Li You

Summary

Affiliation: CIIT Centers for Health Research
Country: USA

Publications

  1. ncbi request reprint Modulation of mammary gland development in prepubertal male rats exposed to genistein and methoxychlor
    Li You
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709 2137, USA
    Toxicol Sci 66:216-25. 2002
  2. ncbi request reprint Androgen receptor expression in the testes and epididymides of prenatal and postnatal Sprague-Dawley rats
    L You
    Endocrine, Reproductive, and Developmental Toxicology Program, Chemical Industry Institute of Toxicology, Research Triangle Park, NC 27709 2137, USA
    Endocrine 9:253-61. 1998
  3. ncbi request reprint In utero exposure to antiandrogens alters the responsiveness of the prostate to p,p'-DDE in adult rats and may induce prostatic inflammation
    L You
    Chemical Industry Institute of Toxicology, 6 Davis Drive, North Carolina, 27709 2137, USA
    Toxicol Appl Pharmacol 161:258-66. 1999
  4. ncbi request reprint Induction of hepatic aromatase by p,p'-DDE in adult male rats
    L You
    Endocrine, Reproductive, and Developmental Toxicology Research Program, CIIT Centers for Health Research, 6 Davis Drive, P O Box 12137, Research Triangle Park, NC 27709 2137, USA
    Mol Cell Endocrinol 178:207-14. 2001
  5. ncbi request reprint Combined effects of dietary phytoestrogen and synthetic endocrine-active compound on reproductive development in Sprague-Dawley rats: genistein and methoxychlor
    Li You
    CIIT Centers for Health Research, 6 Davis Drive, Research Triangle Park, North Carolina 27709 2137, USA
    Toxicol Sci 66:91-104. 2002
  6. ncbi request reprint Phytoestrogen genistein and its pharmacological interactions with synthetic endocrine-active compounds
    Li You
    CIIT Centers for Health Research, 6 Davis Drive, Research Triangle Park, NC 27709, USA
    Curr Pharm Des 10:2749-57. 2004
  7. ncbi request reprint Steroid hormone biotransformation and xenobiotic induction of hepatic steroid metabolizing enzymes
    Li You
    CIIT Centers for Health Research, 6 Davis Drive, P O Box 12137, Research Triangle Park, NC 27709 2137, USA
    Chem Biol Interact 147:233-46. 2004
  8. ncbi request reprint Di-n-butyl phthalate activates constitutive androstane receptor and pregnane X receptor and enhances the expression of steroid-metabolizing enzymes in the liver of rat fetuses
    Michael E Wyde
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 86:281-90. 2005
  9. ncbi request reprint Impaired male sexual development in perinatal Sprague-Dawley and Long-Evans hooded rats exposed in utero and lactationally to p,p'-DDE
    L You
    Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 45:162-73. 1998
  10. ncbi request reprint Altered mammary gland development in male rats exposed to genistein and methoxychlor
    Xiao Juan Wang
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 91:93-103. 2006

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Modulation of mammary gland development in prepubertal male rats exposed to genistein and methoxychlor
    Li You
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709 2137, USA
    Toxicol Sci 66:216-25. 2002
    ....
  2. ncbi request reprint Androgen receptor expression in the testes and epididymides of prenatal and postnatal Sprague-Dawley rats
    L You
    Endocrine, Reproductive, and Developmental Toxicology Program, Chemical Industry Institute of Toxicology, Research Triangle Park, NC 27709 2137, USA
    Endocrine 9:253-61. 1998
    ....
  3. ncbi request reprint In utero exposure to antiandrogens alters the responsiveness of the prostate to p,p'-DDE in adult rats and may induce prostatic inflammation
    L You
    Chemical Industry Institute of Toxicology, 6 Davis Drive, North Carolina, 27709 2137, USA
    Toxicol Appl Pharmacol 161:258-66. 1999
    ..While other types of hormonal manipulations have been shown to incite similar responses in rat prostate, the possible linkage between in utero antiandrogen treatment and prostatic inflammation needs to be further evaluated...
  4. ncbi request reprint Induction of hepatic aromatase by p,p'-DDE in adult male rats
    L You
    Endocrine, Reproductive, and Developmental Toxicology Research Program, CIIT Centers for Health Research, 6 Davis Drive, P O Box 12137, Research Triangle Park, NC 27709 2137, USA
    Mol Cell Endocrinol 178:207-14. 2001
    ..This study supports the notion that induction of aromatase by DDE is a contributory factor to its reproductive developmental effects...
  5. ncbi request reprint Combined effects of dietary phytoestrogen and synthetic endocrine-active compound on reproductive development in Sprague-Dawley rats: genistein and methoxychlor
    Li You
    CIIT Centers for Health Research, 6 Davis Drive, Research Triangle Park, North Carolina 27709 2137, USA
    Toxicol Sci 66:91-104. 2002
    ....
  6. ncbi request reprint Phytoestrogen genistein and its pharmacological interactions with synthetic endocrine-active compounds
    Li You
    CIIT Centers for Health Research, 6 Davis Drive, Research Triangle Park, NC 27709, USA
    Curr Pharm Des 10:2749-57. 2004
    ..The complexities of such interactions are difficult to predict based on their in vitro steroid receptor reactivities...
  7. ncbi request reprint Steroid hormone biotransformation and xenobiotic induction of hepatic steroid metabolizing enzymes
    Li You
    CIIT Centers for Health Research, 6 Davis Drive, P O Box 12137, Research Triangle Park, NC 27709 2137, USA
    Chem Biol Interact 147:233-46. 2004
    ..While enzyme induction by xenobiotics may increase clearance of the endogenous steroid, regulatory mechanisms for steroid homeostasis may adapt and compensate for altered clearance...
  8. ncbi request reprint Di-n-butyl phthalate activates constitutive androstane receptor and pregnane X receptor and enhances the expression of steroid-metabolizing enzymes in the liver of rat fetuses
    Michael E Wyde
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 86:281-90. 2005
    ..Our study shows that DBP is broadly reactive with multiple pathways involved in maintaining steroid and lipid homeostasis...
  9. ncbi request reprint Impaired male sexual development in perinatal Sprague-Dawley and Long-Evans hooded rats exposed in utero and lactationally to p,p'-DDE
    L You
    Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 45:162-73. 1998
    ....
  10. ncbi request reprint Altered mammary gland development in male rats exposed to genistein and methoxychlor
    Xiao Juan Wang
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 91:93-103. 2006
    ..The distinctive responses associated with the GE+MXC combination were likely linked to enhanced actions of insulin-like growth factor 1 and related downstream pathways...
  11. ncbi request reprint Regulation of phase I and phase II steroid metabolism enzymes by PPAR alpha activators
    Li Qun Fan
    CIIT Centers for Health Research, Six Davis Drive, PO Box 12137, Research Triangle Park, NC 27709 2137, USA
    Toxicology 204:109-21. 2004
    ..The changes in these enzymes may help explain why exposure to some PP leads to adverse effects in endocrine tissues that produce or are the targets of sex hormones...
  12. ncbi request reprint The environmental pollutant 1,1-dichloro-2,2-bis (p-chlorophenyl)ethylene induces rat hepatic cytochrome P450 2B and 3A expression through the constitutive androstane receptor and pregnane X receptor
    Michael E Wyde
    CIIT Centers for Health Research, Research Triangle Park, North Carolina, USA
    Mol Pharmacol 64:474-81. 2003
    ..This study suggests that regulation by environmental compounds of hepatic enzymes via CAR and PXR may have impact on the metabolism of endogenous and exogenous substrates...
  13. ncbi request reprint Anti-influenza prodrug oseltamivir is activated by carboxylesterase human carboxylesterase 1, and the activation is inhibited by antiplatelet agent clopidogrel
    Deshi Shi
    Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI 02881, USA
    J Pharmacol Exp Ther 319:1477-84. 2006
    ..This is epidemiologically of significance because people who receive oseltamivir and clopidogrel simultaneously may maintain susceptibility to influenza infection or a source of spreading influenza virus if already infected...