Sylvia T Singer

Summary

Affiliation: Children's Hospital and Research Center
Country: USA

Publications

  1. ncbi request reprint Fetal haemoglobin augmentation in E/beta(0) thalassaemia: clinical and haematological outcome
    Sylvia T Singer
    Children s Hospital and Research Center at Oakland, CA 94609, USA
    Br J Haematol 131:378-88. 2005
  2. doi request reprint Variable clinical phenotypes of alpha-thalassemia syndromes
    Sylvia Titi Singer
    Hematology Oncology Department, Children s Hospital and Research Center CHRCO, Oakland, CA, USA
    ScientificWorldJournal 9:615-25. 2009
  3. pmc Hydroxycarbamide-induced changes in E/beta thalassemia red blood cells
    Sylvia T Singer
    Hematology Oncology Department and Clinical Research Center at Oakland, CA, USA
    Am J Hematol 83:842-5. 2008
  4. pmc Reproductive capacity in iron overloaded women with thalassemia major
    Sylvia T Singer
    Department of Hematology Oncology, Children s Hospital and Research Center, Oakland, CA 94609, USA
    Blood 118:2878-81. 2011
  5. ncbi request reprint Pulmonary hypertension in thalassemia: association with platelet activation and hypercoagulable state
    Sylvia T Singer
    Children s Hospital and Research Center at Oakland, Hematology Oncology Department, Oakland, CA 94609 1808, USA
    Am J Hematol 81:670-5. 2006
  6. ncbi request reprint Single and combination drug therapy for fetal hemoglobin augmentation in hemoglobin E-beta 0-thalassemia: Considerations for treatment
    Sylvia T Singer
    Children s Hospital and Research Center at Oakland, 747 52nd St, Oakland, CA 94609, USA
    Ann N Y Acad Sci 1054:250-6. 2005
  7. doi request reprint Heterogeneity of hemoglobin H disease in childhood
    Ashutosh Lal
    Hematology Oncology, Children s Hospital and Research Center Oakland, Oakland, CA 94609, USA
    N Engl J Med 364:710-8. 2011
  8. ncbi request reprint Clinical hemoglobinopathies: iron, lungs and new blood
    Claudia R Morris
    Children s Hospital and Research Center Oakland, Oakland, CA 94609, USA
    Curr Opin Hematol 13:407-18. 2006
  9. doi request reprint Fertility potential in thalassemia major women: current findings and future diagnostic tools
    Sylvia T Singer
    Hematology Oncology Department, Children s Hospital and Research Center at Oakland, California, USA
    Ann N Y Acad Sci 1202:226-30. 2010
  10. ncbi request reprint Outcomes of preimplantation genetic diagnosis therapy in treatment of beta-thalassemia: A retrospective analysis
    Naveen Qureshi
    Department of Hematology Oncology, Children s Hospital and Research Center at Oakland, 747 52nd St, 2nd Floor, Oakland, CA 94609, USA
    Ann N Y Acad Sci 1054:500-3. 2005

Research Grants

  1. Pulmonary Hypertension in Thalassemia
    SYLVIA SINGER; Fiscal Year: 2007

Detail Information

Publications11

  1. ncbi request reprint Fetal haemoglobin augmentation in E/beta(0) thalassaemia: clinical and haematological outcome
    Sylvia T Singer
    Children s Hospital and Research Center at Oakland, CA 94609, USA
    Br J Haematol 131:378-88. 2005
    ..Continuous monitoring of toxicity and growth is required...
  2. doi request reprint Variable clinical phenotypes of alpha-thalassemia syndromes
    Sylvia Titi Singer
    Hematology Oncology Department, Children s Hospital and Research Center CHRCO, Oakland, CA, USA
    ScientificWorldJournal 9:615-25. 2009
    ..The high prevalence of the carrier state and the burden of these diseases (and other alpha-thalassemia variants) call for more attention for improved screening methods and better care...
  3. pmc Hydroxycarbamide-induced changes in E/beta thalassemia red blood cells
    Sylvia T Singer
    Hematology Oncology Department and Clinical Research Center at Oakland, CA, USA
    Am J Hematol 83:842-5. 2008
    ..These findings underscore the disappointing results of hydroxyurea treatment in clinical trials and the importance of examining the effect on RBC characteristics for the development and understanding of HbF-enhancing agents...
  4. pmc Reproductive capacity in iron overloaded women with thalassemia major
    Sylvia T Singer
    Department of Hematology Oncology, Children s Hospital and Research Center, Oakland, CA 94609, USA
    Blood 118:2878-81. 2011
    ..AMH can be useful in future studies aiming at improved chelation for fertility preservation, whereas NTBI and labile plasma iron may be valuable for monitoring iron effect on the reproductive system...
  5. ncbi request reprint Pulmonary hypertension in thalassemia: association with platelet activation and hypercoagulable state
    Sylvia T Singer
    Children s Hospital and Research Center at Oakland, Hematology Oncology Department, Oakland, CA 94609 1808, USA
    Am J Hematol 81:670-5. 2006
    ..This study underscores the role of platelet activation in the development of PAH and stresses its occurrence even among patients who are regularly transfused, especially those who are older and have had splenectomies...
  6. ncbi request reprint Single and combination drug therapy for fetal hemoglobin augmentation in hemoglobin E-beta 0-thalassemia: Considerations for treatment
    Sylvia T Singer
    Children s Hospital and Research Center at Oakland, 747 52nd St, Oakland, CA 94609, USA
    Ann N Y Acad Sci 1054:250-6. 2005
    ..After 5 years of follow-up, a subset of patients remained off transfusions. Hydroxyurea should be considered for a subset of Hb E-beta 0-thalassemia patients...
  7. doi request reprint Heterogeneity of hemoglobin H disease in childhood
    Ashutosh Lal
    Hematology Oncology, Children s Hospital and Research Center Oakland, Oakland, CA 94609, USA
    N Engl J Med 364:710-8. 2011
    ..Early diagnosis during newborn screening or infancy has enabled the observation of the natural history of hemoglobin H disease, a subtype of α-thalassemia...
  8. ncbi request reprint Clinical hemoglobinopathies: iron, lungs and new blood
    Claudia R Morris
    Children s Hospital and Research Center Oakland, Oakland, CA 94609, USA
    Curr Opin Hematol 13:407-18. 2006
    ..As a result, chronic health impairments that significantly reduce the quality of life such as pulmonary hypertension and the consequences of transfusional iron overload have become principal challenges...
  9. doi request reprint Fertility potential in thalassemia major women: current findings and future diagnostic tools
    Sylvia T Singer
    Hematology Oncology Department, Children s Hospital and Research Center at Oakland, California, USA
    Ann N Y Acad Sci 1202:226-30. 2010
    ....
  10. ncbi request reprint Outcomes of preimplantation genetic diagnosis therapy in treatment of beta-thalassemia: A retrospective analysis
    Naveen Qureshi
    Department of Hematology Oncology, Children s Hospital and Research Center at Oakland, 747 52nd St, 2nd Floor, Oakland, CA 94609, USA
    Ann N Y Acad Sci 1054:500-3. 2005
    ..Improvements in PGD therapy's efficacy and cost will make this a more viable option for affected families...
  11. ncbi request reprint Measuring chromosome breaks in patients with thalassemia
    Tal Offer
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Ann N Y Acad Sci 1054:439-44. 2005
    ..Our findings indicate that higher levels of micronuclei frequencies are present in thalassemic RBCs...

Research Grants2

  1. Pulmonary Hypertension in Thalassemia
    SYLVIA SINGER; Fiscal Year: 2007
    ....