
    Thomas X Lu
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Immunol 187:3362-73. 2011
    ..Thus, our results define miR-21 as a major regulator of Th1 versus Th2 responses, defining a new mechanism for regulating polarized immunoinflammatory responses...
  22. pmc Onecut-2 knockout mice fail to thrive during early postnatal period and have altered patterns of gene expression in small intestine
    Mary R Dusing
    Division of Developmental Biology, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    Physiol Genomics 42:115-25. 2010
    ..Many of the genes with altered patterns of expression in Onecut-2 knockout mouse duodenum displayed changes in the timing of gene expression...
  23. pmc Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart
    Joerg Heineke
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Clin Invest 117:3198-210. 2007
    ..To our knowledge, these results demonstrate [corrected] a previously unrecognized function for GATA4 as a regulator of cardiac angiogenesis through a nonhypoxic, load, and/or disease-responsive mechanism...
  24. pmc The transcription factor GATA-6 regulates pathological cardiac hypertrophy
    Jop H van Berlo
    Howard Hughes Medical Institute, Cincinnati Children s Hospital Medical Center, 240 Albert Sabin Way, Cincinnati, OH 45229 3039, USA
    Circ Res 107:1032-40. 2010
    ..The highly related transcription factor GATA-6 is also expressed in the adult heart, although its role in controlling the hypertrophic program is unknown...
  25. doi request reprint Engineered human skin substitutes undergo large-scale genomic reprogramming and normal skin-like maturation after transplantation to athymic mice
    Jennifer M Klingenberg
    Research Department, Shriners Hospitals for Children Cincinnati, Cincinnati, Ohio 45229, USA
    J Invest Dermatol 130:587-601. 2010
    ..These analyses suggest important areas for guiding further improvement of engineered skin for both increased homology with native skin and enhanced wound healing...
  26. pmc PolyDoms: a whole genome database for the identification of non-synonymous coding SNPs with the potential to impact disease
    Anil G Jegga
    Division of Biomedical Informatics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Nucleic Acids Res 35:D700-6. 2007
    ..PolyDoms will continue to be curated to improve its usefulness...
  27. doi request reprint Molecular engineering and validation of an oncolytic herpes simplex virus type 1 transcriptionally targeted to midkine-positive tumors
    Arturo R Maldonado
    Division of Pediatric General and Thoracic Surgery, The Center for Molecular Fetal Therapy, Children s Hospital Medical Center, Cincinnati, OH, USA
    J Gene Med 12:613-23. 2010
    ..In the present study, we sought to leverage its selective expression to develop a novel oncolytic herpes simplex virus (oHSV) capable of targeting developmentally primitive cancers that express MDK...
  28. pmc High-throughput detection of mutations responsible for childhood hearing loss using resequencing microarrays
    Prachi Kothiyal
    1Biomedical Informatics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    BMC Biotechnol 10:10. 2010
    ..We present results from hearing loss arrays developed in two different research facilities and highlight some of the approaches we adopted to enhance the applicability of resequencing arrays in a clinical setting...
  29. pmc Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as a biomarker and survival gene
    Shyra J Miller
    Division of Experimental Hematology, Cincinnati Children s Hospital, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    EMBO Mol Med 1:236-48. 2009
    ..SOX9 immunoreactivity was robust in NF and MPSNT tissue sections and targeting SOX9 - strongly expressed in NF1-related tumours - caused MPNST cell death. SOX9 is a biomarker of NF and MPNST, and possibly a therapeutic target in NF1...
  30. doi request reprint Gene expression analysis identifies potential biomarkers of neurofibromatosis type 1 including adrenomedullin
    Trent R Hummel
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Clin Cancer Res 16:5048-57. 2010
    ..There are no identified serum biomarkers of pNF tumor burden or transformation to MPNST. Serum biomarkers would be useful to verify NF1 diagnosis, monitor tumor burden, and/or detect transformation...
  31. pmc Atlas of gene expression in the developing kidney at microanatomic resolution
    Eric W Brunskill
    Division of Developmental Biology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Dev Cell 15:781-91. 2008
    ..In addition, the results provide deeper insight into the genetic regulatory mechanisms of kidney development...
  32. doi request reprint Ras-driven transcriptome analysis identifies aurora kinase A as a potential malignant peripheral nerve sheath tumor therapeutic target
    Ami V Patel
    Divisions of Experimental Hematology and Cancer Biology, Oncology, and Biomedical Informatics, Cincinnati Children s Hospital Medical Center, Cincinnati, USA
    Clin Cancer Res 18:5020-30. 2012
    ..The goal of this study was to use comprehensive gene expression analysis to identify novel therapeutic targets...
  33. pmc Microarray and comparative genomics-based identification of genes and gene regulatory regions of the mouse immune system
    John J Hutton
    Department of Pediatrics and Biomedical Informatics, University of Cincinnati and Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    BMC Genomics 5:82. 2004
    ..Using expression pattern criteria, we identified 360 genes with preferential expression in thymus, spleen, peripheral blood mononuclear cells, lymph nodes (unstimulated or stimulated), or in vitro activated T-cells...
  34. pmc Improved human disease candidate gene prioritization using mouse phenotype
    Jing Chen
    Division of Biomedical Informatics, Cincinnati Children s Hospital Medical Center, Cincinnati, USA
    BMC Bioinformatics 8:392. 2007
    ....
  35. ncbi request reprint RB loss abrogates cell cycle control and genome integrity to promote liver tumorigenesis
    Christopher N Mayhew
    Department of Cell and Cancer Biology, University of Cincinnati, Cincinnati, Ohio 45267 0521, USA
    Gastroenterology 133:976-84. 2007
    ..We investigated the impact of RB loss on carcinogen-induced liver tumorigenesis...
  36. ncbi request reprint Critical role for transcription factor AP-2alpha in human trophoblast differentiation
    You Hong Cheng
    Department of Endocrinology, Children s Hospital Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Physiol Genomics 18:99-107. 2004
    ..AP-2, however, is not required for the fusion of cytotrophoblast cells to form a syncytium or the expression of syncytin...
  37. ncbi request reprint Large-scale reprogramming of cranial neural crest gene expression by retinoic acid exposure
    Sarah S Williams
    Division of Biomedical Informatics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Physiol Genomics 19:184-97. 2004
    ....
  38. ncbi request reprint Microarray-based discovery of highly expressed olfactory mucosal genes: potential roles in the various functions of the olfactory system
    Mary Beth Genter
    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio 45267 0056, USA
    Physiol Genomics 16:67-81. 2003
    ..Further exploration of this database will provide additional insights into genes and pathways critical for olfactory neurogenesis, neuronal differentiation, olfaction, and mucosal defense...
  39. pmc Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis
    Abhinav Diwan
    Center for Molecular Cardiovascular Research and Department of Pediatrics, Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45267, USA
    Proc Natl Acad Sci U S A 104:6794-9. 2007
    ..These results suggest that physiological codependence and coordinated regulation of pro- and antiapoptotic Bcl2 family members may represent a general regulatory paradigm in hematopoiesis...
  40. ncbi request reprint Microarray analysis of gene expression during early stages of mild and severe cardiac hypertrophy
    Sudarsan Rajan
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Physiol Genomics 27:309-17. 2006
    ..quot; Confirmation of the microarray analysis was conducted by quantitative real-time PCR on gene transcripts commonly associated with cardiac hypertrophy...
  41. pmc Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo
    Jop H van Berlo
    Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 108:12331-6. 2011
    ..Moreover, hearts from Gata4-S105A mice had significant changes in the expression of hypertrophy-inducible, fetal, and remodeling-related genes...
  42. pmc Disease candidate gene identification and prioritization using protein interaction networks
    Jing Chen
    Division of Biomedical Informatics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    BMC Bioinformatics 10:73. 2009
    ..In the current study, we describe a candidate gene prioritization method that is entirely based on protein-protein interaction network (PPIN) analyses...
  43. ncbi request reprint Human blood genomics: distinct profiles for gender, age and neurofibromatosis type 1
    Yang Tang
    Department of Neurology, University of Cincinnati, Vontz Center, Room 2327, 3125 Eden Avenue, Cincinnati, OH 45267 0536, USA
    Brain Res Mol Brain Res 132:155-67. 2004
    ....
  44. ncbi request reprint Activation of a novel long-chain free fatty acid generation and export system in mitochondria of diabetic rat hearts
    Lamar K Gerber
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 43267 0575, USA
    Am J Physiol Cell Physiol 291:C1198-207. 2006
    ..We suggest that its activation may facilitate, and inhibition may limit, enhancement of FAO...
  45. pmc ToppGene Suite for gene list enrichment analysis and candidate gene prioritization
    Jing Chen
    Department of Environmental Health, University of Cincinnati, Cincinnati, OH, USA
    Nucleic Acids Res 37:W305-11. 2009
    ..ToppGene ranked 19 of 20 (95%) candidate genes within the top 20%, while ToppNet ranked 12 of 16 (75%) candidate genes among the top 20%...
  46. pmc Novel resequencing chip customized to diagnose mutations in patients with inherited syndromes of intrahepatic cholestasis
    Cong Liu
    Cincinnati Children s Hospital Medical Center and Department of Pediatrics, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Gastroenterology 132:119-26. 2007
    ..Here, we aimed to develop a technological tool that reads out the nucleotide sequence of these genes rapidly and accurately...
  47. pmc MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors
    Walter J Jessen
    Children s Hospital Medical Center, Division of Experimental Hematology and Cancer Biology, 3333 Burnet Ave, M L C 7013, Cincinnati, Ohio 45229, USA
    J Clin Invest 123:340-7. 2013
    ..Our data demonstrate that deregulated Ras/ERK signaling is critical for the growth of NF1 peripheral nerve tumors and provide a strong rationale for testing MEK inhibitors in NF1 clinical trials...
  48. ncbi request reprint Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice
    Jian Xu
    Departments of Pharmacology and Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Biol Chem 281:9152-62. 2006
    ....
  49. ncbi request reprint Gene expression microarray data analysis of decidual and placental cell differentiation
    Sue Kong
    Division of Biomedical Informatics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Methods Mol Med 121:425-38. 2006
    ....
  50. ncbi request reprint Genetic susceptibility to nickel-induced acute lung injury
    Daniel R Prows
    Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267 0056, USA
    Chemosphere 51:1139-48. 2003
    ..Together, results from QTL and microarray analyses of nickel-induced acute lung injury survival allowed us to generate a short list of candidate genes...
  51. pmc CisMols Analyzer: identification of compositionally similar cis-element clusters in ortholog conserved regions of coordinately expressed genes
    Anil G Jegga
    Division of Biomedical Informatics, Children s Hospital Research Foundation, CCHMC, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Nucleic Acids Res 33:W408-11. 2005
    ..CisMols Analyzer is accessible via a Web interface at http://cismols.cchmc.org/...
  52. pmc Bayesian hierarchical model for transcriptional module discovery by jointly modeling gene expression and ChIP-chip data
    Xiangdong Liu
    Department of Environmental Health, University of Cincinnati, 3223 Eden Ave, ML 56, Cincinnati, Ohio 45267, USA
    BMC Bioinformatics 8:283. 2007
    ..The optimal approach to joint modeling of data generated by these two complementary biological assays, with the goal of identifying and characterizing TMs, is an important open problem in computational biomedicine...
  53. pmc Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease
    YuanYuan Gu
    Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Nature 458:1039-42. 2009
    ..These data indicate that IFRD1 modulates the pathogenesis of cystic fibrosis lung disease through the regulation of neutrophil effector function...
  54. pmc Modulation of chromatin position and gene expression by HDAC4 interaction with nucleoporins
    Izhak Kehat
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    J Cell Biol 193:21-9. 2011
    ..We thus propose a novel mechanism of action for HDAC4, suggesting it can function to dynamically regulate gene expression through changes in chromatin-nucleoporin association...
  55. pmc MicroRNA signature in patients with eosinophilic esophagitis, reversibility with glucocorticoids, and assessment as disease biomarkers
    Thomas X Lu
    Division of Allergy and Immunology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    J Allergy Clin Immunol 129:1064-75.e9. 2012
    ..The role of microRNAs (miRNAs), a key class of regulators of mRNA expression and translation, in patients with eosinophilic esophagitis (EoE) has not been explored...
  56. pmc LMO7 mediates cell-specific activation of the Rho-myocardin-related transcription factor-serum response factor pathway and plays an important role in breast cancer cell migration
    Qiande Hu
    Department of Cancer and Cell Biology, Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0521, USA
    Mol Cell Biol 31:3223-40. 2011
    ....
  57. ncbi request reprint Transcript signatures in experimental asthma: identification of STAT6-dependent and -independent pathways
    Nives Zimmermann
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Immunol 172:1815-24. 2004
    ..These results provide unprecedented insight into the complex steps involved in the pathogenesis of allergic airway responses; as such, these results have significant therapeutic and clinical implications...
  58. ncbi request reprint Transcriptional response to persistent beta2-adrenergic receptor signaling reveals regulation of phospholamban, which alters airway contractility
    Dennis W McGraw
    Pulmonary and Critical Care Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Physiol Genomics 27:171-7. 2006
    ..These genes or pathways may also represent additional targets in the treatment of asthma and related obstructive lung diseases...
  59. ncbi request reprint Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues
    Shyra J Miller
    Division of Experimental Hematology, Cincinnati Children s Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Cancer Res 66:2584-91. 2006
    ....
  60. ncbi request reprint Hypoxia induces chondrocyte-specific gene expression in mesenchymal cells in association with transcriptional activation of Sox9
    Jared C Robins
    Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, OH 45221, USA
    Bone 37:313-22. 2005
    ..These findings suggest that hypoxia promotes the differentiation of mesenchymal cells along a chondrocyte pathway in part by activating Sox-9 via a HIF-1alpha-dependent mechanism...
  61. ncbi request reprint Altered gene expression profiles in nasal respiratory epithelium reflect stable versus acute childhood asthma
    Jesus R Guajardo
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Allergy Clin Immunol 115:243-51. 2005
    ..Asthma is the most common chronic disease of childhood and has a strong genetic component...
  62. pmc Calcium influx is sufficient to induce muscular dystrophy through a TRPC-dependent mechanism
    Douglas P Millay
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 106:19023-8. 2009
    ..These results demonstrate that calcium itself is sufficient to induce muscular dystrophy in vivo, and that TRPC channels are key disease initiators downstream of the unstable membrane that characterizes many types of muscular dystrophy...
  63. ncbi request reprint Dynamic interaction between T cell-mediated beta-cell damage and beta-cell repair in the run up to autoimmune diabetes of the NOD mouse
    Sankaranand S Vukkadapu
    Diabetes Research Center, Division of Endocrinology, Cincinnati Children s Hospital Research Foundation and College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Physiol Genomics 21:201-11. 2005
    ....
  64. ncbi request reprint Transcriptional profiles of intestinal tumors in Apc(Min) mice are unique from those of embryonic intestine and identify novel gene targets dysregulated in human colorectal tumors
    Tim Reichling
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45267, USA
    Cancer Res 65:166-76. 2005
    ..Real-time reverse transcription-PCR analysis of human colorectal cancer cell lines and adenocarcinomas revealed that altered expression levels were also observed for six of the genes Igfbp5, Lcn2, Ly6d, N4wbp4 (PMEPA1), S100c, and Sox4...
  65. pmc Wnt/beta-catenin signaling is required for development of the exocrine pancreas
    James M Wells
    Department of Developmental Biology, Cincinnati Children s Hospital Research 45267, Cincinnati, OH 45267, USA
    BMC Dev Biol 7:4. 2007
    ..A Pdx1-cre mouse line was used to delete a floxed beta-catenin allele specifically in the developing pancreas, and embryonic pancreata were studied by immunohistochemistry and microarray analysis...
  66. doi request reprint Dysfunctional genomics: toward an integrative biology of disease and health--application to IBDs
    Bruce J Aronow
    University of Cincinnati Children s Hospital, College of Medicine, Cincinnati, OH, USA
    J Pediatr Gastroenterol Nutr 46:E3-4. 2008
  67. ncbi request reprint Genomics of the periinfarction cortex after focal cerebral ischemia
    Aigang Lu
    Department of Neurology, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Cereb Blood Flow Metab 23:786-810. 2003
    ..Genes regulated acutely after stroke may modulate cell survival and death; also, late regulated genes may be related to tissue repair and functional recovery...