T R Fennell

Summary

Affiliation: CIIT Centers for Health Research
Country: USA

Publications

  1. ncbi request reprint Hemoglobin adducts from acrylonitrile and ethylene oxide in cigarette smokers: effects of glutathione S-transferase T1-null and M1-null genotypes
    T R Fennell
    Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 27709, USA
    Cancer Epidemiol Biomarkers Prev 9:705-12. 2000
  2. ncbi request reprint A physiologically based pharmacokinetic model for ethylene oxide in mouse, rat, and human
    T R Fennell
    CIIT Centers for Health Research, Research Triangle Park, North Carolina, 27709, USA
    Toxicol Appl Pharmacol 173:161-75. 2001
  3. ncbi request reprint Role of cytochrome P450 2E1 in the metabolism of acrylamide and acrylonitrile in mice
    S C Sumner
    Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 27709 2137, USA
    Chem Res Toxicol 12:1110-6. 1999
  4. ncbi request reprint Human exposure and internal dose assessments of acrylamide in food
    E Dybing
    Norwegian Institute of Public Health, Division of Environmental Medicine, P O Box 4404, Nydalen, NO 0403 Oslo, Norway
    Food Chem Toxicol 43:365-410. 2005

Collaborators

  • Burhan I Ghanayem
  • T A Moore
  • S C Sumner
  • E Dybing
  • S Olin
  • M Andersen
  • S Tuijtelaars
  • J A Scimeca
  • S P D Lalljie
  • B J Petersen
  • J Schlatter
  • D J G Müller
  • M Tornqvist
  • P B Farmer
  • P Verger
  • N Slimani
  • G Scholz

Detail Information

Publications4

  1. ncbi request reprint Hemoglobin adducts from acrylonitrile and ethylene oxide in cigarette smokers: effects of glutathione S-transferase T1-null and M1-null genotypes
    T R Fennell
    Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 27709, USA
    Cancer Epidemiol Biomarkers Prev 9:705-12. 2000
    ..The ratio of HEVal:CEVal was also elevated in GSTT1-null smokers (1.50 +/- 0.57 versus 0.88 +/- 0.24; P = 0.0002). The lack of a functional GSTT1 is estimated to increase the internal dose of EO derived from cigarette smoke by 50-70%...
  2. ncbi request reprint A physiologically based pharmacokinetic model for ethylene oxide in mouse, rat, and human
    T R Fennell
    CIIT Centers for Health Research, Research Triangle Park, North Carolina, 27709, USA
    Toxicol Appl Pharmacol 173:161-75. 2001
    ..These models represent an essential step in developing a mechanistically based EO exposure-dose-response description for estimating human risk from exposure to EO...
  3. ncbi request reprint Role of cytochrome P450 2E1 in the metabolism of acrylamide and acrylonitrile in mice
    S C Sumner
    Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 27709 2137, USA
    Chem Res Toxicol 12:1110-6. 1999
    ..P450 2E1-null mice may be an appropriate model for the investigation of the role of oxidative metabolism in the toxicity or carcinogenicity of these compounds...
  4. ncbi request reprint Human exposure and internal dose assessments of acrylamide in food
    E Dybing
    Norwegian Institute of Public Health, Division of Environmental Medicine, P O Box 4404, Nydalen, NO 0403 Oslo, Norway
    Food Chem Toxicol 43:365-410. 2005
    ..Each of the sections concludes with a summary of remaining gaps and uncertainties...