Selma Feldman Witchel

Summary

Affiliation: Children's Hospital of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Monozygotic twins with congenital adrenal hyperplasia: long-term endocrine evaluation and gene analysis
    Theodore W AvRuskin
    Department of Pediatrics, Division of Pediatric Endocrinology and Metabolism, The Brookdale University Hospital and Medical Center, State University of New York at Brooklyn, NY 11212 3198, USA
    J Pediatr Endocrinol Metab 16:565-70. 2003
  2. doi request reprint Management of CAH during pregnancy: optimizing outcomes
    Selma Feldman Witchel
    Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, Pennsylvania 15224, USA
    Curr Opin Endocrinol Diabetes Obes 19:489-96. 2012
  3. doi request reprint Prenatal treatment of congenital adrenal hyperplasia-not standard of care
    Selma Feldman Witchel
    Department of Pediatrics, Division of Pediatric Endocrinology, Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh, PA 15224, USA
    J Genet Couns 21:615-24. 2012
  4. doi request reprint Nonclassic congenital adrenal hyperplasia
    Selma Feldman Witchel
    Division of Pediatric Endocrinology, Childrens Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania 15224, USA
    Curr Opin Endocrinol Diabetes Obes 19:151-8. 2012
  5. doi request reprint Congenital adrenal hyperplasia
    Selma Feldman Witchel
    Division of Pediatric Endocrinology, Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Pediatr Adolesc Gynecol 24:116-26. 2011
  6. doi request reprint Reverse referral: from pathology to endocrinology
    Selma Feldman Witchel
    Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA
    Endocr Pathol 20:78-83. 2009
  7. pmc Association of the -243 A-->G polymorphism of the glutamate decarboxylase 2 gene with obesity in girls with premature pubarche
    Selma Feldman Witchel
    Department of Pediatrics, Division of Endocrinology, Children s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Fertil Steril 91:1869-76. 2009
  8. ncbi request reprint Puberty and polycystic ovary syndrome
    Selma Feldman Witchel
    Children s Hospital of Pittsburgh, University of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Mol Cell Endocrinol 254:146-53. 2006
  9. ncbi request reprint Prevalence of CYP21 mutations and IRS1 variant among women with polycystic ovary syndrome and adrenal androgen excess
    Selma F Witchel
    Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Fertil Steril 83:371-5. 2005
  10. ncbi request reprint Frequency of the T228A polymorphism in the SORBS1 gene in children with premature pubarche and in adolescent girls with hyperandrogenism
    Selma F Witchel
    Division of Endocrinology, Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Fertil Steril 80:128-32. 2003

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Monozygotic twins with congenital adrenal hyperplasia: long-term endocrine evaluation and gene analysis
    Theodore W AvRuskin
    Department of Pediatrics, Division of Pediatric Endocrinology and Metabolism, The Brookdale University Hospital and Medical Center, State University of New York at Brooklyn, NY 11212 3198, USA
    J Pediatr Endocrinol Metab 16:565-70. 2003
    ..Parental DNA samples confirmed that the mutations were on different alleles...
  2. doi request reprint Management of CAH during pregnancy: optimizing outcomes
    Selma Feldman Witchel
    Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, Pennsylvania 15224, USA
    Curr Opin Endocrinol Diabetes Obes 19:489-96. 2012
    ..The purpose of this review is to provide current information regarding the pathophysiology of CAH, factors relevant for female and male fertility, and recommendations for management during pregnancy...
  3. doi request reprint Prenatal treatment of congenital adrenal hyperplasia-not standard of care
    Selma Feldman Witchel
    Department of Pediatrics, Division of Pediatric Endocrinology, Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh, PA 15224, USA
    J Genet Couns 21:615-24. 2012
    ....
  4. doi request reprint Nonclassic congenital adrenal hyperplasia
    Selma Feldman Witchel
    Division of Pediatric Endocrinology, Childrens Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania 15224, USA
    Curr Opin Endocrinol Diabetes Obes 19:151-8. 2012
    ..Affected individuals typically present due to signs and symptoms of androgen excess. The purpose of this review is to provide current information regarding the pathophysiology, molecular genetics, and management of this common disorder...
  5. doi request reprint Congenital adrenal hyperplasia
    Selma Feldman Witchel
    Division of Pediatric Endocrinology, Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Pediatr Adolesc Gynecol 24:116-26. 2011
    ..For adolescent and adult women, treatment goals include regularization of menses, prevention of progression of hirsutism, and fertility. This article will review key aspects regarding pathophysiology, diagnosis, and treatment of CAH...
  6. doi request reprint Reverse referral: from pathology to endocrinology
    Selma Feldman Witchel
    Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA
    Endocr Pathol 20:78-83. 2009
    ..The patient elected to have surgery at which time she was found to have parathyroid hyperplasia. This case emphasizes the usefulness of cutaneous findings for the diagnosis and management of MEN1...
  7. pmc Association of the -243 A-->G polymorphism of the glutamate decarboxylase 2 gene with obesity in girls with premature pubarche
    Selma Feldman Witchel
    Department of Pediatrics, Division of Endocrinology, Children s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Fertil Steril 91:1869-76. 2009
    ....
  8. ncbi request reprint Puberty and polycystic ovary syndrome
    Selma Feldman Witchel
    Children s Hospital of Pittsburgh, University of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Mol Cell Endocrinol 254:146-53. 2006
    ..Future investigations are needed to uncover the relevant genetic and hormonal factors and identify effective interventions...
  9. ncbi request reprint Prevalence of CYP21 mutations and IRS1 variant among women with polycystic ovary syndrome and adrenal androgen excess
    Selma F Witchel
    Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Fertil Steril 83:371-5. 2005
    ....
  10. ncbi request reprint Frequency of the T228A polymorphism in the SORBS1 gene in children with premature pubarche and in adolescent girls with hyperandrogenism
    Selma F Witchel
    Division of Endocrinology, Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Fertil Steril 80:128-32. 2003
    ..We tested the hypothesis that the frequency of the protective allele would be decreased in children with premature pubarche and adolescent girls with hyperandrogenism...
  11. ncbi request reprint Association of the GAA1013-->GAG polymorphism of the insulin-like growth factor-1 receptor (IGF1R) gene with premature pubarche
    Maria Belen Roldan
    Division of Endocrinology, Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Fertil Steril 88:410-7. 2007
    ....
  12. ncbi request reprint Frequencies of the D85 and Y85 variants of UGT2B15 in children and adolescent girls with hyperandrogenism
    Marlah Tomboc
    Division of Pediatric Endocrinology, Children s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Pediatr Endocrinol Metab 16:719-26. 2003
    ..Although D85 and Y85 appear to be common variants, we cannot exclude the possibility that the UGT2B15 gene represents a minor modifying locus...
  13. ncbi request reprint Mutational analysis of the melanocortin-4 receptor (MC4R) gene in children with premature pubarche and adolescent girls with hyperandrogenism
    Maria Belen Roldan Martin
    Division of Pediatric Endocrinology, Department of Pediatrics, and Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania
    Fertil Steril 82:1460-2. 2004
    ..DNA sequence analysis of the conformers identified by SSCP revealed variants in six patients (two silent and one missense) and in none of the control subjects...
  14. ncbi request reprint Detection and assignment of CYP21 mutations using peptide mass signature genotyping
    Xuemei Zeng
    SpectraGenetics LLC, 4415 Fifth Avenue, Suite 160, Pittsburgh, PA 15213, USA
    Mol Genet Metab 82:38-47. 2004
    ....
  15. doi request reprint Prenatal treatment of congenital adrenal hyperplasia: risks outweigh benefits
    Walter L Miller
    Department of Pediatrics, University of California, San Francisco, San Francisco, CA Electronic address
    Am J Obstet Gynecol 208:354-9. 2013
    ....
  16. ncbi request reprint Polycystic ovary syndrome
    Constance Y Baldwin
    Division of Pediatric Endocrinology, Children s Hospital of Pittsburgh, University of Pittsburgh, PA 15213, USA
    Pediatr Ann 35:888-96. 2006
    ....
  17. ncbi request reprint Inter- and intrafamilial variability in premature pubarche and polycystic ovary syndrome
    Ellen B Sanders
    Department of Human Genetics, Graduate School of Public Health, Pittsburgh, Pennsylvania, USA
    Fertil Steril 78:473-8. 2002
    ..To ascertain the extent of phenotypic heterogeneity for premature pubarche and polycystic ovary syndrome between and within families...
  18. pmc The patient with Turner syndrome: puberty and medical management concerns
    Luisa González
    Division of Pediatric Endocrinology, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania 15224, USA
    Fertil Steril 98:780-6. 2012
    ....
  19. doi request reprint Congenital adrenal hyperplasia
    Cem Demirci
    Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, Pennsylvania PA 15213, USA
    Dermatol Ther 21:340-53. 2008
    ..There is also a brief discussion of other steroidogenic enzyme defects that are associated with clinical features due to excessive androgen secretion...
  20. pmc Nonclassic congenital adrenal hyperplasia
    Selma Feldman Witchel
    Division of Pediatric Endocrinology, Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Int J Pediatr Endocrinol 2010:625105. 2010
    ..For adolescent and adult women, treatment goals include regularization of menses, prevention of progression of hirsutism, and fertility. This paper will review key aspects regarding pathophysiology, diagnosis, and treatment of NCAH...
  21. pmc Guidelines for the Development of Comprehensive Care Centers for Congenital Adrenal Hyperplasia: Guidance from the CARES Foundation Initiative
    Richard J Auchus
    Division of Endocrinology, Department of Medicine, University of Texas Southwestern Medical School, Dallas, TX 75390, USA
    Int J Pediatr Endocrinol 2010:275213. 2010
    ..Thus, this document should serve as a "roadmap" for the development phases of comprehensive care centers (CCC) for individuals and families affected by CAH...
  22. pmc Evaluating protocols for embryonic stem cell differentiation into insulin-secreting beta-cells using insulin II-GFP as a specific and noninvasive reporter
    Ahmi Ben-Yehudah
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Pittsburgh Development Center, Magee Womens Research Institute and Foundation, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Cloning Stem Cells 11:245-57. 2009
    ..Therefore, improved beta-cells differentiation protocols are needed, and these insulin II GFP cells may prove to be an important tool to accelerate this process...
  23. ncbi request reprint Hyperandrogenism in adolescents
    Selma F Witchel
    Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children s Hospital of Pittsburgh, Pennsylvania 15213, USA
    Adolesc Med 13:89-99, vi-vii. 2002
    ..Brief discussions of androgen metabolism and steroidogenesis are followed by particulars of specific disorders. The chapter concludes with suggestions about differential diagnoses...
  24. ncbi request reprint Increased frequency of the G972R variant of the insulin receptor substrate-1 (irs-1) gene among girls with a history of precocious pubarche
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
    Fertil Steril 78:1288-93. 2002
    ..The low mean SHBG concentration found among G972R carriers suggests that this variant may be a minor locus associated with development of hyperinsulinemic insulin resistance and ovarian androgen excess in girls with a history of PP...
  25. ncbi request reprint Genotype analysis of the neuropeptide Y (NPY) Y1 and NPY Y5 receptor genes in gonadotropin-releasing hormone-dependent precocious gonadarche
    Mandi Barker-Gibb
    Fertil Steril 82:491-4. 2004
  26. doi request reprint Environmental factors and puberty timing: expert panel research needs
    Germaine M Buck Louis
    Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, 6100 Executive Blvd, Room 7B03, Rockville, MD 20852, USA
    Pediatrics 121:S192-207. 2008
    ..Coupled with comparative species studies, such research may provide insight regarding the causal ordering of events that underlie pubertal onset and progression and their role in the pathway of adult-onset disease...