Benjamin Shneider

Summary

Affiliation: Children's Hospital of Pittsburgh
Country: USA

Publications

  1. pmc c-Fos mediates repression of the apical sodium-dependent bile acid transporter by fibroblast growth factor-19 in mice
    Ayantika Ghosh
    Children s Hospital of Pittsburgh of UPMC, Division of Pediatric Gastroenterology, Hepatology and Nutrition, 4401 Penn Ave, Pittsburgh, PA 15224
    Am J Physiol Gastrointest Liver Physiol 306:G163-71. 2014
  2. pmc Portal hypertension in children and young adults with biliary atresia
    Benjamin L Shneider
    Children s Hospital Pittsburgh of UPMC, Division of Pediatric Gastoenterology, Hepatology and Nutrition, PA 15224
    J Pediatr Gastroenterol Nutr 55:567-73. 2012
  3. pmc Efficacy of fat-soluble vitamin supplementation in infants with biliary atresia
    Benjamin L Shneider
    Department of Pediatrics, Children s Hospital Pittsburgh of UPMC, Pittsburgh, PA 15224, USA
    Pediatrics 130:e607-14. 2012
  4. doi request reprint Portal hypertension in children: expert pediatric opinion on the report of the Baveno v Consensus Workshop on Methodology of Diagnosis and Therapy in Portal Hypertension
    Benjamin L Shneider
    Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA
    Pediatr Transplant 16:426-37. 2012
  5. doi request reprint Diagnostic and therapeutic challenges in pediatric primary sclerosing cholangitis
    Benjamin L Shneider
    Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children s Hospital of Pittsburgh of UPMC, 4401 Penn Avenue, Pittsburgh, PA 15224, USA
    Liver Transpl 18:277-81. 2012
  6. ncbi request reprint Biliary atresia: a transplant perspective
    Benjamin L Shneider
    Department of Pediatrics, Thomas E Starzl Transplantation Institute, Children s Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Liver Transpl 13:1482-95. 2007
  7. ncbi request reprint Prospective analysis of nonadherence in autoimmune hepatitis: a common problem
    Nanda Kerkar
    Department of Pediatrics, Division of Pediatric Hepatology, Recanati Miller Transplant Institute, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Pediatr Gastroenterol Nutr 43:629-34. 2006
  8. doi request reprint A retrospective single-center review of primary sclerosing cholangitis in children
    Tamir Miloh
    Department of Pediatrics, and Recanati Miller Transplant Institute, Mount Sinai Hospital, New York, New York, USA
    Clin Gastroenterol Hepatol 7:239-45. 2009
  9. pmc Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group
    Robert H Squires
    University of Pittsburgh, Children s Hospital of Pittsburgh, PA 15213, USA
    J Pediatr 148:652-658. 2006
  10. ncbi request reprint Genetic induction of proinflammatory immunity in children with biliary atresia
    Jorge A Bezerra
    Division of Pediatric Gastroenterology, Children s Hospital Medical Center and University of Cincinnati, Cincinnati, OH 45229, USA
    Lancet 360:1653-9. 2002

Research Grants

  1. Molecular Mechanisms of Intrahepatic Cholestasis
    Benjamin L Shneider; Fiscal Year: 2010
  2. Biliary Atresia Clinical Research Consortium: Pittsburgh
    Benjamin Shneider; Fiscal Year: 2007
  3. MOLECULAR REGULATION OF ILEAL/RENAL BILE ACID TRANSPORT
    Benjamin Shneider; Fiscal Year: 2005
  4. MOLECULAR REGULATION OF ILEAL/RENAL BILE ACID TRANSPORT
    Benjamin Shneider; Fiscal Year: 2006
  5. MOLECULAR REGULATION OF ILEAL/RENAL BILE ACID TRANSPORT
    Benjamin Shneider; Fiscal Year: 2007
  6. MOLECULAR REGULATION OF ILEAL/RENAL BILE ACID TRANSPORT
    Benjamin L Shneider; Fiscal Year: 2010
  7. MOLECULAR REGULATION OF ILEAL/RENAL BILE ACID TRANSPORT
    Benjamin Shneider; Fiscal Year: 2004
  8. MOLECULAR REGULATION OF ILEAL/RENAL BILE ACID TRANSPORT
    Benjamin Shneider; Fiscal Year: 2003
  9. Molecular Mechanisms of Intrahepatic Cholestasis
    Benjamin Shneider; Fiscal Year: 2006
  10. MOLECULAR REGULATION OF ILEAL/RENAL BILE ACID TRANSPORT
    Benjamin Shneider; Fiscal Year: 2006

Collaborators

Detail Information

Publications38

  1. pmc c-Fos mediates repression of the apical sodium-dependent bile acid transporter by fibroblast growth factor-19 in mice
    Ayantika Ghosh
    Children s Hospital of Pittsburgh of UPMC, Division of Pediatric Gastroenterology, Hepatology and Nutrition, 4401 Penn Ave, Pittsburgh, PA 15224
    Am J Physiol Gastrointest Liver Physiol 306:G163-71. 2014
    ..The studies demonstrate that FGF-19 represses the expression of ASBT in the ileum and gallbladder via a signal transduction pathway involving MEK1/2, ERK1/2, JNK1, JNK2, and c-Fos. ..
  2. pmc Portal hypertension in children and young adults with biliary atresia
    Benjamin L Shneider
    Children s Hospital Pittsburgh of UPMC, Division of Pediatric Gastoenterology, Hepatology and Nutrition, PA 15224
    J Pediatr Gastroenterol Nutr 55:567-73. 2012
    ..The Childhood Liver Disease Research and Education Network was used to perform a cross-sectional multicentered analysis of PHT in children with BA...
  3. pmc Efficacy of fat-soluble vitamin supplementation in infants with biliary atresia
    Benjamin L Shneider
    Department of Pediatrics, Children s Hospital Pittsburgh of UPMC, Pittsburgh, PA 15224, USA
    Pediatrics 130:e607-14. 2012
    ..In this prospective multicenter study, we assessed the prevalence of FSV deficiency in infants with BA who received this FSV/TPGS preparation...
  4. doi request reprint Portal hypertension in children: expert pediatric opinion on the report of the Baveno v Consensus Workshop on Methodology of Diagnosis and Therapy in Portal Hypertension
    Benjamin L Shneider
    Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA
    Pediatr Transplant 16:426-37. 2012
    ..The opinions of that expert panel are reported...
  5. doi request reprint Diagnostic and therapeutic challenges in pediatric primary sclerosing cholangitis
    Benjamin L Shneider
    Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children s Hospital of Pittsburgh of UPMC, 4401 Penn Avenue, Pittsburgh, PA 15224, USA
    Liver Transpl 18:277-81. 2012
    ..This review summarizes current challenges in the diagnosis and treatment of this rare form of pediatric liver disease...
  6. ncbi request reprint Biliary atresia: a transplant perspective
    Benjamin L Shneider
    Department of Pediatrics, Thomas E Starzl Transplantation Institute, Children s Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Liver Transpl 13:1482-95. 2007
  7. ncbi request reprint Prospective analysis of nonadherence in autoimmune hepatitis: a common problem
    Nanda Kerkar
    Department of Pediatrics, Division of Pediatric Hepatology, Recanati Miller Transplant Institute, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Pediatr Gastroenterol Nutr 43:629-34. 2006
    ....
  8. doi request reprint A retrospective single-center review of primary sclerosing cholangitis in children
    Tamir Miloh
    Department of Pediatrics, and Recanati Miller Transplant Institute, Mount Sinai Hospital, New York, New York, USA
    Clin Gastroenterol Hepatol 7:239-45. 2009
    ..Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by inflammation and progressive bile duct fibrosis. There are limited data on pediatric PSC...
  9. pmc Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group
    Robert H Squires
    University of Pittsburgh, Children s Hospital of Pittsburgh, PA 15213, USA
    J Pediatr 148:652-658. 2006
    ..To determine short-term outcome for children with acute liver failure (ALF) as it relates to cause, clinical status, and patient demographics and to determine prognostic factors...
  10. ncbi request reprint Genetic induction of proinflammatory immunity in children with biliary atresia
    Jorge A Bezerra
    Division of Pediatric Gastroenterology, Children s Hospital Medical Center and University of Cincinnati, Cincinnati, OH 45229, USA
    Lancet 360:1653-9. 2002
    ..Because of clinical heterogeneity and experimental difficulties in addressing molecular mechanisms underlying multifactorial disorders in human beings, we searched for genomic signatures of biliary atresia in affected infants...
  11. ncbi request reprint Expert pediatric opinion on the Report of the Baveno IV consensus workshop on methodology of diagnosis and therapy in portal hypertension
    Benjamin Shneider
    Division of Pediatric Hepatology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Pediatr Transplant 10:893-907. 2006
    ....
  12. ncbi request reprint Bullous pemphigoid after liver transplantation for liver failure
    Nanda Kerkar
    Division of Pediatric Hepatology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA
    Liver Transpl 12:1705-10. 2006
    ..This child is unique in that his liver function and hemolytic anemia appeared to normalize after liver transplant, but neutropenia and BP both thought to be autoimmune in etiology, developed more than a year post-transplant...
  13. ncbi request reprint Liver transplantation for pediatric metabolic disease
    George Mazariegos
    Hillman Center for Pediatric Transplantation, Children s Hospital of Pittsburgh of UPMC, Faculty Pavilion, 4401 Penn Avenue, Pittsburgh, PA 15224, USA University of Pittsburgh School of Medicine UPMC Department of Surgery, Thomas E Starzl Transplantation Institute, E1540 Biomedical Science Tower BST, 200 Lothrop Street, Pittsburgh, PA 15261, USA Electronic address
    Mol Genet Metab 111:418-27. 2014
    ....
  14. ncbi request reprint Inflammatory-mediated repression of the rat ileal sodium-dependent bile acid transporter by c-fos nuclear translocation
    Frank Chen
    Division of Pediatric Gastroenterology, Nutrition and Liver Diseases, Department of Pediatrics and the Immunobiology Center, Mount Sinai School of Medicine, New York, New York 10029, USA
    Gastroenterology 123:2005-16. 2002
    ..Ileal malabsorption of bile salts is observed in Crohn's ileitis. We define the transcriptional mechanisms involved in cytokine-mediated repression of the rat apical sodium-dependent bile acid transporter (ASBT)...
  15. pmc Liver transplantation for classical maple syrup urine disease: long-term follow-up in 37 patients and comparative United Network for Organ Sharing experience
    George V Mazariegos
    University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    J Pediatr 160:116-21.e1. 2012
    ..To assess clinical and neurocognitive function in children who have undergone liver transplantation for classical maple syrup urine disease (MSUD)...
  16. ncbi request reprint Hepatitis C in children: a quaternary referral center perspective
    Carolina Rumbo
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Pediatr Gastroenterol Nutr 43:209-16. 2006
    ..3% of children in the United States, and the general impression is that it has a benign course in childhood. We analyzed a pediatric population with chronic HCV in a quaternary referral center...
  17. ncbi request reprint Abnormal concentrations of esterified carnitine in bile: a feature of pediatric acute liver failure with poor prognosis
    Benjamin L Shneider
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 41:717-21. 2005
    ..In conclusion, the findings raise the hypothesis that abnormalities in fatty acid oxidation may predispose to a worse outcome in acute liver failure...
  18. ncbi request reprint Critical analysis of the pediatric end-stage liver disease scoring system: a single center experience
    Benjamin L Shneider
    Department of Pediatrics, Mount Sinai School of Medicine, OneGustave L Levy Place, New York, NY 10029, USA
    Liver Transpl 11:788-95. 2005
    ..In conclusion the United Network for Organ Sharing policy that permits granting of exceptions has circumvented these problems with the PELD scoring system...
  19. ncbi request reprint Resolution of hepatopulmonary syndrome after auxiliary partial orthotopic liver transplantation in Abernethy malformation. A case report
    Sukru Emre
    Department of Pediatrics, Mount Sinai Medical Center, Mount Sinai School of Medicine, New York, NY, USA
    Liver Transpl 13:1662-8. 2007
    ..APOLT is a feasible and successful surgical procedure for patients with Abernethy malformation and HPS...
  20. ncbi request reprint Recent advances in pediatric liver transplantation
    Debora Kogan-Liberman
    Department of Pediatrics, Recanati Miller Transplantation Institute, Mount Sinai School of Medicine, Box 1656, One Gustave L Levy Place, New York, NY 10029, USA
    Curr Gastroenterol Rep 4:84-97. 2002
    ..This report highlights many recent published findings representing advances that have led to current successful approaches...
  21. pmc Successful split liver-kidney transplant for factor H associated hemolytic uremic syndrome
    Jeffrey M Saland
    Department of Pediatrics, The Mount Sinai Medical Center, One Gustave L Levy Place, New York, NY 10029, USA
    Clin J Am Soc Nephrol 4:201-6. 2009
    ..A male infant with a family history of thrombotic microangiopathy developed atypical hemolytic uremic syndrome (aHUS)...
  22. doi request reprint A hybrid strategy for the prevention of cytomegalovirus-related complications in pediatric liver transplantation recipients
    Rebecca P Madan
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Transplantation 87:1318-24. 2009
    ..This single center, retrospective study describes experience with a hybrid prevention strategy combining short-course antiviral prophylaxis and preemptive cytomegalovirus (CMV) polymerase chain reaction (PCR) monitoring...
  23. ncbi request reprint Medication adherence in pediatric and adolescent liver transplant recipients
    Eyal Shemesh
    Department of Pediatrics, Mount Sinai Medical Center, New York, New York 10029, USA
    Pediatrics 113:825-32. 2004
    ..There are also no published data about the age of transition at which a child assumes responsibility over taking the medications. This information is important if interventions to improve adherence are contemplated...
  24. doi request reprint Recurrent low gamma-glutamyl transpeptidase cholestasis following liver transplantation for bile salt export pump (BSEP) disease (posttransplant recurrent BSEP disease)
    Leah Siebold
    Children s Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA
    Liver Transpl 16:856-63. 2010
    ..Three of the patients with "recurrent" disease ultimately died, 2 as a direct result of complications of their liver disease...
  25. ncbi request reprint National and regional analysis of exceptions to the Pediatric End-Stage Liver Disease scoring system (2003-2004)
    Benjamin L Shneider
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Liver Transpl 12:40-5. 2006
    ..Therefore exceptions to the scoring system are required when children compete with adults for donor organs. In conclusion, urgent reassessment of the PELD scoring system is needed to avoid morbidity and mortality in children...
  26. ncbi request reprint A multicenter study of the outcome of biliary atresia in the United States, 1997 to 2000
    Benjamin L Shneider
    Department of Pediatrics, Mount Sinai Medical Center, New York, NY 10029, Department of Biostatistics, University of Michigan, Ann Arbor, MI, and Department of Pediatrics, Children s Hospital of Philadelphia, PA, USA
    J Pediatr 148:467-474. 2006
    ..To determine the prognostic factors and optimal approaches to the diagnosis and management of biliary atresia, the leading indication for liver transplantation in children...
  27. pmc Growth failure and outcomes in infants with biliary atresia: a report from the Biliary Atresia Research Consortium
    Patricia A DeRusso
    Johns Hopkins School of Medicine and The Johns Hopkins Children s Center, Baltimore, Maryland, USA
    Hepatology 46:1632-8. 2007
    ..The combination of intermediate bilirubin concentrations and poor mean weight z-scores 3 months after HPE was also associated with poor clinical outcome...
  28. ncbi request reprint Azathioprine metabolite measurements in the treatment of autoimmune hepatitis in pediatric patients: a preliminary report
    Carolina Rumbo
    Division of Pediatric Hepatology, Mount Sanai School of Medicine, New York, New York 10029, USA
    J Pediatr Gastroenterol Nutr 35:391-8. 2002
    ..Potential adverse effects of azathioprine (AZA), such as neutropenia and hepatotoxicity, make its use in autoimmune hepatitis (AIH) problematic...
  29. ncbi request reprint Pediatric liver transplantation in metabolic disease: clinical decision making
    Benjamin L Shneider
    Department of Pediatric Liver Transplant Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Pediatr Transplant 6:25-9. 2002
    ..The natural history of these disorders are considered in the context of the risks of liver transplantation. Indications, contraindications, and both current and future alternatives to transplantation, are considered...
  30. ncbi request reprint Disorders of bile formation and biliary transport
    Gitit Tomer
    Division of Pediatric Gastroenetrology, One Gustave L Levy Place, Box 1656, Mount Sinai Medical Center, New York, NY 10029, USA
    Gastroenterol Clin North Am 32:839-55, vi. 2003
    ..Defects in bile acid biosynthesis and aminophospholipid transport may be responsive to medical or non-transplant surgical approaches...
  31. ncbi request reprint MR cholangiography in the evaluation of neonatal cholestasis: initial results
    Karen I Norton
    Department of Radiology, Mount Sinai School of Medicine, 1 Gustave L Levy Pl, Box 1234, New York, NY 10029, USA
    Radiology 222:687-91. 2002
    ....
  32. ncbi request reprint Coordinate expression of regulatory genes differentiates embryonic and perinatal forms of biliary atresia
    Dong Yi Zhang
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition of the Cincinnati Children s Hospital Medical Center and University of Cincinnati, Cincinnati, OH, USA
    Hepatology 39:954-62. 2004
    ..Further studies exploring these biological processes are required to determine the significance of these findings...
  33. ncbi request reprint Rapid evolution of congenital hepatic fibrosis after liver transplantation for acute liver failure: the potential role of extrahepatic factors
    Judith Flores
    Department of Gastroenterology, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico
    Liver Transpl 14:660-4. 2008
    ..Examination of the explanted liver revealed remarkable progression of the congenital hepatic fibrosis, suggesting that the phenotype of this disease may be dependent in part on extrahepatic factors...
  34. doi request reprint Screening for biliary atresia: A ray of hope
    Benjamin L Shneider
    Hepatology 47:1105-7. 2008
  35. ncbi request reprint Childhood abuse, nonadherence, and medical outcome in pediatric liver transplant recipients
    Eyal Shemesh
    Department of Psychiatry, Recanati Miller Transplant Institute at Mount Sinai Medical Center, New York, NY, USA
    J Am Acad Child Adolesc Psychiatry 46:1280-9. 2007
    ..The study assessed the relationship between a history of child abuse, nonadherence to medications, and medical outcome in children who had a liver transplant...
  36. ncbi request reprint Liver disease in autosomal recessive polycystic kidney disease
    Benjamin L Shneider
    Recanati Miller Transplantation Institute, New York, USA
    Pediatr Transplant 9:634-9. 2005
    ..The implications of hepatic disease need to be considered in the decision-making regarding renal transplantation in ARPKD...
  37. ncbi request reprint Primary sclerosing cholangitis: summary of a workshop
    Nicholas F Larusso
    Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
    Hepatology 44:746-64. 2006
    ..Thus, significant opportunities remain for basic and clinical research into the cause, natural history, and therapy of PSC...
  38. ncbi request reprint Pediatric liver transplantation: past, present, and future
    Benjamin L Shneider
    Liver Transpl 12:511-3. 2006

Research Grants15

  1. Molecular Mechanisms of Intrahepatic Cholestasis
    Benjamin L Shneider; Fiscal Year: 2010
    ..Recent molecular discoveries provide an opportunity to understand this disease (providing new therapies) and to explore basic physiology of the liver, pancreas, gastrointestinal tract and lungs. ..
  2. Biliary Atresia Clinical Research Consortium: Pittsburgh
    Benjamin Shneider; Fiscal Year: 2007
    ..This third project is designed to identify new diagnostic and/or prognostic markers and to provide leads for further basic research on the pathobiology of BA. ..
  3. MOLECULAR REGULATION OF ILEAL/RENAL BILE ACID TRANSPORT
    Benjamin Shneider; Fiscal Year: 2005
    ....
  4. MOLECULAR REGULATION OF ILEAL/RENAL BILE ACID TRANSPORT
    Benjamin Shneider; Fiscal Year: 2006
    ....
  5. MOLECULAR REGULATION OF ILEAL/RENAL BILE ACID TRANSPORT
    Benjamin Shneider; Fiscal Year: 2007
    ....
  6. MOLECULAR REGULATION OF ILEAL/RENAL BILE ACID TRANSPORT
    Benjamin L Shneider; Fiscal Year: 2010
    ..These studies will advance our understanding of the regulation of ASBT and provide new ways to understand and treat intestinal and liver diseases. ..
  7. MOLECULAR REGULATION OF ILEAL/RENAL BILE ACID TRANSPORT
    Benjamin Shneider; Fiscal Year: 2004
    ....
  8. MOLECULAR REGULATION OF ILEAL/RENAL BILE ACID TRANSPORT
    Benjamin Shneider; Fiscal Year: 2003
    ....
  9. Molecular Mechanisms of Intrahepatic Cholestasis
    Benjamin Shneider; Fiscal Year: 2006
    ..These innovative studies will delineate a novel set of mechanisms that underlie the pathogenesis of PFIC1 and will develop a new area of cellular regulation of lipid membrane asymmetry. ..
  10. MOLECULAR REGULATION OF ILEAL/RENAL BILE ACID TRANSPORT
    Benjamin Shneider; Fiscal Year: 2006
    ....