Research Topics
Genomes and Genes
| James M WellsSummaryAffiliation: Children's Hospital Medical Center Country: USA Publications
| Collaborators
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Detail Information
Publications
Identification of molecular markers that are expressed in discrete anterior-posterior domains of the endoderm from the gastrula stage to mid-gestationBillie A Moore-Scott
Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
Dev Dyn 236:1997-2003. 2007....- Genes expressed in the developing endocrine pancreas and their importance for stem cell and diabetes researchJames M Wells
Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, OH 45229 3039, USA
Diabetes Metab Res Rev 19:191-201. 2003.... 
Sox17 regulates organ lineage segregation of ventral foregut progenitor cellsJason R Spence
Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Dev Cell 17:62-74. 2009..Restricting SOX17+ biliary progenitor cells to the ventral region of the gut requires the notch effector Hes1. Our results highlight the role of Sox17 and Hes1 in patterning and morphogenetic segregation of ventral foregut lineages...- Klf5 regulates lineage formation in the pre-implantation mouse embryoSuh Chin J Lin
Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Development 137:3953-63. 2010..These findings demonstrate that Klf5 is a dynamic regulator of all three lineages in the pre-implantation embryo by promoting the TE and epiblast lineages while suppressing the PE lineage... - Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cellsDebora Sinner
Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, Ohio 45229 3039, USA
Mol Cell Biol 27:7802-15. 2007..These findings indicate that Sox proteins can act as both antagonists and agonists of beta-catenin/TCF activity, and this mechanism may regulate Wnt signaling responses in many developmental and disease contexts... - Sox17 influences the differentiation of respiratory epithelial cellsKwon Sik Park
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
Dev Biol 294:192-202. 2006..Sites of expression and the effects of Sox17 in vivo and in vitro are consistent with a role for Sox17 or other members of the Sox family of transcription factors in differentiation of the conducting airway epithelium... - Molecular basis of vertebrate endoderm developmentAaron M Zorn
Division of Developmental Biology, Cincinnati Children s Hospital Research, Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Int Rev Cytol 259:49-111. 2007.... 
Generating human intestinal tissue from pluripotent stem cells in vitroKyle W McCracken
Division of Developmental Biology, Cincinnati, Ohio, USA
Nat Protoc 6:1920-8. 2011..To date, this is the only method for efficiently directing the differentiation of hPSCs into 3D human intestinal tissue in vitro...- Directed differentiation of human pluripotent stem cells into intestinal tissue in vitroJason R Spence
Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229 3039, USA
Nature 470:105-9. 2011..PSC-derived human intestinal tissue should allow for unprecedented studies of human intestinal development and disease... - Molecular pathways controlling pancreas inductionKyle W McCracken
Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Semin Cell Dev Biol 23:656-62. 2012.... - Generating intestinal tissue from stem cells: potential for research and therapyJonathan C Howell
Division of Endocrinology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Regen Med 6:743-55. 2011.... - Translational embryology: using embryonic principles to generate pancreatic endocrine cells from embryonic stem cellsJason R Spence
Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Cincinnati Ohio 45229 3039, USA
Dev Dyn 236:3218-27. 2007.... - Generation of mice with a conditional null allele for WntlessApril C Carpenter
Visual Systems Group, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Genesis 48:554-8. 2010..This Wls conditional null allele will be valuable in detecting novel Wnt functions in development and disease... - Converting human pluripotent stem cells into beta-cells: recent advances and future challengesChristopher N Mayhew
Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Curr Opin Organ Transplant 15:54-60. 2010.... - Vertebrate endoderm development and organ formationAaron M Zorn
Division of Developmental Biology, Cincinnati Children s Research Foundation and Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA
Annu Rev Cell Dev Biol 25:221-51. 2009.... - Wnt/beta-catenin signaling is required for development of the exocrine pancreasJames M Wells
Department of Developmental Biology, Cincinnati Children s Hospital Research 45267, Cincinnati, OH 45267, USA
BMC Dev Biol 7:4. 2007..A Pdx1-cre mouse line was used to delete a floxed beta-catenin allele specifically in the developing pancreas, and embryonic pancreata were studied by immunohistochemistry and microarray analysis... - Transdifferentiation of ciliated cells during repair of the respiratory epitheliumKwon-Sik Park
Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA
Am J Respir Cell Mol Biol 34:151-7. 2006..Taken together, these findings demonstrate that ciliated epithelial cells spread and transdifferentiate into distinct epithelial cell types to repair the airway epithelium... - Comparative genomics of the Hlx homeobox gene and protein: conservation of structure and expression from fish to mammalsMichael D Bates
Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Gene 352:45-56. 2005..These results suggest that the function of Hlx and the mechanisms regulating its expression are highly conserved in mammals, birds, amphibians and fish... - Endonuclease G is required for early embryogenesis and normal apoptosis in miceJianhua Zhang
Department of Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Proc Natl Acad Sci U S A 100:15782-7. 2003..These findings indicate that EndoG is essential during early embryogenesis and plays a critical role in normal apoptosis and nuclear DNA fragmentation... - Global expression analysis of gene regulatory pathways during endocrine pancreatic developmentGuoqiang Gu
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Development 131:165-79. 2004..In addition to identifying new genes that regulate endocrine cell fate, this global gene expression analysis has uncovered informative biological trends that occur during endocrine differentiation... - Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lungAmanda E Serls
Department of Pathology, University of Colorado Health Sciences Center, The Children s Hospital, 1056 East 19th Avenue, Denver, CO 80218, USA
Development 132:35-47. 2005..Together, the findings suggest that a concentration threshold of FGFs emanating from the cardiac mesoderm are involved in patterning the foregut endoderm... - FGF signaling is necessary for establishing gut tube domains along the anterior-posterior axis in vivoJessica Dessimoz
ISREC, Chemin des Boveresses 155, CH1066, Epalinges Lausanne, Switzerland
Mech Dev 123:42-55. 2006..These data show that FGF signaling is critical for patterning the gut tube by promoting posterior and inhibiting anterior endoderm cell fate...