Abhay N Vats

Summary

Affiliation: Children's Hospital of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Genetics of idiopathic nephrotic syndrome
    Abhay N Vats
    Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, PA, USA
    Indian J Pediatr 72:777-83. 2005
  2. ncbi request reprint Improved late graft survival and half-lives in pediatric kidney transplantation: a single center experience
    Abhay Vats
    Department of Pediatrics, Children s Hospital of Pittsburgh, USA
    Am J Transplant 2:939-45. 2002
  3. ncbi request reprint Quantitative viral load monitoring and cidofovir therapy for the management of BK virus-associated nephropathy in children and adults
    Abhay Vats
    Department of Pediatrics, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Transplantation 75:105-12. 2003
  4. ncbi request reprint Glomerular structural factors in progression of congenital nephrotic syndrome
    Abhay N Vats
    Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Pediatr Nephrol 18:234-40. 2003
  5. ncbi request reprint Steroid-resistant nephrotic syndrome and congenital anomalies of kidneys: evidence of locus on chromosome 13q
    Abhay N Vats
    Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Kidney Int 64:17-24. 2003
  6. doi request reprint Pediatric living donor kidney transplantation under alemtuzumab pretreatment and tacrolimus monotherapy: 4-year experience
    Henkie P Tan
    the Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Transplantation 86:1725-31. 2008
  7. ncbi request reprint A locus for renal malformations including vesico-ureteric reflux on chromosome 13q33-34
    Kalyani R Vats
    Department of Pediatrics, Division of Pediatric Nephrology, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    J Am Soc Nephrol 17:1158-67. 2006
  8. pmc Antilymphoid antibody preconditioning and tacrolimus monotherapy for pediatric kidney transplantation
    Ron Shapiro
    Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Pediatr 148:813-8. 2006
  9. ncbi request reprint Viral load monitoring in BK virus-associated nephropathy
    Abhay Vats
    University of Pittsburgh School of Medicine, Children s Hospital of Pittsburgh, PA, USA
    Nephrol News Issues . 2002
  10. ncbi request reprint Detection of CD8+ T cells sensitized to BK virus large T antigen in healthy volunteers and kidney transplant recipients
    Parmjeet S Randhawa
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Hum Immunol 67:298-302. 2006

Research Grants

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Genetics of idiopathic nephrotic syndrome
    Abhay N Vats
    Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, PA, USA
    Indian J Pediatr 72:777-83. 2005
    ..Associations with various genes (NPHS1, ACTN4, NPHS2, WT-1) and linkage to several chromosomal regions (such as 19q13, 11q21, 11q24) have been reported in patients with familial NS/FSGS...
  2. ncbi request reprint Improved late graft survival and half-lives in pediatric kidney transplantation: a single center experience
    Abhay Vats
    Department of Pediatrics, Children s Hospital of Pittsburgh, USA
    Am J Transplant 2:939-45. 2002
    ..Hence, preferential use of living donor and prevention of acute rejection episodes in the first year are key variables that can improve long-term renal graft survival in children...
  3. ncbi request reprint Quantitative viral load monitoring and cidofovir therapy for the management of BK virus-associated nephropathy in children and adults
    Abhay Vats
    Department of Pediatrics, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Transplantation 75:105-12. 2003
    ..BK virus (BKV)-associated nephropathy (BKVAN) has been increasingly recognized as an important cause of renal transplant dysfunction. We report the role of quantitative viral load monitoring in the management of BKVAN...
  4. ncbi request reprint Glomerular structural factors in progression of congenital nephrotic syndrome
    Abhay N Vats
    Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Pediatr Nephrol 18:234-40. 2003
    ..Thus atubular glomeruli may play an important role in disease progression in CNF, as it is associated with a progressive decrease in hypertrophied "normal" glomeruli and an increase in largely atubular microcystic glomeruli...
  5. ncbi request reprint Steroid-resistant nephrotic syndrome and congenital anomalies of kidneys: evidence of locus on chromosome 13q
    Abhay N Vats
    Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Kidney Int 64:17-24. 2003
    ..We present the results of deletion mapping studies to identify the critical regions...
  6. doi request reprint Pediatric living donor kidney transplantation under alemtuzumab pretreatment and tacrolimus monotherapy: 4-year experience
    Henkie P Tan
    the Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Transplantation 86:1725-31. 2008
    ..Alemtuzumab has been used in off-label studies of solid organ transplantation...
  7. ncbi request reprint A locus for renal malformations including vesico-ureteric reflux on chromosome 13q33-34
    Kalyani R Vats
    Department of Pediatrics, Division of Pediatric Nephrology, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    J Am Soc Nephrol 17:1158-67. 2006
    ..Herein is reported a new locus on chromosome 13q33q34 that can be associated with VUR with several genes showing mRNA expression patterns that suggest their potential for involvement in renal/urinary tract developmental anomalies...
  8. pmc Antilymphoid antibody preconditioning and tacrolimus monotherapy for pediatric kidney transplantation
    Ron Shapiro
    Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Pediatr 148:813-8. 2006
    ....
  9. ncbi request reprint Viral load monitoring in BK virus-associated nephropathy
    Abhay Vats
    University of Pittsburgh School of Medicine, Children s Hospital of Pittsburgh, PA, USA
    Nephrol News Issues . 2002
  10. ncbi request reprint Detection of CD8+ T cells sensitized to BK virus large T antigen in healthy volunteers and kidney transplant recipients
    Parmjeet S Randhawa
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Hum Immunol 67:298-302. 2006
    ..T-antigen-specific T-cytotoxic cells circulate in healthy blood donors, implying that transient expression of T antigen presumably occurs at sites of viral latency and helps maintain a constant pool of circulating CD8+ T memory cells...
  11. ncbi request reprint Viral regulatory region sequence variations in kidney tissue obtained from patients with BK virus nephropathy
    Parmjeet Randhawa
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Kidney Int 64:743-7. 2003
    ..We hypothesized that DNA sequence variations in this region play a role in the pathogenesis of BK virus allograft nephropathy (BKVAN)...
  12. ncbi request reprint Low incidence of BK virus nephropathy after simultaneous kidney pancreas transplantation
    Gaurav Gupta
    Department of Pediatrics, Children s Hospital of Pittsburgh, PA 15213, USA
    Transplantation 82:382-8. 2006
    ..We analyzed our data on the incidence of BKVAN and its outcome in SKPT recipients at University of Pittsburgh Medical Center (UPMC) and affiliated centers and report significant differences compared to previous studies...
  13. ncbi request reprint A comparative study of BK and JC virus infections in organ transplant recipients
    Parmjeet Randhawa
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Med Virol 77:238-43. 2005
    ..BKV viremia was seen in kidney but not liver recipients. The mechanisms underlying these notable phenomena remain to be investigated...
  14. ncbi request reprint Proteomic analysis of urine in kidney transplant patients with BK virus nephropathy
    Timo Jahnukainen
    Department of Pediatrics, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    J Am Soc Nephrol 17:3248-56. 2006
    ..Proteomic analysis of urine may offer a noninvasive way to differentiate BKVAN from AR in clinical practice. The identification of individual proteomic peaks can improve further the clinical utility of this screening method...
  15. pmc Renal transplantation in children managed with lymphocyte depleting agents and low-dose maintenance tacrolimus monotherapy
    Demetrius Ellis
    Children s Hospital of Pittsburgh, Department of Family Medicine and Clinical Epidemiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Transplantation 83:1563-70. 2007
    ..Describe the safety and efficacy of antithymocyte globulin or alemtuzumab preconditioning, steroid avoidance and reduced calcineurin inhibitor (CNI) immunosuppression in 34 children undergoing renal transplantation...
  16. ncbi request reprint Systemic anticoagulation and bleeding in children with hemodialysis catheters
    Michael L Moritz
    Department of Pediatrics, Division of Nephrology, Children s Hospital of Pittsburgh, University of Pittsburg School of Medicine, Pennsylvania, USA
    Pediatr Nephrol 18:68-70. 2003
    ..Guidelines are presented to prevent hemorrhagic complications from inadvertent systemic anticoagulation...
  17. ncbi request reprint Polyomavirus allograft nephropathy: sequential assessment of histologic viral load, tubulitis, and graft function following changes in immunosuppression
    Betul Celik
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Transplant 3:1378-82. 2003
    ..Lack of parallelism between viral load, tubulitis grade, and serum creatinine illustrates a complex interplay of viral and alloimmune factors leading to graft injury...
  18. ncbi request reprint Long-term antiproteinuric and renoprotective efficacy and safety of losartan in children with proteinuria
    Demetrius Ellis
    Division of Pediatric Nephrology, Children s Hospital of Pittsburgh and Department of Family Medicine and Clinical Epidemiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Pediatr 143:89-97. 2003
    ..As a consequence, such agents retard progressive renal dysfunction in adults with chronic proteinuria. Long-term efficacy and tolerability data in children are unavailable...
  19. ncbi request reprint Antihypertensive and renoprotective efficacy and safety of losartan. A long-term study in children with renal disorders
    Demetrius Ellis
    Division of Pediatric Nephrology, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Hypertens 17:928-35. 2004
    ..We assessed the long term efficacy and safety of losartan in lowering blood pressure (BP) and in preserving renal function in hypertensive children with chronic renal disorders...
  20. pmc Development of a loop-mediated isothermal amplification assay for rapid detection of BK virus
    Bipin Raj Bista
    Department of Pediatrics, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    J Clin Microbiol 45:1581-7. 2007
    ..BKV LAMP was also successful for urine and plasma specimens without the need for DNA extraction. Due to its simplicity and specificity, the LAMP assay can potentially be developed for "point of care" screening of BKV...
  21. ncbi request reprint Effect of leflunomide and cidofovir on replication of BK virus in an in vitro culture system
    Noush Afarin Farasati
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Transplantation 79:116-8. 2005
    ..Cidofovir and Leflunomide are used empirically in the treatment of BK virus nephropathy. The aim of this study is to quantify the antiviral activity of these drugs...
  22. ncbi request reprint Quantitation of viral DNA in renal allograft tissue from patients with BK virus nephropathy
    Parmjeet S Randhawa
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Transplantation 74:485-8. 2002
    ..Quantitative polymerase chain reaction (PCR) assay for renal biopsy has not been evaluated as a diagnostic test. Determination of renal BKV load may identify patients at risk for disease before histologic nephropathy...
  23. ncbi request reprint Polyomavirus BK non-coding control region rearrangements in health and disease
    Preety M Sharma
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Med Virol 79:1199-207. 2007
    ..BK virus is an increasingly recognized pathogen in transplanted patients. DNA sequencing of this virus shows considerable genomic variability...
  24. pmc Phylogenetic analysis of polyomavirus BK sequences
    Preety M Sharma
    Division of Transplant Pathology, E737 UPMC Montefiore Hospital, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
    J Virol 80:8869-79. 2006
    ..However, within the kidney transplant population, BKV strains derived from patients with asymptomatic viruria did not show complete separation from strains associated with allograft nephropathy...
  25. ncbi request reprint Diagnosis and treatment of BK virus-associated transplant nephropathy
    Abhay Vats
    Children s Hospital of Pittsburgh, University of Pittsburgh, Pennsylvania, USA
    Adv Exp Med Biol 577:213-27. 2006
    ..More recently several other agents have also been utilized to treat BKVAN, with variable success. This chapter summarizes the current diagnostic modalities and therapeutic options for BKVAN...
  26. ncbi request reprint Quantitation of DNA of polyomaviruses BK and JC in human kidneys
    Parmjeet Randhawa
    Division of Transplantation Pathology, Department of Pathology, University of Pittsburgh, PA 15213, USA
    J Infect Dis 192:504-9. 2005
    ..Because virus in urine can be derived from the kidneys, ureter, or urinary bladder, we evaluated whether measurement of intrarenal concentrations of viral DNA might serve as a more reliable monitoring tool...
  27. pmc Correlates of quantitative measurement of BK polyomavirus (BKV) DNA with clinical course of BKV infection in renal transplant patients
    Parmjeet Randhawa
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Clin Microbiol 42:1176-80. 2004
    ..In conclusion, serial measurement of viral loads by quantitative PCR is a useful tool in monitoring the course of BK virus infection. The results should be interpreted in conjunction with the clinical picture and biopsy findings...
  28. pmc Immunoglobulin G, A, and M responses to BK virus in renal transplantation
    Parmjeet S Randhawa
    Department of Pathology, Division of Transplant Pathology, University of Pittsburgh, E 737 UPMC Montefiore Hospital, 3459 Fifth Ave, PA 15213, USA
    Clin Vaccine Immunol 13:1057-63. 2006
    ..In conclusion, measurement of anti-BKV antibody titer and class response can be used to detect the onset of viral replication. ELISAs can be quite specific despite considerable sequence homology between BK virus and JC virus...
  29. ncbi request reprint Monitoring for polyomavirus BK And JC in urine: comparison of quantitative polymerase chain reaction with urine cytology
    Parmjeet Randhawa
    Division of Transplant Pathology, Department of Pathology, University of Pittsburgh, PA 15213, USA
    Transplantation 79:984-6. 2005
    ..Compared with PCR, urine cytology is a less sensitive technique, which requires morphologically intact cells, and cannot distinguish BKV from JC virus...
  30. ncbi request reprint Infantile systemic lupus erythematosus presenting with pulmonary hemorrhage
    James Kreindler
    Division of Pulmonology, Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Pediatr Nephrol 20:522-5. 2005
    ....
  31. ncbi request reprint The pathobiology of polyomavirus infection in man
    Parmjeet Randhawa
    University of Pittsburgh Medical Center, Pennsylvania, USA
    Adv Exp Med Biol 577:148-59. 2006
    ..Finally, we present biochemical mechanisms that could potentially explain several key elements of tissue pathology characteristic of BKV mediated damage to human kidney...
  32. ncbi request reprint DNA sequencing of viral capsid protein VP-1 region in patients with BK virus interstitial nephritis
    Parmjeet S Randhawa
    Division of Transplantation Pathology, Department of Pathology, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Transplantation 73:1090-4. 2002
    ..This study sought to determine whether analogous viral genetic changes occur in human BK virus (BKV) interstitial nephritis (ISN)...

Research Grants9

  1. Genetic Epidemiology Of Kidney Anomalies
    Abhay Vats; Fiscal Year: 2004
    ..We wish to pursue further gene localization studies on chromosome 13 in this application in order to identify the causative genes. ..
  2. GENETIC EPIDEMIOLOGY OF IDIOPATHIC NEPHROTIC SYNDROME
    Abhay Vats; Fiscal Year: 2005
    ....
  3. Biomarkers Based Studies of Polyomaviruses
    Abhay Vats; Fiscal Year: 2007
    ..We would then confirm these findings in a prospective cohort study that will be initiated at UPMC and affiliated hospitals as a part of this project. ..
  4. Rapid tests for Chlamydia and Neglected Tropical Diseases
    Abhay N Vats; Fiscal Year: 2010
    ..This will ultimately help in the public health goal of elimination of blinding trachoma. ..