Jeffrey A Whitsett

Summary

Affiliation: Children's Hospital Medical Center
Country: USA

Publications

  1. pmc Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice
    Elizabeth L Kramer
    Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Am J Respir Cell Mol Biol 41:415-25. 2009
  2. pmc Intrinsic and innate defenses in the lung: intersection of pathways regulating lung morphogenesis, host defense, and repair
    Jeffrey A Whitsett
    Children s Hospital Medical Center, Divisions of Neonatology and Pulmonary Biology, 3333 Burnet Avenue, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 109:565-9. 2002
  3. ncbi request reprint Use of transgenic mice to study autocrine-paracrine signaling in lung morphogenesis and differentiation
    J A Whitsett
    Division of Neonatology, Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Clin Perinatol 23:753-69. 1996
  4. ncbi request reprint Fibroblast growth factor 18 influences proximal programming during lung morphogenesis
    Jeffrey A Whitsett
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 277:22743-9. 2002
  5. ncbi request reprint Hydrophobic surfactant proteins in lung function and disease
    Jeffrey A Whitsett
    Division of Neonatology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    N Engl J Med 347:2141-8. 2002
  6. ncbi request reprint Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis
    Huajing Wan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 280:13809-16. 2005
  7. pmc Foxa2 is required for transition to air breathing at birth
    Huajing Wan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Proc Natl Acad Sci U S A 101:14449-54. 2004
  8. pmc Calcineurin/Nfat signaling is required for perinatal lung maturation and function
    Vrushank Dave
    Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Clin Invest 116:2597-609. 2006
  9. ncbi request reprint Nuclear factor of activated T cells regulates transcription of the surfactant protein D gene (Sftpd) via direct interaction with thyroid transcription factor-1 in lung epithelial cells
    Vrushank Dave
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Biol Chem 279:34578-88. 2004
  10. doi request reprint Kruppel-like factor 5 is required for perinatal lung morphogenesis and function
    Huajing Wan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Development 135:2563-72. 2008

Collaborators

Detail Information

Publications165 found, 100 shown here

  1. pmc Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice
    Elizabeth L Kramer
    Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Am J Respir Cell Mol Biol 41:415-25. 2009
    ..This provides a unique model to study the processes causing pulmonary fibrosis and ASM thickening without the complicating effects of inflammation...
  2. pmc Intrinsic and innate defenses in the lung: intersection of pathways regulating lung morphogenesis, host defense, and repair
    Jeffrey A Whitsett
    Children s Hospital Medical Center, Divisions of Neonatology and Pulmonary Biology, 3333 Burnet Avenue, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 109:565-9. 2002
  3. ncbi request reprint Use of transgenic mice to study autocrine-paracrine signaling in lung morphogenesis and differentiation
    J A Whitsett
    Division of Neonatology, Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Clin Perinatol 23:753-69. 1996
    ....
  4. ncbi request reprint Fibroblast growth factor 18 influences proximal programming during lung morphogenesis
    Jeffrey A Whitsett
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 277:22743-9. 2002
    ..Effects were unique to FGF-18 because expression of other members of the FGF family had different consequences. These data show that FGF-18 is capable of enhancing proximal and inhibiting peripheral programs during lung morphogenesis...
  5. ncbi request reprint Hydrophobic surfactant proteins in lung function and disease
    Jeffrey A Whitsett
    Division of Neonatology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    N Engl J Med 347:2141-8. 2002
  6. ncbi request reprint Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis
    Huajing Wan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 280:13809-16. 2005
    ..Foxa family members regulate signaling and transcriptional programs required for morphogenesis and cell differentiation during formation of the lung...
  7. pmc Foxa2 is required for transition to air breathing at birth
    Huajing Wan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Proc Natl Acad Sci U S A 101:14449-54. 2004
    ..Foxa2 regulates a complex pulmonary program of epithelial cell maturation required for transition to air breathing at birth...
  8. pmc Calcineurin/Nfat signaling is required for perinatal lung maturation and function
    Vrushank Dave
    Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Clin Invest 116:2597-609. 2006
    ..The calcineurin/Nfat pathway controls the morphologic maturation of lungs prior to birth and regulates expression of genes involved in surfactant homeostasis that are critical for adaptation to air breathing...
  9. ncbi request reprint Nuclear factor of activated T cells regulates transcription of the surfactant protein D gene (Sftpd) via direct interaction with thyroid transcription factor-1 in lung epithelial cells
    Vrushank Dave
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Biol Chem 279:34578-88. 2004
    ..Components of the calcineurin/NFAT pathway were identified in respiratory epithelial cells of the lung that potentially augment rapid assembly of a multiprotein transcription complex on Sftpd promoter inducing SP-D expression...
  10. doi request reprint Kruppel-like factor 5 is required for perinatal lung morphogenesis and function
    Huajing Wan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Development 135:2563-72. 2008
    ..KLF5 regulates genes controlling paracrine interactions during lung morphogenesis, as well as those regulating the maturation of the respiratory epithelium that is required for lung function after birth...
  11. pmc Forkhead Box m1 transcription factor is required for perinatal lung function
    Tanya V Kalin
    Division of Pulmonary Biology, Cincinnati Children s Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 105:19330-5. 2008
    ..Foxm1 is critical for surfactant homeostasis and lung maturation before birth and is required for adaptation to air breathing...
  12. pmc Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis
    Thomas R Korfhagen
    Department of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Am J Respir Cell Mol Biol 41:562-72. 2009
    ....
  13. ncbi request reprint TAZ interacts with TTF-1 and regulates expression of surfactant protein-C
    Kwon Sik Park
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 279:17384-90. 2004
    ..TAZ binds to TTF-1, increasing the transcriptional activity of TTF-1 on the SP-C promoter. Developmental and cell-selective regulation of TAZ provides a mechanism by which the activity of TTF-1 on target genes is modulated...
  14. ncbi request reprint beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis
    Michael L Mucenski
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 278:40231-8. 2003
    ..These observations establish, for the first time, both the sites and timing of specification of the proximal and peripheral airways in the developing lung, and that beta-catenin is one of the essential components of this specification...
  15. ncbi request reprint Neither SP-A nor NH2-terminal domains of SP-A can substitute for SP-D in regulation of alveolar homeostasis
    Liqian Zhang
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, OH 45229, USA
    Am J Physiol Lung Cell Mol Physiol 291:L181-90. 2006
    ....
  16. pmc FOXM1 promotes allergen-induced goblet cell metaplasia and pulmonary inflammation
    Xiaomeng Ren
    Division of Pulmonary Biology, Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio, USA
    Mol Cell Biol 33:371-86. 2013
    ..Finally, pharmacological inhibition of FOXM1 by ARF peptide prevented HDM-mediated pulmonary responses. FOXM1 regulates genes critical for allergen-induced lung inflammation and goblet cell metaplasia...
  17. ncbi request reprint Midkine is regulated by hypoxia and causes pulmonary vascular remodeling
    Paul R Reynolds
    Divisions of Pulmonary Biology and Human Genetics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Biol Chem 279:37124-32. 2004
    ..These data provide a model wherein the respiratory epithelium responds to hypoxia via HIF-1alpha-dependent regulation of MK, enhancing myocardin expression to influence pulmonary vascular gene expression...
  18. pmc Transcriptional programs controlling perinatal lung maturation
    Yan Xu
    The Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology, University of Cincinnati, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    PLoS ONE 7:e37046. 2012
    ..The present study systemically mapped key regulators, bioprocesses, and transcriptional networks controlling lung maturation, providing the basis for new therapeutic strategies to enhance lung function in preterm infants...
  19. pmc SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production
    Gang Chen
    The Perinatal Institute, Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati School of Medicine, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    J Clin Invest 119:2914-24. 2009
    ..These data show that SPDEF plays a critical role in regulating a transcriptional network mediating the goblet cell differentiation and mucus hyperproduction associated with chronic pulmonary disorders...
  20. doi request reprint R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis
    Sheila M Bell
    Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Development 135:1049-58. 2008
    ..Interbreeding the Rspo2(Tg) and Lrp6(-) alleles resulted in more severe defects consisting of marked lung hypoplasia and absence of tracheal-bronchial rings, laryngeal structures and all limb skeletal elements...
  21. ncbi request reprint Beta-catenin regulates differentiation of respiratory epithelial cells in vivo
    Michael L Mucenski
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 289:L971-9. 2005
    ....
  22. pmc Airway epithelial transcription factor NK2 homeobox 1 inhibits mucous cell metaplasia and Th2 inflammation
    Yutaka Maeda
    Perinatal Institute, Divisions of Neonatology, Perinatal, and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Am J Respir Crit Care Med 184:421-9. 2011
    ..Elucidation of the molecular mechanisms regulating mucous metaplasia and hypersecretion provides the scientific basis for diagnostic and therapeutic opportunities to improve the care of chronic pulmonary diseases...
  23. doi request reprint Foxa2 programs Th2 cell-mediated innate immunity in the developing lung
    Gang Chen
    Section of Neonatology, Perinatal and Pulmonary Biology, Perinatal Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    J Immunol 184:6133-41. 2010
    ..The respiratory epithelium plays a central role in the regulation of Th2-mediated inflammation and innate immunity in the developing lung in a process regulated by Foxa2...
  24. pmc Conditional recombination reveals distinct subsets of epithelial cells in trachea, bronchi, and alveoli
    Anne Karina T Perl
    Division of Pulmonary Biology and Neonatology, Cincinnati Children s Hospital Medical Center, Ohio 45229 3039, USA
    Am J Respir Cell Mol Biol 33:455-62. 2005
    ..Conditional expression of Cre-recombinase in the respiratory epithelium provides a useful model for the study of gene expression and function in the mouse respiratory tract and in the lung...
  25. ncbi request reprint The role of pulmonary collectin N-terminal domains in surfactant structure, function, and homeostasis in vivo
    Nades Palaniyar
    Division of Pulmonary Critical Care Medicine, Department of Medicine, Children s Hospital Research Foundation, University of Cincinnati School of Medicine, Cincinnati, OH 45267 0564, USA
    J Biol Chem 277:26971-9. 2002
    ....
  26. pmc STAT3 regulates ABCA3 expression and influences lamellar body formation in alveolar type II cells
    Yohei Matsuzaki
    Cincinnati Children s Hospital Medical Center, Section of Neonatology, Perinatal and Pulmonary Biology, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Am J Respir Cell Mol Biol 38:551-8. 2008
    ..ABCA3 expression is regulated by IL-6 in a pathway that includes STAT3, PI3K, AKT, SCAP, and SREBP. Activation of STAT3 after exposure to IL-6 enhances ABCA3 expression, which, in turn, influences pulmonary surfactant homeostasis...
  27. pmc Pulmonary surfactant surface tension influences alveolar capillary shape and oxygenation
    Machiko Ikegami
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Am J Respir Cell Mol Biol 41:433-9. 2009
    ....
  28. pmc C/EBP{alpha} is required for pulmonary cytoprotection during hyperoxia
    Yan Xu
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Ohio 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 297:L286-98. 2009
    ..While C/EBPalpha did not play a critical role in postnatal pulmonary function under normal conditions, C/EBPalpha mediated protection of the lung during acute lung injury induced by hyperoxia...
  29. ncbi request reprint Sox17 influences the differentiation of respiratory epithelial cells
    Kwon Sik Park
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Dev Biol 294:192-202. 2006
    ..Sites of expression and the effects of Sox17 in vivo and in vitro are consistent with a role for Sox17 or other members of the Sox family of transcription factors in differentiation of the conducting airway epithelium...
  30. ncbi request reprint C/EBPalpha is required for lung maturation at birth
    Prithy C Martis
    Division of Pulmonary Biology and Neonatology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Development 133:1155-64. 2006
    ..C/EBPalpha participates in a transcriptional network that is required for the regulation of genes mediating perinatal lung maturation and surfactant homeostasis that is necessary for adaptation to air breathing at birth...
  31. ncbi request reprint Reversibility of lung inflammation caused by SP-B deficiency
    Machiko Ikegami
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 289:L962-70. 2005
    ..SP-B reversed inflammation and maintained lung function in vivo, indicating its potential utility for the prevention and treatment of pulmonary injury and surfactant deficiency...
  32. ncbi request reprint Correction of pulmonary abnormalities in Sftpd-/- mice requires the collagenous domain of surfactant protein D
    Paul S Kingma
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 281:24496-505. 2006
    ..The collagen domain of SP-D is required for the regulation of pulmonary macrophage activation, airspace remodeling, and surfactant lipid homeostasis...
  33. ncbi request reprint Pneumonitis and emphysema in sp-C gene targeted mice
    Stephan W Glasser
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Ohio 45229 3039, USA
    J Biol Chem 278:14291-8. 2003
    ..Absence of SP-C caused a severe progressive pulmonary disorder with histologic features consistent with interstitial pneumonitis...
  34. ncbi request reprint Macrophage dysfunction and susceptibility to pulmonary Pseudomonas aeruginosa infection in surfactant protein C-deficient mice
    Stephan W Glasser
    Division of Pulmonary Biology, Department of Pediatrics, Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    J Immunol 181:621-8. 2008
    ..SP-C plays an important role in innate host defense of the lung, enhancing macrophage-mediated Pseudomonas phagocytosis, clearance and limiting pulmonary inflammatory responses...
  35. pmc Gene expression and biological processes influenced by deletion of Stat3 in pulmonary type II epithelial cells
    Yan Xu
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH, USA
    BMC Genomics 8:455. 2007
    ..Differentially expressed genes were identified from Affymetrix Murine GeneChips analysis and subjected to gene ontology classification, promoter analysis, pathway mapping and literature mining...
  36. pmc Kruppel-like factor 5 is not required for K-RasG12D lung tumorigenesis, but represses ABCG2 expression and is associated with better disease-specific survival
    Sara E Meyer
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Am J Pathol 177:1503-13. 2010
    ..In summary, while KLF5 is not required for oncogenic mutant K-Ras-induced lung tumorigenesis, KLF5 regulation of ABCG2 expression may be important for chemotherapeutic resistance and patient survival...
  37. pmc SPDEF regulates goblet cell hyperplasia in the airway epithelium
    Kwon Sik Park
    Division of Pulmonary Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Clin Invest 117:978-88. 2007
    ..SPDEF was induced following intratracheal allergen exposure and after Th2 cytokine stimulation and was sufficient to cause goblet cell differentiation of Clara cells in vivo...
  38. ncbi request reprint Stat3 is required for cytoprotection of the respiratory epithelium during adenoviral infection
    Yohei Matsuzaki
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Immunol 177:527-37. 2006
    ..Thus, Stat3 plays a critical cytoprotective role that is required for epithelial cell survival and maintenance of alveolar structures during the early phases of pulmonary adenoviral infection...
  39. ncbi request reprint FGF signaling is required for pulmonary homeostasis following hyperoxia
    Isamu Hokuto
    Cincinnati Children s Hospital Medical Center, Div of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 286:L580-7. 2004
    ..FGF signaling is required for maintenance of surfactant homeostasis and lung function during hyperoxia in vivo, mediated, at least in part, by its role in the maintenance of SP-B expression...
  40. pmc Stat-3 is required for pulmonary homeostasis during hyperoxia
    Isamu Hokuto
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 113:28-37. 2004
    ..Expression of Stat-3 in respiratory epithelial cells is not required for lung formation, but plays a critical role in maintenance of surfactant homeostasis and lung function during oxygen injury...
  41. pmc SAM-pointed domain ETS factor mediates epithelial cell-intrinsic innate immune signaling during airway mucous metaplasia
    Thomas R Korfhagen
    Division of Neonatology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 109:16630-5. 2012
    ....
  42. pmc Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition
    David Balli
    Department of Pediatrics, Division of Pulmonary Biology, The Perinatal Institute, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    EMBO J 32:231-44. 2013
    ..Foxm1 is required for radiation-induced pulmonary fibrosis by enhancing the expression of genes critical for lung inflammation and EMT...
  43. ncbi request reprint Sterol response element binding protein and thyroid transcription factor-1 (Nkx2.1) regulate Abca3 gene expression
    Valérie Besnard
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 293:L1395-405. 2007
    ..Abca3 gene expression is mediated by discrete cis-acting cassettes that mediate pulmonary cell- and lipid-sensitive pathways regulating surfactant homeostasis...
  44. doi request reprint Surfactant protein-D regulates the postnatal maturation of pulmonary surfactant lipid pool sizes
    Machiko Ikegami
    Div of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, ML 7029, 3333 Burnet Ave, Cincinnati, Ohio 45229 3039, USA
    J Appl Physiol (1985) 106:1545-52. 2009
    ..SP-D regulates the dramatic decreases in the surfactant pool size that occurs in the newborn period...
  45. doi request reprint Surfactant protein D alters allergic lung responses in mice and human subjects
    Eric B Brandt
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 121:1140-1147.e2. 2008
    ..Surfactant protein (SP) D has been proposed to be protective in allergic airway responses...
  46. ncbi request reprint Functional genomic responses to cystic fibrosis transmembrane conductance regulator (CFTR) and CFTR(delta508) in the lung
    Yan Xu
    Division of Pulmonary Biology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 281:11279-91. 2006
    ..Genes and pathways involved in the response to CFTR may be of interest as modifiers of CF...
  47. pmc Sox17 promotes cell cycle progression and inhibits TGF-beta/Smad3 signaling to initiate progenitor cell behavior in the respiratory epithelium
    Alexander W Lange
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 4:e5711. 2009
    ....
  48. pmc Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis
    William D Hardie
    Division of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, Ohio 45229, USA
    Am J Respir Cell Mol Biol 37:309-21. 2007
    ..These studies support a role for epithelial cell-derived TGF-alpha in the regulation of processes that alter the airway and vascular architecture and function...
  49. ncbi request reprint Inhibition of alveolarization and altered pulmonary mechanics in mice expressing GATA-6
    Cong Liu
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 285:L1246-54. 2003
    ..Normal postnatal morphogenesis of the lung depends upon precise temporal-spatial regulation of GATA-6...
  50. pmc Klf5 regulates lineage formation in the pre-implantation mouse embryo
    Suh Chin J Lin
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Development 137:3953-63. 2010
    ..These findings demonstrate that Klf5 is a dynamic regulator of all three lineages in the pre-implantation embryo by promoting the TE and epiblast lineages while suppressing the PE lineage...
  51. pmc Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma
    Timothy D Le Cras
    Division of Pulmonary Biology, Cincinnati Children s Hospital, OH 45229, USA
    Am J Physiol Lung Cell Mol Physiol 300:L414-21. 2011
    ..This study demonstrates that EGFR signaling, especially in the airway epithelium, plays an important role in mediating AHR and remodeling in a chronic allergic asthma model...
  52. ncbi request reprint Role of Sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung
    Leigh Anne D Miller
    Department of Pediatrics, Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Dev Dyn 231:57-71. 2004
    ..SHH regulates branching morphogenesis and influences differentiation of the peripheral lung mesenchyme required for formation of bronchial and vascular smooth muscle...
  53. pmc GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium
    Hiroshi Kida
    Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Am J Pathol 172:1542-54. 2008
    ..In the present study, we show that GP130-STAT3 signaling functions in a cell-autonomous manner to restore cell shape and numbers required for repair of the bronchiolar epithelium following injury...
  54. pmc Foxm1 transcription factor is critical for proliferation and differentiation of Clara cells during development of conducting airways
    Vladimir Ustiyan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Research Foundation, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Dev Biol 370:198-212. 2012
    ..In co-transfection experiments, Foxm1 directly bound to and induced transcriptional activity of Scgb1a1 and Sox2 promoters. Foxm1 is required for differentiation and maintenance of epithelial cells lining conducting airways...
  55. pmc Increased expression of FoxM1 transcription factor in respiratory epithelium inhibits lung sacculation and causes Clara cell hyperplasia
    I Ching Wang
    Division of Pulmonary Biology, Perinatal Institute of the Cincinnati Children s Hospital Research Foundation, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Dev Biol 347:301-14. 2010
    ....
  56. doi request reprint STAT-3 regulates surfactant phospholipid homeostasis in normal lung and during endotoxin-mediated lung injury
    Machiko Ikegami
    Cincinnati Children s Hospital, Div of Pulmonary Biology, Cincinnati, OH 45229 3039, USA
    J Appl Physiol (1985) 104:1753-60. 2008
    ..STAT-3 plays a critical role in the regulation of surfactant lipid synthesis in the normal lung and during lung injury caused by LPS...
  57. ncbi request reprint TGF-alpha perturbs surfactant homeostasis in vivo
    Machiko Ikegami
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 289:L34-43. 2005
    ..Abnormalities in surfactant function and decreased surfactant level in the airways may contribute to the pathophysiology induced by TGF-alpha in both the developing and adult lung...
  58. ncbi request reprint Vascular endothelial growth factor-A induces prenatal neovascularization and alters bronchial development in mice
    Ann L Akeson
    Division of Pulmonary Biology, Cincinnati Children s Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Pediatr Res 57:82-8. 2005
    ..Bronchial expression of VEGF-A alters late-stage morphogenesis of conducting airways and primary bronchial arteries and causes respiratory failure at birth...
  59. pmc Kruppel-like factor 5 is required for formation and differentiation of the bladder urothelium
    Sheila M Bell
    Perinatal Institute of Cincinnati Children s Hospital Medical Center, Division of Neonatology Perinatal Pulmonary Biology, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Dev Biol 358:79-90. 2011
    ..Deletion of Klf5 from the developing bladder urothelium blocked epithelial cell differentiation, impaired bladder morphogenesis and function causing hydroureter and hydronephrosis at birth...
  60. pmc Deletion of Scap in alveolar type II cells influences lung lipid homeostasis and identifies a compensatory role for pulmonary lipofibroblasts
    Valérie Besnard
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, The University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 284:4018-30. 2009
    ..Deletion of the SCAP/SREBP pathway in respiratory epithelial cells altered lung lipid homeostasis and induced compensatory lipid accumulation and synthesis in lung lipofibroblasts...
  61. ncbi request reprint Endocytic internalization of adenovirus, nonspecific phagocytosis, and cytoskeletal organization are coordinately regulated in alveolar macrophages by GM-CSF and PU.1
    Pierre Yves Berclaz
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 169:6332-42. 2002
    ..1, regulates endocytosis of small ( approximately 100 nm) pathogens/inert particles and phagocytosis of very large inert particles and suggests regulation of cytoskeletal organization by GM-CSF/PU.1 as the molecular basis of this control...
  62. ncbi request reprint Reversibility of pulmonary abnormalities by conditional replacement of surfactant protein D (SP-D) in vivo
    Liqian Zhang
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 277:38709-13. 2002
    ..However, once established, emphysema was not reversed by SP-D. SP-D-dependent processes regulating surfactant lipid homeostasis were disassociated from those mediating emphysema...
  63. ncbi request reprint Duration-dependent cytoprotective versus inflammatory effects of lung epithelial fibroblast growth factor-7 expression
    Jay W Tichelaar
    Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Exp Lung Res 33:385-417. 2007
    ..FGF7 improved survival during acute lung injury in adult mouse lung after short-term expression, but paradoxically induced inflammation and injury after persistent expression...
  64. ncbi request reprint Normal lung development and function after Sox9 inactivation in the respiratory epithelium
    Anne Karina T Perl
    Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
    Genesis 41:23-32. 2005
    ..Although Sox9 is expressed at high levels throughout lung morphogenesis, inactivation of Sox9 from the respiratory epithelial cells does not alter lung structure, postnatal survival, or repair following oxygen injury...
  65. pmc GM-CSF regulates a PU.1-dependent transcriptional program determining the pulmonary response to LPS
    Pierre Yves Berclaz
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45229, USA
    Am J Respir Cell Mol Biol 36:114-21. 2007
    ..1-dependent. These results show that GM-CSF, via PU.1, enables AM responses to P. aeruginosa LPS by regulating expression of a specific subset of components of the TLR-4 signaling pathway...
  66. doi request reprint EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis
    William D Hardie
    Division of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Am J Physiol Lung Cell Mol Physiol 294:L1217-25. 2008
    ....
  67. ncbi request reprint SP-B deficiency causes respiratory failure in adult mice
    Kristin R Melton
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 285:L543-9. 2003
    ..Reduction of alveolar SP-B content causes surfactant dysfunction and respiratory failure, indicating that SP-B is required for postnatal lung function...
  68. pmc GM-CSF-deficient mice are susceptible to pulmonary group B streptococcal infection
    A M Levine
    Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 103:563-9. 1999
    ..GM-CSF plays an important role in GBS clearance in vivo, mediated in part by its role in enhancing superoxide and hydrogen peroxide production and bacterial killing by alveolar macrophages...
  69. ncbi request reprint Distinct changes in pulmonary surfactant homeostasis in common beta-chain- and GM-CSF-deficient mice
    J A Reed
    Children s Hospital Medical Center, Cincinnati, Ohio 43229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 278:L1164-71. 2000
    ..surfactant metabolism; alveolar macrophage; granulocyte-macrophage colony-stimulating factor..
  70. ncbi request reprint Surfactant protein B inhibits endotoxin-induced lung inflammation
    Ralph Epaud
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Am J Respir Cell Mol Biol 28:373-8. 2003
    ....
  71. ncbi request reprint GATA-6 activates transcription of surfactant protein A
    M D Bruno
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 275:1043-9. 2000
    ..GATA-6 is expressed in respiratory epithelial cells and binds to a cis-acting element in the SP-A gene promoter, activating the transcriptional activity of the gene...
  72. ncbi request reprint Stage-specific regulation of respiratory epithelial cell differentiation by Foxa1
    V Besnard
    Department of Pediatrics, Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 289:L750-9. 2005
    ....
  73. ncbi request reprint Surfactant protein-D regulates surfactant phospholipid homeostasis in vivo
    T R Korfhagen
    Division of Pulmonary Biology, Department of Pediatrics, Children s Hospital Research Foundation, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 273:28438-43. 1998
    ..Targeting of the mouse SP-D gene caused accumulation of surfactant lipid and altered phospholipid structures, demonstrating a previously unsuspected role for SP-D in surfactant lipid homeostasis in vivo...
  74. ncbi request reprint FGF-10 disrupts lung morphogenesis and causes pulmonary adenomas in vivo
    J C Clark
    Division of Pulmonary Biology, Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 280:L705-15. 2001
    ..FGF-10 disrupted lung morphogenesis and induced multifocal pulmonary tumors in vivo and caused reversible type II cell differentiation of the respiratory epithelium...
  75. ncbi request reprint Complementation of pulmonary abnormalities in SP-D(-/-) mice with an SP-D/conglutinin fusion protein
    Liqian Zhang
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 277:22453-9. 2002
    ..Our findings also strongly suggest that the molecular mechanisms underlying impaired pulmonary host defense and abnormal lipid metabolism are distinct from those that promote ongoing inflammation and the development of emphysema...
  76. ncbi request reprint Surfactant protein A-deficient mice are susceptible to group B streptococcal infection
    A M Levine
    Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45229, USA
    J Immunol 158:4336-40. 1997
    ..SP-A plays an important role in vivo, enhancing clearance of GBS from the lung and inhibiting systemic dissemination of the organism...
  77. ncbi request reprint Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung
    L Zhou
    Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
    J Histochem Cytochem 44:1183-93. 1996
    ..The early expression of TTF-1 and HNF-3beta, preceding and overlapping that of pro-SP-B, mature SP-B, pro-SP-C, and CCSP, supports a regulatory role for TTF-1 and HNF-3beta in lung-specific gene expression...
  78. ncbi request reprint GM-CSF regulates protein and lipid catabolism by alveolar macrophages
    M Yoshida
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 280:L379-86. 2001
    ..These findings demonstrate the important role of GM-CSF in the regulation of alveolar macrophage lipid and SP-A catabolism...
  79. ncbi request reprint Conditional expression of fibroblast growth factor-7 in the developing and mature lung
    J W Tichelaar
    Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 275:11858-64. 2000
    ..The Sp-c-rtta and Ccsp-rtta activator mice provide models in which expression is conditionally controlled in respiratory epithelial cells in the developing and mature lung, altering lung morphogenesis, differentiation, and proliferation...
  80. pmc Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice
    S E Wert
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Proc Natl Acad Sci U S A 97:5972-7. 2000
    ..SP-D plays a critical role in the suppression of alveolar macrophage activation, which may contribute to the pathogenesis of chronic inflammation and emphysema...
  81. ncbi request reprint Lung cell-specific expression of the murine surfactant protein A (SP-A) gene is mediated by interactions between the SP-A promoter and thyroid transcription factor-1
    M D Bruno
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039
    J Biol Chem 270:6531-6. 1995
    ..TTF-1 interacts with complex protein/DNA binding sites located in the 5'-flanking region of the murine SP-A gene enhancing lung epithelial cell-specific expression in vitro...
  82. ncbi request reprint Activity of pulmonary surfactant protein-D (SP-D) in vivo is dependent on oligomeric structure
    L Zhang
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 276:19214-9. 2001
    ..Disulfide cross-linked SP-D oligomers are required for the regulation of surfactant phospholipid homeostasis and the prevention of emphysema and foamy macrophages in vivo...
  83. ncbi request reprint Surfactant protein-A binds group B streptococcus enhancing phagocytosis and clearance from lungs of surfactant protein-A-deficient mice
    A M Levine
    Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
    Am J Respir Cell Mol Biol 20:279-86. 1999
    ..SP-A plays an important role in GBS clearance in vivo, mediated in part by binding to and enhancing GBS phagocytosis and by increasing SO production by alveolar macrophages...
  84. ncbi request reprint GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1
    Y Shibata
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Immunity 15:557-67. 2001
    ..We conclude that PU.1 mediates GM-CSF-dependent effects on terminal differentiation of AMs regulating innate immune functions and surfactant catabolism by AMs...
  85. ncbi request reprint The collagen-like region of surfactant protein A (SP-A) is required for correction of surfactant structural and functional defects in the SP-A null mouse
    M Ikegami
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Cincinnati School of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 276:38542-8. 2001
    ....
  86. ncbi request reprint GM-CSF enhances lung growth and causes alveolar type II epithelial cell hyperplasia in transgenic mice
    J A Huffman Reed
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Am J Physiol 273:L715-25. 1997
    ....
  87. ncbi request reprint Immunosuppressed surfactant protein A-deficient mice have increased susceptibility to Pneumocystis carinii infection
    M J Linke
    Research Service, Department of Veterans Affairs Medical Center, and Divisions of Infectious Diseases and Pulmonary Critical Care Medicine, University of Cincinnati, Cincinnati, OH 45220, USA
    J Infect Dis 183:943-52. 2001
    ..carinii to the macrophages. Thus, SP-A plays a role in host defense against P. carinii in vivo, perhaps by functioning as a nonimmune opsonin...
  88. ncbi request reprint Pulmonary collectins and innate host defense of the lung
    A M Levine
    Children's Hospital Medical Center, Division of Neonatology and Pulmonary Biology, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA
    Microbes Infect 3:161-6. 2001
    ..SP-A and SP-D play critical and distinct roles in the regulation of alveolar macrophage function and inflammation, contributing to innate defense of the lung...
  89. ncbi request reprint HNF-3/forkhead homologue-4 influences lung morphogenesis and respiratory epithelial cell differentiation in vivo
    J W Tichelaar
    Division of Pulmonary Biology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio, 45229 3039, USA
    Dev Biol 213:405-17. 1999
    ..Ectopic expression of HFH-4 in developing mouse lung altered epithelial cell differentiation and morphology, restricting the expression of markers typical of nonciliated cells of the distal lung parenchyma...
  90. ncbi request reprint Purification of a cell-surface receptor for surfactant protein A
    Z C Chroneos
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 271:16375-83. 1996
    ..In a separate report we have determined that antibodies to the SP-A receptor block the SP-A-mediated uptake of Mycobacterium bovis, indicating that the macrophage SP-A receptor is involved in SP-A-mediated clearance of pathogens...
  91. ncbi request reprint Surfactant protein deficiency in familial interstitial lung disease
    R S Amin
    Children s Hospital Medical Center, Department of Pediatrics, Cincinnati, Ohio 45229 3039, USA
    J Pediatr 139:85-92. 2001
    ..To determine the contribution of surfactant protein abnormalities to the development of chronic lung injury in a familial form of interstitial lung disease...
  92. ncbi request reprint Surfactant protein D regulates NF-kappa B and matrix metalloproteinase production in alveolar macrophages via oxidant-sensitive pathways
    M Yoshida
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 166:7514-9. 2001
    ..Oxidant production and reactive oxygen species were increased in lungs of SP-D(-/-) mice, in turn activating NF-kappaB and MMP expression. SP-D plays an unexpected inhibitory role in the regulation of NF-kappaB in AMs...
  93. ncbi request reprint TGF-beta1 perturbs vascular development and inhibits epithelial differentiation in fetal lung in vivo
    X Zeng
    Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
    Dev Dyn 221:289-301. 2001
    ..TGF-beta1 perturbed both epithelial cell differentiation and formation of the pulmonary vasculature, supporting the concept that precise control of signaling via the TGF-beta receptor pathway is critical for normal lung morphogenesis...
  94. ncbi request reprint Surfactant proteins and cell markers in the respiratory epithelium of the amphibian, Ambystoma mexicanum
    L D Miller
    Children's Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45229-3039, USA
    Comp Biochem Physiol A Mol Integr Physiol 129:141-9. 2001
    ..Pulmonary surfactant and host defense proteins are shared across diverse phyla supporting the concept that pulmonary structure and function have evolved from common ancestors...
  95. pmc Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice
    J C Clark
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Proc Natl Acad Sci U S A 92:7794-8. 1995
    ..Ablation of the SP-B gene disrupts the routing, storage, and function of surfactant phospholipids and proteins, causing respiratory failure at birth...
  96. ncbi request reprint Pulmonary alveolar proteinosis
    Bruce C Trapnell
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    N Engl J Med 349:2527-39. 2003
  97. ncbi request reprint Conditional gene expression in the respiratory epithelium of the mouse
    Anne Karina T Perl
    Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio, USA
    Transgenic Res 11:21-9. 2002
    ..The SP-C-rtTA and CCSP-rtTA activator mice control the expression of transgenes in the developing and mature respiratory epithelium, and will be useful for the study of gene function in the lung...
  98. ncbi request reprint HNF-3/forkhead homologue-4 (HFH-4) is expressed in ciliated epithelial cells in the developing mouse lung
    J W Tichelaar
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio, USA
    J Histochem Cytochem 47:823-32. 1999
    ..Co-localization of HFH-4 and beta-tubulin IV staining in various tissues during mouse development supports a role for HFH-4 in the differentiation of ciliated cell lineages...
  99. pmc Nuclear localization domain of thyroid transcription factor-1 in respiratory epithelial cells
    M Ghaffari
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Biochem J 328:757-61. 1997
    ..Nuclear translocation of TITF-1 depends on both an NLS and the homeodomain of the polypeptide. Both C- and N-terminal regions of TITF-1 are involved in transactivation of surfactant protein B gene expression in pulmonary cells...
  100. ncbi request reprint Characteristics of surfactant from SP-A-deficient mice
    M Ikegami
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Am J Physiol 275:L247-54. 1998
    ..Although the absence of SP-A changed the structure and in vitro properties of surfactant, the in vivo function of surfactant in SP-A(-/-) mice was not changed under the conditions of these experiments...
  101. ncbi request reprint Clara cell secretory protein: a determinant of PCB bioaccumulation in mammals
    B R Stripp
    Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229
    Am J Physiol 271:L656-64. 1996
    ....