Christopher F Spurney
Affiliation: Children's National Medical Center
- Fetal mouse imaging using echocardiography: a review of current technologyChristopher F Spurney
Division of Cardiology, Children s National Medical Center, Washington, DC 20010, USA
Echocardiography 23:891-9. 2006....
- Dystrophin-deficient cardiomyopathy in mouse: expression of Nox4 and Lox are associated with fibrosis and altered functional parameters in the heartChristopher F Spurney
Center for Genetic Medicine Research, Children s National Medical Center, 111 Michigan Avenue, NW, Washington, DC 20010, USA
Neuromuscul Disord 18:371-81. 2008..This is the first report of an altered profibrotic gene expression profile in cardiac tissue of dystrophic mice showing echocardiographic evidence of cardiomyopathy...
- Cardiomyopathy of Duchenne muscular dystrophy: current understanding and future directionsChristopher F Spurney
Division of Cardiology, Research Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
Muscle Nerve 44:8-19. 2011..This review provides a summary of the current literature and discussion of potential new therapies for DMD cardiomyopathy...
- Membrane sealant Poloxamer P188 protects against isoproterenol induced cardiomyopathy in dystrophin deficient miceChristopher F Spurney
Children s National Heart Institute, Division of Cardiology, Children s National Medical Center, Washington, DC, USA
BMC Cardiovasc Disord 11:20. 2011..The absence of dystrophin leads to loss of membrane integrity, cell death and fibrosis in cardiac muscle. Treatment of cardiomyocyte membrane instability could help prevent cardiomyopathy...
- Losartan decreases cardiac muscle fibrosis and improves cardiac function in dystrophin-deficient mdx miceChristopher F Spurney
Division of Cardiology, Children s National Medical Center, Washington, DC, USA
J Cardiovasc Pharmacol Ther 16:87-95. 2011..Chronic treatment with losartan decreases cardiac and skeletal muscle fibrosis and improves cardiac systolic function in dystrophin-deficient mdx mice...
- Evaluation of skeletal and cardiac muscle function after chronic administration of thymosin beta-4 in the dystrophin deficient mouseChristopher F Spurney
Division of Cardiology, Children s National Medical Center, Washington, District of Columbia, United States of America
PLoS ONE 5:e8976. 2010....
- Functional and molecular effects of arginine butyrate and prednisone on muscle and heart in the mdx mouse model of Duchenne Muscular DystrophyAlfredo D Guerron
Center for Genetic Medicine Research, Children s National Medical Center, Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA
PLoS ONE 5:e11220. 2010..One of the proposed strategies is to use drugs that are known to act by multiple different mechanisms including inducing of homologous fetal form of adult genes, for example utrophin in place of dystrophin...
- Glucocorticoid-treated mice are an inappropriate positive control for long-term preclinical studies in the mdx mouseArpana Sali
Children s National Medical Center, Washington DC, United States of America
PLoS ONE 7:e34204. 2012..Our investigation addressed not only the effects of GC on the disease phenotype but also the question of whether GCs can be used as a positive control for preclinical drug evaluations...
- Preclinical drug trials in the mdx mouse: assessment of reliable and sensitive outcome measuresChristopher F Spurney
Research Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
Muscle Nerve 39:591-602. 2009..These data provide an experimental basis upon which standardization of preclinical drug testing can be developed. Muscle Nerve, 2008...
- d-Propranolol protects against oxidative stress and progressive cardiac dysfunction in iron overloaded ratsJay H Kramer
Biochemistry and Molecular Biology, Division of Experimental Medicine, The George Washington University Medical Center, Washington, DC 20037, USA
Can J Physiol Pharmacol 90:1257-68. 2012..Since d-Pro is an antioxidant and reduces cardiac Fe uptake as well as inflammation, these properties may preserve cardiac function during Fe overload...
- High-frequency ultrasound database profiling growth, development, and cardiovascular function in C57BL/6J mouse fetusesChristopher F Spurney
Department of Cardiology, Children's National Medical Center, Washington, DC 20010, USA
J Am Soc Echocardiogr 17:893-900. 2004..Spectral Doppler was readily obtained and the myocardial performance index was calculated. CONCLUSIONS: These results provide an essential foundation for the evaluation of cardiovascular defects in mutagenized and transgenic mice...
- Demographics, trends, and outcomes in pediatric acute myocarditis in the United States, 2006 to 2011Sunil J Ghelani
Division of Cardiology, Division of Critical Care Medicine, and Clinical Data Operations, Children s National Medical Center, Washington, DC 20010, USA
Circ Cardiovasc Qual Outcomes 5:622-7. 2012..There is a lack of clear diagnostic and management guidelines for acute myocarditis in the pediatric population. We used a multi-institutional database to characterize demographics, practice variability, and outcomes in this population...
- Use of a hand-carried ultrasound device by critical care physicians for the diagnosis of pericardial effusions, decreased cardiac function, and left ventricular enlargement in pediatric patientsChristopher F Spurney
Department of Cardiology, Childrden's National Medical Center, Washington, DC 20010, USA
J Am Soc Echocardiogr 18:313-9. 2005..Left ventricular systolic function was correctly diagnosed in 22 of 23 patients (96%). These results show that, with appropriate instruction, pediatric critical care physicians are effective using limited portable echocardiography...
- The EGFR tyrosine kinase inhibitor tyrphostin AG-1478 causes hypomagnesemia and cardiac dysfunctionWilliam B Weglicki
Department of Biochemistry and Molecular Biology, Division of Experimental Medicine, The George Washington University, Washington, DC 20037, USA
Can J Physiol Pharmacol 90:1145-9. 2012..Since hypomagnesemia alone can trigger oxidative stress and cardiac injury, we suggest that inhibition of EGFR-TK caused magnesium wasting, which partly contributed to decreased cardiac contractility...
- CINRG pilot trial of coenzyme Q10 in steroid-treated Duchenne muscular dystrophyChristopher F Spurney
Children s National Medical Center, George Washington University, Washington, DC, USA
Muscle Nerve 44:174-8. 2011..Corticosteroid treatment slows disease progression and is the standard of care for Duchenne muscular dystrophy (DMD). Coenzyme Q10 (CoQ10) is a potent antioxidant that may improve function in dystrophin-deficient muscle...
- Quercetin and ethanol attenuate the progression of atherosclerotic plaques with concomitant up regulation of paraoxonase1 (PON1) gene expression and PON1 activity in LDLR-/- miceLeslie C Leckey
The Lipid Research Laboratory, Veterans Affairs Medical Center, Washington, District of Columbia 20422, USA
Alcohol Clin Exp Res 34:1535-42. 2010..Our objective is to demonstrate the potential benefits of the wine components, quercetin and ethanol, on the development of aortic plaques with parallel changes in antiatherogenic factors...
- Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomerBo Wu
McColl Lockwood Laboratory for Muscular Dystrophy, Neuromuscular ALS Center, Carolinas Medical Center, Charlotte, NC 28231, USA
Proc Natl Acad Sci U S A 105:14814-9. 2008..The high degree of potency of the oligomer in targeting all muscles and the lack of detectable toxicity and immune response support the feasibility of testing the novel oligomer in treating Duchenne muscular dystrophy patients...