T R Fennell
Affiliation: CIIT Centers for Health Research
- Hemoglobin adducts from acrylonitrile and ethylene oxide in cigarette smokers: effects of glutathione S-transferase T1-null and M1-null genotypesT R Fennell
Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 27709, USA
Cancer Epidemiol Biomarkers Prev 9:705-12. 2000..The ratio of HEVal:CEVal was also elevated in GSTT1-null smokers (1.50 +/- 0.57 versus 0.88 +/- 0.24; P = 0.0002). The lack of a functional GSTT1 is estimated to increase the internal dose of EO derived from cigarette smoke by 50-70%...
- A physiologically based pharmacokinetic model for ethylene oxide in mouse, rat, and humanT R Fennell
CIIT Centers for Health Research, Research Triangle Park, North Carolina, 27709, USA
Toxicol Appl Pharmacol 173:161-75. 2001..These models represent an essential step in developing a mechanistically based EO exposure-dose-response description for estimating human risk from exposure to EO...
- Role of cytochrome P450 2E1 in the metabolism of acrylamide and acrylonitrile in miceS C Sumner
Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 27709 2137, USA
Chem Res Toxicol 12:1110-6. 1999..P450 2E1-null mice may be an appropriate model for the investigation of the role of oxidative metabolism in the toxicity or carcinogenicity of these compounds...
- Human exposure and internal dose assessments of acrylamide in foodE Dybing
Norwegian Institute of Public Health, Division of Environmental Medicine, P O Box 4404, Nydalen, NO 0403 Oslo, Norway
Food Chem Toxicol 43:365-410. 2005..Each of the sections concludes with a summary of remaining gaps and uncertainties...