Sheila Collins

Summary

Affiliation: CIIT Centers for Health Research
Country: USA

Publications

  1. ncbi request reprint Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels
    Fabienne de Bilbao
    Department of Psychiatry, University Hospitals Geneva, Geneva, Switzerland
    J Neurochem 89:1283-92. 2004
  2. ncbi request reprint beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels
    Jakob D Wikstrom
    Tufts University, Department of Pharmacology and Experimental Therapeutics, 136 Harrison Ave, Boston, MA 02111, USA
    Diabetes 56:2569-78. 2007
  3. ncbi request reprint Learning new tricks from old dogs: beta-adrenergic receptors teach new lessons on firing up adipose tissue metabolism
    Sheila Collins
    CIIT Centers for Health Research, Six Davis Drive, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 18:2123-31. 2004
  4. ncbi request reprint Overview of clinical perspectives and mechanisms of obesity
    Sheila Collins
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Birth Defects Res A Clin Mol Teratol 73:470-1. 2005
  5. pmc Orphan nuclear receptor NOR-1 enhances 3',5'-cyclic adenosine 5'-monophosphate-dependent uncoupling protein-1 gene transcription
    Naresh Kumar
    Division of Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 22:1057-64. 2008
  6. pmc Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis
    Yongyong Hou
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 52:462-72. 2012
  7. pmc Acute stimulation of white adipocyte respiration by PKA-induced lipolysis
    Einav Yehuda-Shnaidman
    Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA
    Diabetes 59:2474-83. 2010
  8. pmc Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function
    Jingbo Pi
    Division of Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 150:3040-8. 2009
  9. pmc Suppression of hepatic glucose production by human neutrophil alpha-defensins through a signaling pathway distinct from insulin
    Hui Yu Liu
    Division of Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 283:12056-63. 2008
  10. ncbi request reprint Requirement of vimentin filament assembly for beta3-adrenergic receptor activation of ERK MAP kinase and lipolysis
    Naresh Kumar
    Program in Endocrine Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 282:9244-50. 2007

Research Grants

  1. BETA 3-ADRENOCEPTORS AND MAP KINASE IN ADIPOCYTES
    Sheila Collins; Fiscal Year: 2003
  2. Mechanism Regulating Expression of the UCP2 Gene
    Sheila Collins; Fiscal Year: 2005

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels
    Fabienne de Bilbao
    Department of Psychiatry, University Hospitals Geneva, Geneva, Switzerland
    J Neurochem 89:1283-92. 2004
    ..Moreover, our data imply that UCP2 is not directly involved in the regulation of ROS production but acts by regulating mitochondrial GSH levels in microglia...
  2. ncbi request reprint beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels
    Jakob D Wikstrom
    Tufts University, Department of Pharmacology and Experimental Therapeutics, 136 Harrison Ave, Boston, MA 02111, USA
    Diabetes 56:2569-78. 2007
    ..This study offers insight into the different metabolic states of beta-cell mitochondria...
  3. ncbi request reprint Learning new tricks from old dogs: beta-adrenergic receptors teach new lessons on firing up adipose tissue metabolism
    Sheila Collins
    CIIT Centers for Health Research, Six Davis Drive, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 18:2123-31. 2004
    ....
  4. ncbi request reprint Overview of clinical perspectives and mechanisms of obesity
    Sheila Collins
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Birth Defects Res A Clin Mol Teratol 73:470-1. 2005
  5. pmc Orphan nuclear receptor NOR-1 enhances 3',5'-cyclic adenosine 5'-monophosphate-dependent uncoupling protein-1 gene transcription
    Naresh Kumar
    Division of Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 22:1057-64. 2008
    ..7-kb Ucp1 promoter. These results extend our understanding of the combinatorial complexity in the signaling pathways that control this tissue-specific gene...
  6. pmc Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis
    Yongyong Hou
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 52:462-72. 2012
    ....
  7. pmc Acute stimulation of white adipocyte respiration by PKA-induced lipolysis
    Einav Yehuda-Shnaidman
    Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA
    Diabetes 59:2474-83. 2010
    ..We examined the effect of β-adrenergic receptor (βAR) activation and cAMP-elevating agents on respiration and mitochondrial uncoupling in human adipocytes and probed the underlying molecular mechanisms...
  8. pmc Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function
    Jingbo Pi
    Division of Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 150:3040-8. 2009
    ..These data show that the chronic absence of UCP2 causes oxidative stress, including in islets, and is accompanied by impaired glucose-stimulated insulin secretion...
  9. pmc Suppression of hepatic glucose production by human neutrophil alpha-defensins through a signaling pathway distinct from insulin
    Hui Yu Liu
    Division of Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 283:12056-63. 2008
    ..Together, our results support the hypothesis that HNPs can suppress hepatic glucose production through an intracellular mechanism distinct from the classical insulin signaling pathway...
  10. ncbi request reprint Requirement of vimentin filament assembly for beta3-adrenergic receptor activation of ERK MAP kinase and lipolysis
    Naresh Kumar
    Program in Endocrine Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 282:9244-50. 2007
    ..These results indicate that vimentin plays an essential role in the signal transduction pathway from beta3AR to the activation ERK and its contribution to lipolysis...
  11. pmc Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype
    Haibo Wang
    The Hamner Institutes for Health Sciences, 6 Davis Drive, P O Box 12137, Research Triangle Park, NC 27709, USA
    Mol Cell Biol 28:2187-200. 2008
    ..The ability of LXRalpha to dampen energy expenditure in this way provides another mechanism for maintaining a balance between energy storage and utilization...
  12. pmc ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function
    Jingbo Pi
    Division of Translational Biology, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 244:77-83. 2010
    ..In addition, we summarized our recent findings that persistent oxidative stress due to absence of uncoupling protein 2 activates cellular adaptive response which is associated with impaired pancreatic beta-cell function...
  13. pmc Low-level arsenic impairs glucose-stimulated insulin secretion in pancreatic beta cells: involvement of cellular adaptive response to oxidative stress
    Jingqi Fu
    Division of Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 118:864-70. 2010
    ..Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a central transcription factor regulating cellular adaptive response to oxidative stress...
  14. ncbi request reprint Maximal beta3-adrenergic regulation of lipolysis involves Src and epidermal growth factor receptor-dependent ERK1/2 activation
    Jacques Robidoux
    Program in Endocrine Biology, Division of Biological Sciences, CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 281:37794-802. 2006
    ..Together these results illustrate the distinct and complementary roles for PKA and ERK in catecholamine-stimulated lipolysis...
  15. ncbi request reprint Activation of Nrf2-mediated oxidative stress response in macrophages by hypochlorous acid
    Jingbo Pi
    Division of Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 226:236-43. 2008
    ..Taken together, we provide direct evidence that HOCl activates Nrf2-mediated antioxidant response, which protects cells from oxidative damage...
  16. pmc Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2
    Jingbo Pi
    Laboratory of Comparative Carcinogenesis, NCI at NIEHS, NIH, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 42:1797-806. 2007
    ..In contrast, Nrf2-118 is more susceptible to degradation. These results provide evidence for phosphorylation by CK2 as a critical controlling factor in Nrf2-mediated cellular antioxidant response...
  17. pmc Persistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production
    Yushi Bai
    Division of Biological Sciences, Endocrine Biology Program, CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709 2137, USA
    J Biol Chem 280:19062-9. 2005
    ..We conclude that mitochrondrially derived reactive oxygen from Ucp2-/- cells constitutively activates NF-kappa B, resulting in a "primed" state to both potentiate and amplify the inflammatory response upon subsequent stimulation...
  18. ncbi request reprint Reactive oxygen species as a signal in glucose-stimulated insulin secretion
    Jingbo Pi
    Endocrine Biology Program, The Hamner Institutes for Health Sciences, 6 Davis Dr, Research Triangle Park, NC 27709, USA
    Diabetes 56:1783-91. 2007
    ..Taken together, these findings suggest that H2O2 derived from glucose metabolism is one of the metabolic signals for insulin secretion, whereas oxidative stress may disturb its signaling function...
  19. ncbi request reprint p38 Mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis
    Wenhong Cao
    Endocrine Biology Program, CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 280:42731-7. 2005
    ....
  20. ncbi request reprint Beta-adrenergic receptors and regulation of energy expenditure: a family affair
    Jacques Robidoux
    Departments of Pharmacology, Psychiatry, and Behavioral Sciences, and The Sarah W Stedman Center for Nutritional Studies, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Pharmacol Toxicol 44:297-323. 2004
    ..They illustrate how betaAR signaling can orchestrate a coordinated set of intracellular responses for fine control of metabolic balance...
  21. pmc p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene
    Wenhong Cao
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 24:3057-67. 2004
    ..In conclusion, our findings illustrate that by orchestrating the activity of multiple transcription factors, p38 MAPK is a central mediator of the cAMP signaling mechanism of brown fat that promotes thermogenesis...
  22. pmc Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes
    Jacques Robidoux
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 25:5466-79. 2005
    ..Therefore, in the brown adipocyte the recently described scaffold protein JIP2 assembles the required factors MKK3 and p38alpha MAPK linking PKA to the control of thermogenic gene expression...
  23. ncbi request reprint Regulation of the uncoupling protein-2 gene in INS-1 beta-cells by oleic acid
    Alexander V Medvedev
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 277:42639-44. 2002
    ..These data support a model in which SREBP is the major modulator of UCP2 gene transcription by FFA, while E-Box binding factors play a supportive role...
  24. ncbi request reprint Genetic vulnerability to diet-induced obesity in the C57BL/6J mouse: physiological and molecular characteristics
    Sheila Collins
    Department of Pharmacology, Duke University Medical Center, Durham, NC 27710, USA
    Physiol Behav 81:243-8. 2004
    ..This review highlights metabolic and signal transduction features that are altered during the course of disease progression, many of which mirror the human situation...
  25. ncbi request reprint An interview with Sheila Collins, Ph.D. Interview by Vicki Glaser
    Sheila Collins
    Assay Drug Dev Technol 3:253-60. 2005

Research Grants3

  1. BETA 3-ADRENOCEPTORS AND MAP KINASE IN ADIPOCYTES
    Sheila Collins; Fiscal Year: 2003
    ..abstract_text> ..
  2. Mechanism Regulating Expression of the UCP2 Gene
    Sheila Collins; Fiscal Year: 2005
    ..These studies will characterize the interplay between FFAs and glucose on control of UCP2 expression at the molecular level as well as the consequence of UCP2 modulation on insulin secretion. ..