J S Kimbell

Summary

Affiliation: CIIT Centers for Health Research
Country: USA

Publications

  1. ncbi request reprint Nasal dosimetry of inhaled gases and particles: where do inhaled agents go in the nose?
    J S Kimbell
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 34:270-3. 2006
  2. ncbi request reprint Computer simulation of inspiratory airflow in all regions of the F344 rat nasal passages
    J S Kimbell
    Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 27709, USA
    Toxicol Appl Pharmacol 145:388-98. 1997
  3. ncbi request reprint Correlation of regional formaldehyde flux predictions with the distribution of formaldehyde-induced squamous metaplasia in F344 rat nasal passages
    J S Kimbell
    Chemical Industry Institute of Toxicology, Research Triangle Park, NC 27709 2137, USA
    Mutat Res 380:143-54. 1997
  4. ncbi request reprint Characterization of deposition from nasal spray devices using a computational fluid dynamics model of the human nasal passages
    Julia S Kimbell
    The Hamner Institutes for Health Sciences
    J Aerosol Med 20:59-74. 2007
  5. ncbi request reprint Use of computational fluid dynamics models for dosimetry of inhaled gases in the nasal passages
    J S Kimbell
    CIIT Centers for Health Research, 6 Davis Drive, PO Box 12137, Research Triangle Park, NC 27709 2137, USA
    Inhal Toxicol 13:325-34. 2001
  6. ncbi request reprint Dosimetry modeling of inhaled formaldehyde: binning nasal flux predictions for quantitative risk assessment
    J S Kimbell
    CIIT Centers for Health Research, P O Box 12137, 6 Davis Drive, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 64:111-21. 2001
  7. ncbi request reprint Dosimetry modeling of inhaled formaldehyde: comparisons of local flux predictions in the rat, monkey, and human nasal passages
    J S Kimbell
    CIIT Centers for Health Research, P O Box 12137, 6 Davis Drive, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 64:100-10. 2001
  8. ncbi request reprint Dosimetry modeling of inhaled formaldehyde: the human respiratory tract
    J H Overton
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 64:122-34. 2001
  9. ncbi request reprint Simulation modeling of the tissue disposition of formaldehyde to predict nasal DNA-protein cross-links in Fischer 344 rats, rhesus monkeys, and humans
    R B Conolly
    Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 108:919-24. 2000
  10. ncbi request reprint Deposition of fine and coarse aerosols in a rat nasal mold
    J T Kelly
    CIIT Centers for Health Research, 6 Davis Drive, PO Box 12137, Research Triangle Park, NC 27709, USA
    Inhal Toxicol 13:577-88. 2001

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Nasal dosimetry of inhaled gases and particles: where do inhaled agents go in the nose?
    J S Kimbell
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 34:270-3. 2006
    ..Estimates such as these can be used to test hypotheses about mechanisms of toxicity and supply species-specific information for risk assessment, thus reducing uncertainty in extrapolating animal data to humans...
  2. ncbi request reprint Computer simulation of inspiratory airflow in all regions of the F344 rat nasal passages
    J S Kimbell
    Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 27709, USA
    Toxicol Appl Pharmacol 145:388-98. 1997
    ..This information, combined with models of disposition in the airway lining, will provide comprehensive dosimetry models for extrapolating animal response data to humans...
  3. ncbi request reprint Correlation of regional formaldehyde flux predictions with the distribution of formaldehyde-induced squamous metaplasia in F344 rat nasal passages
    J S Kimbell
    Chemical Industry Institute of Toxicology, Research Triangle Park, NC 27709 2137, USA
    Mutat Res 380:143-54. 1997
    ..These results indicate that information on the permeability of squamous epithelium in rats, monkeys, and humans is important for accurate prediction of uptake in regions posterior to the nasal vestibule...
  4. ncbi request reprint Characterization of deposition from nasal spray devices using a computational fluid dynamics model of the human nasal passages
    Julia S Kimbell
    The Hamner Institutes for Health Sciences
    J Aerosol Med 20:59-74. 2007
    ..These predictions contribute to more effective design of drug delivery devices through a better understanding of the effects of nasal airflow and spray characteristics on particle transport in the nose...
  5. ncbi request reprint Use of computational fluid dynamics models for dosimetry of inhaled gases in the nasal passages
    J S Kimbell
    CIIT Centers for Health Research, 6 Davis Drive, PO Box 12137, Research Triangle Park, NC 27709 2137, USA
    Inhal Toxicol 13:325-34. 2001
    ..Limited resources can then be focused on reduction of important sources of uncertainty to make risk estimates more accurate...
  6. ncbi request reprint Dosimetry modeling of inhaled formaldehyde: binning nasal flux predictions for quantitative risk assessment
    J S Kimbell
    CIIT Centers for Health Research, P O Box 12137, 6 Davis Drive, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 64:111-21. 2001
    ..Formaldehyde risk models that incorporate flux binning derived from anatomically realistic CFD models will have significantly reduced uncertainty compared with risk estimates based on default methods...
  7. ncbi request reprint Dosimetry modeling of inhaled formaldehyde: comparisons of local flux predictions in the rat, monkey, and human nasal passages
    J S Kimbell
    CIIT Centers for Health Research, P O Box 12137, 6 Davis Drive, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 64:100-10. 2001
    ..Regional formaldehyde flux estimates are directly applicable to clonal growth modeling of formaldehyde carcinogenesis to help reduce uncertainty in human cancer risk estimates...
  8. ncbi request reprint Dosimetry modeling of inhaled formaldehyde: the human respiratory tract
    J H Overton
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 64:122-34. 2001
    ..Use of these fluxes will reduce uncertainty in a risk assessment for formaldehyde carcinogenicity...
  9. ncbi request reprint Simulation modeling of the tissue disposition of formaldehyde to predict nasal DNA-protein cross-links in Fischer 344 rats, rhesus monkeys, and humans
    R B Conolly
    Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 108:919-24. 2000
    ..This modeling approach reduces uncertainty in the prediction of human nasal mucosal DPX resulting from formaldehyde inhalation...
  10. ncbi request reprint Deposition of fine and coarse aerosols in a rat nasal mold
    J T Kelly
    CIIT Centers for Health Research, 6 Davis Drive, PO Box 12137, Research Triangle Park, NC 27709, USA
    Inhal Toxicol 13:577-88. 2001
    ..The results suggest that the pulsating nature of breathing is an important consideration when determining the deposition of fine and coarse particles...
  11. ncbi request reprint Reconstruction of complex passageways for simulations of transport phenomena: development of a graphical user interface for biological applications
    M N Godo
    Chemical Industry Institute of Toxicology, Research Triangle Park, NC 27709, USA
    Comput Methods Programs Biomed 47:97-112. 1995
    ..The use of these programs and their application to studies of respiratory tract toxicology are described...
  12. ncbi request reprint Dose response for formaldehyde-induced cytotoxicity in the human respiratory tract
    R B Conolly
    Center for Computational Biology and Extrapolation Modeling, CIIT Centers for Health Research, Six Davis Drive, Research Triangle Park, North Carolina 27709, USA
    Regul Toxicol Pharmacol 35:32-43. 2002
    ....
  13. ncbi request reprint Dosimetric adjustment factors for methyl methacrylate derived from a steady-state analysis of a physiologically based clearance-extraction model
    M E Andersen
    K S Crump Group, ICF Consulting, Research Triangle Park, North Carolina 27709, USA
    Inhal Toxicol 11:899-926. 1999
    ..145. These steady-state calculations with this PBCE model should be useful in risk assessment calculations for a variety of vapors and gases that are converted to toxic metabolites in cells in the respiratory tract...
  14. ncbi request reprint Nasal uptake of inhaled acrolein in rats
    Melanie F Struve
    CIIT at The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA
    Inhal Toxicol 20:217-25. 2008
    ....
  15. ncbi request reprint Modeling approaches for estimating the dosimetry of inhaled toxicants in children
    Gary L Ginsberg
    Connecticut Department of Public Health, Hartford, CT 06134, UAS
    J Toxicol Environ Health A 71:166-95. 2008
    ..A decision framework is discussed that considers these different approaches and modeling structures including assessment of parameter values, supporting data, reliability, and selection of dose metrics...
  16. ncbi request reprint Three-dimensional mapping of ozone-induced injury in the nasal airways of monkeys using magnetic resonance imaging and morphometric techniques
    Stephan A Carey
    Comparative Medicine and Integrative Biology, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824 1224, USA
    Toxicol Pathol 35:27-40. 2007
    ..These correlations are critical for accurate predictive modeling of exposure-dose-response relationships in the nasal airways, and subsequent extrapolation of nasal findings in animals to humans for determining risk...
  17. ncbi request reprint Analysis of particle deposition in the turbinate and olfactory regions using a human nasal computational fluid dynamics model
    Jeffry D Schroeter
    CIIT Centers for Health Research, Research Triangle Park, North Carolina, 27709 2137, USA
    J Aerosol Med 19:301-13. 2006
    ....
  18. ncbi request reprint Atrophic rhinitis: a CFD study of air conditioning in the nasal cavity
    Guilherme J M Garcia
    The Hamner Institutes for Health Sciences, 6 Davis Dr, P O Box 12137, Research Triangle Park, NC 27709, USA
    J Appl Physiol 103:1082-92. 2007
    ..We conclude that the main goals of a surgery to treat atrophic rhinitis should be 1) to restore the original surface area of the nose, 2) to restore the physiological airflow distribution, and 3) to create symmetric cavities...
  19. ncbi request reprint Use of a pharmacokinetic-driven computational fluid dynamics model to predict nasal extraction of hydrogen sulfide in rats and humans
    Jeffry D Schroeter
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709 2137, USA
    Toxicol Sci 94:359-67. 2006
    ....
  20. ncbi request reprint Incorporation of tissue reaction kinetics in a computational fluid dynamics model for nasal extraction of inhaled hydrogen sulfide in rats
    Jeffry D Schroeter
    CIIT Centers for Health Research, 6 Davis Drive, P O Box 12137, Research Triangle Park, North Carolina 27709 2137, USA
    Toxicol Sci 90:198-207. 2006
    ..The CFD model provides estimates of localized H2S flux to airway walls and can be used to calibrate lesion sites by dose...
  21. ncbi request reprint Human respiratory tract cancer risks of inhaled formaldehyde: dose-response predictions derived from biologically-motivated computational modeling of a combined rodent and human dataset
    Rory B Conolly
    Center for Computational Systems Biology and Human Health Assessment, CIIT Centers for Health Research, 6 Davis Drive, Research Triangle Park, NC 27709, USA
    Toxicol Sci 82:279-96. 2004
    ....
  22. ncbi request reprint A distributed-parameter model for formaldehyde uptake and disposition in the rat nasal lining
    Anna V Georgieva
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Inhal Toxicol 15:1435-63. 2003
    ..The model structure facilitates extrapolation to primates and humans and application to other soluble, reactive gases...
  23. ncbi request reprint Biologically motivated computational modeling of formaldehyde carcinogenicity in the F344 rat
    Rory B Conolly
    CIIT Centers for Health Research, 6 Davis Drive, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 75:432-47. 2003
    ....
  24. ncbi request reprint Use of a hybrid computational fluid dynamics and physiologically based inhalation model for interspecies dosimetry comparisons of ester vapors
    Clay B Frederick
    Toxicology Department, Rohm and Haas Company, Spring House, Pennsylvania 19477, USA
    Toxicol Appl Pharmacol 183:23-40. 2002
    ....
  25. ncbi request reprint Predicted regional flux of hydrogen sulfide correlates with distribution of nasal olfactory lesions in rats
    Frederic J M Moulin
    CIIT Centers for Health Research, 6 Davis Drive, P O Box 12137, Research Triangle Park, North Carolina 27709 2137, USA
    Toxicol Sci 66:7-15. 2002
    ....
  26. ncbi request reprint Application of physiological computational fluid dynamics models to predict interspecies nasal dosimetry of inhaled acrolein
    Jeffry D Schroeter
    The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709 2137, USA
    Inhal Toxicol 20:227-43. 2008
    ..Assuming that equivalent tissue dose will induce similar effects across species, a NOAEL human equivalent concentration for inhaled acrolein was estimated to be 8 ppb...