C J Glueck

Summary

Affiliation: Cholesterol Center
Country: USA

Publications

  1. ncbi Association between the T-786C eNOS polymorphism and idiopathic osteonecrosis of the head of the femur
    Charles J Glueck
    Cholesterol Center, Jewish Hospital of Cincinnati, 3200 Burnet Avenue, Cincinnati, OH 45229, USA
    J Bone Joint Surg Am 89:2460-8. 2007
  2. ncbi Ocular vascular thrombotic events: a diagnostic window to familial thrombophilia (compound factor V Leiden and prothrombin gene heterozygosity) and thrombosis
    Charles J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, Ohio 45229, USA
    Clin Appl Thromb Hemost 15:12-8. 2009
  3. ncbi Obesity, free testosterone, and cardiovascular risk factors in adolescents with polycystic ovary syndrome and regularly cycling adolescents
    Charles J Glueck
    Cholesterol Center, Alliance Hospitals, Cincinnati, OH 45229, USA
    Metabolism 55:508-14. 2006
  4. ncbi Thrombophilia, hypofibrinolysis, the eNOS T-786C polymorphism, and multifocal osteonecrosis
    Charles J Glueck
    Cholesterol Center, Jewish Hospital of Cincinnati, Cincinnati, OH 45229, USA
    J Bone Joint Surg Am 90:2220-9. 2008
  5. ncbi Should high creatine kinase discourage the initiation or continuance of statins for the treatment of hypercholesterolemia?
    Charles J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, OH 45229, USA
    Metabolism 58:233-8. 2009
  6. ncbi Associations of thrombophilia, hypofibrinolysis, and retinal vein occlusion
    Charles J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, Ohio 45229, USA
    Clin Appl Thromb Hemost 11:375-89. 2005
  7. ncbi Obesity and extreme obesity, manifest by ages 20-24 years, continuing through 32-41 years in women, should alert physicians to the diagnostic likelihood of polycystic ovary syndrome as a reversible underlying endocrinopathy
    Charles J Glueck
    The Cholesterol Center, Jewish Hospital, ABC Building, Cincinnati, OH 45229, USA
    Eur J Obstet Gynecol Reprod Biol 122:206-12. 2005
  8. ncbi Amaurosis fugax: associations with heritable thrombophilia
    C J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, Ohio 45229, USA
    Clin Appl Thromb Hemost 11:235-41. 2005
  9. ncbi Insulin resistance, obesity, hypofibrinolysis, hyperandrogenism, and coronary heart disease risk factors in 25 pre-perimenarchal girls age < or =14 years, 13 with precocious puberty, 23 with a first-degree relative with polycystic ovary syndrome
    Charles J Glueck
    Cholesterol Center, Jewish Hospital of Cincinnati, Cincinnati, OH 45229, USA
    J Pediatr Endocrinol Metab 21:973-84. 2008
  10. ncbi Coronary heart disease risk factors in adult premenopausal white women with polycystic ovary syndrome compared with a healthy female population
    Charles J Glueck
    Cholesterol Center, Jewish Hospital of Cincinnati, Cincinnati, OH 45229, USA
    Metabolism 58:714-21. 2009

Collaborators

Detail Information

Publications92

  1. ncbi Association between the T-786C eNOS polymorphism and idiopathic osteonecrosis of the head of the femur
    Charles J Glueck
    Cholesterol Center, Jewish Hospital of Cincinnati, 3200 Burnet Avenue, Cincinnati, OH 45229, USA
    J Bone Joint Surg Am 89:2460-8. 2007
    ..We studied relationships between the T-786C eNOS polymorphism and idiopathic and secondary necrosis of the head of the femur in order to better understand the pathophysiology of osteonecrosis...
  2. ncbi Ocular vascular thrombotic events: a diagnostic window to familial thrombophilia (compound factor V Leiden and prothrombin gene heterozygosity) and thrombosis
    Charles J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, Ohio 45229, USA
    Clin Appl Thromb Hemost 15:12-8. 2009
    ....
  3. ncbi Obesity, free testosterone, and cardiovascular risk factors in adolescents with polycystic ovary syndrome and regularly cycling adolescents
    Charles J Glueck
    Cholesterol Center, Alliance Hospitals, Cincinnati, OH 45229, USA
    Metabolism 55:508-14. 2006
    ....
  4. ncbi Thrombophilia, hypofibrinolysis, the eNOS T-786C polymorphism, and multifocal osteonecrosis
    Charles J Glueck
    Cholesterol Center, Jewish Hospital of Cincinnati, Cincinnati, OH 45229, USA
    J Bone Joint Surg Am 90:2220-9. 2008
    ....
  5. ncbi Should high creatine kinase discourage the initiation or continuance of statins for the treatment of hypercholesterolemia?
    Charles J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, OH 45229, USA
    Metabolism 58:233-8. 2009
    ..High pretreatment CK, particularly 1 to 5 times the UNL, should not be an impediment to start or continue statins to lower LDLC...
  6. ncbi Associations of thrombophilia, hypofibrinolysis, and retinal vein occlusion
    Charles J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, Ohio 45229, USA
    Clin Appl Thromb Hemost 11:375-89. 2005
    ..Associations between heritable coagulation disorders and RVO, most marked in cases < or = age 55, and often amplified in women by thrombophilic HRT, are, speculatively, causal...
  7. ncbi Obesity and extreme obesity, manifest by ages 20-24 years, continuing through 32-41 years in women, should alert physicians to the diagnostic likelihood of polycystic ovary syndrome as a reversible underlying endocrinopathy
    Charles J Glueck
    The Cholesterol Center, Jewish Hospital, ABC Building, Cincinnati, OH 45229, USA
    Eur J Obstet Gynecol Reprod Biol 122:206-12. 2005
    ..Document obesity-extreme obesity in most 20-24, 25-29, and 32-41 years old women with PCOS as a stimulus for physicians to consider the diagnosis of PCOS, an underlying reversible endocrinopathy...
  8. ncbi Amaurosis fugax: associations with heritable thrombophilia
    C J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, Ohio 45229, USA
    Clin Appl Thromb Hemost 11:235-41. 2005
    ....
  9. ncbi Insulin resistance, obesity, hypofibrinolysis, hyperandrogenism, and coronary heart disease risk factors in 25 pre-perimenarchal girls age < or =14 years, 13 with precocious puberty, 23 with a first-degree relative with polycystic ovary syndrome
    Charles J Glueck
    Cholesterol Center, Jewish Hospital of Cincinnati, Cincinnati, OH 45229, USA
    J Pediatr Endocrinol Metab 21:973-84. 2008
    ..Pre-peri-menarchal diagnosis of polycystic ovary syndrome (PCOS) is important, because intervention with metformin-diet may prevent progression to full blown PCOS...
  10. ncbi Coronary heart disease risk factors in adult premenopausal white women with polycystic ovary syndrome compared with a healthy female population
    Charles J Glueck
    Cholesterol Center, Jewish Hospital of Cincinnati, Cincinnati, OH 45229, USA
    Metabolism 58:714-21. 2009
    ..Identification of women with clinical features of PCOS should alert the clinician to potentially increased risk for CHD and prompt CHD risk factor testing...
  11. ncbi Insulin resistance and triglycerides
    Charles J Glueck
    Cholesterol Center, Jewish Hospital of Cincinnati, Cincinnati, OH 45229, USA
    J Investig Med 57:874-81. 2009
    ..Homeostasis model assessment IR is a significant, potentially reversible explanatory variable for TG in patients referred because of hyperlipidemia and in population subjects...
  12. ncbi Ramifications of four concurrent thrombophilic mutations and one hypofibrinolytic mutation
    Charles J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, Ohio, USA
    Clin Appl Thromb Hemost 10:365-71. 2004
    ..Beyond aspirin, avoidance of exogenous estrogens, and enoxaparin prophylaxis during pregnancy, it is not known whether the proband's daughter should have lifelong anticoagulation therapy, or only after her first thrombotic event...
  13. ncbi Pregnancy loss, polycystic ovary syndrome, thrombophilia, hypofibrinolysis, enoxaparin, metformin
    Charles J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, Ohio, USA
    Clin Appl Thromb Hemost 10:323-34. 2004
    ..6, p <. 0001). There were no adverse maternal or fetal therapy effects. Enoxaparin-metformin reduces pregnancy loss in women with PCOS with one or more previous SAB, who also have thrombophilia and/or hypofibrinolysis...
  14. ncbi Metformin, pre-eclampsia, and pregnancy outcomes in women with polycystic ovary syndrome
    C J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, OH 45229, USA
    Diabet Med 21:829-36. 2004
    ..Was metformin during pregnancy in women with polycystic ovary syndrome (PCOS) associated with pre-eclampsia, and was it safe for mother and neonate?..
  15. ncbi The factor V Leiden mutation, high factor VIII, and high plasminogen activator inhibitor activity: etiologies for sporadic miscarriage
    Charles J Glueck
    Cholesterol Center, Department of Medicine, Jewish Hospital of Cincinnati, Cincinnati, OH 45229, USA
    Metabolism 54:1345-9. 2005
    ..05) in measures of thrombophilia and hypofibrinolysis. After unexplained sporadic first trimester miscarriage, we suggest that measurements be done of the FV mutation, PAI-Fx, and factor VIII, etiologies for sporadic miscarriage...
  16. ncbi Response to diet and metformin in women with idiopathic intracranial hypertension with and without concurrent polycystic ovary syndrome or hyperinsulinemia
    Charles J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, Ohio, USA
    MedGenMed 7:41. 2005
  17. ncbi Growth, motor, and social development in breast- and formula-fed infants of metformin-treated women with polycystic ovary syndrome
    Charles J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, Ohio 45229, USA
    J Pediatr 148:628-632. 2006
    ..To test the hypothesis that metformin during lactation versus formula feeding would have no adverse effects on infants' growth, motor-social development, or intercurrent illness...
  18. ncbi Legg-Calve-Perthes disease, venous and arterial thrombi, and the factor V Leiden mutation in a four-generation kindred
    Charles J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, OH 45229, USA
    J Pediatr Orthop 27:834-7. 2007
    ....
  19. ncbi Ocular vascular thrombotic events: central retinal vein and central retinal artery occlusions
    Charles J Glueck
    Jewish Hospital Cholesterol Center, Cincinnati, OH 45229, USA
    Clin Appl Thromb Hemost 14:286-94. 2008
    ....
  20. ncbi Prevention of gestational diabetes by metformin plus diet in patients with polycystic ovary syndrome
    Charles J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, Ohio 45229, USA
    Fertil Steril 89:625-34. 2008
    ..To prospectively assess whether metformin diet safely provides primary and secondary prevention of gestational diabetes (GD)...
  21. ncbi Thrombophilia-hypofibrinolysis and atherothrombotic cardiovascular disease < or = age 45 years
    Charles J Glueck
    Cholesterol Center, Cincinnati, Ohio 45229, USA
    Transl Res 150:93-100. 2007
    ....
  22. ncbi High factor XI, recurrent pregnancy loss, enoxaparin
    Charles J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, Ohio 45229, USA
    Fertil Steril 94:2828-31. 2010
    ..Three of the 5 women with high factor XI and recurrent pregnancy loss, with 19 previous pregnancy losses and 0 live births, were given enoxaparin during 5 subsequent pregnancies, and had 6 term live births and 1 miscarriage...
  23. ncbi Factor V Leiden mutation: a treatable etiology for sporadic and recurrent pregnancy loss
    Charles J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, Ohio 45229, USA
    Fertil Steril 89:410-6. 2008
    ..We hypothesized that the thrombophilic G1691A factor V Leiden (FVL) gene mutation was a common, significant, and treatable cause of sporadic and recurrent pregnancy loss (RPL)...
  24. ncbi Amaurosis fugax caused by heritable thrombophilia-hypofibrinolysis in cases without carotid atherosclerosis: thromboprophylaxis prevents subsequent transient monocular partial blindness
    Charles J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, OH 45229, USA
    Clin Appl Thromb Hemost 13:124-9. 2007
    ..When amaurosis fugax occurs without carotid artery atherosclerosis or other known causes, thrombophilia or hypofibrinolysis, or both are nearly universal, safely treatable, reversible pathoetiologies...
  25. ncbi Metformin before and during pregnancy and lactation in polycystic ovary syndrome
    Charles J Glueck
    Jewish Hospital, Cholesterol Center, ABC Building, Cincinnati, OH, USA
    Expert Opin Drug Saf 6:191-8. 2007
    ..Systematic studies have not yet been done assessing how hyperinsulinemia, polycystic ovary syndrome and metformin may affect lactation...
  26. ncbi Heritable thrombophilia-hypofibrinolysis and osteonecrosis of the femoral head
    Charles J Glueck
    Cholesterol Center, Jewish Hospital, ABC Building, 3200 Burnet Avenue, Cincinnati, OH 45229, USA
    Clin Orthop Relat Res 466:1034-40. 2008
    ..Our data suggest inherited thrombophilia and hypofibrinolysis are risk factors for both idiopathic and secondary osteonecrosis of the head of the femur...
  27. ncbi Sustainability of 8% weight loss, reduction of insulin resistance, and amelioration of atherogenic-metabolic risk factors over 4 years by metformin-diet in women with polycystic ovary syndrome
    Charles J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, OH 45229, USA
    Metabolism 55:1582-9. 2006
    ..Metformin-diet in women with polycystic ovary syndrome effectively and safely reduces weight and LDL-C while raising HDL-C, and maintains these outcomes stable over 4 years...
  28. ncbi An observational study of reduction of insulin resistance and prevention of development of type 2 diabetes mellitus in women with polycystic ovary syndrome treated with metformin and diet
    Charles J Glueck
    Jewish Hospital Cholesterol Center, Cincinnati, OH 45229, USA
    Metabolism 57:954-60. 2008
    ..017) from an increased IR slope (P = .049) in women who had GD. In women with PCOS, pretreatment glucose and IR, and lesser reduction in IR on metformin diet were associated with T2DM and GD...
  29. ncbi Stromelysin-1 5A/6A and eNOS T-786C polymorphisms, MTHFR C677T and A1298C mutations, and cigarette-cannabis smoking: a pilot, hypothesis-generating study of gene-environment pathophysiological associations with Buerger's disease
    Charles J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, Ohio 45229, USA
    Clin Appl Thromb Hemost 12:427-39. 2006
    ..Further blinded, placebo-controlled studies are needed to determine whether our observations can be generalized to larger BD cohorts...
  30. ncbi Metformin-diet ameliorates coronary heart disease risk factors and facilitates resumption of regular menses in adolescents with polycystic ovary syndrome
    C J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, OH 45229, USA
    J Pediatr Endocrinol Metab 19:831-42. 2006
    ..8 kg/m2, we assessed effeicacy of metformin-diet for 1 year for reduction of weight, insulin, HOMA insulin resistance (IR), cholesterol, triglycerides, and resumption of regular menses...
  31. ncbi Rosuvastatin 5 and 10 mg/d: a pilot study of the effects in hypercholesterolemic adults unable to tolerate other statins and reach LDL cholesterol goals with nonstatin lipid-lowering therapies
    Charles J Glueck
    The Cholesterol Center, Jewish Hospital, Cincinnati, OH 45229, USA
    Clin Ther 28:933-42. 2006
    ....
  32. ncbi Height, weight, and motor-social development during the first 18 months of life in 126 infants born to 109 mothers with polycystic ovary syndrome who conceived on and continued metformin through pregnancy
    C J Glueck
    Cholesterol Center, ABC Building, 3200 Burnet Avenue, Cincinnati, OH 45229, USA
    Hum Reprod 19:1323-30. 2004
    ..5-2.55 g/day) through pregnancy...
  33. ncbi Metformin to restore normal menses in oligo-amenorrheic teenage girls with polycystic ovary syndrome (PCOS)
    C J Glueck
    Cholesterol Center, Jewish Hospital and Molecular Diagnostics Laboratories, Cincinnati, Ohio 45229, USA
    J Adolesc Health 29:160-9. 2001
    ..To describe our clinical experience in using Metformin combined with a high protein-low carbohydrate diet to restore normal menstrual cycles in teenaged females with polycystic ovary syndrome (PCOS)...
  34. ncbi Effect of exogenous estrogen on atherothrombotic vascular disease risk related to the presence or absence of the factor V Leiden mutation (resistance to activated protein C)
    C J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, Ohio 45229, USA HYPERLINK
    Am J Cardiol 84:549-54. 1999
    ..A second, much larger group of women will also be identified without the factor V Leiden mutation (96%), in whom ERT may reduce the risk for atherothrombosis...
  35. ncbi Endothelial nitric oxide synthase T-786C mutation, a reversible etiology of Prinzmetal's angina pectoris
    Charles J Glueck
    Cholesterol Center, Jewish Hospital of Cincinnati, Cincinnati, Ohio, USA
    Am J Cardiol 105:792-6. 2010
    ..001). In conclusion, the eNOS T-786C mutation appears to be a reversible etiology of Prinzmetal's variant angina in white Americans whose angina might be ameliorated by l-arginine...
  36. ncbi The contentious nature of gestational diabetes: diet, insulin, glyburide and metformin
    Charles J Glueck
    Cholesterol Center, ABC Building, Jewish Hospital of Cincinnati, 3200 Burnet Avenue, Cincinnati, OH 45229, USA
    Expert Opin Pharmacother 3:1557-68. 2002
    ..Recent studies suggest that glyburide may be efficaciously substituted for insulin. Preliminary studies suggest that metformin may have the unique potential to prevent the development of GD...
  37. ncbi Polycystic ovary syndrome, infertility, familial thrombophilia, familial hypofibrinolysis, recurrent loss of in vitro fertilized embryos, and miscarriage
    C J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, Ohio 45299, USA
    Fertil Steril 74:394-7. 2000
    ..To study reversible determinants of infertility and recurrent loss of transferred embryos after failure of 7 of 10 embryo transfers, 1 live birth, and 2 miscarriages...
  38. ncbi Continuing metformin throughout pregnancy in women with polycystic ovary syndrome appears to safely reduce first-trimester spontaneous abortion: a pilot study
    C J Glueck
    The Cholesterol Center, Jewish Hospital, Cincinnati, Ohio 45229, USA
    Fertil Steril 75:46-52. 2001
    ..To determine whether metformin would safely reduce the rate of first-trimester spontaneous abortion without teratogenicity in 19 women with the polycystic ovary syndrome (PCOS)...
  39. ncbi Treatment of polycystic ovary syndrome with insulin-lowering agents
    Charles J Glueck
    Cholesterol Center, ABC Building, 3200 Burnet Avenue, Cincinnati, Ohio, USA
    Expert Opin Pharmacother 3:1177-89. 2002
    ....
  40. ncbi Estrogen replacement in a protein S deficient patient leads to diarrhea, hyperglucagonemia, and osteonecrosis
    C J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, Ohio 45229, USA
    JOP 2:323-9. 2001
    ..Our specific aim was to assess thrombophilic interactions of estrogen replacement therapy and familial protein S deficiency leading to osteonecrosis, hyperglucagonemia, and diarrhea...
  41. ncbi Metformin therapy throughout pregnancy reduces the development of gestational diabetes in women with polycystic ovary syndrome
    C J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, Ohio 45229, USA
    Fertil Steril 77:520-5. 2002
    ..To assess whether metformin safely reduced development of gestational diabetes in women with the polycystic ovary syndrome (PCOS)...
  42. ncbi Anticoagulant therapy for osteonecrosis associated with heritable hypofibrinolysis and thrombophilia
    C J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, OH 45229, USA
    Expert Opin Investig Drugs 10:1309-16. 2001
    ..This has the potential of preventing femoral head collapse which usually leads to total hip replacement...
  43. ncbi Plasminogen activator inhibitor activity, 4G5G polymorphism of the plasminogen activator inhibitor 1 gene, and first-trimester miscarriage in women with polycystic ovary syndrome
    Charles J Glueck
    Cholesterol Center, Jewish Hospital, MDL Laboratories, Cincinnati, OH 45229, USA
    Metabolism 55:345-52. 2006
    ..Preconception and first-trimester decrements in PAI-1 activity on Glucophage are associated with live births, whereas increments or no change in PAI-1 activity despite Glucophage appears to be associated with first-trimester miscarriage...
  44. ncbi Cardiovascular and medical ramifications of treatment of subclinical hypothyroidism
    Charles J Glueck
    Cholesterol Center Jewish Hospital, 3200 Burnet Avenue, Cincinnati, OH 45229, USA
    Curr Atheroscler Rep 5:73-7. 2003
    ....
  45. ncbi T-786C polymorphism of the endothelial nitric oxide synthase gene and neuralgia-inducing cavitational osteonecrosis of the jaws
    Charles J Glueck
    Cholesterol Center, Jewish Hospital of Cincinnati, Cincinnati, Ohio, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:548-53. 2010
    ....
  46. ncbi Nonarteritic anterior ischemic optic neuropathy: associations with homozygosity for the C677T methylenetetrahydrofolate reductase mutation
    Charles J Glueck
    Cholesterol Center, Cincinnati, OH 45229, USA
    J Lab Clin Med 143:184-92. 2004
    ..Confirmation of a causal relationship between coagulation disorders and NAION should facilitate its prevention and treatment and help protect against thrombi in other vascular beds...
  47. ncbi Metformin during pregnancy reduces insulin, insulin resistance, insulin secretion, weight, testosterone and development of gestational diabetes: prospective longitudinal assessment of women with polycystic ovary syndrome from preconception throughout preg
    C J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, OH 45229, USA
    Hum Reprod 19:510-21. 2004
    ..We assessed the hypothesis that diet-metformin (MET) lessens the physiological gestational increase in IR and reduces gestational weight gain, thus reducing GD...
  48. ncbi Role of thrombosis in osteonecrosis
    C J Glueck
    Cholesterol Center, ABC Building, 3200 Burnet Avenue, Cincinnati, OH 45229, USA
    Curr Hematol Rep 2:417-22. 2003
    ..Placebo-controlled trials with a 2-year follow-up or longer in adults will be required to assess the promise of the pilot anticoagulant studies in osteonecrosis...
  49. ncbi Metformin-diet ameliorates coronary heart disease risk factors and facilitates resumption of regular menses in adolescents with polycystic ovary syndrome
    Charles J Glueck
    Jewish Hospital, Cholesterol Center, ABC Building, 3200 Burnet Ave, Cincinnati, OH 45229, USA
    J Pediatr Endocrinol Metab 22:815-26. 2009
    ..In 20 adolescents age < or = 17 (16 +/- 1 yr) with polycystic ovary syndrome (PCOS), we assessed efficacy and safety of metformin-diet for 1 year in treatment of endocrinopathy and coronary heart disease (CHD) risk factors...
  50. ncbi Pioglitazone and metformin in obese women with polycystic ovary syndrome not optimally responsive to metformin
    Charles J Glueck
    Cholesterol Center, Jewish Hospital, ABC Building, 3200 Burnet Avenue, Cincinnati, OH 45229, USA
    Hum Reprod 18:1618-25. 2003
    ..We also compared these 13 women to 26 women with PCOS, who were responsive to metformin diet, matched by age and by pre- treatment menstrual history and not different by obesity categories...
  51. ncbi Metformin and gestational diabetes
    Charles J Glueck
    Jewish Hospital Cholesterol Center, ABC Building, 3200 Burnet Avenue, Cincinnati, OH 45229, USA
    Curr Diab Rep 3:303-12. 2003
    ..We postulate that interventions that reduce insulin resistance and lower requirements for endogenous insulin secretion can preserve b-cell function and prevent the development of type 2 diabetes mellitus...
  52. ncbi Heritable thrombophilia and hypofibrinolysis. Possible causes of retinal vein occlusion
    C J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, Ohio, USA
    Arch Ophthalmol 117:43-9. 1999
    ..To determine whether heritable thrombophilia and hypofibrinolysis were risk factors for retinal vein occlusion...
  53. ncbi Evidence that anticardiolipin antibodies are independent risk factors for atherosclerotic vascular disease
    C J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, Ohio 45229, USA
    Am J Cardiol 83:1490-4, A8. 1999
    ....
  54. ncbi Interaction of heritable and estrogen-induced thrombophilia: possible etiologies for ischemic optic neuropathy and ischemic stroke
    C J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, Ohio 45229, USA
    Thromb Haemost 85:256-9. 2001
    ....
  55. ncbi Incidence and treatment of metabolic syndrome in newly referred women with confirmed polycystic ovarian syndrome
    C J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, OH 45229, USA
    Metabolism 52:908-15. 2003
    ..Metformin and diet ameliorate many of the features of the metabolic syndrome, present in 46% of women with PCOS in the current study, and should reduce risk for atherothrombosis and type 2 diabetes mellitus (DM) in PCOS...
  56. ncbi Polycystic ovary syndrome, the G1691A factor V Leiden mutation, and plasminogen activator inhibitor activity: associations with recurrent pregnancy loss
    Charles J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, OH 45229, USA
    Metabolism 52:1627-32. 2003
    ..1 U/mL), 38% versus 8%, p(f) =. 004. The thrombophilic G1691A Factor V Leiden mutation is associated with RPL in women with and without PCOS; hypofibrinolysis (high PAI-Fx) is also associated with RPL in women with PCOS...
  57. ncbi Metformin reduces weight, centripetal obesity, insulin, leptin, and low-density lipoprotein cholesterol in nondiabetic, morbidly obese subjects with body mass index greater than 30
    C J Glueck
    Cholesterol Center, Jewish Hospital, and Molecular Diagnostics Laboratories, Cincinnati, OH 45229, USA
    Metabolism 50:856-61. 2001
    ....
  58. ncbi Interaction of estrogen replacement therapy with the thrombophilic 20210 G/A prothrombin gene mutation for atherothrombotic vascular disease: a cross-sectional study of 275 hyperlipidemic women
    C J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, OH, USA
    Metabolism 50:360-5. 2001
    ....
  59. ncbi Population-specific alleles: the polymorphism (K121Q) of the human glycoprotein PC-1 gene is strongly associated with race but not with insulin resistance in black and white children
    John A Morrison
    Division of Cardiology, Children s Hospital Medical Center, Cincinnati, OH, USA
    Metabolism 53:465-8. 2004
    ..However, the QQ genotype was population-specific, encompassing most black children versus 1% to 3% of white children. As such, K121Q genotyping should be useful in epidemiology, population genetics, and forensic anthropology...
  60. ncbi Thrombophilia, hypofibrinolysis, and alveolar osteonecrosis of the jaws
    C J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, Ohio, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 81:557-66. 1996
    ....
  61. ncbi Estrogen replacement therapy, thrombophilia, and atherothrombosis
    Charles J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, OH 45229, USA
    Metabolism 51:724-32. 2002
    ..50 and 95% CI of 0.29 to 0.87 P =.014. PTG and FV may increase risk for ATCVD, particularly in the presence of ERT, whereas ERT may be protective against ATCVD when PTG and FV are absent...
  62. ncbi Enoxaparin-metformin and enoxaparin alone may safely reduce pregnancy loss
    Ganga Ramidi
    Cholesterol Center, Jewish Hospital, Cincinnati, OH 45229, USA
    Transl Res 153:33-43. 2009
    ..No adverse maternal-fetal side effects were reported on enoxaparin alone or enoxaparin-metformin. Enoxaparin-metformin reduces pregnancy loss in women with PCOS-coagulation disorders and in women with coagulation disorders-thrombi...
  63. ncbi Genetic hypofibrinolysis in complicated pregnancies
    C J Glueck
    Cholesterol Center, Alliance Hospitals, Cincinnati, Ohio 45229, USA
    Obstet Gynecol 97:44-8. 2001
    ..To assess the hypofibrinolytic 4G/4G mutation of the plasminogen activator inhibitor (PAI-1) gene as a possible factor contributing to severe preeclampsia, abruptio placentae, fetal growth restriction, and stillbirth...
  64. ncbi Determinants of persistent obesity and hyperinsulinemia in a biracial cohort: a 15-year prospective study of schoolgirls
    John A Morrison
    Division of Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Pediatr 157:559-65. 2010
    ..To identify childhood-adolescent determinants of persistent hyperinsulinemia and obesity...
  65. ncbi Childhood predictors of adult type 2 diabetes at 9- and 26-year follow-ups
    John A Morrison
    Division of Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Arch Pediatr Adolesc Med 164:53-60. 2010
    ....
  66. ncbi Preteen insulin levels interact with caloric intake to predict increases in obesity at ages 18 to 19 years: a 10-year prospective study of black and white girls
    John A Morrison
    Division of Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 42559, USA
    Metabolism 59:718-27. 2010
    ..Evaluating BMI and insulin at ages 9 to 10 years could identify girls (particularly black) who would optimally benefit from dietary and exercise interventions to avoid obesity...
  67. ncbi Changes in weight, papilledema, headache, visual field, and life status in response to diet and metformin in women with idiopathic intracranial hypertension with and without concurrent polycystic ovary syndrome or hyperinsulinemia
    Charles J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, Ohio 45229, USA
    Transl Res 148:215-22. 2006
    ..04). As many women with IIH have PCOS, and because weight loss is central to IIH treatment, diet-MET is a novel approach to treat IIH in women with concurrent PCOS or hyperinsulinemia without PCOS...
  68. ncbi Metformin-diet benefits in women with polycystic ovary syndrome in the bottom and top quintiles for insulin resistance
    Naila Goldenberg
    Cholesterol Center, Jewish Hospital, Cincinnati, OH 45229, USA
    Metabolism 54:113-21. 2005
    ..Metformin-diet should benefit most women with PCOS, even those with normal serum insulin, without IR...
  69. ncbi Homeostasis model assessment of insulin resistance*body mass index interactions at ages 9 to 10 years predict metabolic syndrome risk factor aggregate score at ages 18 to 19 years: a 10-year prospective study of black and white girls
    John A Morrison
    Division of Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Metabolism 58:290-5. 2009
    ....
  70. ncbi Safety and efficacy of treatment of pediatric cholesteryl ester storage disease with lovastatin
    C J Glueck
    Jewish Hospital Cholesterol Center, Cincinnati, Ohio 45229
    Pediatr Res 32:559-65. 1992
    ..Normal and expected accretion of height and weight occurred during the treatment period for both children. Lovastatin appears to be a safe and effective treatment for pediatric cholesteryl ester storage disease...
  71. ncbi Paradoxically high adiponectin and the healthy obese phenotype in obese black and white 16-year-old girls
    John A Morrison
    Division of Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Transl Res 156:302-8. 2010
    ..20, 95% confidence intervals 0.04-0.95, P = 0.043). We conclude that paradoxically high adiponectin is associated with the healthy obese phenotype in obese adolescent black and white girls...
  72. ncbi Idiopathic intracranial hypertension: associations with coagulation disorders and polycystic-ovary syndrome
    Charles J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, OH 45229, USA
    J Lab Clin Med 142:35-45. 2003
    ..Exogenous estrogens (n = 23), clomiphene (n = 1), or pregnancy (n = 4) accompanied the first appearance of IIH in 28 women. PCOS and coagulation disorders, often augmented by exogenous estrogens or pregnancy, are associated with IIH...
  73. ncbi Idiopathic intracranial hypertension, polycystic-ovary syndrome, and thrombophilia
    Charles J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, OH 45229, USA
    J Lab Clin Med 145:72-82. 2005
    ....
  74. ncbi Pre-teen insulin resistance predicts weight gain, impaired fasting glucose, and type 2 diabetes at age 18-19 y: a 10-y prospective study of black and white girls
    John A Morrison
    Division of Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Am J Clin Nutr 88:778-88. 2008
    ..Identifying early pre-teen predictors of adolescent weight gain and the development of impaired fasting glucose (IFG) and type 2 diabetes (T2DM) at age 18-19 y could provide avenues for prevention...
  75. ncbi Pediatric triglycerides predict cardiovascular disease events in the fourth to fifth decade of life
    John A Morrison
    Division of Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Metabolism 58:1277-84. 2009
    ..4; 95% confidence interval, 4.24-114.2). Pediatric hypertriglyceridemia appears to be a significant, independent, potentially reversible correlate of young adult CVD...
  76. ncbi Pregnancy outcomes among women with polycystic ovary syndrome treated with metformin
    Charles J Glueck
    Cholesterol Center, Jewish Hospital, ABC Building, 3200 Burnet Avenue, Cincinnati, OH 45229, USA
    Hum Reprod 17:2858-64. 2002
    ....
  77. ncbi Legg-Calve-Perthes disease and thrombophilia
    Vinod V Balasa
    Hemophilia and Thrombosis Center, Hematology Oncology Division, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    J Bone Joint Surg Am 86:2642-7. 2004
    ..We prospectively studied the association between Legg-Calve-Perthes disease and coagulation abnormalities by comparing seventy-two children who had the disease with 197 healthy controls...
  78. ncbi Metabolic syndrome in childhood predicts adult metabolic syndrome and type 2 diabetes mellitus 25 to 30 years later
    John A Morrison
    Division of Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    J Pediatr 152:201-6. 2008
    ..To prospectively assess the association of the metabolic syndrome in childhood with adult metabolic syndrome and type 2 diabetes mellitus (T2DM) 25 to 30 years later...
  79. ncbi Idiopathic intracranial hypertension: associations with thrombophilia and hypofibrinolysis in men
    Charles J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati Ohio 45229, USA
    Clin Appl Thromb Hemost 11:441-8. 2005
    ..Understanding contributions of hypofibrinolysis and thrombophilia to the development of IIH should facilitate development of novel new approaches to treat this often-disabling neurologic disorder...
  80. ncbi Is pharmacogenomics our future? Metformin, ovulation and polymorphism of the STK11 gene in polycystic ovary syndrome
    Naila Goldenberg
    Cholesterol Center, Jewish Hospital of Cincinnati, ABC Builiding, 3200 Burnet Ave, Cincinnati, OH 45229, USA
    Pharmacogenomics 9:1163-5. 2008
    ..66). This elegant study is of great importance because despite treatment, many women with polycystic ovary syndrome fail to ovulate, 24.9% in the clomiphene group, 44.7% in the metformin group and 16.7% in the clomiphene-metformin group...
  81. ncbi Low serum 25 (OH) vitamin D levels (<32 ng/mL) are associated with reversible myositis-myalgia in statin-treated patients
    Waqas Ahmed
    Cholesterol Center, Jewish Hospital of Cincinnati, Cincinnati, OH 45229, USA
    Transl Res 153:11-6. 2009
    ..We speculate that symptomatic myalgia in statin-treated patients with concurrent vitamin D deficiency may reflect a reversible interaction between vitamin D deficiency and statins on skeletal muscle...
  82. ncbi Dietary trans fatty acid intake is associated with increased fetal loss
    John A Morrison
    Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Fertil Steril 90:385-90. 2008
    ..of pregnancies - no. of live births). The basis of our inquiry derives from the facts that the PPAR-gamma receptor plays a pivotal role in placental function and that TFAs down-regulate PPAR-gamma gene mRNA expression...
  83. ncbi An observational study of severe hypertriglyceridemia, hypertriglyceridemic acute pancreatitis, and failure of triglyceride-lowering therapy when estrogens are given to women with and without familial hypertriglyceridemia
    Naila M Goldenberg
    Cholesterol Center, Alliance Hospitals, ABC Building, 3200 Burnet Avenue, Cincinnati, OH 45229, USA
    Clin Chim Acta 332:11-9. 2003
    ..Triglyceride-lowering diets and drugs often fail in the presence of HT and/or poorly controlled diabetes mellitus, but commonly succeed when HT is stopped and diabetes mellitus is tightly controlled...
  84. ncbi Ocular thrombosis: a hypercoagulable disease
    Charles J Glueck
    The Jewish Hospital Cholesterol Center, Cincinnati, OH 45236, USA
    Clin Adv Hematol Oncol 5:289-92. 2007
  85. ncbi Beyond bisphosphonates: thrombophilia, hypofibrinolysis, and jaw osteonecrosis
    Robert E McMahon
    J Oral Maxillofac Surg 64:1704-5. 2006
  86. ncbi Procoagulants and osteonecrosis
    Lynne C Jones
    Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21239, USA
    J Rheumatol 30:783-91. 2003
    ..To study the relationship between hypofibrinolysis, thrombophilia, and osteonecrosis. We evaluated the frequency of abnormal concentrations of 9 coagulation factors in patients diagnosed with osteonecrosis...
  87. ncbi Correlation of thrombophilia and hypofibrinolysis with pulmonary embolism following total hip arthroplasty: an analysis of genetic factors
    Geoffrey H Westrich
    The Hospital for Special Surgery Weill Medical College of Cornell University, New York, NY 10021, USA
    J Bone Joint Surg Am 84:2161-7. 2002
    ....
  88. ncbi The John Charnley Award: heritable thrombophilia and development of thromboembolic disease after total hip arthroplasty
    Eduardo A Salvati
    Hospital for Special Surgery, New York, NY 10021, USA
    Clin Orthop Relat Res 441:40-55. 2005
    ..LEVEL OF EVIDENCE: Prognostic study, Level II-1 (lesser-quality RCT). See the Guidelines for Authors for a complete description of levels of evidence...
  89. ncbi Osteonecrosis: a multifactorial etiology
    Robert E McMahon
    J Oral Maxillofac Surg 62:904-5. 2004
  90. ncbi Interaction of duloxetine and warfarin causing severe elevation of international normalized ratio
    Charles J Glueck
    JAMA 295:1517-8. 2006
  91. ncbi Staging bisphosphonate-related osteonecrosis of the jaw should include early stages of disease
    Robert E McMahon
    J Oral Maxillofac Surg 65:1899-900. 2007
  92. ncbi Bone marrow edema: mild or nascent variant of ischemic bone disease
    Jerry E Bouquot
    J Oral Maxillofac Surg 66:205-8. 2008