Research Topics
| J S KimbellSummaryAffiliation: CIIT Centers for Health Research Country: USA Publications
| Collaborators
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Detail Information
Publications
Nasal dosimetry of inhaled gases and particles: where do inhaled agents go in the nose?J S Kimbell
CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
Toxicol Pathol 34:270-3. 2006..Estimates such as these can be used to test hypotheses about mechanisms of toxicity and supply species-specific information for risk assessment, thus reducing uncertainty in extrapolating animal data to humans...- Computer simulation of inspiratory airflow in all regions of the F344 rat nasal passagesJ S Kimbell
Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 27709, USA
Toxicol Appl Pharmacol 145:388-98. 1997..This information, combined with models of disposition in the airway lining, will provide comprehensive dosimetry models for extrapolating animal response data to humans... - Correlation of regional formaldehyde flux predictions with the distribution of formaldehyde-induced squamous metaplasia in F344 rat nasal passagesJ S Kimbell
Chemical Industry Institute of Toxicology, Research Triangle Park, NC 27709 2137, USA
Mutat Res 380:143-54. 1997..These results indicate that information on the permeability of squamous epithelium in rats, monkeys, and humans is important for accurate prediction of uptake in regions posterior to the nasal vestibule... - Characterization of deposition from nasal spray devices using a computational fluid dynamics model of the human nasal passagesJulia S Kimbell
The Hamner Institutes for Health Sciences
J Aerosol Med 20:59-74. 2007..These predictions contribute to more effective design of drug delivery devices through a better understanding of the effects of nasal airflow and spray characteristics on particle transport in the nose... - Use of computational fluid dynamics models for dosimetry of inhaled gases in the nasal passagesJ S Kimbell
CIIT Centers for Health Research, 6 Davis Drive, PO Box 12137, Research Triangle Park, NC 27709 2137, USA
Inhal Toxicol 13:325-34. 2001..Limited resources can then be focused on reduction of important sources of uncertainty to make risk estimates more accurate... - Dosimetry modeling of inhaled formaldehyde: binning nasal flux predictions for quantitative risk assessmentJ S Kimbell
CIIT Centers for Health Research, P O Box 12137, 6 Davis Drive, Research Triangle Park, North Carolina 27709, USA
Toxicol Sci 64:111-21. 2001..Formaldehyde risk models that incorporate flux binning derived from anatomically realistic CFD models will have significantly reduced uncertainty compared with risk estimates based on default methods... - Dosimetry modeling of inhaled formaldehyde: comparisons of local flux predictions in the rat, monkey, and human nasal passagesJ S Kimbell
CIIT Centers for Health Research, P O Box 12137, 6 Davis Drive, Research Triangle Park, North Carolina 27709, USA
Toxicol Sci 64:100-10. 2001..Regional formaldehyde flux estimates are directly applicable to clonal growth modeling of formaldehyde carcinogenesis to help reduce uncertainty in human cancer risk estimates... - Dosimetry modeling of inhaled formaldehyde: the human respiratory tractJ H Overton
Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 64:122-34. 2001..Use of these fluxes will reduce uncertainty in a risk assessment for formaldehyde carcinogenicity... - Simulation modeling of the tissue disposition of formaldehyde to predict nasal DNA-protein cross-links in Fischer 344 rats, rhesus monkeys, and humansR B Conolly
Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina, USA
Environ Health Perspect 108:919-24. 2000..This modeling approach reduces uncertainty in the prediction of human nasal mucosal DPX resulting from formaldehyde inhalation... - Deposition of fine and coarse aerosols in a rat nasal moldJ T Kelly
CIIT Centers for Health Research, 6 Davis Drive, PO Box 12137, Research Triangle Park, NC 27709, USA
Inhal Toxicol 13:577-88. 2001..The results suggest that the pulsating nature of breathing is an important consideration when determining the deposition of fine and coarse particles... - Reconstruction of complex passageways for simulations of transport phenomena: development of a graphical user interface for biological applicationsM N Godo
Chemical Industry Institute of Toxicology, Research Triangle Park, NC 27709, USA
Comput Methods Programs Biomed 47:97-112. 1995..The use of these programs and their application to studies of respiratory tract toxicology are described... - Dose response for formaldehyde-induced cytotoxicity in the human respiratory tractR B Conolly
Center for Computational Biology and Extrapolation Modeling, CIIT Centers for Health Research, Six Davis Drive, Research Triangle Park, North Carolina 27709, USA
Regul Toxicol Pharmacol 35:32-43. 2002.... - Dosimetric adjustment factors for methyl methacrylate derived from a steady-state analysis of a physiologically based clearance-extraction modelM E Andersen
K S Crump Group, ICF Consulting, Research Triangle Park, North Carolina 27709, USA
Inhal Toxicol 11:899-926. 1999..145. These steady-state calculations with this PBCE model should be useful in risk assessment calculations for a variety of vapors and gases that are converted to toxic metabolites in cells in the respiratory tract... - Nasal uptake of inhaled acrolein in ratsMelanie F Struve
CIIT at The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA
Inhal Toxicol 20:217-25. 2008.... - Modeling approaches for estimating the dosimetry of inhaled toxicants in childrenGary L Ginsberg
Connecticut Department of Public Health, Hartford, CT 06134, UAS
J Toxicol Environ Health A 71:166-95. 2008..A decision framework is discussed that considers these different approaches and modeling structures including assessment of parameter values, supporting data, reliability, and selection of dose metrics... - Three-dimensional mapping of ozone-induced injury in the nasal airways of monkeys using magnetic resonance imaging and morphometric techniquesStephan A Carey
Comparative Medicine and Integrative Biology, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824 1224, USA
Toxicol Pathol 35:27-40. 2007..These correlations are critical for accurate predictive modeling of exposure-dose-response relationships in the nasal airways, and subsequent extrapolation of nasal findings in animals to humans for determining risk... - Analysis of particle deposition in the turbinate and olfactory regions using a human nasal computational fluid dynamics modelJeffry D Schroeter
CIIT Centers for Health Research, Research Triangle Park, North Carolina, 27709 2137, USA
J Aerosol Med 19:301-13. 2006.... - Atrophic rhinitis: a CFD study of air conditioning in the nasal cavityGuilherme J M Garcia
The Hamner Institutes for Health Sciences, 6 Davis Dr, P O Box 12137, Research Triangle Park, NC 27709, USA
J Appl Physiol 103:1082-92. 2007..We conclude that the main goals of a surgery to treat atrophic rhinitis should be 1) to restore the original surface area of the nose, 2) to restore the physiological airflow distribution, and 3) to create symmetric cavities... - Use of a pharmacokinetic-driven computational fluid dynamics model to predict nasal extraction of hydrogen sulfide in rats and humansJeffry D Schroeter
CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709 2137, USA
Toxicol Sci 94:359-67. 2006.... - Incorporation of tissue reaction kinetics in a computational fluid dynamics model for nasal extraction of inhaled hydrogen sulfide in ratsJeffry D Schroeter
CIIT Centers for Health Research, 6 Davis Drive, P O Box 12137, Research Triangle Park, North Carolina 27709 2137, USA
Toxicol Sci 90:198-207. 2006..The CFD model provides estimates of localized H2S flux to airway walls and can be used to calibrate lesion sites by dose... - Human respiratory tract cancer risks of inhaled formaldehyde: dose-response predictions derived from biologically-motivated computational modeling of a combined rodent and human datasetRory B Conolly
Center for Computational Systems Biology and Human Health Assessment, CIIT Centers for Health Research, 6 Davis Drive, Research Triangle Park, NC 27709, USA
Toxicol Sci 82:279-96. 2004.... - A distributed-parameter model for formaldehyde uptake and disposition in the rat nasal liningAnna V Georgieva
CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
Inhal Toxicol 15:1435-63. 2003..The model structure facilitates extrapolation to primates and humans and application to other soluble, reactive gases... - Biologically motivated computational modeling of formaldehyde carcinogenicity in the F344 ratRory B Conolly
CIIT Centers for Health Research, 6 Davis Drive, Research Triangle Park, North Carolina 27709, USA
Toxicol Sci 75:432-47. 2003.... - Use of a hybrid computational fluid dynamics and physiologically based inhalation model for interspecies dosimetry comparisons of ester vaporsClay B Frederick
Toxicology Department, Rohm and Haas Company, Spring House, Pennsylvania 19477, USA
Toxicol Appl Pharmacol 183:23-40. 2002.... - Predicted regional flux of hydrogen sulfide correlates with distribution of nasal olfactory lesions in ratsFrederic J-M Moulin
CIIT Centers for Health Research, 6 Davis Drive, P.O. Box 12137, Research Triangle Park, North Carolina 27709-2137, USA
Toxicol Sci 66:7-15. 2002.... - Application of physiological computational fluid dynamics models to predict interspecies nasal dosimetry of inhaled acroleinJeffry D Schroeter
The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709 2137, USA
Inhal Toxicol 20:227-43. 2008..Assuming that equivalent tissue dose will induce similar effects across species, a NOAEL human equivalent concentration for inhaled acrolein was estimated to be 8 ppb...