P M Foster

Summary

Affiliation: CIIT Centers for Health Research
Country: USA

Publications

  1. ncbi request reprint Endocrine active agents: implications of adverse and non-adverse changes
    Paul M D Foster
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709 2137, USA
    Toxicol Pathol 30:59-65. 2002
  2. ncbi request reprint Effects of phthalate esters on the developing reproductive tract of male rats
    P M Foster
    Endocrine Reproductive and Developmental Toxicology Program, CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Hum Reprod Update 7:231-5. 2001
  3. ncbi request reprint Androgen-mediated development in male rat offspring exposed to flutamide in utero: permanence and correlation of early postnatal changes in anogenital distance and nipple retention with malformations in androgen-dependent tissues
    B S McIntyre
    CIIT Centers for Health Research, Six Davis Drive, P. O. Box 12137, Research Triangle Park, NC 27709-2137, USA
    Toxicol Sci 62:236-49. 2001
  4. ncbi request reprint Altered gene profiles in fetal rat testes after in utero exposure to di(n-butyl) phthalate
    V D Shultz
    CIIT Centers for Health Research, P.O. Box 12137, Research Triangle Park, NC 27709, USA
    Toxicol Sci 64:233-42. 2001
  5. ncbi request reprint Fertility and developmental neurotoxicity effects of inhaled hydrogen sulfide in Sprague-Dawley rats
    D C Dorman
    Chemical Industry Institute of Toxicology, Research Triangle Park, NC 27709 2137, USA
    Neurotoxicol Teratol 22:71-84. 2000
  6. ncbi request reprint Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the developing male Wistar(Han) rat. II: Chronic dosing causes developmental delay
    David R Bell
    School of Biology, University of Nottingham, University Park, Nottingham, NG7 2RD, UK
    Toxicol Sci 99:224-33. 2007
  7. ncbi request reprint Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters
    Paul M D Foster
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Int J Androl 29:140-7; discussion 181-5. 2006
  8. ncbi request reprint Critical window of male reproductive tract development in rats following gestational exposure to di-n-butyl phthalate
    Christina M Carruthers
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Birth Defects Res B Dev Reprod Toxicol 74:277-85. 2005
  9. ncbi request reprint Changes in androgen-mediated reproductive development in male rat offspring following exposure to a single oral dose of flutamide at different gestational ages
    Paul M D Foster
    Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 85:1024-32. 2005
  10. ncbi request reprint Male reproductive tract lesions at 6, 12, and 18 months of age following in utero exposure to di(n-butyl) phthalate
    Norman J Barlow
    CIIT Centers for Health Research, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 32:79-90. 2004

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Endocrine active agents: implications of adverse and non-adverse changes
    Paul M D Foster
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709 2137, USA
    Toxicol Pathol 30:59-65. 2002
    ....
  2. ncbi request reprint Effects of phthalate esters on the developing reproductive tract of male rats
    P M Foster
    Endocrine Reproductive and Developmental Toxicology Program, CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Hum Reprod Update 7:231-5. 2001
    ..Examination of testes from fetal rats indicated markedly reduced testosterone levels and increased Leydig cell numbers after DBP administration to the dams. Leydig cells were positive for AR and 3-betahydroxysteroid dehydrogenase...
  3. ncbi request reprint Androgen-mediated development in male rat offspring exposed to flutamide in utero: permanence and correlation of early postnatal changes in anogenital distance and nipple retention with malformations in androgen-dependent tissues
    B S McIntyre
    CIIT Centers for Health Research, Six Davis Drive, P. O. Box 12137, Research Triangle Park, NC 27709-2137, USA
    Toxicol Sci 62:236-49. 2001
    ..These data suggest that flutamide-mediated changes in AGD and nipple retention are not sensitive predictors of altered T-mediated development...
  4. ncbi request reprint Altered gene profiles in fetal rat testes after in utero exposure to di(n-butyl) phthalate
    V D Shultz
    CIIT Centers for Health Research, P.O. Box 12137, Research Triangle Park, NC 27709, USA
    Toxicol Sci 64:233-42. 2001
    ..Future studies will explore the link between these identified gene expression alterations and ultimate adverse responses...
  5. ncbi request reprint Fertility and developmental neurotoxicity effects of inhaled hydrogen sulfide in Sprague-Dawley rats
    D C Dorman
    Chemical Industry Institute of Toxicology, Research Triangle Park, NC 27709 2137, USA
    Neurotoxicol Teratol 22:71-84. 2000
    ..The results of our study suggest that H2S is neither a reproductive toxicant nor a behavioral developmental neurotoxicant in the rat at occupationally relevant exposure concentrations (< or =10 ppm)...
  6. ncbi request reprint Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the developing male Wistar(Han) rat. II: Chronic dosing causes developmental delay
    David R Bell
    School of Biology, University of Nottingham, University Park, Nottingham, NG7 2RD, UK
    Toxicol Sci 99:224-33. 2007
    ....
  7. ncbi request reprint Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters
    Paul M D Foster
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Int J Androl 29:140-7; discussion 181-5. 2006
    ..However humans are exposed to and produce the critical phthalate metabolites that have been detected in blood of the general population, in children and also human amniotic fluid...
  8. ncbi request reprint Critical window of male reproductive tract development in rats following gestational exposure to di-n-butyl phthalate
    Christina M Carruthers
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Birth Defects Res B Dev Reprod Toxicol 74:277-85. 2005
    ..This study was conducted to identify the critical days for the abnormal development of the male reproductive tract, specifically the testis and epididymis...
  9. ncbi request reprint Changes in androgen-mediated reproductive development in male rat offspring following exposure to a single oral dose of flutamide at different gestational ages
    Paul M D Foster
    Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 85:1024-32. 2005
    ....
  10. ncbi request reprint Male reproductive tract lesions at 6, 12, and 18 months of age following in utero exposure to di(n-butyl) phthalate
    Norman J Barlow
    CIIT Centers for Health Research, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 32:79-90. 2004
    ..While the morphology and incidence of this DBP-induced testicular developmental lesion has been fully characterized by this study, the detailed pathogenesis warrants further investigation...
  11. ncbi request reprint Effects of in utero exposure to finasteride on androgen-dependent reproductive development in the male rat
    Christopher J Bowman
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 74:393-406. 2003
    ..In summary, prenatal exposure to finasteride specifically inhibited DHT-mediated development with little to no change in T-mediated development...
  12. ncbi request reprint Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the developing male Wistar(Han) rat. I: No decrease in epididymal sperm count after a single acute dose
    David R Bell
    School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Toxicol Sci 99:214-23. 2007
    ..These data show that TCDD is a potent developmental toxin after exposure of the developing fetus but that acute developmental exposure to TCDD on GD15 caused no decrease in sperm counts...
  13. ncbi request reprint Male rats exposed to linuron in utero exhibit permanent changes in anogenital distance, nipple retention, and epididymal malformations that result in subsequent testicular atrophy
    Barry S McIntyre
    CIIT Centers for Health Research, P O Box 12137, Research Triangle Park, North Carolina 27709 2137, USA
    Toxicol Sci 65:62-70. 2002
    ....
  14. ncbi request reprint Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonocytes in rats exposed to di(n-butyl) phthalate
    Eve Mylchreest
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Reprod Toxicol 16:19-28. 2002
    ..The overall decrease in androgen concentration is not corrected and results in reproductive tract malformations. The multinuclearity and proliferation of gonocytes suggests an underlying Sertoli cell dysfunction...
  15. ncbi request reprint Effects of in utero linuron exposure on rat Wolffian duct development
    Barry S McIntyre
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Reprod Toxicol 16:131-9. 2002
    ..However, the absence of testicular lesions or alterations in fetal testosterone levels would suggest that the effect of linuron on the developing Wolffian ducts is distinctly different from DBP or DEHP...
  16. ncbi request reprint Effects of in utero exposure to the organophosphate insecticide fenitrothion on androgen-dependent reproductive development in the Crl:CD(SD)BR rat
    Katie J Turner
    CIIT Centers for Health Research, P O Box 12137, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 68:174-83. 2002
    ..Based on observed fetotoxicity at 20 mg/kg/day, the lowest observed adverse effect level (LOAEL) for developmental effects can be lowered from 25 to 20 mg/kg/day...
  17. ncbi request reprint Altered gene expression during rat Wolffian duct development following di(n-butyl) phthalate exposure
    Christopher J Bowman
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 86:161-74. 2005
    ....
  18. ncbi request reprint Quantitative changes in gene expression in fetal rat testes following exposure to di(n-butyl) phthalate
    Norman J Barlow
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 73:431-41. 2003
    ..Diminished Leydig cell lipid content and alteration of cholesterol transport genes also support altered cholesterol metabolism and transport as a potential mechanism for decreased T synthesis following exposure to DBP...
  19. ncbi request reprint Mode of action: impaired fetal leydig cell function--effects on male reproductive development produced by certain phthalate esters
    Paul M D Foster
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Crit Rev Toxicol 35:713-9. 2005
    ....
  20. ncbi request reprint Pathogenesis of male reproductive tract lesions from gestation through adulthood following in utero exposure to Di(n-butyl) phthalate
    Norman J Barlow
    CIIT Centers for Health Research, Six Davis Drive, PO Box 12137, Research Triangle Park, North Carolina 27709 2137, USA
    Toxicol Pathol 31:397-410. 2003
    ..The pathogenesis of lesion development from the fetus to the adult is important for comparison of antiandrogens with differing modes of action...
  21. ncbi request reprint Altered gene expression during rat Wolffian duct development in response to in utero exposure to the antiandrogen linuron
    Katie J Turner
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709 2137, USA
    Toxicol Sci 74:114-28. 2003
    ..The EGF, Notch, IGF-1, BMP4, and FGF signaling pathways may be involved in normal testosterone-mediated development of the Wolffian duct...