Research Topics
Genomes and GenesSpecies | Douglas M SilversteinSummaryAffiliation: Children's National Medical Center Country: USA Publications
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Publications
Serum uric acid is associated with high blood pressure in pediatric hemodialysis patientsDouglas M Silverstein
Department of Nephrology, Children s National Medical Center, 111 Michigan Avenue NW, Washington, D C 20010, USA
Pediatr Nephrol 26:1123-8. 2011..01]. Finally, there was no relationship between serum UA and normalized protein catabolic rate (r = 0.14; p = 0.4). In summary, serum UA impacts BP in pediatric HD patients, independent of volume, nutritional and weight status...- Cinacalcet is efficacious in pediatric dialysis patientsDouglas M Silverstein
Children s National Medical Center, Washington, DC, USA
Pediatr Nephrol 23:1817-22. 2008..6 +/- 2.3 pretreatment vs. 4.3 +/- 1.7 micrograms/day posttreatment pg/ml). We conclude that short-term treatment with the calcimimetic cinacalcet is efficacious in adolescent dialysis patients... - Mesangial hypercellularity in children: presenting features and outcomesDouglas M Silverstein
Department of Pediatrics, Louisiana State University Health Sciences Center and Children s Hospital New Orleans, New Orleans, LA 70118, USA
Pediatr Nephrol 23:921-8. 2008..Among those with positive immunofluorescence (IF), 82% had immunoglobulin M (IgM) alone; those with positive IF were more SS and needed Alk for NS. MH predicts a favorable prognosis. FPF predicts NS and multiple relapses... - Inflammation in chronic kidney disease: role in the progression of renal and cardiovascular diseaseDouglas M Silverstein
Department of Nephrology, Children s National Medical Center, 111 Michigan Avenue NW, Washington D C 20010, USA
Pediatr Nephrol 24:1445-52. 2009..This review focuses on traditional and novel mediators of inflammation in CKD and ESKD, and the deleterious effect inflammation has on the progression of renal and cardiovascular disease... - Assessment of relationship between nutrition and growth in pediatric hemodialysis patientsDouglas M Silverstein
Department of Nephrology, Children s National Medical Center, Washington, DC 20010, USA
J Ren Nutr 19:422-31. 2009..We hypothesized that there is a discrepancy among traditional measures of nutrition, and that adequate nutrition may not reliably predict growth... - Outcome of accidental peritoneal dialysis catheter holes or tip exposureDouglas M Silverstein
Division of Nephrology, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
Pediatr Nephrol 25:1147-51. 2010.... - Cause and outcome of central venous catheter infections in paediatric haemodialysis patientsDouglas M Silverstein
Department of Nephrology, Children s National Medical Center, Washington, DC, USA
Nephrol Dial Transplant 25:3332-7. 2010..Paediatric patients with end-stage renal disease often receive haemodialysis (HD) via a central venous catheter (CVC). The most common problem with CVC is infection... 
Tracking of blood pressure and its impact on graft function in pediatric renal transplant patientsDouglas M Silverstein
Division of Nephrology, Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA, USA
Pediatr Transplant 11:860-7. 2007..52 mL/min/1.73 m(2) (high BP throughout), p = 0.02]. We conclude that PT hypertension is common in PRTP and predicts lower GFR...- Malnutrition-inflammation-coronary calcification in pediatric patients receiving chronic hemodialysisPoyyapakkam R Srivaths
Department of Pediatrics, Renal Section, Baylor College of Medicine, Houston, Texas, USA
Hemodial Int 14:263-9. 2010..Coronary calcification was prevalent in older children receiving maintenance hemodialysis with a longer dialysis vintage. Worse renal osteodystrophy control and malnutrition (low cholesterol) may contribute to CC development... - Elevated FGF 23 and phosphorus are associated with coronary calcification in hemodialysis patientsPoyyapakkam R Srivaths
Department of Pediatrics, Renal Section, Baylor College of Medicine, Houston, TX, 77030, USA
Pediatr Nephrol 26:945-51. 2011..This study confirms the occurrence of CC in pediatric HD patients and is the first to show a significant association between CC and elevated serum FGF 23 in children... - Anti-erythropoietin antibodies followed by endogenous erythropoietin production in a dialysis patientParnell Mattison
Department of Nephrology, Children s National Medical Center, Washington, DC 20010, USA
Pediatr Nephrol 25:971-6. 2010..For the following 6 months, the patient maintained adequate (>10 g/dL) hemoglobin levels and did not require red cell transfusions... - NMDA agonists and antagonists induce renal culture cell toxicityJocelyn C Leung
Department of Pediatrics, Louisiana State University Health Sciences Center and Children s Hospital, New Orleans, Louisiana 70112, USA
Med Chem 4:565-71. 2008..Finally, pre-treatment of OK cells with the renal cytoprotective glycine completely blunted the affect of MK-801 on renal cell survival. We conclude that excessive stimulation or blockade of the renal NMDAR results in cell death... - Results of one-year follow-up of steroid-free immunosuppression in pediatric renal transplant patientsDouglas M Silverstein
Division of Nephrology, Department of Pediatrics, Louisiana State University Health Sciences Center and Children s Hospital, New Orleans, LA 70124, USA
Pediatr Transplant 9:589-97. 2005..Taken together, our data suggests that at one-year follow-up, steroid-free immunosuppression is safe, and efficacious in pediatric renal transplant recipients... - Frequent hemodialysis with NxStage system in pediatric patients receiving maintenance hemodialysisStuart L Goldstein
Department of Pediatrics, Renal, Baylor College of Medicine, Houston, TX, USA
Pediatr Nephrol 23:129-35. 2008..Variable changes in proinflammatory cytokine levels were observed. We suggest that frequent HD with the NxStage system be considered for children who would benefit from home-based maintenance dialysis... - Assessment of risk factors for cardiovasuclar disease in pediatric renal transplant patientsDouglas M Silverstein
Department of Pediatrics, Division of Nephrology, Louisiana State University Health Sciences Center, New Orleans, LA, USA
Pediatr Transplant 11:721-9. 2007..Similarly, SBP and DBP trended higher and CHOL was significantly higher in patients receiving SRL vs. mycophenolate mofetil. We conclude that the majority of pediatric renal TP patients exhibit multiple CVD RF... - Pro- and anti-inflammatory cytokines in chronic pediatric dialysis patients: effect of aspirinStuart L Goldstein
Department of Pediatrics, Renal Section, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas, USA
Clin J Am Soc Nephrol 1:979-86. 2006..It is concluded that proinflammatory cytokines are elevated in pediatric HD and PD patients without counterbalance from anti-inflammatory cytokines, and aspirin therapy attenuates inflammation... - Treatment of primary and secondary hypertension in childrenDouglas M Silverstein
Department of Pediatrics, Division of Nephrology, Louisiana State University Health Sciences Center, New Orleans, LA, USA
Pediatr Nephrol 21:820-7. 2006..We conclude that (1) significant lowering of BP with either CCB or ACEI is achievable in most children with HTN, and (2) SH patients respond better to therapy than those with PH... - High incidence of initial and late steroid resistance in childhood nephrotic syndromeJung Sue Kim
Department of Pediatrics, Louisiana State University Health Sciences Center and Children's Hospital, New Orleans, Louisiana 70118, USA
Kidney Int 68:1275-81. 2005..The results suggest that in the current era, NS in children may not be as benign as indicated by earlier studies... - Does pravastatin safely and effectively improve lipid profiles in children who have received a kidney transplant?Douglas M Silverstein
Division of Nephrology, Department of Pediatrics, Louisiana State University, Health Sciences Center and Children s Hospital, New Orleans, LA 70124, USA
Nat Clin Pract Nephrol 2:306-7. 2006 - Altered NMDA receptor expression in renal toxicity: Protection with a receptor antagonistJocelyn C Leung
Department of Pediatrics, Division of Neonatology and Division of Nephrology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
Kidney Int 66:167-76. 2004..NMDA antagonism ameliorated renal damage after exposure to short-term gentamicin... - Risk factors for cardiovascular disease in pediatric renal transplant recipientsDouglas M Silverstein
Louisiana State University Health Sciences Center, Department of Pediatrics, Children s Hospital, New Orleans, LA, USA
Pediatr Transplant 8:386-93. 2004.... - Effect of age, ethnicity, and glucocorticoid use on tacrolimus pharmacokinetics in pediatric renal transplant patientsJung Sue Kim
Department of Pediatrics, Louisiana State University Health Sciences Center and Children's Hospital, New Orleans, LA, USA
Pediatr Transplant 9:162-9. 2005..Our results show an inverse correlation between age and required tacrolimus dose, wide interindividual variation, and greater exposure with steroid-free regimen despite no change in trough level... - Parathormone sensitivity and responses to protein kinases in subclones of opossum kidney cellsDouglas M Silverstein
Division of Nephrology, Department of Pediatrics, Health Sciences Center, Louisiana State University, New Orleans, 70118, USA
Pediatr Nephrol 20:721-4. 2005..Finally, Br-cAMP (10(-7) M) inhibited Na-(32)Pi transport by 23%. We conclude that different groups OK cells have markedly different responses to regulators of Na-Pi cotransport... - False-positive human immunodeficiency virus antibody test in a dialysis patientDouglas M Silverstein
Louisiana State University Health Sciences Center, LA 70112, New Orleans, USA
Pediatr Nephrol 19:547-9. 2004..Throughout this period and thereafter, the patient has exhibited no symptoms of HIV infection... - Altered expression of immune modulator and structural genes in neonatal unilateral ureteral obstructionDouglas M Silverstein
Division of Nephrology, Department of Pediatrics, Gene Therapy Program, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70124, USA
Kidney Int 64:25-35. 2003..The renal consequences of chronic unilateral ureteral obstruction (UUO) in the neonatal rat are similar to those of clinical congenital obstructive nephropathy... - Gross hematuria in a young child with axillary lymphadenopathyKelly J Cramm
Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans 70118, USA
Clin Pediatr (Phila) 41:357-9. 2002 - Indications and outcome of treatment of hyperlipidemia in pediatric allograft recipientsDouglas M Silverstein
Pediatr Transplant 7:7-10. 2003