ELIZABETH C contact THEIL

Summary

Affiliation: Children's Hospital Oakland Research Institute
Country: USA

Publications

  1. pmc Coordinating subdomains of ferritin protein cages with catalysis and biomineralization viewed from the C4 cage axes
    Elizabeth C Theil
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA, 94609, USA
    J Biol Inorg Chem 19:615-22. 2014
  2. pmc Absorption of iron from ferritin is independent of heme iron and ferrous salts in women and rat intestinal segments
    Elizabeth C Theil
    Children s Hospital Oakland Research Institute, Oakland, CA, USA
    J Nutr 142:478-83. 2012
  3. pmc Mathematical modeling of the dynamic storage of iron in ferritin
    J Cristian Salgado
    Laboratory of Process Modeling and Distributed Computing, Department of Chemical Engineering and Biotechnology, University of Chile, Santiago, Chile
    BMC Syst Biol 4:147. 2010
  4. pmc Iron homeostasis and nutritional iron deficiency
    Elizabeth C Theil
    Council on BioIron at Children s Hospital Oakland Research Institute, Department of Nutrition Sciences and Toxicology, University of California, Berkeley, CA 94609, USA
    J Nutr 141:724S-728S. 2011
  5. pmc Ferritin protein nanocages use ion channels, catalytic sites, and nucleation channels to manage iron/oxygen chemistry
    Elizabeth C Theil
    CHORI Children s Hospital Oakland Research Institute, 5700 Martin Luther King, Jr Way, Oakland, CA 94609, USA
    Curr Opin Chem Biol 15:304-11. 2011
  6. pmc Ferritin iron minerals are chelator targets, antioxidants, and coated, dietary iron
    Elizabeth C Theil
    Children s Hospital Oakland Research Institute, Oakland, California, USA
    Ann N Y Acad Sci 1202:197-204. 2010
  7. ncbi request reprint Coordinating responses to iron and oxygen stress with DNA and mRNA promoters: the ferritin story
    Elizabeth C Theil
    CHORI Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Biometals 20:513-21. 2007
  8. ncbi request reprint Integrating iron and oxygen/antioxidant signals via a combinatorial array of DNA - (antioxidant response elements) and mRNA (iron responsive elements) sequences
    Elizabeth C Theil
    CHORI Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    J Inorg Biochem 100:2074-8. 2006
  9. ncbi request reprint Ferritins: iron/oxygen biominerals in protein nanocages
    Elizabeth C Theil
    CHORI Children s Hospital Research Institute Oakland, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    J Biol Inorg Chem 11:803-10. 2006
  10. ncbi request reprint Iron, ferritin, and nutrition
    Elizabeth C Theil
    CHORI Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Annu Rev Nutr 24:327-43. 2004

Research Grants

  1. Fe, O2, mRNA and Ferritin in Vitro & in Cells
    Elizabeth Theil; Fiscal Year: 2003
  2. Ferritin and Iron Nutrition in Health and Disease
    Elizabeth Theil; Fiscal Year: 2004
  3. Workshop on BioIron in Thalassemia, Sickle Cell Disease and Hemochromatosis
    Elizabeth Theil; Fiscal Year: 2004
  4. Fe, O2, mRNA and Ferritin in Vitro & in Cells
    Elizabeth Theil; Fiscal Year: 2004
  5. Ferritin and Iron Nutrition in Health and Disease
    Elizabeth Theil; Fiscal Year: 2005
  6. Fe, O2, mRNA and Ferritin in Vitro & in Cells
    Elizabeth Theil; Fiscal Year: 2005
  7. Fe, O2, mRNA and Ferritin in Vitro & in Cells
    Elizabeth Theil; Fiscal Year: 2006
  8. Fe, O2, mRNA and Ferritin in Vitro & in Cells
    Elizabeth Theil; Fiscal Year: 2007
  9. Ferritin: Protein/mRNA/DNA in Fe/O Regulation/Metabolism
    Elizabeth Theil; Fiscal Year: 2009
  10. Ferritin: Protein/mRNA/DNA in Fe/O Regulation/Metabolism
    ELIZABETH C contact THEIL; Fiscal Year: 2010

Collaborators

Detail Information

Publications34

  1. pmc Coordinating subdomains of ferritin protein cages with catalysis and biomineralization viewed from the C4 cage axes
    Elizabeth C Theil
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA, 94609, USA
    J Biol Inorg Chem 19:615-22. 2014
    ..Biological and nanotechnological uses of ferritin protein cage fourfold symmetry and solid-state mineral properties remain largely unexplored. ..
  2. pmc Absorption of iron from ferritin is independent of heme iron and ferrous salts in women and rat intestinal segments
    Elizabeth C Theil
    Children s Hospital Oakland Research Institute, Oakland, CA, USA
    J Nutr 142:478-83. 2012
    ....
  3. pmc Mathematical modeling of the dynamic storage of iron in ferritin
    J Cristian Salgado
    Laboratory of Process Modeling and Distributed Computing, Department of Chemical Engineering and Biotechnology, University of Chile, Santiago, Chile
    BMC Syst Biol 4:147. 2010
    ..A set of differential equations were established considering kinetic expressions for the main reactions and mass balances for ferritin, iron and a discrete population of ferritin species defined by their respective iron content...
  4. pmc Iron homeostasis and nutritional iron deficiency
    Elizabeth C Theil
    Council on BioIron at Children s Hospital Oakland Research Institute, Department of Nutrition Sciences and Toxicology, University of California, Berkeley, CA 94609, USA
    J Nutr 141:724S-728S. 2011
    ..Recognition of 2 nutritional nonheme iron sources, small and large (FTN), will aid the solution of iron deficiency, a major public health problem, and the development of new policies on iron nutrition...
  5. pmc Ferritin protein nanocages use ion channels, catalytic sites, and nucleation channels to manage iron/oxygen chemistry
    Elizabeth C Theil
    CHORI Children s Hospital Oakland Research Institute, 5700 Martin Luther King, Jr Way, Oakland, CA 94609, USA
    Curr Opin Chem Biol 15:304-11. 2011
    ....
  6. pmc Ferritin iron minerals are chelator targets, antioxidants, and coated, dietary iron
    Elizabeth C Theil
    Children s Hospital Oakland Research Institute, Oakland, California, USA
    Ann N Y Acad Sci 1202:197-204. 2010
    ....
  7. ncbi request reprint Coordinating responses to iron and oxygen stress with DNA and mRNA promoters: the ferritin story
    Elizabeth C Theil
    CHORI Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Biometals 20:513-21. 2007
    ..The analysis illustrates the centrality of the ferritins to life with iron and oxygen and models how Nature harnesses potentially dangerous chemistry for biology...
  8. ncbi request reprint Integrating iron and oxygen/antioxidant signals via a combinatorial array of DNA - (antioxidant response elements) and mRNA (iron responsive elements) sequences
    Elizabeth C Theil
    CHORI Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    J Inorg Biochem 100:2074-8. 2006
    ..The potential of manipulating mRNA function with small molecules targeted to specific RNA regulatory structures, e.g., ferritin mRNA in iron overload, or viral mRNA control structures for replication, is high...
  9. ncbi request reprint Ferritins: iron/oxygen biominerals in protein nanocages
    Elizabeth C Theil
    CHORI Children s Hospital Research Institute Oakland, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    J Biol Inorg Chem 11:803-10. 2006
    ..Ferritin DNA responds more to oxygen signals, and ferritin mRNA responds more to iron signals. Ferritin genes (DNA and RNA) and protein function at the intersection of iron and oxygen chemistry in biology...
  10. ncbi request reprint Iron, ferritin, and nutrition
    Elizabeth C Theil
    CHORI Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Annu Rev Nutr 24:327-43. 2004
    ..and of the interactions dependent on food sources, genes, and gender, is required to design diets that will eradicate global iron deficiency in the twenty-first century...
  11. ncbi request reprint Ferritin: at the crossroads of iron and oxygen metabolism
    Elizabeth C Theil
    Children s Hospital and Research Center at Oakland, Oakland, CA 94609, USA
    J Nutr 133:1549S-53S. 2003
    ....
  12. ncbi request reprint Iron homeostasis during transfusional iron overload in beta-thalassemia and sickle cell disease: changes in iron regulatory protein, hepcidin, and ferritin expression
    Zandra A Jenkins
    Council for BioIron at CHORI, Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Pediatr Hematol Oncol 24:237-43. 2007
    ..Finally, the absence of a detectable change in ferritin mRNA indicates insufficient oxidative stress to significantly activate MARE/ARE promoters...
  13. ncbi request reprint Ferritins: dynamic management of biological iron and oxygen chemistry
    Xiaofeng Liu
    Center for BioIron at CHORI Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Acc Chem Res 38:167-75. 2005
    ..Gated pores (eight or four), symmetrically arranged, control iron flow. The multiple ferritin functions combine pore, channel, and catalytic functions in compact protein structures required for life and disease response...
  14. pmc DNA and mRNA elements with complementary responses to hemin, antioxidant inducers, and iron control ferritin-L expression
    Korry J Hintze
    Center for BioIron at CHORI, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Proc Natl Acad Sci U S A 102:15048-52. 2005
    ..Combining DNA and mRNA mechanisms of regulation, as for ferritin-L, illustrates the advantages of using two types of genetic targets to achieve sensitive responses to multiple signals...
  15. ncbi request reprint Ferritin as an iron concentrator and chelator target
    Xiaofeng Liu
    CeBIC Center for BioIron at CHORI, The Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Ann N Y Acad Sci 1054:136-40. 2005
    ....
  16. pmc The ferritin Fe2 site at the diiron catalytic center controls the reaction with O2 in the rapid mineralization pathway
    Takehiko Tosha
    Council on BioIron at Children s Hospital Oakland Research Institute, 5700 Martin Luther King, Jr, Way, Oakland, CA 94609, USA
    Proc Natl Acad Sci U S A 105:18182-7. 2008
    ..g., Glu/Gln and His/Asp pairs share 2 of 3 nucleotides-illustrate the potential simplicity of evolving active sites for diiron cofactors or diiron substrates...
  17. ncbi request reprint Peptides selected for the protein nanocage pores change the rate of iron recovery from the ferritin mineral
    Xiaofeng S Liu
    CHORI Children s Hospital Oakland Research Institute and Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Oakland, California 94609, USA
    J Biol Chem 282:31821-5. 2007
    ..The results emphasize that small peptides can exploit the structural plasticity of protein pores to modulate function...
  18. pmc Opening protein pores with chaotropes enhances Fe reduction and chelation of Fe from the ferritin biomineral
    Xiaofeng Liu
    Children s Hospital of Oakland Research Institute, 5700 Martin Luther King, Jr Way, Oakland, CA 94609, USA
    Proc Natl Acad Sci U S A 100:3653-8. 2003
    ..Biological molecules may have evolved to control gating of ferritin pores in response to cell iron need and, if mimicked by designer drugs, could impact chelation therapies in iron-overload diseases...
  19. ncbi request reprint Paired Bacillus anthracis Dps (mini-ferritin) have different reactivities with peroxide
    Xiaofeng Liu
    Children s Hospital Oakland Research Institute, California 94609, USA
    J Biol Chem 281:27827-35. 2006
    ..Destruction of H(2)O(2) by Ba Dps2 proceeds via an unknown mechanism with an intermediate similar spectrally (A(650 nm)) and kinetically to the maxi-ferritin diferric peroxo complex...
  20. ncbi request reprint Bach1 repression of ferritin and thioredoxin reductase1 is heme-sensitive in cells and in vitro and coordinates expression with heme oxygenase1, beta-globin, and NADP(H) quinone (oxido) reductase1
    Korry J Hintze
    Council for BioIron at CHORI, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    J Biol Chem 282:34365-71. 2007
    ....
  21. ncbi request reprint Multiple, conserved iron-responsive elements in the 3'-untranslated region of transferrin receptor mRNA enhance binding of iron regulatory protein 2
    Ronit Erlitzki
    Children s Hospital Oakland Research Institute, The Research Institute of the Children s Hospital and Medical Center Oakland, 5700 Martin Luther King, Jr Way, Oakland, California 94609 1673, USA
    J Biol Chem 277:42579-87. 2002
    ....
  22. ncbi request reprint Iron in ferritin or in salts (ferrous sulfate) is equally bioavailable in nonanemic women
    Penni Davila-Hicks
    Department of Nutrition, University of California, Davis, CA, USA
    Am J Clin Nutr 80:936-40. 2004
    ..However, direct evidence for this is lacking because the soybeans were intrinsically labeled; thus, iron bound to other ligands, such as phytate, was also labeled...
  23. pmc Iron uptake in ferritin is blocked by binding of [Cr(TREN)(H(2)O)(OH)](2+), a slow dissociating model for [Fe(H(2)O)(6)](2+)
    Carmen M Barnes
    Department of Chemistry, University of California, Berkeley, CA 94720 1460, USA
    Proc Natl Acad Sci U S A 99:5195-200. 2002
    ..These results show the advantage of using stable model complexes to explore properties of transient Fe-protein complexes during Fe mineralization in ferritin...
  24. ncbi request reprint Iron absorption from soybean ferritin in nonanemic women
    Bo Lonnerdal
    Department of Nutrition, University of California, Davis, Davis, CA 95616, USA
    Am J Clin Nutr 83:103-7. 2006
    ..Plant ferritin, the most common dietary ferritin, has not been studied. Iron from animal ferritin is absorbed as well as is iron from FeSO4 in women...
  25. ncbi request reprint Ferrocentric memories of Edward I. Stiefel
    Elizabeth C Theil
    Council for BioIron at CHORI, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    J Inorg Biochem 101:1548-9. 2007
    ..I. Stiefel's discovery of heme, maxi-ferritins in bacteria, recognition of the relationship to animal maxi-ferritins, and other reminiscences of ferritin defined as a storage battery...
  26. pmc Ferritin reactions: direct identification of the site for the diferric peroxide reaction intermediate
    Xiaofeng Liu
    Center for BioIron at Children s Hospital Oakland Research Institute, 5700 Martin Luther King Way, Oakland, CA 94609, USA
    Proc Natl Acad Sci U S A 101:8557-62. 2004
    ....
  27. ncbi request reprint Liver ferritin subunit ratios in neonatal hemochromatosis
    Ward Hagar
    Children s Hospital, Oakland, Research Institute, Oakland, California 95609, USA
    Pediatr Hematol Oncol 20:229-35. 2003
    ..This first report of a marked increase in the ferritin H/L-subunit ratio may point to an underlying mechanism of disease in this enigmatic disorder...
  28. ncbi request reprint Daphnia magna ecotoxicogenomics provides mechanistic insights into metal toxicity
    Helen C Poynton
    Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720, USA
    Environ Sci Technol 41:1044-50. 2007
    ..By integrating gene expression profiling into an environmentally important organism, this study provides experimental support for the utility of ecotoxicogenomics...
  29. pmc Spectroscopic definition of the ferroxidase site in M ferritin: comparison of binuclear substrate vs cofactor active sites
    Jennifer K Schwartz
    Department of Chemistry, Stanford University, 333 Campus Drive, Stanford, California 94305, USA
    J Am Chem Soc 130:9441-50. 2008
    ....
  30. ncbi request reprint Structure of dual function iron regulatory protein 1 complexed with ferritin IRE-RNA
    William E Walden
    Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL 60612 7344, USA
    Science 314:1903-8. 2006
    ..Extensive conformational changes related to binding the IRE or an iron-sulfur cluster explain the alternate functions of IRP1 as an mRNA regulator or enzyme...
  31. pmc Caco-2 intestinal epithelial cells absorb soybean ferritin by mu2 (AP2)-dependent endocytosis
    Carol D San Martin
    Department of Biology, Faculty of Sciences, and Cell Dynamics and Biotechnology Institute, Universidad de Chile, Santiago, Chile
    J Nutr 138:659-66. 2008
    ..The large number of iron atoms in SBFn makes iron transport across the cell membrane a much more efficient event for SBFn than for single iron atoms as heme or ferrous ions...
  32. ncbi request reprint Women with low iron stores absorb iron from soybeans
    Laura E Murray-Kolb
    Department of Nutrition, The Pennsylvania State University, University Park, USA
    Am J Clin Nutr 77:180-4. 2003
    ....
  33. ncbi request reprint Stoichiometric production of hydrogen peroxide and parallel formation of ferric multimers through decay of the diferric-peroxo complex, the first detectable intermediate in ferritin mineralization
    Guy N L Jameson
    Department of Physics, Emory University, Atlanta, Georgia 30322, USA
    Biochemistry 41:13435-43. 2002
    ....
  34. ncbi request reprint Transgenic rice is a source of iron for iron-depleted rats
    Laura E Murray-Kolb
    Department of Nutrition, The Pennsylvania State University, University Park, PA, USA
    J Nutr 132:957-60. 2002
    ..These data suggest that Mendelian and biotechnological approaches to manipulating ferritin expression of seed iron in rice may contribute to a sustainable solution to global problems of iron deficiency...

Research Grants24

  1. Fe, O2, mRNA and Ferritin in Vitro & in Cells
    Elizabeth Theil; Fiscal Year: 2003
    ..abstract_text> ..
  2. Ferritin and Iron Nutrition in Health and Disease
    Elizabeth Theil; Fiscal Year: 2004
    ..The results will clarify mechanisms of ferritin iron uptake and characterize molecular genetic differences in iron uptake for improving dietary iron sources in health and disease. ..
  3. Workshop on BioIron in Thalassemia, Sickle Cell Disease and Hemochromatosis
    Elizabeth Theil; Fiscal Year: 2004
    ..Fuller understanding of iron homeostasis in Thalassemia, Sickle Cell Disease and Hemochromatosis and improved disease management strategies can be expected. ..
  4. Fe, O2, mRNA and Ferritin in Vitro & in Cells
    Elizabeth Theil; Fiscal Year: 2004
    ..abstract_text> ..
  5. Ferritin and Iron Nutrition in Health and Disease
    Elizabeth Theil; Fiscal Year: 2005
    ..The results will clarify mechanisms of ferritin iron uptake and characterize molecular genetic differences in iron uptake for improving dietary iron sources in health and disease. ..
  6. Fe, O2, mRNA and Ferritin in Vitro & in Cells
    Elizabeth Theil; Fiscal Year: 2005
    ..abstract_text> ..
  7. Fe, O2, mRNA and Ferritin in Vitro & in Cells
    Elizabeth Theil; Fiscal Year: 2006
    ..abstract_text> ..
  8. Fe, O2, mRNA and Ferritin in Vitro & in Cells
    Elizabeth Theil; Fiscal Year: 2007
    ..abstract_text> ..
  9. Ferritin: Protein/mRNA/DNA in Fe/O Regulation/Metabolism
    Elizabeth Theil; Fiscal Year: 2009
    ....
  10. Ferritin: Protein/mRNA/DNA in Fe/O Regulation/Metabolism
    ELIZABETH C contact THEIL; Fiscal Year: 2010
    ....
  11. Ferritin and Iron Nutrition in Health and Disease
    Elizabeth Theil; Fiscal Year: 2003
    ..The results will clarify mechanisms of ferritin iron uptake and characterize molecular genetic differences in iron uptake for improving dietary iron sources in health and disease. ..
  12. Workshop on Biolron in Thalassemia & Sickle Cell Disease
    Elizabeth Theil; Fiscal Year: 2002
    ..abstract_text> ..
  13. FERRITIN AND IRON DEFICIENCY--A NEW LOOK AT THE PROBLEM
    Elizabeth Theil; Fiscal Year: 1999
    ....
  14. FERRITIN, ISO-IRES AND IRON IN VITRO AND IN CELLS
    Elizabeth Theil; Fiscal Year: 1999
    ..3. Iso- IRE/protein "footprint" interactions in vivo. Long term goals are the targeting of ferritin mRNA and protein for therapies in iron overload and targeting mRNAs in viral and oncogenic diseases. ..
  15. FERRITIN, ISO-IRES AND IRON IN VITRO AND IN CELLS
    Elizabeth Theil; Fiscal Year: 2000
    ..3. Iso- IRE/protein "footprint" interactions in vivo. Long term goals are the targeting of ferritin mRNA and protein for therapies in iron overload and targeting mRNAs in viral and oncogenic diseases. ..
  16. FERRITIN AND IRON DEFICIENCY--A NEW LOOK AT THE PROBLEM
    Elizabeth Theil; Fiscal Year: 2000
    ....
  17. IRON & OXYGEN BIOLOGY IN SCH, HH & BETA-THAL MICE
    Elizabeth Theil; Fiscal Year: 2000
    ..The resulting information will be used to help probe the efficiency of presently available and experimental chelators, not only in promoting iron excretion but also in the prevention of defined types of cellular damage. ..
  18. FERRITIN, ISO-IRES AND IRON IN VITRO AND IN CELLS
    Elizabeth Theil; Fiscal Year: 2001
    ..3. Iso- IRE/protein "footprint" interactions in vivo. Long term goals are the targeting of ferritin mRNA and protein for therapies in iron overload and targeting mRNAs in viral and oncogenic diseases. ..
  19. IRON & OXYGEN BIOLOGY IN SCD, HH & BETA-THAL MICE
    Elizabeth Theil; Fiscal Year: 2001
    ..The resulting information will be used to help probe the efficiency of presently available and experimental chelators, not only in promoting iron excretion but also in the prevention of defined types of cellular damage. ..
  20. Ferritin and Iron Nutrition in Health and Disease
    Elizabeth Theil; Fiscal Year: 2002
    ..The results will clarify mechanisms of ferritin iron uptake and characterize molecular genetic differences in iron uptake for improving dietary iron sources in health and disease. ..
  21. IRON & OXYGEN BIOLOGY IN SCD, HH & BETA-THAL MICE
    Elizabeth Theil; Fiscal Year: 2002
    ..The resulting information will be used to help probe the efficiency of presently available and experimental chelators, not only in promoting iron excretion but also in the prevention of defined types of cellular damage. ..
  22. FERRITIN, ISO-IRES AND IRON IN VITRO AND IN CELLS
    Elizabeth Theil; Fiscal Year: 2002
    ..3. Iso- IRE/protein "footprint" interactions in vivo. Long term goals are the targeting of ferritin mRNA and protein for therapies in iron overload and targeting mRNAs in viral and oncogenic diseases. ..
  23. Ferritin: Protein/mRNA/DNA in Fe/O Regulation/Metabolism
    ELIZABETH C contact THEIL; Fiscal Year: 2010
    ....