Research Topics
Genomes and GenesSpecies | Hui Ju TsaiSummaryAffiliation: Children's Memorial Hospital Country: USA Publications
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Publications
Familial aggregation of food allergy and sensitization to food allergens: a family-based studyH J Tsai
Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital and Children s Memorial Research Center, Chicago, IL, USA
Clin Exp Allergy 39:101-9. 2009..The increasing prevalence of food allergy (FA) is a growing clinical and public health problem. The contribution of genetic factors to FA remains largely unknown...- Maternal cigarette smoking, metabolic gene polymorphisms, and preterm delivery: new insights on GxE interactions and pathogenic pathwaysHui Ju Tsai
Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital and Children s Memorial Research Center, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
Hum Genet 123:359-69. 2008..Taken together, maternal smoking significantly increased the risk of PTD among women with high-risk CYP1A1 and GSTT1 genotypes. Such joint associations were strongest among PTD accompanied by histologic chorioamnionitis... - Association of genetic ancestry with preterm delivery and related traits among African American mothersHui Ju Tsai
Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital and Children s Memorial Research Center, Chicago, IL 60614 3394, USA
Am J Obstet Gynecol 201:94.e1-10. 2009..In the United States, the rate of preterm delivery (PTD) is higher in African Americans (17.8%) than non-Hispanic whites (11.5%). Such disparity cannot be fully explained by differences in socioenvironmental factors... - Race, ancestry, and development of food-allergen sensitization in early childhoodRajesh Kumar
aDivision of Allergy and Immunology, Children s Memorial Hospital, Chicago, Illinois 60614, USA
Pediatrics 128:e821-9. 2011..We examined whether the risk of food-allergen sensitization varied according to self-identified race or genetic ancestry... 
The joint association between F5 gene polymorphisms and maternal smoking during pregnancy on preterm deliveryYunxian Yu
Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital and Children s Memorial Research Center, Chicago, IL, USA
Hum Genet 124:659-68. 2009..Similar pattern of interactions was found between rs6022 and maternal smoking on PTD. In summary, our data indicated that F5 gene variants and maternal smoking may synergistically increase the risk of PTD...- Genetic and environmental influences on serum lipid tracking: a population-based, longitudinal Chinese twin studyShanchun Zhang
Department of Pediatrics, Children s Memorial Hospital, Children s Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60614, USA
Pediatr Res 68:316-22. 2010..Our study underscores the importance of considering both environmental and genetic factors in studying the etiology of dyslipidemia... - Percent fat mass is inversely associated with bone mass and hip geometry in rural Chinese adolescentsXiumei Hong
Mary Ann and J Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children s Memorial Hospital and Children s Memorial Research Center, Chicago, IL 60614, USA
J Bone Miner Res 25:1544-54. 2010.... - Plasma adipokines, bone mass, and hip geometry in rural Chinese adolescentsXiumei Hong
Mary Ann and J Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children s Memorial Hospital and Children s Memorial Research Center, Chicago, Illinois 60614, USA
J Clin Endocrinol Metab 95:1644-52. 2010..Adipokines have been linked to bone phenotypes recently, but with conflicting results. Few such studies have been conducted in adolescents... - Gene polymorphisms, breast-feeding, and development of food sensitization in early childhoodXiumei Hong
Mary Ann and J Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children s Memorial Hospital and Children s Memorial Research Center, Chicago, IL 60614, USA
J Allergy Clin Immunol 128:374-81.e2. 2011..The effect of breast-feeding on the development of allergic disease is uncertain. There are no data that show whether this relationship varies by individual genotypes... - A large-scale genome-wide linkage analysis to map loci linked to stature in Chinese populationXiumei Hong
Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital and Children s Memorial Research Center, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60614, USA
J Clin Endocrinol Metab 93:4511-8. 2008..A number of genome-wide scans of stature have been reported previously, but with inconsistent results. The inconsistency may be partly due to differential population characteristics and gender- and/or age-specific effects on this trait... - Role of African ancestry and gene-environment interactions in predicting preterm birthHui Ju Tsai
Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital and Children s Memorial Research Center, Chicago, Illinois, USA
Obstet Gynecol 118:1081-9. 2011..To estimate whether African ancestry, specific gene polymorphisms, and gene-environment interactions could account for some of the unexplained preterm birth variance within African American women... - Individual variation and longitudinal pattern of genome-wide DNA methylation from birth to the first two years of lifeDeli Wang
Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Epigenetics 7:594-605. 2012..Further studies are needed to replicate our findings, including analysis by specific cell types, and link those individual variations and longitudinal changes with specific health outcomes in early childhood and later life... - Associations between gene polymorphisms in fatty acid metabolism pathway and preterm delivery in a US urban black populationXin Liu
Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital, Children s Memorial Research Center, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
Hum Genet 131:341-51. 2012..Further investigation of these gene polymorphisms jointly with fatty acid measures and other genetic factors would help better understand the pathogenesis of PTD... - Does genetic regulation of IgE begin in utero? Evidence from T(H)1/T(H)2 gene polymorphisms and cord blood total IgEXiumei Hong
Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital and Children s Memorial Research Center, Chicago, Ill 60614 3394, USA
J Allergy Clin Immunol 126:1059-67, 1067.e1. 2010..In contrast with numerous genetic studies of total serum IgE in children and adults, limited genetic studies on CBIgE have been conducted... - Genetic and environmental contributions to phenotypic components of metabolic syndrome: a population-based twin studyShanchun Zhang
Mary Ann and J Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children s Memorial Hospital and Children s Memorial Research Center, Chicago, Illinois, USA
Obesity (Silver Spring) 17:1581-7. 2009..Our study underscores the importance of examining MS components as intercorrelated traits, and to carefully consider environmental and genetic factors in studying MS etiology... - Genetics of food allergyXiumei Hong
Mary Ann and J Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children s Memorial Hospital and Children s Memorial Research Center, Chicago, Illinois 60614, USA
Curr Opin Pediatr 21:770-6. 2009..The purpose of this review is to summarize recent advances in food allergy genetic research... - Association of plasma leptin concentrations with adiposity measurements in rural Chinese adolescentsShanchun Zhang
Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital and Children s Memorial Research Center, Department of Pediatrics, Feinberg School of Medicine of Northwestern University, Chicago, Illinois 60611, USA
J Clin Endocrinol Metab 94:3497-504. 2009..There is evidence that leptin is involved in the etiology of obesity-related cardiovascular disease in adults. This raises the question of whether leptin levels in adolescence are indicative of adiposity-related cardiovascular risk... 
Applying novel genome-wide linkage strategies to search for loci influencing type 2 diabetes and adult height in American SamoaKarolina Aberg
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, A300 Crabtree Hall, 130 DeSoto St, Pittsburgh, PA 15261, USA
Hum Biol 80:99-123. 2008..Our finding suggests that the 9q31 region may be a strong quantitative trait locus for adult height, which is likely to be of importance across populations...- Latino populations: a unique opportunity for the study of race, genetics, and social environment in epidemiological researchEsteban Gonzalez Burchard
Department of Medicine, University of California, San Francisco, CA 94143 0833, USA
Am J Public Health 95:2161-8. 2005.... - Comparison of three methods to estimate genetic ancestry and control for stratification in genetic association studies among admixed populationsHui Ju Tsai
Department of Medicine, University of California, Box 0833, San Francisco, CA, 94143 0833, USA
Hum Genet 118:424-33. 2005..These simulations are meant to provide some practical guidelines for investigators conducting association studies in admixed populations... - CD14 tobacco gene-environment interaction modifies asthma severity and immunoglobulin E levels in Latinos with asthmaShweta Choudhry
University of California San Francisco, DNA Bank Lung Biology Center, San Francisco General Hospital, Bldg 30, 5th Floor, Room 3501H, 1001 Potrero Avenue, San Francisco, CA 94110, USA
Am J Respir Crit Care Med 172:173-82. 2005..A recent family-based genomewide screen revealed linkage between the 5q31 region and the diagnosis of asthma, but only in those exposed to environmental tobacco smoke (ETS). Among the candidate genes in this region is CD14... - Admixture-matched case-control study: a practical approach for genetic association studies in admixed populationsHui Ju Tsai
Department of Medicine, Study of African American, Asthma, Genes and Environments, SAGE, University of California, 0833, San Francisco, 94143 0833, USA
Hum Genet 118:626-39. 2006..Our present work demonstrates that admixture-matched case-control strategies can efficiently control population stratification confounding in admixed populations... - Population stratification confounds genetic association studies among LatinosShweta Choudhry
University of California, San Francisco, 94143-0833, USA
Hum Genet 118:652-64. 2006..Our findings suggest that empirical assessment of the effects of stratification is critical to appropriately interpret the results of case-control studies in admixed populations... - Comparison of methods incorporating quantitative covariates into affected sib pair linkage analysisHui-Ju Tsai
Department of Human Genetics, University of Pittsburgh, PA 15261, USA
Genet Epidemiol 30:77-93. 2006..However, most of these statistics do not provide better power than S(all). Thus, while inclusion of the "correct" covariate can lead to increased power, careful selection of appropriate covariates is vital for success... - Beta 2-adrenergic receptor polymorphisms: pharmacogenetic response to bronchodilator among African American asthmaticsHui Ju Tsai
Department of Medicine, University of California, San Francisco, CA 94143 0833, USA
Hum Genet 119:547-57. 2006..Our findings highlight the importance of investigating genetic risk factors for asthma in different populations... - The PTGDR gene is not associated with asthma in 3 ethnically diverse populationsYuhjung J Tsai
University of California, San Francisco, San Francisco, CA 94143 2911, USA
J Allergy Clin Immunol 118:1242-8. 2006..The significance of PTGDR gene variants in asthma has yet to be determined in Latinos, the largest US minority population, nor has the association been replicated in other populations... - Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthmaNatalie C Battle
University of California, San Francisco, San Francisco, CA 94143 2911, USA
Am J Respir Crit Care Med 175:881-7. 2007..Furthermore, interaction between these genes has been shown to affect asthma in white and Chinese populations... - Arsenic methylation capability, heme oxygenase-1 and NADPH quinone oxidoreductase-1 genetic polymorphisms and the stage and grade of urothelial carcinomasSteven K Huang
Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
Urol Int 80:405-12. 2008..To explore the distribution of the arsenic methylation capability in patients with different stages and grades of UCs, 100 UC cases were recruited between September 2002 and May 2004 for this study... - Age-related maculopathy: a genomewide scan with continued evidence of susceptibility loci within the 1q31, 10q26, and 17q25 regionsDaniel E Weeks
Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA
Am J Hum Genet 75:174-89. 2004..The OSAs generate the interesting hypothesis that the effect of smoking on the risk of ARM is accentuated by a gene in the 10q26 region--a region implicated by four other studies...