Research Topics
| ELIZABETH C contact THEILSummaryAffiliation: Children's Hospital Oakland Research Institute Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Absorption of iron from ferritin is independent of heme iron and ferrous salts in women and rat intestinal segmentsElizabeth C Theil
Children s Hospital Oakland Research Institute, Oakland, CA, USA
J Nutr 142:478-83. 2012....- Mathematical modeling of the dynamic storage of iron in ferritinJ Cristian Salgado
Laboratory of Process Modeling and Distributed Computing, Department of Chemical Engineering and Biotechnology, University of Chile, Santiago, Chile
BMC Syst Biol 4:147. 2010..A set of differential equations were established considering kinetic expressions for the main reactions and mass balances for ferritin, iron and a discrete population of ferritin species defined by their respective iron content... - Iron homeostasis and nutritional iron deficiencyElizabeth C Theil
Council on BioIron at Children s Hospital Oakland Research Institute, Department of Nutrition Sciences and Toxicology, University of California, Berkeley, CA 94609, USA
J Nutr 141:724S-728S. 2011..Recognition of 2 nutritional nonheme iron sources, small and large (FTN), will aid the solution of iron deficiency, a major public health problem, and the development of new policies on iron nutrition... - Ferritin protein nanocages use ion channels, catalytic sites, and nucleation channels to manage iron/oxygen chemistryElizabeth C Theil
CHORI Children s Hospital Oakland Research Institute, 5700 Martin Luther King, Jr Way, Oakland, CA 94609, USA
Curr Opin Chem Biol 15:304-11. 2011.... - Ferritin iron minerals are chelator targets, antioxidants, and coated, dietary ironElizabeth C Theil
Children s Hospital Oakland Research Institute, Oakland, California, USA
Ann N Y Acad Sci 1202:197-204. 2010.... 
Coordinating responses to iron and oxygen stress with DNA and mRNA promoters: the ferritin storyElizabeth C Theil
CHORI Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
Biometals 20:513-21. 2007..The analysis illustrates the centrality of the ferritins to life with iron and oxygen and models how Nature harnesses potentially dangerous chemistry for biology...- Integrating iron and oxygen/antioxidant signals via a combinatorial array of DNA - (antioxidant response elements) and mRNA (iron responsive elements) sequencesElizabeth C Theil
CHORI Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
J Inorg Biochem 100:2074-8. 2006..The potential of manipulating mRNA function with small molecules targeted to specific RNA regulatory structures, e.g., ferritin mRNA in iron overload, or viral mRNA control structures for replication, is high... - Ferritins: iron/oxygen biominerals in protein nanocagesElizabeth C Theil
CHORI Children s Hospital Research Institute Oakland, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
J Biol Inorg Chem 11:803-10. 2006..Ferritin DNA responds more to oxygen signals, and ferritin mRNA responds more to iron signals. Ferritin genes (DNA and RNA) and protein function at the intersection of iron and oxygen chemistry in biology... - Iron, ferritin, and nutritionElizabeth C Theil
CHORI Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
Annu Rev Nutr 24:327-43. 2004..and of the interactions dependent on food sources, genes, and gender, is required to design diets that will eradicate global iron deficiency in the twenty-first century... - Ferritin: at the crossroads of iron and oxygen metabolismElizabeth C Theil
Children s Hospital and Research Center at Oakland, Oakland, CA 94609, USA
J Nutr 133:1549S-53S. 2003.... - Iron homeostasis during transfusional iron overload in beta-thalassemia and sickle cell disease: changes in iron regulatory protein, hepcidin, and ferritin expressionZandra A Jenkins
Council for BioIron at CHORI, Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
Pediatr Hematol Oncol 24:237-43. 2007..Finally, the absence of a detectable change in ferritin mRNA indicates insufficient oxidative stress to significantly activate MARE/ARE promoters... - Ferritins: dynamic management of biological iron and oxygen chemistryXiaofeng Liu
Center for BioIron at CHORI (Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA
Acc Chem Res 38:167-75. 2005..Gated pores (eight or four), symmetrically arranged, control iron flow. The multiple ferritin functions combine pore, channel, and catalytic functions in compact protein structures required for life and disease response... - DNA and mRNA elements with complementary responses to hemin, antioxidant inducers, and iron control ferritin-L expressionKorry J Hintze
Center for BioIron at CHORI, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
Proc Natl Acad Sci U S A 102:15048-52. 2005..Combining DNA and mRNA mechanisms of regulation, as for ferritin-L, illustrates the advantages of using two types of genetic targets to achieve sensitive responses to multiple signals... - Ferritin as an iron concentrator and chelator targetXiaofeng Liu
CeBIC (Center for BioIron at CHORI, The Children's Hospital Oakland Research Institute, Oakland, California 94609, USA
Ann N Y Acad Sci 1054:136-40. 2005.... - The ferritin Fe2 site at the diiron catalytic center controls the reaction with O2 in the rapid mineralization pathwayTakehiko Tosha
Council on BioIron at Children s Hospital Oakland Research Institute, 5700 Martin Luther King, Jr, Way, Oakland, CA 94609, USA
Proc Natl Acad Sci U S A 105:18182-7. 2008..g., Glu/Gln and His/Asp pairs share 2 of 3 nucleotides-illustrate the potential simplicity of evolving active sites for diiron cofactors or diiron substrates... - Opening protein pores with chaotropes enhances Fe reduction and chelation of Fe from the ferritin biomineralXiaofeng Liu
Children's Hospital of Oakland Research Institute, 5700 Martin Luther King, Jr. Way, Oakland, CA 94609, USA
Proc Natl Acad Sci U S A 100:3653-8. 2003..Biological molecules may have evolved to control gating of ferritin pores in response to cell iron need and, if mimicked by designer drugs, could impact chelation therapies in iron-overload diseases... - Peptides selected for the protein nanocage pores change the rate of iron recovery from the ferritin mineralXiaofeng S Liu
CHORI Children s Hospital Oakland Research Institute and Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Oakland, California 94609, USA
J Biol Chem 282:31821-5. 2007..The results emphasize that small peptides can exploit the structural plasticity of protein pores to modulate function... - Bach1 repression of ferritin and thioredoxin reductase1 is heme-sensitive in cells and in vitro and coordinates expression with heme oxygenase1, beta-globin, and NADP(H) quinone (oxido) reductase1Korry J Hintze
Council for BioIron at CHORI, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
J Biol Chem 282:34365-71. 2007.... - Paired Bacillus anthracis Dps (mini-ferritin) have different reactivities with peroxideXiaofeng Liu
Children's Hospital Oakland Research Institute, California 94609, USA
J Biol Chem 281:27827-35. 2006..Destruction of H(2)O(2) by Ba Dps2 proceeds via an unknown mechanism with an intermediate similar spectrally (A(650 nm)) and kinetically to the maxi-ferritin diferric peroxo complex... - Multiple, conserved iron-responsive elements in the 3'-untranslated region of transferrin receptor mRNA enhance binding of iron regulatory protein 2Ronit Erlitzki
Children s Hospital Oakland Research Institute, The Research Institute of the Children s Hospital and Medical Center Oakland, 5700 Martin Luther King, Jr Way, Oakland, California 94609 1673, USA
J Biol Chem 277:42579-87. 2002.... - Iron uptake in ferritin is blocked by binding of [Cr(TREN)(H(2)O)(OH)](2+), a slow dissociating model for [Fe(H(2)O)(6)](2+)Carmen M Barnes
Department of Chemistry, University of California, Berkeley, CA 94720 1460, USA
Proc Natl Acad Sci U S A 99:5195-200. 2002..These results show the advantage of using stable model complexes to explore properties of transient Fe-protein complexes during Fe mineralization in ferritin... - Iron absorption from soybean ferritin in nonanemic womenBo Lonnerdal
Department of Nutrition, University of California, Davis, Davis, CA 95616, USA
Am J Clin Nutr 83:103-7. 2006..Plant ferritin, the most common dietary ferritin, has not been studied. Iron from animal ferritin is absorbed as well as is iron from FeSO4 in women... - Iron in ferritin or in salts (ferrous sulfate) is equally bioavailable in nonanemic womenPenni Davila-Hicks
Department of Nutrition, University of California, Davis, CA, USA
Am J Clin Nutr 80:936-40. 2004..CONCLUSIONS: Iron is equally well absorbed from ferritin and ferrous sulfate independent of the phosphate content of the ferritin iron mineral. Thus, dietary ferritin iron is likely to be a good source of iron... - Ferritin reactions: direct identification of the site for the diferric peroxide reaction intermediateXiaofeng Liu
Center for BioIron at Children's Hospital Oakland Research Institute, 5700 Martin Luther King Way, Oakland, CA 94609, USA
Proc Natl Acad Sci U S A 101:8557-62. 2004.... - Liver ferritin subunit ratios in neonatal hemochromatosisWard Hagar
Children s Hospital, Oakland, Research Institute, Oakland, California 95609, USA
Pediatr Hematol Oncol 20:229-35. 2003..This first report of a marked increase in the ferritin H/L-subunit ratio may point to an underlying mechanism of disease in this enigmatic disorder... - Ferrocentric memories of Edward I. StiefelElizabeth C Theil
Council for BioIron at CHORI, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
J Inorg Biochem 101:1548-9. 2007..I. Stiefel's discovery of heme, maxi-ferritins in bacteria, recognition of the relationship to animal maxi-ferritins, and other reminiscences of ferritin defined as a storage battery... - Daphnia magna ecotoxicogenomics provides mechanistic insights into metal toxicityHelen C Poynton
Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720, USA
Environ Sci Technol 41:1044-50. 2007..By integrating gene expression profiling into an environmentally important organism, this study provides experimental support for the utility of ecotoxicogenomics... - Caco-2 intestinal epithelial cells absorb soybean ferritin by mu2 (AP2)-dependent endocytosisCarol D San Martin
Department of Biology, Faculty of Sciences, and Cell Dynamics and Biotechnology Institute, Universidad de Chile, Santiago, Chile
J Nutr 138:659-66. 2008..The large number of iron atoms in SBFn makes iron transport across the cell membrane a much more efficient event for SBFn than for single iron atoms as heme or ferrous ions... - Spectroscopic definition of the ferroxidase site in M ferritin: comparison of binuclear substrate vs cofactor active sitesJennifer K Schwartz
Department of Chemistry, Stanford University, 333 Campus Drive, Stanford, California 94305, USA
J Am Chem Soc 130:9441-50. 2008.... - Structure of dual function iron regulatory protein 1 complexed with ferritin IRE-RNAWilliam E Walden
Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL 60612-7344, USA
Science 314:1903-8. 2006..Extensive conformational changes related to binding the IRE or an iron-sulfur cluster explain the alternate functions of IRP1 as an mRNA regulator or enzyme... - Women with low iron stores absorb iron from soybeansLaura E Murray-Kolb
Department of Nutrition, The Pennsylvania State University, University Park, USA
Am J Clin Nutr 77:180-4. 2003..More study is needed on the effect of plant nodulation on the form of soybean iron, aimed at enhancing bioavailability to combat iron deficiency in at-risk populations... - Stoichiometric production of hydrogen peroxide and parallel formation of ferric multimers through decay of the diferric-peroxo complex, the first detectable intermediate in ferritin mineralizationGuy N L Jameson
Department of Physics, Emory University, Atlanta, Georgia 30322, USA
Biochemistry 41:13435-43. 2002.... - Transgenic rice is a source of iron for iron-depleted ratsLaura E Murray-Kolb
Department of Nutrition, The Pennsylvania State University, University Park, PA, USA
J Nutr 132:957-60. 2002..These data suggest that Mendelian and biotechnological approaches to manipulating ferritin expression of seed iron in rice may contribute to a sustainable solution to global problems of iron deficiency...
Research Grants
- Workshop on BioIron in Thalassemia, Sickle Cell Disease and HemochromatosisElizabeth Theil; Fiscal Year: 2004..Fuller understanding of iron homeostasis in Thalassemia, Sickle Cell Disease and Hemochromatosis and improved disease management strategies can be expected. ..
- Ferritin and Iron Nutrition in Health and DiseaseElizabeth Theil; Fiscal Year: 2005..The results will clarify mechanisms of ferritin iron uptake and characterize molecular genetic differences in iron uptake for improving dietary iron sources in health and disease. ..
- Fe, O2, mRNA and Ferritin in Vitro & in CellsElizabeth Theil; Fiscal Year: 2007..abstract_text> ..
- Ferritin: Protein/mRNA/DNA in Fe/O Regulation/MetabolismElizabeth Theil; Fiscal Year: 2009....
- Ferritin: Protein/mRNA/DNA in Fe/O Regulation/MetabolismELIZABETH C contact THEIL; Fiscal Year: 2010....
- Workshop on Biolron in Thalassemia & Sickle Cell DiseaseElizabeth Theil; Fiscal Year: 2002..abstract_text> ..
- FERRITIN AND IRON DEFICIENCY--A NEW LOOK AT THE PROBLEMElizabeth Theil; Fiscal Year: 2000....
- IRON & OXYGEN BIOLOGY IN SCD, HH & BETA-THAL MICEElizabeth Theil; Fiscal Year: 2002..The resulting information will be used to help probe the efficiency of presently available and experimental chelators, not only in promoting iron excretion but also in the prevention of defined types of cellular damage. ..
- FERRITIN, ISO-IRES AND IRON IN VITRO AND IN CELLSElizabeth Theil; Fiscal Year: 2002..3. Iso- IRE/protein "footprint" interactions in vivo. Long term goals are the targeting of ferritin mRNA and protein for therapies in iron overload and targeting mRNAs in viral and oncogenic diseases. ..
- Ferritin: Protein/mRNA/DNA in Fe/O Regulation/MetabolismELIZABETH C contact THEIL; Fiscal Year: 2010....