Douglas M Silverstein

Summary

Affiliation: Children's National Medical Center
Country: USA

Publications

  1. doi request reprint Serum uric acid is associated with high blood pressure in pediatric hemodialysis patients
    Douglas M Silverstein
    Department of Nephrology, Children s National Medical Center, 111 Michigan Avenue NW, Washington, D C 20010, USA
    Pediatr Nephrol 26:1123-8. 2011
  2. doi request reprint Cinacalcet is efficacious in pediatric dialysis patients
    Douglas M Silverstein
    Children s National Medical Center, Washington, DC, USA
    Pediatr Nephrol 23:1817-22. 2008
  3. doi request reprint Mesangial hypercellularity in children: presenting features and outcomes
    Douglas M Silverstein
    Department of Pediatrics, Louisiana State University Health Sciences Center and Children s Hospital New Orleans, New Orleans, LA 70118, USA
    Pediatr Nephrol 23:921-8. 2008
  4. doi request reprint Inflammation in chronic kidney disease: role in the progression of renal and cardiovascular disease
    Douglas M Silverstein
    Department of Nephrology, Children s National Medical Center, 111 Michigan Avenue NW, Washington D C 20010, USA
    Pediatr Nephrol 24:1445-52. 2009
  5. doi request reprint Assessment of relationship between nutrition and growth in pediatric hemodialysis patients
    Douglas M Silverstein
    Department of Nephrology, Children s National Medical Center, Washington, DC 20010, USA
    J Ren Nutr 19:422-31. 2009
  6. doi request reprint Outcome of accidental peritoneal dialysis catheter holes or tip exposure
    Douglas M Silverstein
    Division of Nephrology, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Pediatr Nephrol 25:1147-51. 2010
  7. doi request reprint Cause and outcome of central venous catheter infections in paediatric haemodialysis patients
    Douglas M Silverstein
    Department of Nephrology, Children s National Medical Center, Washington, DC, USA
    Nephrol Dial Transplant 25:3332-7. 2010
  8. ncbi request reprint Tracking of blood pressure and its impact on graft function in pediatric renal transplant patients
    Douglas M Silverstein
    Division of Nephrology, Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Pediatr Transplant 11:860-7. 2007
  9. doi request reprint Malnutrition-inflammation-coronary calcification in pediatric patients receiving chronic hemodialysis
    Poyyapakkam R Srivaths
    Department of Pediatrics, Renal Section, Baylor College of Medicine, Houston, Texas, USA
    Hemodial Int 14:263-9. 2010
  10. doi request reprint Elevated FGF 23 and phosphorus are associated with coronary calcification in hemodialysis patients
    Poyyapakkam R Srivaths
    Department of Pediatrics, Renal Section, Baylor College of Medicine, Houston, TX, 77030, USA
    Pediatr Nephrol 26:945-51. 2011

Collaborators

Detail Information

Publications27

  1. doi request reprint Serum uric acid is associated with high blood pressure in pediatric hemodialysis patients
    Douglas M Silverstein
    Department of Nephrology, Children s National Medical Center, 111 Michigan Avenue NW, Washington, D C 20010, USA
    Pediatr Nephrol 26:1123-8. 2011
    ..01]. Finally, there was no relationship between serum UA and normalized protein catabolic rate (r = 0.14; p = 0.4). In summary, serum UA impacts BP in pediatric HD patients, independent of volume, nutritional and weight status...
  2. doi request reprint Cinacalcet is efficacious in pediatric dialysis patients
    Douglas M Silverstein
    Children s National Medical Center, Washington, DC, USA
    Pediatr Nephrol 23:1817-22. 2008
    ..6 +/- 2.3 pretreatment vs. 4.3 +/- 1.7 micrograms/day posttreatment pg/ml). We conclude that short-term treatment with the calcimimetic cinacalcet is efficacious in adolescent dialysis patients...
  3. doi request reprint Mesangial hypercellularity in children: presenting features and outcomes
    Douglas M Silverstein
    Department of Pediatrics, Louisiana State University Health Sciences Center and Children s Hospital New Orleans, New Orleans, LA 70118, USA
    Pediatr Nephrol 23:921-8. 2008
    ..Among those with positive immunofluorescence (IF), 82% had immunoglobulin M (IgM) alone; those with positive IF were more SS and needed Alk for NS. MH predicts a favorable prognosis. FPF predicts NS and multiple relapses...
  4. doi request reprint Inflammation in chronic kidney disease: role in the progression of renal and cardiovascular disease
    Douglas M Silverstein
    Department of Nephrology, Children s National Medical Center, 111 Michigan Avenue NW, Washington D C 20010, USA
    Pediatr Nephrol 24:1445-52. 2009
    ..This review focuses on traditional and novel mediators of inflammation in CKD and ESKD, and the deleterious effect inflammation has on the progression of renal and cardiovascular disease...
  5. doi request reprint Assessment of relationship between nutrition and growth in pediatric hemodialysis patients
    Douglas M Silverstein
    Department of Nephrology, Children s National Medical Center, Washington, DC 20010, USA
    J Ren Nutr 19:422-31. 2009
    ..We hypothesized that there is a discrepancy among traditional measures of nutrition, and that adequate nutrition may not reliably predict growth...
  6. doi request reprint Outcome of accidental peritoneal dialysis catheter holes or tip exposure
    Douglas M Silverstein
    Division of Nephrology, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Pediatr Nephrol 25:1147-51. 2010
    ....
  7. doi request reprint Cause and outcome of central venous catheter infections in paediatric haemodialysis patients
    Douglas M Silverstein
    Department of Nephrology, Children s National Medical Center, Washington, DC, USA
    Nephrol Dial Transplant 25:3332-7. 2010
    ..Paediatric patients with end-stage renal disease often receive haemodialysis (HD) via a central venous catheter (CVC). The most common problem with CVC is infection...
  8. ncbi request reprint Tracking of blood pressure and its impact on graft function in pediatric renal transplant patients
    Douglas M Silverstein
    Division of Nephrology, Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Pediatr Transplant 11:860-7. 2007
    ..52 mL/min/1.73 m(2) (high BP throughout), p = 0.02]. We conclude that PT hypertension is common in PRTP and predicts lower GFR...
  9. doi request reprint Malnutrition-inflammation-coronary calcification in pediatric patients receiving chronic hemodialysis
    Poyyapakkam R Srivaths
    Department of Pediatrics, Renal Section, Baylor College of Medicine, Houston, Texas, USA
    Hemodial Int 14:263-9. 2010
    ..Coronary calcification was prevalent in older children receiving maintenance hemodialysis with a longer dialysis vintage. Worse renal osteodystrophy control and malnutrition (low cholesterol) may contribute to CC development...
  10. doi request reprint Elevated FGF 23 and phosphorus are associated with coronary calcification in hemodialysis patients
    Poyyapakkam R Srivaths
    Department of Pediatrics, Renal Section, Baylor College of Medicine, Houston, TX, 77030, USA
    Pediatr Nephrol 26:945-51. 2011
    ..This study confirms the occurrence of CC in pediatric HD patients and is the first to show a significant association between CC and elevated serum FGF 23 in children...
  11. doi request reprint Anti-erythropoietin antibodies followed by endogenous erythropoietin production in a dialysis patient
    Parnell Mattison
    Department of Nephrology, Children s National Medical Center, Washington, DC 20010, USA
    Pediatr Nephrol 25:971-6. 2010
    ..For the following 6 months, the patient maintained adequate (>10 g/dL) hemoglobin levels and did not require red cell transfusions...
  12. ncbi request reprint NMDA agonists and antagonists induce renal culture cell toxicity
    Jocelyn C Leung
    Department of Pediatrics, Louisiana State University Health Sciences Center and Children s Hospital, New Orleans, Louisiana 70112, USA
    Med Chem 4:565-71. 2008
    ..Finally, pre-treatment of OK cells with the renal cytoprotective glycine completely blunted the affect of MK-801 on renal cell survival. We conclude that excessive stimulation or blockade of the renal NMDAR results in cell death...
  13. ncbi request reprint Results of one-year follow-up of steroid-free immunosuppression in pediatric renal transplant patients
    Douglas M Silverstein
    Division of Nephrology, Department of Pediatrics, Louisiana State University Health Sciences Center and Children s Hospital, New Orleans, LA 70124, USA
    Pediatr Transplant 9:589-97. 2005
    ..Taken together, our data suggests that at one-year follow-up, steroid-free immunosuppression is safe, and efficacious in pediatric renal transplant recipients...
  14. ncbi request reprint Frequent hemodialysis with NxStage system in pediatric patients receiving maintenance hemodialysis
    Stuart L Goldstein
    Department of Pediatrics, Renal, Baylor College of Medicine, Houston, TX, USA
    Pediatr Nephrol 23:129-35. 2008
    ..Variable changes in proinflammatory cytokine levels were observed. We suggest that frequent HD with the NxStage system be considered for children who would benefit from home-based maintenance dialysis...
  15. ncbi request reprint Assessment of risk factors for cardiovasuclar disease in pediatric renal transplant patients
    Douglas M Silverstein
    Department of Pediatrics, Division of Nephrology, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Pediatr Transplant 11:721-9. 2007
    ..Similarly, SBP and DBP trended higher and CHOL was significantly higher in patients receiving SRL vs. mycophenolate mofetil. We conclude that the majority of pediatric renal TP patients exhibit multiple CVD RF...
  16. ncbi request reprint Pro- and anti-inflammatory cytokines in chronic pediatric dialysis patients: effect of aspirin
    Stuart L Goldstein
    Department of Pediatrics, Renal Section, Baylor College of Medicine and Texas Children s Hospital, Houston, Texas, USA
    Clin J Am Soc Nephrol 1:979-86. 2006
    ..It is concluded that proinflammatory cytokines are elevated in pediatric HD and PD patients without counterbalance from anti-inflammatory cytokines, and aspirin therapy attenuates inflammation...
  17. ncbi request reprint Treatment of primary and secondary hypertension in children
    Douglas M Silverstein
    Department of Pediatrics, Division of Nephrology, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Pediatr Nephrol 21:820-7. 2006
    ..We conclude that (1) significant lowering of BP with either CCB or ACEI is achievable in most children with HTN, and (2) SH patients respond better to therapy than those with PH...
  18. ncbi request reprint High incidence of initial and late steroid resistance in childhood nephrotic syndrome
    Jung Sue Kim
    Department of Pediatrics, Louisiana State University Health Sciences Center and Children s Hospital, New Orleans, Louisiana 70118, USA
    Kidney Int 68:1275-81. 2005
    ..Recent reports suggest that the histologic pattern of NS in children may be changing, but whether the change is accompanied by a parallel change in steroid sensitivity is unknown...
  19. ncbi request reprint Does pravastatin safely and effectively improve lipid profiles in children who have received a kidney transplant?
    Douglas M Silverstein
    Division of Nephrology, Department of Pediatrics, Louisiana State University, Health Sciences Center and Children s Hospital, New Orleans, LA 70124, USA
    Nat Clin Pract Nephrol 2:306-7. 2006
  20. ncbi request reprint Altered NMDA receptor expression in renal toxicity: Protection with a receptor antagonist
    Jocelyn C Leung
    Department of Pediatrics, Division of Neonatology and Division of Nephrology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Kidney Int 66:167-76. 2004
    ..The N-methyl-d-aspartate (NMDA) receptor is expressed in the kidney. The receptor plays a major role in gentamicin ototoxicity. We assessed the role of the renal NMDA receptor subunits NR1 and NR2C in a model of gentamicin nephrotoxicity...
  21. ncbi request reprint Risk factors for cardiovascular disease in pediatric renal transplant recipients
    Douglas M Silverstein
    Louisiana State University Health Sciences Center, Department of Pediatrics, Children s Hospital, New Orleans, LA, USA
    Pediatr Transplant 8:386-93. 2004
    ....
  22. ncbi request reprint Effect of age, ethnicity, and glucocorticoid use on tacrolimus pharmacokinetics in pediatric renal transplant patients
    Jung Sue Kim
    Department of Pediatrics, Louisiana State University Health Sciences Center and Children s Hospital, New Orleans, LA, USA
    Pediatr Transplant 9:162-9. 2005
    ..Our results show an inverse correlation between age and required tacrolimus dose, wide interindividual variation, and greater exposure with steroid-free regimen despite no change in trough level...
  23. ncbi request reprint Parathormone sensitivity and responses to protein kinases in subclones of opossum kidney cells
    Douglas M Silverstein
    Division of Nephrology, Department of Pediatrics, Health Sciences Center, Louisiana State University, New Orleans, 70118, USA
    Pediatr Nephrol 20:721-4. 2005
    ..Finally, Br-cAMP (10(-7) M) inhibited Na-(32)Pi transport by 23%. We conclude that different groups OK cells have markedly different responses to regulators of Na-Pi cotransport...
  24. ncbi request reprint False-positive human immunodeficiency virus antibody test in a dialysis patient
    Douglas M Silverstein
    Louisiana State University Health Sciences Center, LA 70112, New Orleans, USA
    Pediatr Nephrol 19:547-9. 2004
    ..Throughout this period and thereafter, the patient has exhibited no symptoms of HIV infection...
  25. ncbi request reprint Altered expression of immune modulator and structural genes in neonatal unilateral ureteral obstruction
    Douglas M Silverstein
    Division of Nephrology, Department of Pediatrics, Gene Therapy Program, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70124, USA
    Kidney Int 64:25-35. 2003
    ..The renal consequences of chronic unilateral ureteral obstruction (UUO) in the neonatal rat are similar to those of clinical congenital obstructive nephropathy...
  26. ncbi request reprint Gross hematuria in a young child with axillary lymphadenopathy
    Kelly J Cramm
    Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans 70118, USA
    Clin Pediatr (Phila) 41:357-9. 2002
  27. ncbi request reprint Indications and outcome of treatment of hyperlipidemia in pediatric allograft recipients
    Douglas M Silverstein
    Pediatr Transplant 7:7-10. 2003