D Skoner

Summary

Affiliation: Children's Hospital of Pittsburgh
Country: USA

Publications

  1. ncbi Montelukast in 2- to 5-year-old children with asthma
    D Skoner
    Department of Allergy and Immunology, Children s Hospital of Pittsburgh, 3705 Fifth Ave, 4B 320, Pittsburgh, PA 15213, USA
    Pediatr Pulmonol Suppl 21:46-8. 2001
  2. ncbi Balancing safety and efficacy in pediatric asthma management
    David P Skoner
    Section of Allergy and Immunology, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Pediatrics 109:381-92. 2002
  3. ncbi Evidence for cytokine mediation of disease expression in adults experimentally infected with influenza A virus
    D P Skoner
    Department of Pediatrics, Allergy Immunology Section, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    J Infect Dis 180:10-4. 1999
  4. ncbi Detection of growth suppression in children during treatment with intranasal beclomethasone dipropionate
    D P Skoner
    Children s Hospital, Pittsburgh, Pennsylvania 15231, USA
    Pediatrics 105:E23. 2000
  5. ncbi Growth effects of asthma and asthma therapy
    David P Skoner
    Pediatrics and Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 2583, USA
    Curr Opin Pulm Med 8:45-9. 2002
  6. ncbi The effects of intranasal triamcinolone acetonide and intranasal fluticasone propionate on short-term bone growth and HPA axis in children with allergic rhinitis
    David P Skoner
    Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Ann Allergy Asthma Immunol 90:56-62. 2003
  7. ncbi Outcome measures in childhood asthma
    David P Skoner
    Sections of Allergy and Immunology, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Pediatrics 109:393-8. 2002
  8. ncbi Increased interleukin-6 levels in nasal lavage samples following experimental influenza A virus infection
    D Gentile
    Department of Pediatrics, The Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
    Clin Diagn Lab Immunol 5:604-8. 1998
  9. ncbi Inhaled steroids and the risk of adrenal suppression in children
    Jamar D Robinson
    Children's Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Expert Opin Drug Saf 1:237-44. 2002
  10. ncbi Association between TNF-alpha and TGF-beta genotypes in infants and parental history of allergic rhinitis and asthma
    Deborah A Gentile
    Department of Pediatrics, Allegheny General Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA 15212, USA
    Hum Immunol 65:347-51. 2004

Detail Information

Publications32

  1. ncbi Montelukast in 2- to 5-year-old children with asthma
    D Skoner
    Department of Allergy and Immunology, Children s Hospital of Pittsburgh, 3705 Fifth Ave, 4B 320, Pittsburgh, PA 15213, USA
    Pediatr Pulmonol Suppl 21:46-8. 2001
    ..A 4-mg chewable tablet administered once daily was determined to be the correct dose and was subsequently found to be safe and effective in asthmatic children 2-5 years of age...
  2. ncbi Balancing safety and efficacy in pediatric asthma management
    David P Skoner
    Section of Allergy and Immunology, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Pediatrics 109:381-92. 2002
    ..Physicians must evaluate and compare the balance of safety and efficacy for each agent to determine the appropriate asthma therapy for individual patients...
  3. ncbi Evidence for cytokine mediation of disease expression in adults experimentally infected with influenza A virus
    D P Skoner
    Department of Pediatrics, Allergy Immunology Section, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    J Infect Dis 180:10-4. 1999
    ..These data support a causal relationship between viral replication, cytokine production, and symptom expression, and they suggest that IL-6 may have a role in mediating symptom and sign expression during influenza A infection...
  4. ncbi Detection of growth suppression in children during treatment with intranasal beclomethasone dipropionate
    D P Skoner
    Children s Hospital, Pittsburgh, Pennsylvania 15231, USA
    Pediatrics 105:E23. 2000
    ..This study was undertaken to assess the effects of 1 year of treatment with intranasal BDP on growth in children...
  5. ncbi Growth effects of asthma and asthma therapy
    David P Skoner
    Pediatrics and Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 2583, USA
    Curr Opin Pulm Med 8:45-9. 2002
    ..Ultimately, no child whose disease severity warrants ICS therapy should be denied the tremendous benefits that this therapy can provide because of relatively minor concerns about growth effects...
  6. ncbi The effects of intranasal triamcinolone acetonide and intranasal fluticasone propionate on short-term bone growth and HPA axis in children with allergic rhinitis
    David P Skoner
    Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Ann Allergy Asthma Immunol 90:56-62. 2003
    ....
  7. ncbi Outcome measures in childhood asthma
    David P Skoner
    Sections of Allergy and Immunology, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Pediatrics 109:393-8. 2002
    ..Whether 1 or more of these outcome measures will prove useful clinically in improving the diagnosis and management of childhood asthma remains uncertain, although early research results are encouraging...
  8. ncbi Increased interleukin-6 levels in nasal lavage samples following experimental influenza A virus infection
    D Gentile
    Department of Pediatrics, The Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
    Clin Diagn Lab Immunol 5:604-8. 1998
    ..These results suggest a role for locally produced IL-6 in the pathogenesis and expressed symptomatology of influenza A virus infection...
  9. ncbi Inhaled steroids and the risk of adrenal suppression in children
    Jamar D Robinson
    Children's Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Expert Opin Drug Saf 1:237-44. 2002
    ..This review will discuss adrenal suppression found with common ICS...
  10. ncbi Association between TNF-alpha and TGF-beta genotypes in infants and parental history of allergic rhinitis and asthma
    Deborah A Gentile
    Department of Pediatrics, Allegheny General Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA 15212, USA
    Hum Immunol 65:347-51. 2004
    ..If confirmed by future studies, cytokine genotyping may be a useful tool for identifying at-risk infants who may benefit from the selective use of preventative and/or early intervention treatments for these disorders...
  11. ncbi Diminished dendritic cell interleukin 10 production in atopic children
    Deborah A Gentile
    Division of Allergy, Asthma and Immunology, Department of Pediatrics, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    Ann Allergy Asthma Immunol 92:538-44. 2004
    ..Diminished interleukin 10 (IL-10) and/or IL-12 production may contribute to the pathogenesis of asthma and atopy. Dendritic cells (DCs) produce these cytokines and have been implicated in the pathogenesis of these disorders...
  12. ncbi Concerns about intranasal corticosteroids for over-the-counter use: position statement of the Joint Task Force for the American Academy of Allergy, Asthma and Immunology and the American College of Allergy, Asthma and Immunology
    Leonard Bielory
    Department of Medicine, UMDNJ-New Jersey Medical School, Newark, USA
    Ann Allergy Asthma Immunol 96:514-25. 2006
    ..Thus, as stated, we recommend that intranasal corticosteroids remain prescription-only drugs...
  13. ncbi Evaluation of levalbuterol metered dose inhaler in pediatric patients with asthma: a double-blind, randomized, placebo- and active-controlled trial
    William E Berger
    Allergy and Asthma Associates of Southern California, Mission Viejo, CA, USA
    Curr Med Res Opin 22:1217-26. 2006
    ..CONCLUSIONS: In this study, levalbuterol administered via MDI significantly improved airway function in comparison with placebo in asthmatic children aged 4-11 years with a safety profile that was similar to placebo...
  14. ncbi Assessment of the long-term safety of inhaled ciclesonide on growth in children with asthma
    David P Skoner
    Allegheny General Hospital, Department of Pediatrics, 320 E North Ave, South Tower, Seventh Floor, Pittsburgh, PA 15212, USA
    Pediatrics 121:e1-14. 2008
    ..To assess the effects of the new inhaled corticosteroid ciclesonide on growth in children with asthma...
  15. ncbi The Inhaled Steroid Treatment As Regular Therapy in Early Asthma (START) study 5-year follow-up: effectiveness of early intervention with budesonide in mild persistent asthma
    William W Busse
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, J5 219 CSC, Box 2454, 600 Highland Ave, Madison, WI 53792, USA
    J Allergy Clin Immunol 121:1167-74. 2008
    ....
  16. ncbi Emotional style and susceptibility to the common cold
    Sheldon Cohen
    Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213 3890, USA
    Psychosom Med 65:652-7. 2003
    ..We tested these hypotheses for host resistance to the common cold...
  17. ncbi Effect on growth of long-term treatment with intranasal triamcinolone acetonide aqueous in children with allergic rhinitis
    David P Skoner
    Division of Allergy, Asthma, and Immunology, Department of Pediatrics, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    Ann Allergy Asthma Immunol 101:431-6. 2008
    ..Guidelines recommend treatment with intranasal corticosteroids for patients with allergic rhinitis (AR), but concerns remain about possible adverse effects...
  18. ncbi Cytokine gene polymorphisms moderate illness severity in infants with respiratory syncytial virus infection
    Deborah A Gentile
    Department of Pediatrics, Children s Hospital of Pittsburgh, PA 15213, USA
    Hum Immunol 64:338-44. 2003
    ..If future prospective studies confirm these observations, cytokine genotyping may be a useful tool for identifying "at risk" infants who may benefit from the selective use of preventive or early intervention treatments for RSV...
  19. ncbi Effect of respiratory syncytial virus infection during early infancy on the ontogeny of cytokine immune responses
    Deborah A Gentile
    Department of Pediatrics, Children's Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Allergy Asthma Proc 23:399-405. 2002
    ..Such strategies may include administration of IL-12 or manipulation of DC maturation or function...
  20. ncbi Nasal and oral nitric oxide levels during experimental respiratory syncytial virus infection of adults
    Deborah A Gentile
    Department of Pediatrics, Children s Hospital of Pittsburgh and the University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Acta Otolaryngol 122:61-6. 2002
    ..These results do not support the hypothesis of increased NO production during RSV infection and complement earlier studies that reported a lack of change in nasal NO concentration during experimental influenza and rhinovirus infections...
  21. ncbi Cytokine gene polymorphisms moderate responses to respiratory syncytial virus in adults
    Deborah A Gentile
    Department of Pediatrics, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Hum Immunol 64:93-8. 2003
    ..These results suggest that certain cytokine gene polymorphisms moderate immune responses and illness severity in adults experimentally exposed to RSV...
  22. ncbi Nasal and otologic effects of experimental respiratory syncytial virus infection in adults
    Craig A Buchman
    Department of Otolaryngology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA
    Am J Otolaryngol 23:70-5. 2002
    ..These findings provide further support for the relationship between viral upper respiratory tract infections and otitis media...
  23. ncbi A randomized, double-blind, parallel-group, multicenter, placebo-controlled study of the safety and efficacy of extended-release guaifenesin/pseudoephedrine hydrochloride for symptom relief as an adjunctive therapy to antibiotic treatment of acute respira
    Craig LaForce
    North Carolina Clinical Research Inc, Raleigh, NC, USA
    Postgrad Med 120:53-9. 2008
    ....
  24. ncbi Use of intranasal cromolyn sodium for allergic rhinitis
    Paul H Ratner
    Sylvana Research Associates and Department of Pediatrics, University of Texas Health Science Center, San Antonio, USA
    Mayo Clin Proc 77:350-4. 2002
    ..Intranasal cromolyn has an excellent safety record, is available as an over-the-counter medication, and has been proved to be efficacious in patients with allergic rhinitis...
  25. ncbi Allergy skin test responses during experimental infection with respiratory syncytial virus
    David P Skoner
    Department of Pediatrics, Allegheny Singer Research Institute, Pittsburgh, Pennsylvania 15212, USA
    Ann Allergy Asthma Immunol 96:834-9. 2006
    ..CONCLUSION: These results may have implications for explaining the cause of such well-known complications of RSV infection as otitis media, bronchiolitis, and asthmatic exacerbation...
  26. ncbi Viral infection and allergy: lower airway
    David P Skoner
    Department of Pediatrics and Otolaryngology, University of Pittsburgh School of Medicine, Department of Allergy and Immunology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Allergy Asthma Proc 23:229-32. 2002
    ..Undoubtedly, future efforts will be aimed at the prevention of asthma exacerbations via well-targeted and well-conceived strategies for prevention and/or treatment of upper respiratory infections...
  27. ncbi Evaluation of the safety and efficacy of levalbuterol in 2-5-year-old patients with asthma
    David P Skoner
    Allegheny General Hospital, Division of Allergy, Asthma and Immunology, Pittsburgh, Pennsylvania, USA
    Pediatr Pulmonol 40:477-86. 2005
    ..In this study of levalbuterol in children aged 2-5 years with asthma, LEV was generally well-tolerated, and in children able to perform PEF, led to significant bronchodilation compared with placebo...
  28. ncbi Nasal cytokines as mediators of illness during the common cold
    William J Doyle
    Allegheny Hospital, 320 East North Avenue, Pittsburgh, PA 15212, USA
    Curr Allergy Asthma Rep 5:173-81. 2005
    ..The available evidence for mediation of the common cold is the subject of this manuscript...
  29. ncbi State and trait affect as predictors of salivary cortisol in healthy adults
    Deborah E Polk
    Psychology Department, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA
    Psychoneuroendocrinology 30:261-72. 2005
    ..Differences in rhythmicity found here are noteworthy given the possible role of cortisol dysregulation in disease incidence, morbidity, mortality, and severity...
  30. ncbi New enzyme immunoassay for salivary cortisol
    Hershel Raff
    Clin Chem 49:203-4. 2003
  31. ncbi Elevations of local leukotriene C4 levels during viral upper respiratory tract infections
    Deborah A Gentile
    Department of Pediatrics, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    Ann Allergy Asthma Immunol 91:270-4. 2003
    ..One potential mechanism by which respiratory viruses trigger illness and complications is via the local elaboration of inflammatory mediators...
  32. ncbi Comparison of subject-reported allergy versus skin test results in a common cold trial
    Jason S Krahnke
    Department of Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Rhinol 17:159-62. 2003
    ..These results have implications in both clinical practice and research settings...