Research Topics
Genomes and Genes | T E WeaverSummaryAffiliation: Children's Hospital Medical Center Country: USA Publications
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Detail Information
Publications
Antimicrobial activity of native and synthetic surfactant protein B peptidesMarnie A Ryan
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, and University of Cincinnati College of Medicine, OH 45229 3039, USA
J Immunol 176:416-25. 2006..These results suggest that the role of endogenous SP-B in host defense may be limited; however, synthetic peptides derived from SP-B may be useful in the treatment of bacterial pneumonias...- Biogenesis of lamellar bodies, lysosome-related organelles involved in storage and secretion of pulmonary surfactantTimothy E Weaver
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Semin Cell Dev Biol 13:263-70. 2002.... - Function of surfactant proteins B and CT E Weaver
Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Annu Rev Physiol 63:555-78. 2001..This review attempts to integrate recent findings in humans and transgenic mice with the results of in vitro studies to provide a better understanding of the functions of SP-B and SP-C and the structural basis for their actions... - Use of knockout mice to study surfactant protein structure and functionT E Weaver
Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Biol Neonate 76:15-8. 1999..The effect of transgene expression on lung structure and function was assessed by biochemical, morphological and physiological analyses of the surfactant system in fetal and postnatal offspring... - Synthesis, processing and secretion of surfactant proteins B and CT E Weaver
Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Biochim Biophys Acta 1408:173-9. 1998..8000 and 4000, respectively. The biosynthetic pathway leading to generation and secretion of the biophysically active mature SP-B and SP-C peptides is reviewed... 
Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn miceJ C Clark
Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Proc Natl Acad Sci U S A 92:7794-8. 1995..Ablation of the SP-B gene disrupts the routing, storage, and function of surfactant phospholipids and proteins, causing respiratory failure at birth...- The role of homodimers in surfactant protein B function in vivoD C Beck
Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
J Biol Chem 275:3365-70. 2000..Taken together, these data indicate a role for SP-B dimer in surface tension reduction in the alveolus... - Interleukin-5-mediated allergic airway inflammation inhibits the human surfactant protein C promoter in transgenic miceA Mishra
Division of Pulmonary Medicine, Allergy and Clinical Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Biol Chem 276:8453-9. 2001..These results suggest that alterations in surfactant protein levels may contribute to immune and airway dysfunction in asthma... - Secretion of surfactant protein C, an integral membrane protein, requires the N-terminal propeptideJ J Conkright
Division of Pulmonary Biology, Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA
J Biol Chem 276:14658-64. 2001..Collectively, these studies indicate that the N-terminal propeptide of SP-C is required for intracellular sorting and secretion of SP-C... - Monoclonal antibody to thyroid transcription factor-1: production, characterization, and usefulness in tumor diagnosisA Holzinger
Division of Pulmonary Biology, University of Cincinnati College of Medicine, Ohio 45229 3039, USA
Hybridoma 15:49-53. 1996..These findings demonstrate that anti-TTF-1 MAb 8G7G3/1 specifically binds TTF-1 in cell extracts and tissues and can be used to distinguish between lung and nonlung origin of a tumor... - Partial SP-B deficiency perturbs lung function and causes air space abnormalitiesLori L Nesslein
Cincinnati Children's Hospital Medical Center, Division of Neonatology, 3333 Burnet Ave, Cincinnati, OH 45229-3039, USA
Am J Physiol Lung Cell Mol Physiol 288:L1154-61. 2005..Chronic, nonuniform SP-B deficiency perturbed pulmonary function and caused air space enlargement... - Reversibility of lung inflammation caused by SP-B deficiencyMachiko Ikegami
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Am J Physiol Lung Cell Mol Physiol 289:L962-70. 2005..SP-B reversed inflammation and maintained lung function in vivo, indicating its potential utility for the prevention and treatment of pulmonary injury and surfactant deficiency... - Critical structure-function determinants within the N-terminal region of pulmonary surfactant protein SP-BAlicia G Serrano
Departamento de Bioquimica y Biologia Molecular I, Facultad de Biologia, Universidad Complutense, Madrid, Spain
Biophys J 90:238-49. 2006.... - N-terminally extended surfactant protein (SP) C isolated from SP-B-deficient children has reduced surface activity and inhibited lipopolysaccharide bindingJing Li
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
Biochemistry 43:3891-8. 2004..The results of this study indicate that the early postnatal fatal respiratory distress seen in SP-B-deficient children is combined with the near absence of active variants of SP-C... - Adaptation and increased susceptibility to infection associated with constitutive expression of misfolded SP-CJames P Bridges
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, The University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
J Cell Biol 172:395-407. 2006..The wide variability in the age of onset of ILD in patients with SFTPC mutations may be related to environmental insults that ultimately overwhelm the homeostatic cytoprotective response... - Surface tension influences cell shape and phagocytosis in alveolar macrophagesHiroko Akei
Cincinnati Children s Hospital, Division of Pulmonary Biology, University of Cincinnati, OH 45229 3039, USA
Am J Physiol Lung Cell Mol Physiol 291:L572-9. 2006..SP-B controls surface tension by forming a surfactant phospholipid film that regulates shape and nonspecific phagocytic activity of alveolar macrophages on the alveolar surface... - The peptidoglycan-degrading property of lysozyme is not required for bactericidal activity in vivoJames A Nash
Division of Pulmonary Biology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
J Immunol 177:519-26. 2006..These results indicate that the muramidase activity of lysozyme is not required for bacterial killing in vitro or in vivo... - Processing of pulmonary surfactant protein B by napsin and cathepsin HTakayuki Ueno
Cancer Center Karolinska, Department of Oncology Pathology, Karolinska Institute and Hospital, SE 171 76 Stockholm, Sweden
J Biol Chem 279:16178-84. 2004..These results suggest that napsin, cathepsin H, and at least one other enzyme are involved in maturation of the biologically active SP-B peptide... - Mouse lysozyme M is important in pulmonary host defense against Klebsiella pneumoniae infectionPhilipp Markart
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Am J Respir Crit Care Med 169:454-8. 2004..01). Deficiency of lysozyme M in the lungs increased susceptibility to K. pneumoniae infection, whereas increased expression of lysozyme conferred resistance to infection and enhanced survival... - Expression of a human surfactant protein C mutation associated with interstitial lung disease disrupts lung development in transgenic miceJames P Bridges
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Biol Chem 278:52739-46. 2003..1728 G --> A mutation causes misfolding of the SP-C proprotein with subsequent induction of the unfolded protein response and endoplasmic reticulum-associated degradation pathways ultimately resulting in disrupted lung morphogenesis... - Overexpression of surfactant protein-C mature peptide causes neonatal lethality in transgenic miceJuliana Johnson Conkright
Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Am J Respir Cell Mol Biol 26:85-90. 2002..These results suggest that elevated expression of SP-C(24-57)HA in type II cells resulted in aggregation of SP-C in the early secretory pathway, leading to cytotoxicity and, ultimately, altered lung development... - Deficiency of SP-B reveals protective role of SP-C during oxygen lung injuryMachiko Ikegami
Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
J Appl Physiol 92:519-26. 2002..Genetically decreased levels of SP-B combined with superimposed O(2)-induced injury reveals the distinct contribution of SP-C to pulmonary function in vivo... - Maintenance of the mouse type II cell phenotype in vitroWard R Rice
Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Am J Physiol Lung Cell Mol Physiol 283:L256-64. 2002..2 +/- 2.3 mN/m. This is the first description of the synthesis and secretion of a functional surfactant complex by mouse type II cells after 7 days in primary culture... - Intersubunit disulfide bridge is not required for the protective role of SP-B against lung inflammationMachiko Ikegami
Division of Pulmonary Biology, Cincinnati Children s Hospital, Cincinnati, Ohio 45229 3039, USA
J Appl Physiol 93:505-11. 2002..Overall, increased inflammation in SP-Bmon(+) mice was corrected to a large extent by increased gene dosage, indicating that formation of the intersubunit disulfide bridge is not critical for SP-B function... - Hydrophobic surfactant proteins in lung function and diseaseJeffrey A Whitsett
Division of Neonatology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229-3039, USA
N Engl J Med 347:2141-8. 2002 - Surfactant protein B inhibits endotoxin-induced lung inflammationRalph Epaud
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Am J Respir Cell Mol Biol 28:373-8. 2003.... - SP-B deficiency causes respiratory failure in adult miceKristin R Melton
Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
Am J Physiol Lung Cell Mol Physiol 285:L543-9. 2003..Reduction of alveolar SP-B content causes surfactant dysfunction and respiratory failure, indicating that SP-B is required for postnatal lung function... - TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue-specific gene expressionMario DeFelice
Stazione Zoologica A Dohrn, Villa Comunale, 80121 Naples, Italy
J Biol Chem 278:35574-83. 2003..Direct and indirect transcriptional targets of TTF-1 were identified that are likely to play important roles in lung formation and function... - Use of transgenic mice to study lung morphogenesis and functionJames P Bridges
Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
ILAR J 47:22-31. 2006..In this review, selected transgenic mouse models are highlighted to illustrate the power of this technology, which in many cases has provided important insights that otherwise could not have been obtained... - Mapping and analysis of the lytic and fusogenic domains of surfactant protein BMarnie A Ryan
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Biochemistry 44:861-72. 2005.... - The Brichos domain-containing C-terminal part of pro-surfactant protein C binds to an unfolded poly-val transmembrane segmentHanna Johansson
Department of Molecular Biosciences, Swedish University of Agricultural Sciences, The Biomedical Centre, Uppsala, Sweden
J Biol Chem 281:21032-9. 2006..These findings suggest that CTproSP-C binds nonhelical SP-C and thereby prevents beta-sheet aggregation and that mutations in CTproSP-C can interfere with this function... - Comparison of the microbicidal and muramidase activities of mouse lysozyme M and PPhilipp Markart
Zentrum fur Innere Medizin, Medizinische Klinik II, Klinikstrasse 36, 35392 Giessen, Germany
Biochem J 380:385-92. 2004..This outcome suggests that disruption of both M and P loci would significantly increase susceptibility to airway infections, particularly those associated with colonization by Gram-positive organisms... - Expression of ABCA3 in developing lung and other tissuesMildred T Stahlman
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
J Histochem Cytochem 55:71-83. 2007..The role of ABCA3 in extrapulmonary tissues and organs remains to be elucidated. This manuscript contains online supplemental material at (www.jhc.org). Please visit this article online to view these materials... - Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosisMartina Korfei
University of Giessen Lung Center, Department of Internal Medicine II, Klinikstrasse 36, 35392 Giessen, Germany
Am J Respir Crit Care Med 178:838-46. 2008..The molecular pathomechanisms underlying idiopathic pulmonary fibrosis (IPF) are elusive, but chronic epithelial injury has recently been suggested as key event...