M S Christian

Summary

Country: USA

Publications

  1. ncbi request reprint Evaluation of the developmental toxicity of acetyl cedrene
    Aurelia Lapczynski
    Research Institute for Fragrance Materials, Inc, Woodcliff Lake, New Jersey 07677, USA
    Int J Toxicol 25:423-8. 2006
  2. ncbi request reprint History of the Journal of the American College of Toxicology
    Mildred S Christian
    Argus International, Inc, Horsham, Pennsylvania 19044, USA
    Int J Toxicol 23:281-4. 2004
  3. ncbi request reprint History of the American College of Toxicology (ACT)
    Mildred S Christian
    Argus International, Inc, Horsham, Pennsylvania 19044, USA
    Int J Toxicol 23:285-99. 2004
  4. ncbi request reprint The toxicity profile of hydrolyzed aqueous olive pulp extract
    Mildred S Christian
    Argus International, Inc, Horsham, Pennsylvania 19044, USA
    Drug Chem Toxicol 27:309-30. 2004
  5. ncbi request reprint Developmental (embryo-fetal toxicity/teratogenicity) toxicity studies of synthetic crystalline lycopene in rats and rabbits
    M S Christian
    Argus International Inc 933 Horsham Road, Horsham, PA 19044, USA
    Food Chem Toxicol 41:773-83. 2003
  6. ncbi request reprint Embryo-fetal toxicity signals for 17alpha-hydroxyprogesterone caproate in high-risk pregnancies: a review of the non-clinical literature for embryo-fetal toxicity with progestins
    M S Christian
    Argus International, Horsham, PA 19044, USA
    J Matern Fetal Neonatal Med 20:89-112. 2007
  7. ncbi request reprint Evaluation of the developmental toxicity of lenalidomide in rabbits
    Mildred S Christian
    Argus International, Horsham, Pennsylvania 19044, USA
    Birth Defects Res B Dev Reprod Toxicol 80:188-207. 2007
  8. doi request reprint Introduction and history of the Hungarian project for monitoring suicide attempts in pregnant women
    M S Christian
    Argus International, Inc, Horsham, PA 18934, USA
    Toxicol Ind Health 24:5-9. 2008
  9. ncbi request reprint Biodisposition of dibromoacetic acid (DBA) and bromodichloromethane (BDCM) administered to rats and rabbits in drinking water during range-finding reproduction and developmental toxicity studies
    M S Christian
    Argus Research Laboratories, Inc, Horsham, Pennsylvania 19044, USA
    Int J Toxicol 20:239-53. 2001
  10. ncbi request reprint Oral (drinking water) two-generation reproductive toxicity study of dibromoacetic acid (DBA) in rats
    M S Christian
    Argus Research Laboratories, Inc, Horsham, Pennsylvania 19044, USA
    Int J Toxicol 21:237-76. 2002

Detail Information

Publications27

  1. ncbi request reprint Evaluation of the developmental toxicity of acetyl cedrene
    Aurelia Lapczynski
    Research Institute for Fragrance Materials, Inc, Woodcliff Lake, New Jersey 07677, USA
    Int J Toxicol 25:423-8. 2006
    ..Based on these data, maternal and developmental no-observable-adverse-effect levels (NOAELs) of 50 and 100 mg/kg/day, respectively, were established for AC...
  2. ncbi request reprint History of the Journal of the American College of Toxicology
    Mildred S Christian
    Argus International, Inc, Horsham, Pennsylvania 19044, USA
    Int J Toxicol 23:281-4. 2004
    ..Myron A. Mehlman, Mildred S. Christian, Robert M. Diener and Harihara Mehendale...
  3. ncbi request reprint History of the American College of Toxicology (ACT)
    Mildred S Christian
    Argus International, Inc, Horsham, Pennsylvania 19044, USA
    Int J Toxicol 23:285-99. 2004
    ....
  4. ncbi request reprint The toxicity profile of hydrolyzed aqueous olive pulp extract
    Mildred S Christian
    Argus International, Inc, Horsham, Pennsylvania 19044, USA
    Drug Chem Toxicol 27:309-30. 2004
    ....
  5. ncbi request reprint Developmental (embryo-fetal toxicity/teratogenicity) toxicity studies of synthetic crystalline lycopene in rats and rabbits
    M S Christian
    Argus International Inc 933 Horsham Road, Horsham, PA 19044, USA
    Food Chem Toxicol 41:773-83. 2003
    ..Neither Lycopene 10 CWD nor LycoVit 10% caused direct maternal or developmental toxicity in rats or rabbits at dosages as high as 3000 or 2000 mg/kg/day, respectively...
  6. ncbi request reprint Embryo-fetal toxicity signals for 17alpha-hydroxyprogesterone caproate in high-risk pregnancies: a review of the non-clinical literature for embryo-fetal toxicity with progestins
    M S Christian
    Argus International, Horsham, PA 19044, USA
    J Matern Fetal Neonatal Med 20:89-112. 2007
    ....
  7. ncbi request reprint Evaluation of the developmental toxicity of lenalidomide in rabbits
    Mildred S Christian
    Argus International, Horsham, Pennsylvania 19044, USA
    Birth Defects Res B Dev Reprod Toxicol 80:188-207. 2007
    ..Lenalidomide, a thalidomide analog, is indicated for treatment of patients with deletion-5q myelodysplastic syndromes or multiple myeloma. NZW rabbits were used because of sensitivity to thalidomide's teratogenicity...
  8. doi request reprint Introduction and history of the Hungarian project for monitoring suicide attempts in pregnant women
    M S Christian
    Argus International, Inc, Horsham, PA 18934, USA
    Toxicol Ind Health 24:5-9. 2008
    ..It is envisioned that the information provided will assist physicians and mothers in making better decisions regarding drug exposure during pregnancy...
  9. ncbi request reprint Biodisposition of dibromoacetic acid (DBA) and bromodichloromethane (BDCM) administered to rats and rabbits in drinking water during range-finding reproduction and developmental toxicity studies
    M S Christian
    Argus Research Laboratories, Inc, Horsham, Pennsylvania 19044, USA
    Int J Toxicol 20:239-53. 2001
    ....
  10. ncbi request reprint Oral (drinking water) two-generation reproductive toxicity study of dibromoacetic acid (DBA) in rats
    M S Christian
    Argus Research Laboratories, Inc, Horsham, Pennsylvania 19044, USA
    Int J Toxicol 21:237-76. 2002
    ..Based on the high multiples of human exposure required to produce effects in male rats, DBA should not be identified as a human reproductive or developmental risk...
  11. ncbi request reprint Oral (drinking water) developmental toxicity studies of bromodichloromethane (BDCM) in rats and rabbits
    M S Christian
    Argus Research Laboratories, Inc, Horsham, Pennsylvania 19044, USA
    Int J Toxicol 20:225-37. 2001
    ..3 mg/kg/day). These NOAELs are 56,250 and 69,120 times the human adult exposure level of 0.0008 mg/kg/day, respectively. Based on the results of these studies, BDCM should not be identified as a risk to development of human conceptuses...
  12. ncbi request reprint Lack of effects of nose-only inhalation exposure on testicular toxicity in male rats
    S J Rothenberg
    Primedica Argus, Horsham, Pennsylvania 19044, USA
    Toxicol Sci 53:127-34. 2000
    ..Thus, nose-only exposure for up to 2 h per day for a total of 42 days did not cause adverse effects on the reproductive organs, fertility, or reproductive performance of male rats under the conditions of this study...
  13. ncbi request reprint Lack of developmental neurotoxicity of MN rgp 120/HIV-1 administered subcutaneously to neonatal rats
    J L Bussiere
    Department of Toxicology, Genentech, Inc, South San Francisco, CA 94080, USA
    Toxicol Sci 48:90-9. 1999
    ..Thus, MN rgp120/HIV-1 alone or formulated as a vaccine does not cause neurotoxicity or developmental toxicity in neonatal rats after exposure in utero and/or during the neonatal period...
  14. ncbi request reprint Developmental toxicity studies of four fragrances in rats
    M S Christian
    Argus Research Laboratories Inc, Horsham, PA 19044, USA
    Toxicol Lett 111:169-74. 1999
    ..The results of this study indicate that under conditions of normal use, the tested fragrances do not pose a risk to human conceptuses...
  15. ncbi request reprint Oral (drinking water) two-generation reproductive toxicity study of bromodichloromethane (BDCM) in rats
    M S Christian
    Argus Research Laboratories, Inc, Horsham, Pennsylvania, USA
    Int J Toxicol 21:115-46. 2002
    ..5 to 109.0 mg/kg/day), or 36,875 to 136,250 times the human adult exposure level. Regardless, these data indicate that BDCM should not be identified as a risk to human reproductive performance or development of human conceptuses...
  16. ncbi request reprint Teratogen update: evaluation of the reproductive and developmental risks of caffeine
    M S Christian
    Argus International and Argus Research Laboratories, Horsham, Pennsylvania 19044, USA
    Teratology 64:51-78. 2001
    ..Proven human teratogens have an identifiable syndrome. The malformations described in the animal studies at very high doses fit the description of vascular disruptive types of malformations. (ABSTRACT TRUNCATED)..
  17. doi request reprint Evaluation of the developmental toxicity of 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl) ethanone (OTNE) in rats
    Valerie T Politano
    Research Institute for Fragrance Materials, Inc, Woodcliff Lake, NJ 07677, USA
    Int J Toxicol 28:213-8. 2009
    ..086 mg/kg/d...
  18. doi request reprint Evaluation of the developmental toxicity of dihydromyrcenol in rats
    Valerie T Politano
    Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA
    Int J Toxicol 28:80-7. 2009
    ..02 mg/kg/d...
  19. ncbi request reprint Oral (gavage) two-generation (one litter per generation) reproduction study of pentachlorophenol (penta) in rats
    Bruce K Bernard
    SRA International, Inc, Washington, DC 20036, USA
    Int J Toxicol 21:301-18. 2002
    ..Thus, penta did not selectively affect reproduction or development of the offspring of rats at a dose of 10 mg/kg/day, a dose that is 7000 to 20,000 times higher than human exposure...
  20. doi request reprint Evaluation of the developmental toxicity of linalool in rats
    Valerie T Politano
    Research Institute for Fragrance Materials, Inc, Woodcliff Lake, New Jersey, USA
    Int J Toxicol 27:183-8. 2008
    ..It is concluded that linalool is not a developmental toxicant in rats at maternal doses of up to 1000 mg/kg/day...
  21. ncbi request reprint Introduction/overview: gender-based differences in pharmacologic and toxicologic responses
    M S Christian
    Primedica Argus Research Laboratories, Inc, Horsham, Pennsylvania 19044, USA
    Int J Toxicol 20:145-8. 2001
    ....
  22. doi request reprint Evaluation of the developmental toxicity of methyl dihydrojasmonate (MDJ) in rats
    Valerie T Politano
    Research Institute for Fragrance Materials, Inc, Woodcliff Lake, New Jersey 07677, USA
    Int J Toxicol 27:295-300. 2008
    ..It is concluded that MDJ is not a developmental toxicant in rats under the conditions of this study...
  23. ncbi request reprint Evaluation of the developmental toxicity of alpha-iso-methylionone in rats
    Valerie T Politano
    Research Institute for Fragrance Materials, Inc, Woodcliff Lake, New Jersey 07677, USA
    Int J Toxicol 26:271-6. 2007
    ..It is concluded that alpha-iso-methylionone is not a developmental toxicant in rats at maternal doses of up to 30 mg/kg/day...
  24. ncbi request reprint Evaluation of the developmental toxicity of alpha-methyl-3,4-methylene-dioxyhydrocinnamic aldehyde in rats
    Anne Marie Api
    Research Institute for Fragrance Materials, Inc, Woodcliff Lake, New Jersey 07677, USA
    Int J Toxicol 25:127-32. 2006
    ..It is concluded that MMDHCA is not a developmental toxicant in rats under the conditions of this study and dosing regimen...
  25. ncbi request reprint The perinatal and postnatal toxicity of D-methylphenidate and D,L-methylphenidate in rats
    Steve K Teo
    Celgene Corporation, 7 Powder Horn Drive, Warren, NJ 07059, USA
    Reprod Toxicol 16:353-66. 2002
    ..Neither compound produced any other significant adverse findings in F0 and F1 generation rats at doses that were at least 25 times the maximum daily human therapeutic dose...
  26. pmc Neither antibody to a group B streptococcal conjugate vaccine nor the vaccine itself is teratogenic in rabbits
    Lawrence C Paoletti
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Hum Vaccin 4:435-43. 2008
    ..e., it was non-teratogenic). In addition, that III-TT lot 3-1-96 was found to be safe and immunogenic in two clinical studies involving healthy non-pregnant adults supports a clinical evaluation of this vaccine in pregnant women...
  27. ncbi request reprint D-methylphenidate and D,L-methylphenidate are not developmental toxicants in rats and rabbits
    Steve K Teo
    Celgene Corporation, Warren, New Jersey 07059, USA
    Birth Defects Res B Dev Reprod Toxicol 68:162-71. 2003
    ..The developmental toxicity of both compounds was determined and compared in rats and rabbits according to current International Conference on Harmonization (ICH) guidelines...