Kenneth D R Setchell

Summary

Affiliation: Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi request reprint Pharmacokinetics of a slow-release formulation of soybean isoflavones in healthy postmenopausal women
    Kenneth D R Setchell
    Division of Pathology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Agric Food Chem 53:1938-44. 2005
  2. ncbi request reprint Liver disease caused by failure to racemize trihydroxycholestanoic acid: gene mutation and effect of bile acid therapy
    Kenneth D R Setchell
    Division of Clinical Mass Spectrometry, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Gastroenterology 124:217-32. 2003
  3. ncbi request reprint Comparing the pharmacokinetics of daidzein and genistein with the use of 13C-labeled tracers in premenopausal women
    Kenneth D R Setchell
    Clinical Mass Spectrometry, Children s Hospital Medical Center, Cincinnati, OH, USA
    Am J Clin Nutr 77:411-9. 2003
  4. pmc Soy isoflavone phase II metabolism differs between rodents and humans: implications for the effect on breast cancer risk
    Kenneth D R Setchell
    Division of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, OH 45229, USA
    Am J Clin Nutr 94:1284-94. 2011
  5. ncbi request reprint Bioavailability, disposition, and dose-response effects of soy isoflavones when consumed by healthy women at physiologically typical dietary intakes
    Kenneth D R Setchell
    Division of Clinical Mass Spectrometry, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, OH, USA
    J Nutr 133:1027-35. 2003
  6. pmc Impact of perinatal exposure to equol enantiomers on reproductive development in rodents
    Nadine M Brown
    Department of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Reprod Toxicol 32:33-42. 2011
  7. pmc Equol: history, chemistry, and formation
    Kenneth D R Setchell
    Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Nutr 140:1355S-62S. 2010
  8. doi request reprint Genetic defects in bile Acid conjugation cause fat-soluble vitamin deficiency
    Kenneth D R Setchell
    Department of Pathology and Laboratory Medicine, Children s Hospital Medical Center, Cincinnati, Ohio Electronic address
    Gastroenterology 144:945-955.e6. 2013
  9. ncbi request reprint Bile acid synthetic defects and liver disease: a comprehensive review
    Kevin E Bove
    Department of Pathology, HT 4, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Pediatr Dev Pathol 7:315-34. 2004
  10. ncbi request reprint Inborn errors of bile acid metabolism
    James E Heubi
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    Semin Liver Dis 27:282-94. 2007

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Pharmacokinetics of a slow-release formulation of soybean isoflavones in healthy postmenopausal women
    Kenneth D R Setchell
    Division of Pathology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Agric Food Chem 53:1938-44. 2005
    ..These findings show that it is feasible to employ polymer matrices that slow the aqueous dissolution for preparing sustained-release formulations of soy isoflavones. Further studies to optimize such formulations are warranted...
  2. ncbi request reprint Liver disease caused by failure to racemize trihydroxycholestanoic acid: gene mutation and effect of bile acid therapy
    Kenneth D R Setchell
    Division of Clinical Mass Spectrometry, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Gastroenterology 124:217-32. 2003
    ....
  3. ncbi request reprint Comparing the pharmacokinetics of daidzein and genistein with the use of 13C-labeled tracers in premenopausal women
    Kenneth D R Setchell
    Clinical Mass Spectrometry, Children s Hospital Medical Center, Cincinnati, OH, USA
    Am J Clin Nutr 77:411-9. 2003
    ..Despite significant interest in the risks and benefits of phytoestrogens to human health, few data exist on their pharmacokinetics in humans...
  4. pmc Soy isoflavone phase II metabolism differs between rodents and humans: implications for the effect on breast cancer risk
    Kenneth D R Setchell
    Division of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, OH 45229, USA
    Am J Clin Nutr 94:1284-94. 2011
    ..Human and animal studies have produced conflicting results with regard to the effect of soy isoflavones on breast cancer risk. This may be due to differences in isoflavone metabolism...
  5. ncbi request reprint Bioavailability, disposition, and dose-response effects of soy isoflavones when consumed by healthy women at physiologically typical dietary intakes
    Kenneth D R Setchell
    Division of Clinical Mass Spectrometry, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, OH, USA
    J Nutr 133:1027-35. 2003
    ..On the basis of the pharmacokinetics, optimum steady-state serum isoflavone concentrations would be expected from modest intakes of soy foods consumed regularly throughout the day rather than from a single highly enriched product...
  6. pmc Impact of perinatal exposure to equol enantiomers on reproductive development in rodents
    Nadine M Brown
    Department of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Reprod Toxicol 32:33-42. 2011
    ..With R-(+)equol this stimulatory effect subsided after exposure was discontinued, but the effect of S-(-)equol was prolonged...
  7. pmc Equol: history, chemistry, and formation
    Kenneth D R Setchell
    Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Nutr 140:1355S-62S. 2010
    ..The following review describes the history, chemistry, and factors governing the intestinal bacterial formation of equol...
  8. doi request reprint Genetic defects in bile Acid conjugation cause fat-soluble vitamin deficiency
    Kenneth D R Setchell
    Department of Pathology and Laboratory Medicine, Children s Hospital Medical Center, Cincinnati, Ohio Electronic address
    Gastroenterology 144:945-955.e6. 2013
    ....
  9. ncbi request reprint Bile acid synthetic defects and liver disease: a comprehensive review
    Kevin E Bove
    Department of Pathology, HT 4, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Pediatr Dev Pathol 7:315-34. 2004
    ..We hypothesize that immature hepatocytes of infants may fuse to form multinucleate hepatocytes whenever atypical or toxic bile acids are present and the pool of normal bile acids is critically reduced...
  10. ncbi request reprint Inborn errors of bile acid metabolism
    James E Heubi
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    Semin Liver Dis 27:282-94. 2007
    ..This review focuses on a description of the disorders of bile acid synthesis that are directly related to single defects in the metabolic pathway, their proposed pathogenesis, treatment, and prognosis...
  11. ncbi request reprint Tauroursodeoxycholic acid (TUDCA) in the prevention of total parenteral nutrition-associated liver disease
    James E Heubi
    Division of Pediatric Gastroenterology, Department of Hepatology and Nutrition, the General Clinical Research Center, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Pediatr 141:237-42. 2002
    ..To determine whether tauroursodeoxycholic acid (TUDCA) would prevent or ameliorate the liver injury in neonates treated with total parenteral nutrition (TPN)...
  12. ncbi request reprint Variations in isoflavone levels in soy foods and soy protein isolates and issues related to isoflavone databases and food labeling
    Kenneth D R Setchell
    Division of Clinical Mass Spectrometry, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Agric Food Chem 51:4146-55. 2003
    ....
  13. ncbi request reprint Dietary phytoestrogens and their effect on bone: evidence from in vitro and in vivo, human observational, and dietary intervention studies
    Kenneth D R Setchell
    Department of Pediatrics, Clinical Mass Spectrometry, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Am J Clin Nutr 78:593S-609S. 2003
    ..On balance, the collective data suggest that diets rich in phytoestrogens have bone-sparing effects in the long term, although the magnitude of the effect and the exact mechanism(s) of action are presently elusive or speculative...
  14. pmc The chemopreventive action of equol enantiomers in a chemically induced animal model of breast cancer
    Nadine M Brown
    Division of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, OH 45229, USA
    Carcinogenesis 31:886-93. 2010
    ..In conclusion, the novel finding that the unnatural enantiomer, R-(+)equol, was potently chemopreventive warrants investigation of its potential for breast cancer prevention and treatment...
  15. doi request reprint The pharmacokinetics of S-(-)equol administered as SE5-OH tablets to healthy postmenopausal women
    Kenneth D R Setchell
    Division of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Nutr 139:2037-43. 2009
    ..Three participants were determined to be equol-producers, representing a 25% frequency, and equol-producer status had no effect on natural S-(-)equol pharmacokinetics...
  16. ncbi request reprint The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavones
    Kenneth D R Setchell
    Clinical Mass Spectrometry, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, OH 45229, USA
    J Nutr 132:3577-84. 2002
    ..The failure to distinguish those subjects who are "equol-producers" from "nonequol producers" in previous clinical studies could plausibly explain the variance in reported data on the health benefits of soy...
  17. pmc Equol: pharmacokinetics and biological actions
    Kenneth D R Setchell
    Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Nutr 140:1363S-8S. 2010
    ..In this review, the plasma and urinary pharmacokinetics of S-(-)equol and R-(+)equol are reviewed and summarized, and some of the more recent evidence supporting potential biological effects of S-(-)equol is considered...
  18. ncbi request reprint Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability
    Kenneth D R Setchell
    Division of Clinical Mass Spectrometry, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Am J Clin Nutr 76:447-53. 2002
    ....
  19. pmc Tissue-specific effects of saposin A and saposin B on glycosphingolipid degradation in mutant mice
    Ying Sun
    The Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Hum Mol Genet 22:2435-50. 2013
    ..These analyses of AB-/- mice continue to delineate the tissue differential interactions of saposins in GSL metabolism...
  20. ncbi request reprint Separation of micelles and vesicles within lumenal aspirates from healthy humans: solubilization of cholesterol after a meal
    Lihang Yao
    Departments of Pathology and Laboratory Medicine, University of Cincinnati Medical School, Cincinnati, OH 45267, USA
    J Lipid Res 43:654-60. 2002
    ....
  21. ncbi request reprint Hemoglobins dioxygenate nitric oxide with high fidelity
    Paul R Gardner
    Division of Critical Care Medicine, Children s Hospital Medical Center, 3333 Burnet Ave, MLC7006, Cincinnati, OH 45229, USA
    J Inorg Biochem 100:542-50. 2006
    ..NO(2) to form nitrate. Hb functions as a .NO dioxygenase by controlling O(2) binding and electrochemistry, guiding .NO diffusion and reaction, and shielding highly reactive intermediates from solvent water and biomolecules...
  22. ncbi request reprint Pasta naturally enriched with isoflavone aglycons from soy germ reduces serum lipids and improves markers of cardiovascular risk
    Carlo Clerici
    Clinica di Gastroenterologia ed Epatologia, Universita degli Studi di Perugia, Perugia, Italy 06100
    J Nutr 137:2270-8. 2007
    ..In conclusion, pasta naturally enriched with isoflavone aglycons and lacking soy protein had a significant hypocholesterolemic effect beyond a Step II diet and improved other cardiovascular risk markers...
  23. pmc Variations in phytoestrogen content between different mill dates of the same diet produces significant differences in the time of vaginal opening in CD-1 mice and F344 rats but not in CD Sprague-Dawley rats
    Julius E Thigpen
    Comparative Medicine Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Environ Health Perspect 115:1717-26. 2007
    ..The optimum test diet and rodent species/strain for evaluating endocrine-disrupting compounds (EDCs) are critical...
  24. ncbi request reprint Method of defining equol-producer status and its frequency among vegetarians
    Kenneth D R Setchell
    Sanitarium Development and Innovation, Cooranbong, NSW 2265, Australia
    J Nutr 136:2188-93. 2006
    ....
  25. ncbi request reprint Defects in bile acid biosynthesis--diagnosis and treatment
    Kenneth D R Setchell
    Department of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, OH, USA
    J Pediatr Gastroenterol Nutr 43:S17-22. 2006
    ..Bile-acid therapy using oral cholic acid has proven effective in most of these bile acid synthetic defects making early diagnosis crucial to optimum clinical prognosis...
  26. ncbi request reprint 3alpha-6alpha-Dihydroxy-7alpha-fluoro-5beta-cholanoate (UPF-680), physicochemical and physiological properties of a new fluorinated bile acid that prevents 17alpha-ethynyl-estradiol-induced cholestasis in rats
    Carlo Clerici
    Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale Università degli Studi di Perugia, 06122 Perugia, Italy
    Toxicol Appl Pharmacol 214:199-208. 2006
    ..This novel fluorinated bile acid may have potential in the treatment of cholestatic liver disease...
  27. ncbi request reprint Effects of soy consumption on gonadotropin secretion and acute pituitary responses to gonadotropin-releasing hormone in women
    Jill Nicholls
    Department of Nutrition, University of California Davis, CA 95616, USA
    J Nutr 132:708-14. 2002
    ..In one premenopausal woman, enhanced LH secretion was observed after soy treatment, suggesting there may be subpopulations of women who are highly sensitive to isoflavones...
  28. ncbi request reprint Dietary phytoestrogens accelerate the time of vaginal opening in immature CD-1 mice
    Julius E Thigpen
    Quality Assurance Laboratory, Comparative Medicine Branch, NIEHS, 111 T W Alexander Drive, Research Triangle Park, North Carolina 27709, USA
    Comp Med 53:607-15. 2003
    ..Phytoestrogen-free diet(s) containing the same amount of ME should be used in bioassays that compare the time of VO, or increases in uterine weight as end points for evaluating the estrogenic activity of an EDC...
  29. ncbi request reprint Bile acids analysis: a tool to assess graft function in human liver transplantation
    Hector Vilca Melendez
    Liver Transplant Surgical Service, King s College Hospital, Denmark Hill, SE5 9RS, London, UK
    Transpl Int 17:286-92. 2004
    ..This study characterises bile acid secretion of liver grafts and remarks the potential value of bile acid analysis to assess donor liver quality and early post-transplant graft function...
  30. ncbi request reprint Soymilk or progesterone for prevention of bone loss--a 2 year randomized, placebo-controlled trial
    Eva Lydeking-Olsen
    Institute for Optimum Nutrition, Teglgaardstraede 4, 1st Floor, 1452, Copenhagen K, Denmark
    Eur J Nutr 43:246-57. 2004
    ..Progesterone has been suggested as a bone-trophic hormone, but the effect of long-term, low dose transdermal progesterone is unknown...
  31. ncbi request reprint Neurobehavioral effects of dietary soy phytoestrogens
    Edwin D Lephart
    Neuroscience Center, 633 WIDB, Brigham Young University, Provo, UT 86402, USA
    Neurotoxicol Teratol 24:5-16. 2002
    ....
  32. ncbi request reprint S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora
    Kenneth D R Setchell
    Division of Pathology, Clinical Mass Spectrometry, Cincinnati Children s Hospital Medical Center, and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati 45229, OH, USA
    Am J Clin Nutr 81:1072-9. 2005
    ..Equol, unlike the soy isoflavones daidzein or genistein, has a chiral center and therefore can occur as 2 distinct diastereoisomers...
  33. ncbi request reprint Phytoestrogens: implications in neurovascular research
    Edwin D Lephart
    Department of Physiology and Developmental Biology, Neuroscience Center, 633 WIDB, Brigham Young University, Provo, Utah 84602, USA
    Curr Neurovasc Res 1:455-64. 2004
    ..Because of their diverse health effects and widespread availability in soy foods, dietary phytoestrogens merit continued research into their effects on human health and cognitive function...
  34. ncbi request reprint Phytoestrogens: hormonal action and brain plasticity
    Edwin D Lephart
    The Neuroscience Center, Brigham Young University, 633 WIDB, Provo, UT 84602, USA
    Brain Res Bull 65:193-8. 2005
    ....
  35. ncbi request reprint Influence of breast feeding, and adapted and hydrolyzed formulas on biliary bile acids in newborn guinea pigs
    Carla Colombo
    Institute of Pediatrics and Neonatology, School of Medicine, Ospedale San Paolo, University of Milan, Via Commenda 9, I 20122 Milan, Italy
    Biol Neonate 83:36-41. 2003
    ..The type of feeding can differently influence bile acid ontogeny during the period of physiologic cholestasis that characterizes early human development...
  36. ncbi request reprint Molecular genetics of 3beta-hydroxy-Delta5-C27-steroid oxidoreductase deficiency in 16 patients with loss of bile acid synthesis and liver disease
    Jeffrey B Cheng
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Clin Endocrinol Metab 88:1833-41. 2003
    ..We conclude that a diverse spectrum of mutations in the HSD3B7 gene underlies this rare form of neonatal cholestasis...
  37. ncbi request reprint Biliary diversion for progressive familial intrahepatic cholestasis: improved liver morphology and bile acid profile
    Amethyst C Kurbegov
    Pediatric Liver Center and Liver Transplantation Program, Department of Pediatrics, University of Colorado School of Medicine and The Children s Hospital, Denver, Colorado, USA
    Gastroenterology 125:1227-34. 2003
    ..Many patients require liver transplantation, but partial external biliary diversion (PEBD) has shown therapeutic promise. However, the effect of PEBD on liver morphology and bile composition has not been evaluated...
  38. ncbi request reprint Equol is a novel anti-androgen that inhibits prostate growth and hormone feedback
    Trent D Lund
    Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80524, USA
    Biol Reprod 70:1188-95. 2004
    ....
  39. ncbi request reprint Endogenous ursodeoxycholic acid and cholic acid in liver disease due to cystic fibrosis
    Jeffery L Smith
    Hepatic Fibrosis Group, The Queensland Institute of Medical Research, Brisbane, Australia
    Hepatology 39:1673-82. 2004
    ..The correlation between both cholic acid and cholic acid/chenodeoxycholic acid levels with histological liver injury and fibrosis progression suggests a potential monitoring role for these bile acids in CFLD...
  40. ncbi request reprint Factors affecting the bioavailability of soy isoflavones in humans after ingestion of physiologically relevant levels from different soy foods
    Aedin Cassidy
    School of Medicine, University of East Anglia, Norwich, UK
    J Nutr 136:45-51. 2006
    ..Only 30% of the subjects were equol producers and no differences in equol production with age or gender were observed...
  41. ncbi request reprint Not all soy products are created equal: caution needed in interpretation of research results
    John W Erdman
    Department of Food Science and Human Nutrition, University of Illinois, Urbana, IL 61801, USA
    J Nutr 134:1229S-1233S. 2004
    ..Efforts are needed by all to reduce the public confusion by adapting standardized approaches to the reporting of data. This paper provides a framework for both standardization of nomenclature and appropriate interpretation of data...
  42. ncbi request reprint Behavioral effects of endocrine-disrupting substances: phytoestrogens
    Edwin D Lephart
    Department of Physiology and Developmental Biology, Neuroscience Center, Brigham Young University, Provo, UT, USA
    ILAR J 45:443-54. 2004
    ..Regulatory behaviors such as food and water intake, adipose deposition and leptin, and insulin levels affected by dietary isoflavones are also discussed...
  43. pmc Analysis of HSD3B7 knockout mice reveals that a 3alpha-hydroxyl stereochemistry is required for bile acid function
    Heidi C Shea
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 104:11526-33. 2007
    ..We conclude that the correct stereochemistry of a single hydroxyl group at carbon 3 in bile acids is required to maintain their physiologic and regulatory functions in mammals...
  44. pmc Assessing risks and benefits of genistein and soy
    Kenneth D R Setchell
    Environ Health Perspect 114:A332-3. 2006
  45. pmc Influences of dietary soy isoflavones on metabolism but not nociception and stress hormone responses in ovariectomized female rats
    Lihong Bu
    Physiology and Developmental Biology Department, Neuroscience Center, Brigham Young University, Provo, Utah 84602, USA
    Reprod Biol Endocrinol 3:58. 2005
    ..Isoflavones, the most abundant phytoestrogens in soy foods, are structurally similar to 17beta-estradiol. Few studies have examined the nociception and stress hormone responses after consumption of soy isoflavones...