Xiaobin Wang

Summary

Affiliation: Children's Memorial Hospital
Country: USA

Publications

  1. pmc Development of the Chicago Food Allergy Research Surveys: assessing knowledge, attitudes, and beliefs of parents, physicians, and the general public
    Ruchi S Gupta
    Smith Child Health Research Program, Children s Memorial Hospital, Chicago, USA
    BMC Health Serv Res 9:142. 2009
  2. ncbi request reprint Efficacy of folic acid supplementation in stroke prevention: a meta-analysis
    Xiaobin Wang
    Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital and Children s Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60614 3394, USA
    Lancet 369:1876-82. 2007
  3. pmc C-reactive protein in adolescent twins: patterns and relationship to adiposity
    Guoying Wang
    Mary Ann and J Milburn Smith Child Health Research Program, Northwestern University Feinberg School of Medicine and Children s Memorial Hospital and Children s Memorial Research Center, Chicago, Illinois 60614, USA
    J Clin Endocrinol Metab 96:3226-33. 2011
  4. pmc Short sleep duration and adiposity in Chinese adolescents
    Yunxian Yu
    The Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital and Children s Memorial Research Center, Northwestern University, Chicago, IL 60614 3394, USA
    Sleep 30:1688-97. 2007
  5. pmc Folic acid therapy and cardiovascular disease in ESRD or advanced chronic kidney disease: a meta-analysis
    Xianhui Qin
    Institute of Biomedicine, Anhui Medical University, Hefei, China
    Clin J Am Soc Nephrol 6:482-8. 2011
  6. doi request reprint Food allergy knowledge, attitudes, and beliefs in the United States
    Ruchi S Gupta
    Children s Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA
    Ann Allergy Asthma Immunol 103:43-50. 2009
  7. pmc Heritability and environmental factors affecting vitamin D status in rural Chinese adolescent twins
    Lester M Arguelles
    M S, Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital and Children s Memorial Research Center, 2300 Children s Plaza, Box 157, Chicago, Illinois 60614 3394, USA
    J Clin Endocrinol Metab 94:3273-81. 2009
  8. pmc Dissociation between the prevalence of atopy and allergic disease in rural China among children and adults
    Jennifer S Kim
    Division of Allergy and Immunology, Children s Memorial Hospital, Chicago, IL, USA
    J Allergy Clin Immunol 122:929-935.e4. 2008
  9. pmc Association of genetic ancestry with preterm delivery and related traits among African American mothers
    Hui Ju Tsai
    Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital and Children s Memorial Research Center, Chicago, IL 60614 3394, USA
    Am J Obstet Gynecol 201:94.e1-10. 2009
  10. pmc Maternal cigarette smoking, metabolic gene polymorphisms, and preterm delivery: new insights on GxE interactions and pathogenic pathways
    Hui Ju Tsai
    Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital and Children s Memorial Research Center, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Hum Genet 123:359-69. 2008

Research Grants

Collaborators

Detail Information

Publications58

  1. pmc Development of the Chicago Food Allergy Research Surveys: assessing knowledge, attitudes, and beliefs of parents, physicians, and the general public
    Ruchi S Gupta
    Smith Child Health Research Program, Children s Memorial Hospital, Chicago, USA
    BMC Health Serv Res 9:142. 2009
    ..The purpose of this paper is to detail the development of the Chicago Food Allergy Research Surveys to assess food allergy knowledge, attitudes, and beliefs among these three populations...
  2. ncbi request reprint Efficacy of folic acid supplementation in stroke prevention: a meta-analysis
    Xiaobin Wang
    Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital and Children s Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60614 3394, USA
    Lancet 369:1876-82. 2007
    ..Our aim was to do a meta-analysis of relevant randomised trials to assess the efficacy of folic acid supplementation in the prevention of stroke...
  3. pmc C-reactive protein in adolescent twins: patterns and relationship to adiposity
    Guoying Wang
    Mary Ann and J Milburn Smith Child Health Research Program, Northwestern University Feinberg School of Medicine and Children s Memorial Hospital and Children s Memorial Research Center, Chicago, Illinois 60614, USA
    J Clin Endocrinol Metab 96:3226-33. 2011
    ..Elevated C-reactive protein (CRP) is a marker of cardiovascular risk in adults. Patterns and determinants of CRP in adolescents have not been well described...
  4. pmc Short sleep duration and adiposity in Chinese adolescents
    Yunxian Yu
    The Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital and Children s Memorial Research Center, Northwestern University, Chicago, IL 60614 3394, USA
    Sleep 30:1688-97. 2007
    ..To investigate the relationship between sleep duration and adiposity measurements in rural Chinese adolescents...
  5. pmc Folic acid therapy and cardiovascular disease in ESRD or advanced chronic kidney disease: a meta-analysis
    Xianhui Qin
    Institute of Biomedicine, Anhui Medical University, Hefei, China
    Clin J Am Soc Nephrol 6:482-8. 2011
    ..We conducted a meta-analysis of relevant randomized trials to further examine this issue...
  6. doi request reprint Food allergy knowledge, attitudes, and beliefs in the United States
    Ruchi S Gupta
    Children s Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA
    Ann Allergy Asthma Immunol 103:43-50. 2009
    ..Members of the general public play a significant role in the well-being of food-allergic children, although little is known about the knowledge, attitudes, and beliefs of food allergy among the public...
  7. pmc Heritability and environmental factors affecting vitamin D status in rural Chinese adolescent twins
    Lester M Arguelles
    M S, Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital and Children s Memorial Research Center, 2300 Children s Plaza, Box 157, Chicago, Illinois 60614 3394, USA
    J Clin Endocrinol Metab 94:3273-81. 2009
    ..Factors associated with the high prevalence of vitamin D deficiency in China are not well described, especially among Chinese adolescents...
  8. pmc Dissociation between the prevalence of atopy and allergic disease in rural China among children and adults
    Jennifer S Kim
    Division of Allergy and Immunology, Children s Memorial Hospital, Chicago, IL, USA
    J Allergy Clin Immunol 122:929-935.e4. 2008
    ..The prevalence of allergic diseases is increasing worldwide, but the reasons are not well understood. Previous studies suggest that this trend might be associated with lifestyle and urbanization...
  9. pmc Association of genetic ancestry with preterm delivery and related traits among African American mothers
    Hui Ju Tsai
    Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital and Children s Memorial Research Center, Chicago, IL 60614 3394, USA
    Am J Obstet Gynecol 201:94.e1-10. 2009
    ..In the United States, the rate of preterm delivery (PTD) is higher in African Americans (17.8%) than non-Hispanic whites (11.5%). Such disparity cannot be fully explained by differences in socioenvironmental factors...
  10. pmc Maternal cigarette smoking, metabolic gene polymorphisms, and preterm delivery: new insights on GxE interactions and pathogenic pathways
    Hui Ju Tsai
    Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital and Children s Memorial Research Center, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Hum Genet 123:359-69. 2008
    ..Taken together, maternal smoking significantly increased the risk of PTD among women with high-risk CYP1A1 and GSTT1 genotypes. Such joint associations were strongest among PTD accompanied by histologic chorioamnionitis...
  11. pmc Race, ancestry, and development of food-allergen sensitization in early childhood
    Rajesh Kumar
    aDivision of Allergy and Immunology, Children s Memorial Hospital, Chicago, Illinois 60614, USA
    Pediatrics 128:e821-9. 2011
    ..We examined whether the risk of food-allergen sensitization varied according to self-identified race or genetic ancestry...
  12. pmc Gestational diabetes, atopic dermatitis, and allergen sensitization in early childhood
    Rajesh Kumar
    Division of Allergy and Immunology, Children s Memorial Hospital, Chicago, Ill 60614, USA
    J Allergy Clin Immunol 124:1031-8.e1-4. 2009
    ..The relationship between the prenatal environment, maternal-fetal interaction, and allergic disease in the offspring remains understudied...
  13. pmc Gene polymorphisms, breast-feeding, and development of food sensitization in early childhood
    Xiumei Hong
    Mary Ann and J Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children s Memorial Hospital and Children s Memorial Research Center, Chicago, IL 60614, USA
    J Allergy Clin Immunol 128:374-81.e2. 2011
    ..The effect of breast-feeding on the development of allergic disease is uncertain. There are no data that show whether this relationship varies by individual genotypes...
  14. pmc Serum folate and DDT isomers and metabolites are inversely associated in Chinese women: a cross-sectional analysis
    Lester M Arguelles
    Center for Population Genetics, University of Illinois at Chicago, School of Public Health, Illinois, USA
    J Am Coll Nutr 28:380-7. 2009
    ..Vitamin nutritional status may influence some xenobiotic metabolism or vice versa...
  15. doi request reprint Food allergy knowledge, attitudes, and beliefs of parents with food-allergic children in the United States
    Ruchi S Gupta
    Smith Child Health Research Program, Children s Memorial Hospital, Chicago, IL 60614, USA
    Pediatr Allergy Immunol 21:927-34. 2010
    ....
  16. pmc Prematurity, chorioamnionitis, and the development of recurrent wheezing: a prospective birth cohort study
    Rajesh Kumar
    Division of Allergy, Children s Memorial Hospital, Chicago, IL 60614, USA
    J Allergy Clin Immunol 121:878-84.e6. 2008
    ..Prematurity (< 37 weeks) has been inconsistently associated with asthma and wheezing. Chorioamnionitis may promote both prematurity and inflammatory pathways in infants' airways...
  17. doi request reprint Food allergy knowledge, attitudes, and beliefs of primary care physicians
    Ruchi S Gupta
    Smith Child Health Research Program, Children s Memorial Hospital, Chicago, Illinois 60614, USA
    Pediatrics 125:126-32. 2010
    ..To provide insight into food allergy knowledge and perceptions among pediatricians and family physicians in the United States...
  18. pmc A large-scale genome-wide linkage analysis to map loci linked to stature in Chinese population
    Xiumei Hong
    Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital and Children s Memorial Research Center, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60614, USA
    J Clin Endocrinol Metab 93:4511-8. 2008
    ..A number of genome-wide scans of stature have been reported previously, but with inconsistent results. The inconsistency may be partly due to differential population characteristics and gender- and/or age-specific effects on this trait...
  19. doi request reprint The joint association between F5 gene polymorphisms and maternal smoking during pregnancy on preterm delivery
    Yunxian Yu
    Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital and Children s Memorial Research Center, Chicago, IL, USA
    Hum Genet 124:659-68. 2009
    ..Similar pattern of interactions was found between rs6022 and maternal smoking on PTD. In summary, our data indicated that F5 gene variants and maternal smoking may synergistically increase the risk of PTD...
  20. pmc Genetic and environmental contributions to phenotypic components of metabolic syndrome: a population-based twin study
    Shanchun Zhang
    Mary Ann and J Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children s Memorial Hospital and Children s Memorial Research Center, Chicago, Illinois, USA
    Obesity (Silver Spring) 17:1581-7. 2009
    ..Our study underscores the importance of examining MS components as intercorrelated traits, and to carefully consider environmental and genetic factors in studying MS etiology...
  21. ncbi request reprint Patterns and interrelationships of body-fat measures among rural Chinese children aged 6 to 18 years
    Hongjian Wang
    Mary Ann and J Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children s Memorial Hospital and Children s Memorial Research Center, Chicago, Illinois 60614, USA
    Pediatrics 120:e94-e101. 2007
    ....
  22. pmc Adiposity is inversely related to insulin sensitivity in relatively lean Chinese adolescents: a population-based twin study
    Fengxiu Ouyang
    Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Am J Clin Nutr 91:662-71. 2010
    ..Adolescence is a critical period for rising adiposity and falling insulin sensitivity (IS), but the independent relation between adiposity and IS remains understudied...
  23. doi request reprint Placental inflammatory response is associated with poor neonatal growth: preterm birth cohort study
    Karen Mestan
    Northwestern University Feinberg School of Medicine, Children s Memorial Hospital, Department of Pediatrics, Division of Neonatology, 2300 Children s Plaza, Box 45, Chicago, IL 60614, USA
    Pediatrics 125:e891-8. 2010
    ..We sought to determine whether placental markers of intrauterine inflammation were associated with poor weight gain among premature infants in the neonatal period...
  24. pmc Association of central adiposity with prediabetes and decreased insulin sensitivity in rural Chinese normal-weight and overweight women
    Yunxian Yu
    Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital and Children s Memorial Research Cente, Chicago, IL 60614 3394, USA
    Metabolism 59:1047-53. 2010
    ..Among relatively lean, rural Chinese women, high %TF was associated with increased odds of prediabetes and lower IS regardless of weight status (normal or overweight)...
  25. pmc Adiposity, serum lipid levels, and allergic sensitization in Chinese men and women
    Fengxiu Ouyang
    Mary Ann and J Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children s Memorial Hospital and Children s Memorial Research Center, Chicago, IL, USA
    J Allergy Clin Immunol 123:940-8.e10. 2009
    ..Obesity and allergic diseases have increased dramatically in recent decades. Although adiposity has been associated with asthma, associations with allergic sensitization have been inconsistent...
  26. doi request reprint Association of surrogate and direct measures of adiposity with risk of metabolic syndrome in rural Chinese women
    Fengxiu Ouyang
    Mary Ann and J Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children s Memorial Hospital and Children s Memorial Research Center, 2300 Children s Plaza, Chicago, IL 60614, USA
    Eur J Nutr 48:323-32. 2009
    ..We hypothesize that direct measures of adiposity may help develop further insight into the link between obesity and MS, thus more accurately identifying individuals at high risk for MS...
  27. ncbi request reprint Monozygotic co-twin analyses of body composition measurements and serum lipids
    Binyan Wang
    Mary Ann J Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Prev Med 45:358-65. 2007
    ..To evaluate BMI and direct measures of body fat (BF) and lean body mass (LBM) in relation to fasting serum lipid profiles in a large Chinese population based twin sample using a monozygotic (MZ) co-twin analysis...
  28. pmc Percent fat mass is inversely associated with bone mass and hip geometry in rural Chinese adolescents
    Xiumei Hong
    Mary Ann and J Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children s Memorial Hospital and Children s Memorial Research Center, Chicago, IL 60614, USA
    J Bone Miner Res 25:1544-54. 2010
    ....
  29. pmc Plasma adipokines, bone mass, and hip geometry in rural Chinese adolescents
    Xiumei Hong
    Mary Ann and J Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children s Memorial Hospital and Children s Memorial Research Center, Chicago, Illinois 60614, USA
    J Clin Endocrinol Metab 95:1644-52. 2010
    ..Adipokines have been linked to bone phenotypes recently, but with conflicting results. Few such studies have been conducted in adolescents...
  30. pmc Genetics of food allergy
    Xiumei Hong
    Mary Ann and J Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children s Memorial Hospital and Children s Memorial Research Center, Chicago, Illinois 60614, USA
    Curr Opin Pediatr 21:770-6. 2009
    ..The purpose of this review is to summarize recent advances in food allergy genetic research...
  31. pmc Association of plasma leptin concentrations with adiposity measurements in rural Chinese adolescents
    Shanchun Zhang
    Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital and Children s Memorial Research Center, Department of Pediatrics, Feinberg School of Medicine of Northwestern University, Chicago, Illinois 60611, USA
    J Clin Endocrinol Metab 94:3497-504. 2009
    ..There is evidence that leptin is involved in the etiology of obesity-related cardiovascular disease in adults. This raises the question of whether leptin levels in adolescence are indicative of adiposity-related cardiovascular risk...
  32. pmc Sleep patterns among rural Chinese twin adolescents
    Fengxiu Ouyang
    Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Sleep Med 10:479-89. 2009
    ..To examine sleep patterns and influencing factors (age, gender, Tanner Stage, weekday vs. weekend, and pre-sleep activity) among rural Chinese adolescents...
  33. ncbi request reprint Bronchodilator responses in Chinese children from asthma index families and the general population
    Rajesh Kumar
    Division of Allergy, Children s Memorial Hospital, Chicago, IL 60612 0064, USA
    J Allergy Clin Immunol 117:1257-63. 2006
    ..Although airway hyperresponsiveness to bronchoconstrictors has been extensively investigated, epidemiologic studies on airway hyperresponsiveness to bronchodilators are limited...
  34. ncbi request reprint Age and gender specific lung function predictive equations provide similar predictions for both a twin population and a general population from age 6 through adolescence
    Yunxian Yu
    Mary Ann and J Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children s Memorial Hospital and Children s Memorial Research Center, Chicago, IL 60614, USA
    Pediatr Pulmonol 42:631-9. 2007
    ..We sought to evaluate this in late childhood and adolescent subjects...
  35. ncbi request reprint Urinary estrogen and progesterone metabolite concentrations in menstrual cycles of fertile women with non-conception, early pregnancy loss or clinical pregnancy
    Scott A Venners
    Division of Epidemiology and Biostatistics, University of Illinois at Chicago, School of Public Health, Chicago, IL, USA
    Hum Reprod 21:2272-80. 2006
    ..Knowledge is limited of how estrogen and progesterone variability in fertile women are associated with achieving pregnancy...
  36. doi request reprint Differential patterns of 27 cord blood immune biomarkers across gestational age
    Nana Matoba
    Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Pediatrics 123:1320-8. 2009
    ..We sought to describe the distribution of immune biomarkers in cord blood across gestational age and to investigate the association between biomarker level patterns and preterm birth...
  37. pmc Does genetic regulation of IgE begin in utero? Evidence from T(H)1/T(H)2 gene polymorphisms and cord blood total IgE
    Xiumei Hong
    Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital and Children s Memorial Research Center, Chicago, Ill 60614 3394, USA
    J Allergy Clin Immunol 126:1059-67, 1067.e1. 2010
    ..In contrast with numerous genetic studies of total serum IgE in children and adults, limited genetic studies on CBIgE have been conducted...
  38. pmc The patterns of glucose tolerance and insulin resistance among rural Chinese twin children, adolescents, and young adults
    Guoying Wang
    The Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital Children s Memorial Research Center, Chicago, IL 60614, USA
    Metabolism 59:1752-9. 2010
    ..Notably, females had higher 2-h PG and higher prevalence of IFG and IGT. Our study underscored that adolescence (even more so in females) is a critical period for developing IR and prediabetes...
  39. pmc Prediabetes is not all about obesity: association between plasma leptin and prediabetes in lean rural Chinese adults
    Guoying Wang
    Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children s Memorial Hospital, Chicago, Illinois 60614, USA
    Eur J Endocrinol 163:243-9. 2010
    ..This study investigated the associations of plasma leptin levels with insulin resistance (IR) and prediabetes in relatively lean, rural Chinese men and women...
  40. ncbi request reprint Prolylcarboxypeptidase gene, chronic hypertension, and risk of preeclampsia
    Lin Wang
    Program for Population Genetics, Harvard School of Public Health, Boston, MA, USA
    Am J Obstet Gynecol 195:162-71. 2006
    ..Prolylcarboxypeptidase encodes a lysosomal enzyme and is a regulator for both renin-angiotensin system and the kallikrein-kinin system. There is no published study on prolylcarboxypeptidase gene and preeclampsia...
  41. ncbi request reprint A candidate gene association study on preterm delivery: application of high-throughput genotyping technology and advanced statistical methods
    Ke Hao
    Program for Population Genetics, Harvard School of Public Health, Boston, MA 02115, USA
    Hum Mol Genet 13:683-91. 2004
    ....
  42. ncbi request reprint Paternal smoking and pregnancy loss: a prospective study using a biomarker of pregnancy
    Scott A Venners
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 159:993-1001. 2004
    ..93 (95% CI: 0.72, 1.20) and for group 3 was 0.78 (95% CI: 0.55, 1.12). The authors conclude that heavy paternal smoking increased the risk of early pregnancy loss through maternal and/or paternal exposure...
  43. ncbi request reprint Preconception B-vitamin and homocysteine status, conception, and early pregnancy loss
    Alayne G Ronnenberg
    Department of Nutrition, University of Massachusetts Amherst, Amherst, MA 01003, and Channing Laboratory, Brigham and Women s Hospital, Boston, USA
    Am J Epidemiol 166:304-12. 2007
    ..7, 95% CI: 0.4, 1.1) than did women with vitamin B6 deficiency. Poor vitamin B6 status appears to decrease the probability of conception and to contribute to the risk of early pregnancy loss in this population...
  44. ncbi request reprint Maternal cigarette smoking, metabolic gene polymorphism, and infant birth weight
    Xiaobin Wang
    Department of Pediatrics, Boston University School of Medicine and Boston Medical Center, 91 E Concord St, Maternity 4, Boston, MA 02118, USA
    JAMA 287:195-202. 2002
    ..Little is known about genetic susceptibility to cigarette smoke in relation to adverse pregnancy outcomes...
  45. pmc Polymorphism in maternal LRP8 gene is associated with fetal growth
    Lin Wang
    Program for Population Genetics, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Hum Genet 78:770-7. 2006
    ..05). In conclusion, results from the two independent samples of black women provide consistent evidence that SNP rs2297660 in LRP8 is associated with fetal growth...
  46. ncbi request reprint Impact of clinical and histologic correlates of maternal and fetal inflammatory response on gestational age in preterm births
    Munish Gupta
    Department of Neonatology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Matern Fetal Neonatal Med 20:39-46. 2007
    ..To evaluate the impact of clinical and histopathologic correlates related to maternal and fetal inflammatory responses (MIR and FIR) on degree of preterm birth...
  47. ncbi request reprint Incorporating individual error rate into association test of unmatched case-control design
    Ke Hao
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Hum Hered 58:154-63. 2004
    ..Furthermore, we propose two association tests incorporating the genotyping quality information with the goal to improve statistical power and inference...
  48. ncbi request reprint A common haplotype on methylenetetrahydrofolate reductase gene modifies the effect of angiotensin-converting enzyme inhibitor on blood pressure in essential hypertension patients--a family-based association study
    Shanqun Jiang
    School of Life Sciences, University of Science and Technology of China, Hefei, China
    Clin Exp Hypertens 27:509-21. 2005
    ..009 in an additive model and 0.006 in a dominant model. Our findings suggest that MTHFR 677C-1298C haplotype modulate blood pressure responsiveness to shortterm treatment of ACE inhibitor in Chinese essential hypertensive patients...
  49. ncbi request reprint Conception, early pregnancy loss, and time to clinical pregnancy: a population-based prospective study
    Xiaobin Wang
    Department of Pediatrics, Boston University School of Medicine and Boston Medical Center, Massachusetts, USA
    Fertil Steril 79:577-84. 2003
    ..To examine rates of conception and pregnancy loss and their relations with time to clinical pregnancy and reproductive outcomes...
  50. ncbi request reprint Low preconception body mass index is associated with birth outcome in a prospective cohort of Chinese women
    Alayne G Ronnenberg
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    J Nutr 133:3449-55. 2003
    ..Although being moderately underweight was not associated with increased risk of adverse pregnancy outcomes, being severely underweight was an important risk factor for reduced fetal growth...
  51. ncbi request reprint Power estimation of multiple SNP association test of case-control study and application
    Ke Hao
    Program for Population Genetics, Harvard School of Public Health, Boston, Massachusetts, USA
    Genet Epidemiol 26:22-30. 2004
    ..0250 by using Cochran-Armitage chi(2)s as "starting" statistics in the procedure. In the following single point analysis, SNPs on IL1RN, IL1R2, ESR1, Factor 5, and OPRM1 genes were identified as possible risk factors in PTD...
  52. ncbi request reprint D919G polymorphism of methionine synthase gene is associated with blood pressure response to benazepril in Chinese hypertensive patients
    Yan Zhang
    Department of Cardiology, Peking University First Hospital, 100034, Beijing, China
    J Hum Genet 49:296-301. 2004
    ..Our finding suggests that the D919G polymorphism of the MTR gene may be a useful genetic marker to predict the antihypertensive effect of short-term benazepril therapy in hypertensive patients of Anhui Province, China...
  53. ncbi request reprint Homocysteine, B vitamins, and cardiovascular disease
    Xiaobin Wang
    N Engl J Med 355:207-9; author reply 209-11. 2006
  54. ncbi request reprint Beta2 adrenergic receptor gene Arg16Gly polymorphism is associated with therapeutic efficacy of benazepril on essential hypertension in Chinese
    Guo Huang
    School of Life Science, University of Science and Technology of China, Hefei, China
    Clin Exp Hypertens 26:581-92. 2004
    ..This study examined whether the therapeutic efficacy of benazepril on essential hypertension is modified by beta2 adrenergic receptor gene (ADRB2) Arg16Gly (R16G) polymorphism...
  55. ncbi request reprint Individual and joint association of alpha1A-adrenergic receptor Arg347Cys polymorphism and plasma irbesartan concentration with blood pressure therapeutic response in Chinese hypertensive subjects
    Shanqun Jiang
    School of Life Sciences, University of Science and Technology of China, Anhui, Hefei, People s Republic of China
    Clin Pharmacol Ther 78:239-48. 2005
    ....
  56. ncbi request reprint Determinants of maximally attained level of pulmonary function
    Xiaobin Wang
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 169:941-9. 2004
    ..To the degree that these factors diminished plateau phase pulmonary function, they may be important predictors of chronic obstructive pulmonary disease in later life...
  57. pmc Ser1369Ala variant in sulfonylurea receptor gene ABCC8 is associated with antidiabetic efficacy of gliclazide in Chinese type 2 diabetic patients
    Yan Feng
    Anhui Biomedical Institute, Anhui Medical University, Hefei, China
    Diabetes Care 31:1939-44. 2008
    ..The purpose of this study was to investigate whether genetic variants could influence the antidiabetic efficacy of gliclazide in type 2 diabetic patients...
  58. ncbi request reprint PON1 polymorphism, diabetes mellitus, obesity, and risk of myocardial infarction: Modifying effect of diabetes mellitus and obesity on the association between PON1 polymorphism and myocardial infarction
    Jianping Li
    Program for Population Genetics, Harvard School of Public Health, Boston, Massachusetts, USA
    Genet Med 7:58-63. 2005
    ..We investigated the association between PON1 Q192R polymorphism and the risk of myocardial infarction (MI) and in particular, whether the association can be modified by diabetes mellitus (DM) and obesity...

Research Grants25

  1. Sleep and Adiposity: A Prospective Twin Study
    Xiaobin Wang; Fiscal Year: 2007
    ..This twin cohort is also a precious resource for future longitudinal studies of sleep and OWO. ..
  2. Epidemiology of the Metabolic Syndrome in Children
    Xiaobin Wang; Fiscal Year: 2009
    ..Furthermore, this large twin cohort will better clarifv the eenetic versus environmental influences on the develooment of MS and its markers. ..
  3. Genome-Wide Association Study of Preterm Birth
    Xiaobin Wang; Fiscal Year: 2009
    ....
  4. Sleep and Adiposity: A Prospective Twin Study
    Xiaobin Wang; Fiscal Year: 2009
    ..This twin cohort is also a precious resource for future longitudinal studies of sleep and OWO. ..
  5. Genome-Wide Association Study of Preterm Birth
    Xiaobin Wang; Fiscal Year: 2010
    ....
  6. Gene Polymorphism, Infection/Inflammation, Preterm Birth
    Xiaobin Wang; Fiscal Year: 2010
    ..See instructions on Page Name Xiaobin Wang, MD, ScD Jerome O. Klein, MD Milton Kotelchuck, PhD Gary Kaufman, MD John Kasznica, MD Paul Wise, MD, MPH 11...
  7. Gene Polymorphism, Infection/Inflammation, Preterm Birth
    Xiaobin Wang; Fiscal Year: 2005
    ..The findings from this proposed study will expand our understanding of the role of infection/inflammation, genetic susceptibility , and gene-environment interactions in the pathogenesis of PTB in determining racial disparities in PTB...
  8. Molecular Epidemiology of Preterm Birth
    Xiaobin Wang; Fiscal Year: 2003
    ....
  9. DDT, Endocrine Disruption and Reproductive Outcomes
    Xiaobin Wang; Fiscal Year: 2003
    ....
  10. Genome-Wide Association Study of Preterm Birth
    Xiaobin Wang; Fiscal Year: 2010
    ....