Research Topics
| M S ChristianSummaryCountry: USA Publications
| Collaborators
|
Detail Information
Publications
Evaluation of the developmental toxicity of acetyl cedreneAurelia Lapczynski
Research Institute for Fragrance Materials, Inc, Woodcliff Lake, New Jersey 07677, USA
Int J Toxicol 25:423-8. 2006..Based on these data, maternal and developmental no-observable-adverse-effect levels (NOAELs) of 50 and 100 mg/kg/day, respectively, were established for AC...- History of the Journal of the American College of ToxicologyMildred S Christian
Argus International, Inc, Horsham, Pennsylvania 19044, USA
Int J Toxicol 23:281-4. 2004..Myron A. Mehlman, Mildred S. Christian, Robert M. Diener and Harihara Mehendale... - History of the American College of Toxicology (ACT)Mildred S Christian
Argus International, Inc, Horsham, Pennsylvania 19044, USA
Int J Toxicol 23:285-99. 2004.... - The toxicity profile of hydrolyzed aqueous olive pulp extractMildred S Christian
Argus International, Inc, Horsham, Pennsylvania 19044, USA
Drug Chem Toxicol 27:309-30. 2004.... - Developmental (embryo-fetal toxicity/teratogenicity) toxicity studies of synthetic crystalline lycopene in rats and rabbitsM S Christian
Argus International Inc 933 Horsham Road, Horsham, PA 19044, USA
Food Chem Toxicol 41:773-83. 2003..Neither Lycopene 10 CWD nor LycoVit 10% caused direct maternal or developmental toxicity in rats or rabbits at dosages as high as 3000 or 2000 mg/kg/day, respectively... - Embryo-fetal toxicity signals for 17alpha-hydroxyprogesterone caproate in high-risk pregnancies: a review of the non-clinical literature for embryo-fetal toxicity with progestinsM S Christian
Argus International, Horsham, PA 19044, USA
J Matern Fetal Neonatal Med 20:89-112. 2007.... - Evaluation of the developmental toxicity of lenalidomide in rabbitsMildred S Christian
Argus International, Horsham, Pennsylvania 19044, USA
Birth Defects Res B Dev Reprod Toxicol 80:188-207. 2007..Lenalidomide, a thalidomide analog, is indicated for treatment of patients with deletion-5q myelodysplastic syndromes or multiple myeloma. NZW rabbits were used because of sensitivity to thalidomide's teratogenicity... 
Introduction and history of the Hungarian project for monitoring suicide attempts in pregnant womenM S Christian
Argus International, Inc, Horsham, PA 18934, USA
Toxicol Ind Health 24:5-9. 2008..It is envisioned that the information provided will assist physicians and mothers in making better decisions regarding drug exposure during pregnancy...- Biodisposition of dibromoacetic acid (DBA) and bromodichloromethane (BDCM) administered to rats and rabbits in drinking water during range-finding reproduction and developmental toxicity studiesM S Christian
Argus Research Laboratories, Inc, Horsham, Pennsylvania 19044, USA
Int J Toxicol 20:239-53. 2001.... - Oral (drinking water) two-generation reproductive toxicity study of dibromoacetic acid (DBA) in ratsM S Christian
Argus Research Laboratories, Inc, Horsham, Pennsylvania 19044, USA
Int J Toxicol 21:237-76. 2002..Based on the high multiples of human exposure required to produce effects in male rats, DBA should not be identified as a human reproductive or developmental risk... - Oral (drinking water) developmental toxicity studies of bromodichloromethane (BDCM) in rats and rabbitsM S Christian
Argus Research Laboratories, Inc, Horsham, Pennsylvania 19044, USA
Int J Toxicol 20:225-37. 2001..3 mg/kg/day). These NOAELs are 56,250 and 69,120 times the human adult exposure level of 0.0008 mg/kg/day, respectively. Based on the results of these studies, BDCM should not be identified as a risk to development of human conceptuses... - Lack of effects of nose-only inhalation exposure on testicular toxicity in male ratsS J Rothenberg
Primedica Argus, Horsham, Pennsylvania 19044, USA
Toxicol Sci 53:127-34. 2000..Thus, nose-only exposure for up to 2 h per day for a total of 42 days did not cause adverse effects on the reproductive organs, fertility, or reproductive performance of male rats under the conditions of this study... - Lack of developmental neurotoxicity of MN rgp 120/HIV-1 administered subcutaneously to neonatal ratsJ L Bussiere
Department of Toxicology, Genentech, Inc, South San Francisco, CA 94080, USA
Toxicol Sci 48:90-9. 1999..Thus, MN rgp120/HIV-1 alone or formulated as a vaccine does not cause neurotoxicity or developmental toxicity in neonatal rats after exposure in utero and/or during the neonatal period... - Developmental toxicity studies of four fragrances in ratsM S Christian
Argus Research Laboratories Inc, Horsham, PA 19044, USA
Toxicol Lett 111:169-74. 1999..The results of this study indicate that under conditions of normal use, the tested fragrances do not pose a risk to human conceptuses... - Oral (drinking water) two-generation reproductive toxicity study of bromodichloromethane (BDCM) in ratsM S Christian
Argus Research Laboratories, Inc, Horsham, Pennsylvania, USA
Int J Toxicol 21:115-46. 2002..5 to 109.0 mg/kg/day), or 36,875 to 136,250 times the human adult exposure level. Regardless, these data indicate that BDCM should not be identified as a risk to human reproductive performance or development of human conceptuses... - Teratogen update: evaluation of the reproductive and developmental risks of caffeineM S Christian
Argus International and Argus Research Laboratories, Horsham, Pennsylvania 19044, USA
Teratology 64:51-78. 2001..Proven human teratogens have an identifiable syndrome. The malformations described in the animal studies at very high doses fit the description of vascular disruptive types of malformations. (ABSTRACT TRUNCATED).. - Evaluation of the developmental toxicity of 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl) ethanone (OTNE) in ratsValerie T Politano
Research Institute for Fragrance Materials, Inc, Woodcliff Lake, NJ 07677, USA
Int J Toxicol 28:213-8. 2009..086 mg/kg/d... - Evaluation of the developmental toxicity of dihydromyrcenol in ratsValerie T Politano
Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA
Int J Toxicol 28:80-7. 2009..02 mg/kg/d... - Oral (gavage) two-generation (one litter per generation) reproduction study of pentachlorophenol (penta) in ratsBruce K Bernard
SRA International, Inc, Washington, DC 20036, USA
Int J Toxicol 21:301-18. 2002..Thus, penta did not selectively affect reproduction or development of the offspring of rats at a dose of 10 mg/kg/day, a dose that is 7000 to 20,000 times higher than human exposure... - Evaluation of the developmental toxicity of linalool in ratsValerie T Politano
Research Institute for Fragrance Materials, Inc, Woodcliff Lake, New Jersey, USA
Int J Toxicol 27:183-8. 2008..It is concluded that linalool is not a developmental toxicant in rats at maternal doses of up to 1000 mg/kg/day... - Introduction/overview: gender-based differences in pharmacologic and toxicologic responsesM S Christian
Primedica Argus Research Laboratories, Inc, Horsham, Pennsylvania 19044, USA
Int J Toxicol 20:145-8. 2001.... - Evaluation of the developmental toxicity of methyl dihydrojasmonate (MDJ) in ratsValerie T Politano
Research Institute for Fragrance Materials, Inc, Woodcliff Lake, New Jersey 07677, USA
Int J Toxicol 27:295-300. 2008..It is concluded that MDJ is not a developmental toxicant in rats under the conditions of this study... - Evaluation of the developmental toxicity of alpha-iso-methylionone in ratsValerie T Politano
Research Institute for Fragrance Materials, Inc, Woodcliff Lake, New Jersey 07677, USA
Int J Toxicol 26:271-6. 2007..It is concluded that alpha-iso-methylionone is not a developmental toxicant in rats at maternal doses of up to 30 mg/kg/day... - Evaluation of the developmental toxicity of alpha-methyl-3,4-methylene-dioxyhydrocinnamic aldehyde in ratsAnne Marie Api
Research Institute for Fragrance Materials, Inc, Woodcliff Lake, New Jersey 07677, USA
Int J Toxicol 25:127-32. 2006..It is concluded that MMDHCA is not a developmental toxicant in rats under the conditions of this study and dosing regimen... - The perinatal and postnatal toxicity of D-methylphenidate and D,L-methylphenidate in ratsSteve K Teo
Celgene Corporation, 7 Powder Horn Drive, Warren, NJ 07059, USA
Reprod Toxicol 16:353-66. 2002..Neither compound produced any other significant adverse findings in F0 and F1 generation rats at doses that were at least 25 times the maximum daily human therapeutic dose... 
Neither antibody to a group B streptococcal conjugate vaccine nor the vaccine itself is teratogenic in rabbitsLawrence C Paoletti
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Hum Vaccin 4:435-43. 2008..e., it was non-teratogenic). In addition, that III-TT lot 3-1-96 was found to be safe and immunogenic in two clinical studies involving healthy non-pregnant adults supports a clinical evaluation of this vaccine in pregnant women...- D-methylphenidate and D,L-methylphenidate are not developmental toxicants in rats and rabbitsSteve K Teo
Celgene Corporation, Warren, New Jersey 07059, USA
Birth Defects Res B Dev Reprod Toxicol 68:162-71. 2003..The developmental toxicity of both compounds was determined and compared in rats and rabbits according to current International Conference on Harmonization (ICH) guidelines...