Affiliation: Children's Hospital of Pittsburgh
- Montelukast in 2- to 5-year-old children with asthmaD Skoner
Department of Allergy and Immunology, Children s Hospital of Pittsburgh, 3705 Fifth Ave, 4B 320, Pittsburgh, PA 15213, USA
Pediatr Pulmonol Suppl 21:46-8. 2001..A 4-mg chewable tablet administered once daily was determined to be the correct dose and was subsequently found to be safe and effective in asthmatic children 2-5 years of age...
- Balancing safety and efficacy in pediatric asthma managementDavid P Skoner
Section of Allergy and Immunology, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Pediatrics 109:381-92. 2002..Physicians must evaluate and compare the balance of safety and efficacy for each agent to determine the appropriate asthma therapy for individual patients...
- Evidence for cytokine mediation of disease expression in adults experimentally infected with influenza A virusD P Skoner
Department of Pediatrics, Allergy Immunology Section, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
J Infect Dis 180:10-4. 1999..These data support a causal relationship between viral replication, cytokine production, and symptom expression, and they suggest that IL-6 may have a role in mediating symptom and sign expression during influenza A infection...
- Detection of growth suppression in children during treatment with intranasal beclomethasone dipropionateD P Skoner
Children s Hospital, Pittsburgh, Pennsylvania 15231, USA
Pediatrics 105:E23. 2000..This study was undertaken to assess the effects of 1 year of treatment with intranasal BDP on growth in children...
- Growth effects of asthma and asthma therapyDavid P Skoner
Pediatrics and Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 2583, USA
Curr Opin Pulm Med 8:45-9. 2002..Ultimately, no child whose disease severity warrants ICS therapy should be denied the tremendous benefits that this therapy can provide because of relatively minor concerns about growth effects...
- The effects of intranasal triamcinolone acetonide and intranasal fluticasone propionate on short-term bone growth and HPA axis in children with allergic rhinitisDavid P Skoner
Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Ann Allergy Asthma Immunol 90:56-62. 2003....
- Outcome measures in childhood asthmaDavid P Skoner
Sections of Allergy and Immunology, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Pediatrics 109:393-8. 2002..Whether 1 or more of these outcome measures will prove useful clinically in improving the diagnosis and management of childhood asthma remains uncertain, although early research results are encouraging...
- Increased interleukin-6 levels in nasal lavage samples following experimental influenza A virus infectionD Gentile
Department of Pediatrics, The Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
Clin Diagn Lab Immunol 5:604-8. 1998..These results suggest a role for locally produced IL-6 in the pathogenesis and expressed symptomatology of influenza A virus infection...
- Inhaled steroids and the risk of adrenal suppression in childrenJamar D Robinson
Children's Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
Expert Opin Drug Saf 1:237-44. 2002..This review will discuss adrenal suppression found with common ICS...
- Association between TNF-alpha and TGF-beta genotypes in infants and parental history of allergic rhinitis and asthmaDeborah A Gentile
Department of Pediatrics, Allegheny General Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA 15212, USA
Hum Immunol 65:347-51. 2004..If confirmed by future studies, cytokine genotyping may be a useful tool for identifying at-risk infants who may benefit from the selective use of preventative and/or early intervention treatments for these disorders...
- Diminished dendritic cell interleukin 10 production in atopic childrenDeborah A Gentile
Division of Allergy, Asthma and Immunology, Department of Pediatrics, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
Ann Allergy Asthma Immunol 92:538-44. 2004..Diminished interleukin 10 (IL-10) and/or IL-12 production may contribute to the pathogenesis of asthma and atopy. Dendritic cells (DCs) produce these cytokines and have been implicated in the pathogenesis of these disorders...
- Concerns about intranasal corticosteroids for over-the-counter use: position statement of the Joint Task Force for the American Academy of Allergy, Asthma and Immunology and the American College of Allergy, Asthma and ImmunologyLeonard Bielory
Department of Medicine, UMDNJ-New Jersey Medical School, Newark, USA
Ann Allergy Asthma Immunol 96:514-25. 2006..Thus, as stated, we recommend that intranasal corticosteroids remain prescription-only drugs...
- Evaluation of levalbuterol metered dose inhaler in pediatric patients with asthma: a double-blind, randomized, placebo- and active-controlled trialWilliam E Berger
Allergy and Asthma Associates of Southern California, Mission Viejo, CA, USA
Curr Med Res Opin 22:1217-26. 2006..CONCLUSIONS: In this study, levalbuterol administered via MDI significantly improved airway function in comparison with placebo in asthmatic children aged 4-11 years with a safety profile that was similar to placebo...
- Assessment of the long-term safety of inhaled ciclesonide on growth in children with asthmaDavid P Skoner
Allegheny General Hospital, Department of Pediatrics, 320 E North Ave, South Tower, Seventh Floor, Pittsburgh, PA 15212, USA
Pediatrics 121:e1-14. 2008..To assess the effects of the new inhaled corticosteroid ciclesonide on growth in children with asthma...
- The Inhaled Steroid Treatment As Regular Therapy in Early Asthma (START) study 5-year follow-up: effectiveness of early intervention with budesonide in mild persistent asthmaWilliam W Busse
Department of Medicine, University of Wisconsin School of Medicine and Public Health, J5 219 CSC, Box 2454, 600 Highland Ave, Madison, WI 53792, USA
J Allergy Clin Immunol 121:1167-74. 2008....
- Emotional style and susceptibility to the common coldSheldon Cohen
Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213 3890, USA
Psychosom Med 65:652-7. 2003..We tested these hypotheses for host resistance to the common cold...
- Effect on growth of long-term treatment with intranasal triamcinolone acetonide aqueous in children with allergic rhinitisDavid P Skoner
Division of Allergy, Asthma, and Immunology, Department of Pediatrics, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
Ann Allergy Asthma Immunol 101:431-6. 2008..Guidelines recommend treatment with intranasal corticosteroids for patients with allergic rhinitis (AR), but concerns remain about possible adverse effects...
- Cytokine gene polymorphisms moderate illness severity in infants with respiratory syncytial virus infectionDeborah A Gentile
Department of Pediatrics, Children s Hospital of Pittsburgh, PA 15213, USA
Hum Immunol 64:338-44. 2003..If future prospective studies confirm these observations, cytokine genotyping may be a useful tool for identifying "at risk" infants who may benefit from the selective use of preventive or early intervention treatments for RSV...
- Effect of respiratory syncytial virus infection during early infancy on the ontogeny of cytokine immune responsesDeborah A Gentile
Department of Pediatrics, Children's Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
Allergy Asthma Proc 23:399-405. 2002..Such strategies may include administration of IL-12 or manipulation of DC maturation or function...
- Nasal and oral nitric oxide levels during experimental respiratory syncytial virus infection of adultsDeborah A Gentile
Department of Pediatrics, Children s Hospital of Pittsburgh and the University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
Acta Otolaryngol 122:61-6. 2002..These results do not support the hypothesis of increased NO production during RSV infection and complement earlier studies that reported a lack of change in nasal NO concentration during experimental influenza and rhinovirus infections...
- Cytokine gene polymorphisms moderate responses to respiratory syncytial virus in adultsDeborah A Gentile
Department of Pediatrics, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
Hum Immunol 64:93-8. 2003..These results suggest that certain cytokine gene polymorphisms moderate immune responses and illness severity in adults experimentally exposed to RSV...
- Nasal and otologic effects of experimental respiratory syncytial virus infection in adultsCraig A Buchman
Department of Otolaryngology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA
Am J Otolaryngol 23:70-5. 2002..These findings provide further support for the relationship between viral upper respiratory tract infections and otitis media...
- A randomized, double-blind, parallel-group, multicenter, placebo-controlled study of the safety and efficacy of extended-release guaifenesin/pseudoephedrine hydrochloride for symptom relief as an adjunctive therapy to antibiotic treatment of acute respiraCraig LaForce
North Carolina Clinical Research Inc, Raleigh, NC, USA
Postgrad Med 120:53-9. 2008....
- Use of intranasal cromolyn sodium for allergic rhinitisPaul H Ratner
Sylvana Research Associates and Department of Pediatrics, University of Texas Health Science Center, San Antonio, USA
Mayo Clin Proc 77:350-4. 2002..Intranasal cromolyn has an excellent safety record, is available as an over-the-counter medication, and has been proved to be efficacious in patients with allergic rhinitis...
- Allergy skin test responses during experimental infection with respiratory syncytial virusDavid P Skoner
Department of Pediatrics, Allegheny Singer Research Institute, Pittsburgh, Pennsylvania 15212, USA
Ann Allergy Asthma Immunol 96:834-9. 2006..CONCLUSION: These results may have implications for explaining the cause of such well-known complications of RSV infection as otitis media, bronchiolitis, and asthmatic exacerbation...
- Viral infection and allergy: lower airwayDavid P Skoner
Department of Pediatrics and Otolaryngology, University of Pittsburgh School of Medicine, Department of Allergy and Immunology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
Allergy Asthma Proc 23:229-32. 2002..Undoubtedly, future efforts will be aimed at the prevention of asthma exacerbations via well-targeted and well-conceived strategies for prevention and/or treatment of upper respiratory infections...
- Evaluation of the safety and efficacy of levalbuterol in 2-5-year-old patients with asthmaDavid P Skoner
Allegheny General Hospital, Division of Allergy, Asthma and Immunology, Pittsburgh, Pennsylvania, USA
Pediatr Pulmonol 40:477-86. 2005..In this study of levalbuterol in children aged 2-5 years with asthma, LEV was generally well-tolerated, and in children able to perform PEF, led to significant bronchodilation compared with placebo...
- Nasal cytokines as mediators of illness during the common coldWilliam J Doyle
Allegheny Hospital, 320 East North Avenue, Pittsburgh, PA 15212, USA
Curr Allergy Asthma Rep 5:173-81. 2005..The available evidence for mediation of the common cold is the subject of this manuscript...
- State and trait affect as predictors of salivary cortisol in healthy adultsDeborah E Polk
Psychology Department, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA
Psychoneuroendocrinology 30:261-72. 2005..Differences in rhythmicity found here are noteworthy given the possible role of cortisol dysregulation in disease incidence, morbidity, mortality, and severity...
- New enzyme immunoassay for salivary cortisolHershel Raff
Clin Chem 49:203-4. 2003
- Elevations of local leukotriene C4 levels during viral upper respiratory tract infectionsDeborah A Gentile
Department of Pediatrics, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
Ann Allergy Asthma Immunol 91:270-4. 2003..One potential mechanism by which respiratory viruses trigger illness and complications is via the local elaboration of inflammatory mediators...
- Comparison of subject-reported allergy versus skin test results in a common cold trialJason S Krahnke
Department of Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
Am J Rhinol 17:159-62. 2003..These results have implications in both clinical practice and research settings...