T E Weaver

Summary

Affiliation: Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi request reprint Antimicrobial activity of native and synthetic surfactant protein B peptides
    Marnie A Ryan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, and University of Cincinnati College of Medicine, OH 45229 3039, USA
    J Immunol 176:416-25. 2006
  2. ncbi request reprint Biogenesis of lamellar bodies, lysosome-related organelles involved in storage and secretion of pulmonary surfactant
    Timothy E Weaver
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Semin Cell Dev Biol 13:263-70. 2002
  3. ncbi request reprint Function of surfactant proteins B and C
    T E Weaver
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Annu Rev Physiol 63:555-78. 2001
  4. ncbi request reprint Use of knockout mice to study surfactant protein structure and function
    T E Weaver
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Biol Neonate 76:15-8. 1999
  5. ncbi request reprint Synthesis, processing and secretion of surfactant proteins B and C
    T E Weaver
    Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Biochim Biophys Acta 1408:173-9. 1998
  6. pmc Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice
    J C Clark
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Proc Natl Acad Sci U S A 92:7794-8. 1995
  7. ncbi request reprint The role of homodimers in surfactant protein B function in vivo
    D C Beck
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 275:3365-70. 2000
  8. ncbi request reprint Interleukin-5-mediated allergic airway inflammation inhibits the human surfactant protein C promoter in transgenic mice
    A Mishra
    Division of Pulmonary Medicine, Allergy and Clinical Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Biol Chem 276:8453-9. 2001
  9. ncbi request reprint Secretion of surfactant protein C, an integral membrane protein, requires the N-terminal propeptide
    J J Conkright
    Division of Pulmonary Biology, Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA
    J Biol Chem 276:14658-64. 2001
  10. ncbi request reprint Monoclonal antibody to thyroid transcription factor-1: production, characterization, and usefulness in tumor diagnosis
    A Holzinger
    Division of Pulmonary Biology, University of Cincinnati College of Medicine, Ohio 45229 3039, USA
    Hybridoma 15:49-53. 1996

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Antimicrobial activity of native and synthetic surfactant protein B peptides
    Marnie A Ryan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, and University of Cincinnati College of Medicine, OH 45229 3039, USA
    J Immunol 176:416-25. 2006
    ..These results suggest that the role of endogenous SP-B in host defense may be limited; however, synthetic peptides derived from SP-B may be useful in the treatment of bacterial pneumonias...
  2. ncbi request reprint Biogenesis of lamellar bodies, lysosome-related organelles involved in storage and secretion of pulmonary surfactant
    Timothy E Weaver
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Semin Cell Dev Biol 13:263-70. 2002
    ....
  3. ncbi request reprint Function of surfactant proteins B and C
    T E Weaver
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Annu Rev Physiol 63:555-78. 2001
    ..This review attempts to integrate recent findings in humans and transgenic mice with the results of in vitro studies to provide a better understanding of the functions of SP-B and SP-C and the structural basis for their actions...
  4. ncbi request reprint Use of knockout mice to study surfactant protein structure and function
    T E Weaver
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Biol Neonate 76:15-8. 1999
    ..The effect of transgene expression on lung structure and function was assessed by biochemical, morphological and physiological analyses of the surfactant system in fetal and postnatal offspring...
  5. ncbi request reprint Synthesis, processing and secretion of surfactant proteins B and C
    T E Weaver
    Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Biochim Biophys Acta 1408:173-9. 1998
    ..8000 and 4000, respectively. The biosynthetic pathway leading to generation and secretion of the biophysically active mature SP-B and SP-C peptides is reviewed...
  6. pmc Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice
    J C Clark
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Proc Natl Acad Sci U S A 92:7794-8. 1995
    ..Ablation of the SP-B gene disrupts the routing, storage, and function of surfactant phospholipids and proteins, causing respiratory failure at birth...
  7. ncbi request reprint The role of homodimers in surfactant protein B function in vivo
    D C Beck
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 275:3365-70. 2000
    ..Taken together, these data indicate a role for SP-B dimer in surface tension reduction in the alveolus...
  8. ncbi request reprint Interleukin-5-mediated allergic airway inflammation inhibits the human surfactant protein C promoter in transgenic mice
    A Mishra
    Division of Pulmonary Medicine, Allergy and Clinical Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Biol Chem 276:8453-9. 2001
    ..These results suggest that alterations in surfactant protein levels may contribute to immune and airway dysfunction in asthma...
  9. ncbi request reprint Secretion of surfactant protein C, an integral membrane protein, requires the N-terminal propeptide
    J J Conkright
    Division of Pulmonary Biology, Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA
    J Biol Chem 276:14658-64. 2001
    ..Collectively, these studies indicate that the N-terminal propeptide of SP-C is required for intracellular sorting and secretion of SP-C...
  10. ncbi request reprint Monoclonal antibody to thyroid transcription factor-1: production, characterization, and usefulness in tumor diagnosis
    A Holzinger
    Division of Pulmonary Biology, University of Cincinnati College of Medicine, Ohio 45229 3039, USA
    Hybridoma 15:49-53. 1996
    ..These findings demonstrate that anti-TTF-1 MAb 8G7G3/1 specifically binds TTF-1 in cell extracts and tissues and can be used to distinguish between lung and nonlung origin of a tumor...
  11. ncbi request reprint Partial SP-B deficiency perturbs lung function and causes air space abnormalities
    Lori L Nesslein
    Cincinnati Children s Hospital Medical Center, Division of Neonatology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 288:L1154-61. 2005
    ..Chronic, nonuniform SP-B deficiency perturbed pulmonary function and caused air space enlargement...
  12. ncbi request reprint Reversibility of lung inflammation caused by SP-B deficiency
    Machiko Ikegami
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 289:L962-70. 2005
    ..SP-B reversed inflammation and maintained lung function in vivo, indicating its potential utility for the prevention and treatment of pulmonary injury and surfactant deficiency...
  13. pmc Critical structure-function determinants within the N-terminal region of pulmonary surfactant protein SP-B
    Alicia G Serrano
    Departamento de Bioquimica y Biologia Molecular I, Facultad de Biologia, Universidad Complutense, Madrid, Spain
    Biophys J 90:238-49. 2006
    ....
  14. ncbi request reprint N-terminally extended surfactant protein (SP) C isolated from SP-B-deficient children has reduced surface activity and inhibited lipopolysaccharide binding
    Jing Li
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Biochemistry 43:3891-8. 2004
    ..The results of this study indicate that the early postnatal fatal respiratory distress seen in SP-B-deficient children is combined with the near absence of active variants of SP-C...
  15. pmc Adaptation and increased susceptibility to infection associated with constitutive expression of misfolded SP-C
    James P Bridges
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, The University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Cell Biol 172:395-407. 2006
    ..The wide variability in the age of onset of ILD in patients with SFTPC mutations may be related to environmental insults that ultimately overwhelm the homeostatic cytoprotective response...
  16. ncbi request reprint Surface tension influences cell shape and phagocytosis in alveolar macrophages
    Hiroko Akei
    Cincinnati Children s Hospital, Division of Pulmonary Biology, University of Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 291:L572-9. 2006
    ..SP-B controls surface tension by forming a surfactant phospholipid film that regulates shape and nonspecific phagocytic activity of alveolar macrophages on the alveolar surface...
  17. ncbi request reprint The peptidoglycan-degrading property of lysozyme is not required for bactericidal activity in vivo
    James A Nash
    Division of Pulmonary Biology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Immunol 177:519-26. 2006
    ..These results indicate that the muramidase activity of lysozyme is not required for bacterial killing in vitro or in vivo...
  18. ncbi request reprint Processing of pulmonary surfactant protein B by napsin and cathepsin H
    Takayuki Ueno
    Cancer Center Karolinska, Department of Oncology Pathology, Karolinska Institute and Hospital, SE 171 76 Stockholm, Sweden
    J Biol Chem 279:16178-84. 2004
    ..These results suggest that napsin, cathepsin H, and at least one other enzyme are involved in maturation of the biologically active SP-B peptide...
  19. ncbi request reprint Mouse lysozyme M is important in pulmonary host defense against Klebsiella pneumoniae infection
    Philipp Markart
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Am J Respir Crit Care Med 169:454-8. 2004
    ..01). Deficiency of lysozyme M in the lungs increased susceptibility to K. pneumoniae infection, whereas increased expression of lysozyme conferred resistance to infection and enhanced survival...
  20. ncbi request reprint Expression of a human surfactant protein C mutation associated with interstitial lung disease disrupts lung development in transgenic mice
    James P Bridges
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Biol Chem 278:52739-46. 2003
    ..1728 G --> A mutation causes misfolding of the SP-C proprotein with subsequent induction of the unfolded protein response and endoplasmic reticulum-associated degradation pathways ultimately resulting in disrupted lung morphogenesis...
  21. ncbi request reprint Overexpression of surfactant protein-C mature peptide causes neonatal lethality in transgenic mice
    Juliana Johnson Conkright
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Am J Respir Cell Mol Biol 26:85-90. 2002
    ..These results suggest that elevated expression of SP-C(24-57)HA in type II cells resulted in aggregation of SP-C in the early secretory pathway, leading to cytotoxicity and, ultimately, altered lung development...
  22. ncbi request reprint Deficiency of SP-B reveals protective role of SP-C during oxygen lung injury
    Machiko Ikegami
    Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
    J Appl Physiol (1985) 92:519-26. 2002
    ..Genetically decreased levels of SP-B combined with superimposed O(2)-induced injury reveals the distinct contribution of SP-C to pulmonary function in vivo...
  23. ncbi request reprint Maintenance of the mouse type II cell phenotype in vitro
    Ward R Rice
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 283:L256-64. 2002
    ..2 +/- 2.3 mN/m. This is the first description of the synthesis and secretion of a functional surfactant complex by mouse type II cells after 7 days in primary culture...
  24. ncbi request reprint Intersubunit disulfide bridge is not required for the protective role of SP-B against lung inflammation
    Machiko Ikegami
    Division of Pulmonary Biology, Cincinnati Children s Hospital, Cincinnati, Ohio 45229 3039, USA
    J Appl Physiol (1985) 93:505-11. 2002
    ..Overall, increased inflammation in SP-Bmon(+) mice was corrected to a large extent by increased gene dosage, indicating that formation of the intersubunit disulfide bridge is not critical for SP-B function...
  25. ncbi request reprint Hydrophobic surfactant proteins in lung function and disease
    Jeffrey A Whitsett
    Division of Neonatology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    N Engl J Med 347:2141-8. 2002
  26. ncbi request reprint Surfactant protein B inhibits endotoxin-induced lung inflammation
    Ralph Epaud
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Am J Respir Cell Mol Biol 28:373-8. 2003
    ....
  27. ncbi request reprint SP-B deficiency causes respiratory failure in adult mice
    Kristin R Melton
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 285:L543-9. 2003
    ..Reduction of alveolar SP-B content causes surfactant dysfunction and respiratory failure, indicating that SP-B is required for postnatal lung function...
  28. ncbi request reprint TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue-specific gene expression
    Mario DeFelice
    Stazione Zoologica A Dohrn, Villa Comunale, 80121 Naples, Italy
    J Biol Chem 278:35574-83. 2003
    ..Direct and indirect transcriptional targets of TTF-1 were identified that are likely to play important roles in lung formation and function...
  29. ncbi request reprint Use of transgenic mice to study lung morphogenesis and function
    James P Bridges
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    ILAR J 47:22-31. 2006
    ..In this review, selected transgenic mouse models are highlighted to illustrate the power of this technology, which in many cases has provided important insights that otherwise could not have been obtained...
  30. ncbi request reprint Mapping and analysis of the lytic and fusogenic domains of surfactant protein B
    Marnie A Ryan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Biochemistry 44:861-72. 2005
    ....
  31. ncbi request reprint The Brichos domain-containing C-terminal part of pro-surfactant protein C binds to an unfolded poly-val transmembrane segment
    Hanna Johansson
    Department of Molecular Biosciences, Swedish University of Agricultural Sciences, The Biomedical Centre, Uppsala, Sweden
    J Biol Chem 281:21032-9. 2006
    ..These findings suggest that CTproSP-C binds nonhelical SP-C and thereby prevents beta-sheet aggregation and that mutations in CTproSP-C can interfere with this function...
  32. pmc Comparison of the microbicidal and muramidase activities of mouse lysozyme M and P
    Philipp Markart
    Zentrum fur Innere Medizin, Medizinische Klinik II, Klinikstrasse 36, 35392 Giessen, Germany
    Biochem J 380:385-92. 2004
    ..This outcome suggests that disruption of both M and P loci would significantly increase susceptibility to airway infections, particularly those associated with colonization by Gram-positive organisms...
  33. ncbi request reprint Expression of ABCA3 in developing lung and other tissues
    Mildred T Stahlman
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    J Histochem Cytochem 55:71-83. 2007
    ..The role of ABCA3 in extrapulmonary tissues and organs remains to be elucidated. This manuscript contains online supplemental material at (www.jhc.org). Please visit this article online to view these materials...
  34. pmc Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosis
    Martina Korfei
    University of Giessen Lung Center, Department of Internal Medicine II, Klinikstrasse 36, 35392 Giessen, Germany
    Am J Respir Crit Care Med 178:838-46. 2008
    ..The molecular pathomechanisms underlying idiopathic pulmonary fibrosis (IPF) are elusive, but chronic epithelial injury has recently been suggested as key event...