Marsha Wills-Karp

Summary

Affiliation: Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi request reprint New insights into the role of the complement pathway in allergy and asthma
    Marsha Wills-Karp
    Division of Immunobiology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Curr Allergy Asthma Rep 5:362-9. 2005
  2. ncbi request reprint Interleukin-13 in asthma pathogenesis
    Marsha Wills-Karp
    Division of Immunobiology, Children s Hospital Medical Center, Cincinnati, OH 45208, USA
    Immunol Rev 202:175-90. 2004
  3. ncbi request reprint Interleukin-13 in asthma pathogenesis
    Marsha Wills-Karp
    Division of Immunobiology, Children s Hospital Medical Center, 3333 Burnett Avenue, MLC 7038, Cincinnati, OH 45208, USA
    Curr Allergy Asthma Rep 4:123-31. 2004
  4. ncbi request reprint The germless theory of allergic disease: revisiting the hygiene hypothesis
    M Wills-Karp
    Division of Immunobiology, Children s Hospital Research Foundation, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Nat Rev Immunol 1:69-75. 2001
  5. pmc Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma
    Stephane Lajoie
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Nat Immunol 11:928-35. 2010
  6. ncbi request reprint Suppressive effect of IL-4 on IL-13-induced genes in mouse lung
    Fred D Finkelman
    Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 174:4630-8. 2005
  7. pmc Mucosal sensitization to German cockroach involves protease-activated receptor-2
    Kristen Page
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
    Respir Res 11:62. 2010
  8. pmc A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma
    Jörg Köhl
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Clin Invest 116:783-96. 2006
  9. ncbi request reprint TLR2-mediated activation of neutrophils in response to German cockroach frass
    Kristen Page
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    J Immunol 180:6317-24. 2008
  10. pmc A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma
    Umasundari Sivaprasad
    Division of Asthma Research, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 127:254-61, 261.e1-6. 2011

Research Grants

  1. Asthma Positional Candidate Genes in Mice and Humans
    Marsha Wills Karp; Fiscal Year: 2010
  2. Asthma Positional Candidate Genes in Mice and Humans
    Marsha Wills Karp; Fiscal Year: 2009
  3. Asthma Positional Candidate Genes in Mice and Humans
    Marsha Wills Karp; Fiscal Year: 2007
  4. Mechanisms: IL-13 Induced Mucus Hypersecretion in Asthma
    Marsha Wills Karp; Fiscal Year: 2006
  5. Asthma Positional Candidate Genes in Mice and Humans
    Marsha Wills Karp; Fiscal Year: 2004
  6. Epithelial Regulation of Th2 Immune Responses in the Lung
    Marsha Wills Karp; Fiscal Year: 2010

Collaborators

Detail Information

Publications63

  1. ncbi request reprint New insights into the role of the complement pathway in allergy and asthma
    Marsha Wills-Karp
    Division of Immunobiology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Curr Allergy Asthma Rep 5:362-9. 2005
    ..Herein, we explore our current understanding of the role of complement activation in asthma pathogenesis and highlight the potential of targeting complement pathways for therapeutic drug development...
  2. ncbi request reprint Interleukin-13 in asthma pathogenesis
    Marsha Wills-Karp
    Division of Immunobiology, Children s Hospital Medical Center, Cincinnati, OH 45208, USA
    Immunol Rev 202:175-90. 2004
    ....
  3. ncbi request reprint Interleukin-13 in asthma pathogenesis
    Marsha Wills-Karp
    Division of Immunobiology, Children s Hospital Medical Center, 3333 Burnett Avenue, MLC 7038, Cincinnati, OH 45208, USA
    Curr Allergy Asthma Rep 4:123-31. 2004
    ....
  4. ncbi request reprint The germless theory of allergic disease: revisiting the hygiene hypothesis
    M Wills-Karp
    Division of Immunobiology, Children s Hospital Research Foundation, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Nat Rev Immunol 1:69-75. 2001
    ..Here, we discuss why we favour a broader 'counter-regulatory' model--one that might also explain the increasing incidence of autoimmune disease in westernized countries...
  5. pmc Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma
    Stephane Lajoie
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Nat Immunol 11:928-35. 2010
    ..The opposing effects of C3a and C5a were mediated through their reciprocal regulation of IL-23 production. These data demonstrate a critical role for complement-mediated regulation of the IL-23-T(H)17 axis in severe asthma...
  6. ncbi request reprint Suppressive effect of IL-4 on IL-13-induced genes in mouse lung
    Fred D Finkelman
    Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 174:4630-8. 2005
    ..These results provide a potential explanation for the dominant role of IL-13 in induction of goblet cell hyperplasia and airway hyperresponsiveness in asthma...
  7. pmc Mucosal sensitization to German cockroach involves protease-activated receptor-2
    Kristen Page
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
    Respir Res 11:62. 2010
    ..The role for PAR-2 in mediating allergic airway inflammation has not been assessed using a real world allergen...
  8. pmc A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma
    Jörg Köhl
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Clin Invest 116:783-96. 2006
    ..e., protection from the development of maladaptive type 2 immune responses during allergen sensitization at the DC/T cell interface but enhancement of airway inflammation and AHR in an established inflammatory environment...
  9. ncbi request reprint TLR2-mediated activation of neutrophils in response to German cockroach frass
    Kristen Page
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    J Immunol 180:6317-24. 2008
    ....
  10. pmc A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma
    Umasundari Sivaprasad
    Division of Asthma Research, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 127:254-61, 261.e1-6. 2011
    ..Asthma is a major public health burden worldwide. Studies from our group and others have demonstrated that SERPINB3 and SERPINB4 are induced in patients with asthma; however, their mechanistic role in asthma has yet to be determined...
  11. pmc Protease-activated receptor 2 activation of myeloid dendritic cells regulates allergic airway inflammation
    Ian P Lewkowich
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Respir Res 12:122. 2011
    ..A common characteristic of allergens is that they contain proteases that can activate protease-activated receptor (PAR-2); however the mechanism by which PAR-2 regulates allergic airway inflammation is unclear...
  12. ncbi request reprint Differences in expression, affinity, and function of soluble (s)IL-4Ralpha and sIL-13Ralpha2 suggest opposite effects on allergic responses
    Marat Khodoun
    Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45220, USA
    J Immunol 179:6429-38. 2007
    ....
  13. doi request reprint A critical role for C5L2 in the pathogenesis of experimental allergic asthma
    Xun Zhang
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Immunol 185:6741-52. 2010
    ..Furthermore, it drives Th2 immune responses independent of mDCs, suggesting a complex role for C5L2 in the development of experimental allergic asthma...
  14. pmc Allergen uptake, activation, and IL-23 production by pulmonary myeloid DCs drives airway hyperresponsiveness in asthma-susceptible mice
    Ian P Lewkowich
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 3:e3879. 2008
    ....
  15. pmc Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection
    Marsha Wills-Karp
    Division of Immunobiology and 2 Division of Asthma Research, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Exp Med 209:607-22. 2012
    ..These experiments extend the biological functions of TFF2 from tissue repair to the initiation and maintenance of mucosal T(H)2 responses...
  16. pmc Particulate matter-induced airway hyperresponsiveness is lymphocyte dependent
    Vanessa Saunders
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Environ Health Perspect 118:640-6. 2010
    ..However, the mechanism(s) by which it induces these features of asthma remains unknown...
  17. doi request reprint Foxa2 programs Th2 cell-mediated innate immunity in the developing lung
    Gang Chen
    Section of Neonatology, Perinatal and Pulmonary Biology, Perinatal Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    J Immunol 184:6133-41. 2010
    ..The respiratory epithelium plays a central role in the regulation of Th2-mediated inflammation and innate immunity in the developing lung in a process regulated by Foxa2...
  18. pmc Differences in susceptibility to German cockroach frass and its associated proteases in induced allergic inflammation in mice
    Kristen Page
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Respir Res 8:91. 2007
    ..Cockroach exposure is a major risk factor for the development of asthma. Inhalation of fecal remnants (frass) is the likely sensitizing agent; however isolated frass has not been tested for its ability to induce experimental asthma in mice...
  19. pmc Matrix metalloproteinase 8 contributes to solubilization of IL-13 receptor alpha2 in vivo
    Weiguo Chen
    Division of Allergy and Immunology, Institute for Personalized and Predictive Medicine, Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    J Allergy Clin Immunol 122:625-32. 2008
    ..IL-13R alpha 2 exists in soluble and membrane forms, which can both bind IL-13 and modulate its activity. Yet the proteolytic processes that contribute to the generation of soluble IL-13R alpha 2 are largely unknown...
  20. pmc Unique and overlapping gene expression patterns driven by IL-4 and IL-13 in the mouse lung
    Christina C Lewis
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 123:795-804.e8. 2009
    ..Although these 2 cytokines share signaling components, the molecular mechanisms by which they mediate different phases of the allergic asthmatic response remain elusive...
  21. doi request reprint Importance of cytokines in murine allergic airway disease and human asthma
    Fred D Finkelman
    Department of Medicine, Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45220, USA
    J Immunol 184:1663-74. 2010
    ..Results of these analyses establish the importance of specific cytokines in MAAD and human asthma and have therapeutic implications...
  22. pmc Selective stimulation of IL-4 receptor on smooth muscle induces airway hyperresponsiveness in mice
    Charles Perkins
    Department of Medicine, Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45220, USA
    J Exp Med 208:853-67. 2011
    ..These observations demonstrate that IL-4Rα promotes AHR through multiple mechanisms and provide a model for testing smooth muscle-directed asthma therapeutics...
  23. pmc Downregulation of glutathione S-transferase pi in asthma contributes to enhanced oxidative stress
    Kathy T Schroer
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    J Allergy Clin Immunol 128:539-48. 2011
    ..Glutathione S-transferase pi (GSTPi) is the predominant redox regulator in the lung. Although evidence implicates an important role for GSTPi in asthma, the mechanism for this has remained elusive...
  24. pmc Partial restoration of T-cell function in aged mice by in vitro blockade of the PD-1/ PD-L1 pathway
    Celine S Lages
    Cincinnati Children s Hospital Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, OH 45229, USA
    Aging Cell 9:785-98. 2010
    ....
  25. pmc A protective role for C5a in the development of allergic asthma associated with altered levels of B7-H1 and B7-DC on plasmacytoid dendritic cells
    Xun Zhang
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Immunol 182:5123-30. 2009
    ..Ex vivo targeting of B7-H1 and B7-DC increased Th2 cytokine production from T cells of wild-type but not of C5aR-targeted mice, suggesting a protective role for C5a through regulation of B7 molecule expression on plasmacytoid DCs...
  26. ncbi request reprint IL-4 induces IL-13-independent allergic airway inflammation
    Charles Perkins
    Division of Immunology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    J Allergy Clin Immunol 118:410-9. 2006
    ..The nonredundant role of IL-13 could reflect unique IL-13 activation of a signaling pathway, inhibitory effects induced by IL-4 but not IL-13, or greater production-potency of IL-13 than IL-4...
  27. ncbi request reprint Complement regulates inhalation tolerance at the dendritic cell/T cell interface
    Jörg Köhl
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Mol Immunol 44:44-56. 2007
    ..The emerging paradigm is that constitutive local generation of C5a and C5aR signaling in airway DCs controls inhalation tolerance directly as well as indirectly through sensitization of airway DCs for T(Reg)-mediated immunosuppression...
  28. ncbi request reprint Expression and regulation of small proline-rich protein 2 in allergic inflammation
    Nives Zimmermann
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Am J Respir Cell Mol Biol 32:428-35. 2005
    ..Thus, SPRR2 is an allergen- and IL-13-induced gene in experimental allergic responses that may be involved in disease pathophysiology...
  29. pmc CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function
    Ian P Lewkowich
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Exp Med 202:1549-61. 2005
    ..These data suggest that resistance to allergen-driven AHR is mediated in part by CD4+CD25+ T reg cell suppression of DC activation and that the absence of this regulatory pathway contributes to susceptibility...
  30. ncbi request reprint Interleukin-13 in asthma
    Marsha Wills-Karp
    Division of Immunobiology, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Curr Opin Pulm Med 9:21-7. 2003
    ....
  31. pmc Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein
    Aurelien Trompette
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Nature 457:585-8. 2009
    ....
  32. pmc Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation
    Fukun Guo
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Research Foundation, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e18002. 2011
    ..Collectively, these data establish that Cdc42 is critically involved in thymopoiesis and plays a restrictive role in effector and memory T cell differentiation and autoimmunity...
  33. doi request reprint The potential role of interleukin-17 in severe asthma
    Yui Hsi Wang
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Curr Allergy Asthma Rep 11:388-94. 2011
    ..Understanding the biology of IL-17 in the context of allergic inflammation may be informative in the development of novel approaches to the diagnosis and treatment of asthma...
  34. pmc Complement activation pathways: a bridge between innate and adaptive immune responses in asthma
    Marsha Wills-Karp
    Division of Immunobiology, Center for Immunological Research, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Proc Am Thorac Soc 4:247-51. 2007
    ....
  35. ncbi request reprint A dual role for complement in allergic asthma
    Jörg Köhl
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Curr Opin Pharmacol 7:283-9. 2007
    ..As such, selective targeting of pro-allergic complement pathways appears an attractive therapeutic option in allergic asthma...
  36. ncbi request reprint Biomedicine. Eosinophils in asthma: remodeling a tangled tale
    Marsha Wills-Karp
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Science 305:1726-9. 2004
  37. pmc Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice
    Kathryn A Niese
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    BMC Immunol 10:33. 2009
    ..Arginase is significantly upregulated in the lungs in murine models of asthma, as well as in human asthma, but its role in allergic airway inflammation has not been fully elucidated in mice...
  38. ncbi request reprint Chitin checking--novel insights into asthma
    Marsha Wills-Karp
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, USA
    N Engl J Med 351:1455-7. 2004
  39. pmc Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease
    YuanYuan Gu
    Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Nature 458:1039-42. 2009
    ..These data indicate that IFRD1 modulates the pathogenesis of cystic fibrosis lung disease through the regulation of neutrophil effector function...
  40. pmc Innate immune responses of airway epithelium to house dust mite are mediated through beta-glucan-dependent pathways
    Amy T Nathan
    Division of Neonatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 123:612-8. 2009
    ....
  41. pmc A TLR2 agonist in German cockroach frass activates MMP-9 release and is protective against allergic inflammation in mice
    Kristen Page
    Division of Critical Care Medicine, Cincinnati Children s Research Foundation, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 183:3400-8. 2009
    ..This suggests a protective role for TLR2 activation and MMP-9 release in the context of experimentally induced asthma in mice...
  42. doi request reprint Untangling the complex web of IL-4- and IL-13-mediated signaling pathways
    Marsha Wills-Karp
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Sci Signal 1:pe55. 2008
    ..A better understanding of the interactions of IL-4 and IL-13 with their cognate receptors may facilitate the development of therapies without unintended side effects...
  43. pmc Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells
    James A Stefater
    The Visual Systems Group, Division of Pediatric Ophthalmology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Nature 474:511-5. 2011
    ..These findings indicate that resident myeloid cells can use a non-canonical, Wnt-Flt1 pathway to suppress angiogenic branching...
  44. ncbi request reprint Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway
    Christopher L Karp
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center, and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Nat Immunol 5:388-92. 2004
    ..These findings suggest that there is a pathophysiologically important defect in lipoxin-mediated anti-inflammatory activity in the cystic fibrosis lung and that lipoxins have therapeutic potential in this lethal autosomal disease...
  45. ncbi request reprint Understanding the origin of asthma and its relationship to breastfeeding
    Marsha Wills-Karp
    Division of Immunobiology, Human Milk Research Program, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Adv Exp Med Biol 554:171-91. 2004
    ....
  46. pmc Identification of Cd101 as a susceptibility gene for Novosphingobium aromaticivorans-induced liver autoimmunity
    Javid P Mohammed
    Division of Immunobiology, Cincinnati Children s Hospital, Cincinnati, OH 45229, USA
    J Immunol 187:337-49. 2011
    ..These data strongly support the hypothesis that allelic variation of the Cd101 gene, located in the Idd10 region, alters the severity of liver autoimmunity induced by N. aromaticivorans...
  47. ncbi request reprint Time to draw breath: asthma-susceptibility genes are identified
    Marsha Wills-Karp
    Division of Immunobiology, Cincinnati Children s Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Nat Rev Genet 5:376-87. 2004
  48. ncbi request reprint Altered gene expression profiles in nasal respiratory epithelium reflect stable versus acute childhood asthma
    Jesus R Guajardo
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Allergy Clin Immunol 115:243-51. 2005
    ..Asthma is the most common chronic disease of childhood and has a strong genetic component...
  49. doi request reprint Allergen-specific pattern recognition receptor pathways
    Marsha Wills-Karp
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, MLC 7038, Cincinnati, OH 45229, United States
    Curr Opin Immunol 22:777-82. 2010
    ..Elucidation of the specific innate immune pathways activated by allergens holds great promise in defining new therapeutic targets for the treatment of allergic diseases...
  50. ncbi request reprint Atorvastatin affects interleukin-2 signaling by altering the lipid raft enrichment of the interleukin-2 receptor beta chain
    Jens Goebel
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital, Cincinnati, OH 45229, USA
    J Investig Med 53:322-8. 2005
    ..We conclude that AS affects IL-2R signaling by altering the raft enrichment of the IL-2R beta chain and propose that this effect is one mechanism underlying the immunomodulatory properties of statins...
  51. ncbi request reprint The anaphylatoxins bridge innate and adaptive immune responses in allergic asthma
    Heiko Hawlisch
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Mol Immunol 41:123-31. 2004
    ..During the effector phase, both anaphylatoxins trigger the inflammatory response and contribute to bronchoconstriction...
  52. pmc Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy
    Faisal Adhami
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Room 3464, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Am J Pathol 169:566-83. 2006
    ..Together, these results suggest that ischemia-hypoxia is a powerful stimulus for spontaneous coagulation leading to reperfusion deficits and autophagic/lysosomal cell death in brain...
  53. ncbi request reprint Complement factor 3 mediates particulate matter-induced airway hyperresponsiveness
    Dianne M Walters
    Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 27:413-8. 2002
    ..These results suggest that exposure to PM may induce AHR through activation of complement factor 3 in the airways...
  54. ncbi request reprint Amb a 1-linked CpG oligodeoxynucleotides reverse established airway hyperresponsiveness in a murine model of asthma
    Joanna V Santeliz
    Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD, USA
    J Allergy Clin Immunol 109:455-62. 2002
    ..However, few studies have addressed the issue of whether these agents will reverse established Tm(H)2-driven allergic airway responses...
  55. doi request reprint Usefulness and optimization of mouse models of allergic airway disease
    Fred D Finkelman
    J Allergy Clin Immunol 121:603-6. 2008
  56. pmc Nonhematopoietic NADPH oxidase regulation of lung eosinophilia and airway hyperresponsiveness in experimentally induced asthma
    Hiam Abdala-Valencia
    Allergy Immunology Division, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1111-25. 2007
    ..Moreover, these studies provide a basis for targeting VCAM-1-dependent signaling pathways in asthma therapies...
  57. ncbi request reprint IL-1 Receptor antagonist as a positional candidate gene in a murine model of allergic asthma
    Ravisankar A Ramadas
    Comparative Medicine and Integrative Biology Program, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    Immunogenetics 58:851-5. 2006
    ..Our results exclude Il1rn as the gene for Abhr1 and indicate that Il1f9 warrants further investigation based on genetic and expression differences observed in our mouse model of allergic asthma...
  58. ncbi request reprint Polymorphisms in the novel gene acyloxyacyl hydroxylase (AOAH) are associated with asthma and associated phenotypes
    Kathleen C Barnes
    Division of Allergy and Clinical Immunology, Department of Medicine, The Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 118:70-7. 2006
    ....
  59. pmc Immunostimulatory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction
    Edith M Hessel
    Dynavax Technologies, Berkeley, CA 94710, USA
    J Exp Med 202:1563-73. 2005
    ..Thus, inhibition by ISS of allergic responses can be explained by two novel mechanisms that culminate in the inhibition of the principal sources of type 2 cytokines in the airways...
  60. pmc A role for immune complexes in enhanced respiratory syncytial virus disease
    Fernando P Polack
    Department of Pediatrics, School of Medicine, Bloomberg School of Public Health at Johns Hopkins University, Baltimore, MD 21205, USA
    J Exp Med 196:859-65. 2002
    ..Further, we show correlation with the enhanced disease observed in children by providing evidence of complement activation in postmortem lung sections from children with enhanced RSV disease...
  61. ncbi request reprint Tubulin polymerization modulates interleukin-2 receptor signal transduction in human T cells
    Jens Goebel
    Department of Pediatrics, University of Kentucky, Lexington, Kentucky, USA
    J Recept Signal Transduct Res 26:87-106. 2006
    ..10 mice stimulated with their nominal antigen. We conclude that altered polymerization of cytoskeletal components, especially tubulin, is accompanied by modulation of IL-2 signaling at the receptor level...
  62. pmc Characterization of a novel PMA-inducible pathway of interleukin-13 gene expression in T cells
    Judith C Keen
    Department of Environmental Health Sciences, Johns Hopkins University School of Medicine, Balitmore, MD 21224, USA
    Immunology 117:29-37. 2006
    ..This promoter region supported the binding of both constitutive and PMA-inducible nuclear factors in gel shift assays...
  63. ncbi request reprint Elevated cytokine levels in children with autism spectrum disorder
    Cynthia A Molloy
    Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, United States
    J Neuroimmunol 172:198-205. 2006
    ..Conclusion: Children with ASD had increased activation of both Th2 and Th1 arms of the adaptive immune response, with a Th2 predominance, and without the compensatory increase in the regulatory cytokine IL-10...

Research Grants14

  1. Asthma Positional Candidate Genes in Mice and Humans
    Marsha Wills Karp; Fiscal Year: 2010
    ..abstract_text> ..
  2. Asthma Positional Candidate Genes in Mice and Humans
    Marsha Wills Karp; Fiscal Year: 2009
    ..abstract_text> ..
  3. Asthma Positional Candidate Genes in Mice and Humans
    Marsha Wills Karp; Fiscal Year: 2007
    ....
  4. Mechanisms: IL-13 Induced Mucus Hypersecretion in Asthma
    Marsha Wills Karp; Fiscal Year: 2006
    ..A better understanding of the mechanisms underlying IL-13-induced mucus hypersecretion should guide the development of novel strategies for the treatment of asthma and other hypersecretory diseases of the lung. ..
  5. Asthma Positional Candidate Genes in Mice and Humans
    Marsha Wills Karp; Fiscal Year: 2004
    ..This combined (mouse and human) approach to the study of asthma genetics should provide insight into the genes controlling susceptibility to human asthma and promote the development of novel therapeutics. ..
  6. Epithelial Regulation of Th2 Immune Responses in the Lung
    Marsha Wills Karp; Fiscal Year: 2010
    ..The identification of specific pathways initiating these responses may lead to the development of novel, effective therapies for the treatment of this ever-increasing disease. ..