Kenneth D R Setchell
Affiliation: Children's Hospital Medical Center
- Dietary phytoestrogens and their effect on bone: evidence from in vitro and in vivo, human observational, and dietary intervention studiesKenneth D R Setchell
Department of Pediatrics, Clinical Mass Spectrometry, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Am J Clin Nutr 78:593S-609S. 2003..On balance, the collective data suggest that diets rich in phytoestrogens have bone-sparing effects in the long term, although the magnitude of the effect and the exact mechanism(s) of action are presently elusive or speculative...
- The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavonesKenneth D R Setchell
Clinical Mass Spectrometry, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, OH 45229, USA
J Nutr 132:3577-84. 2002..The failure to distinguish those subjects who are "equol-producers" from "nonequol producers" in previous clinical studies could plausibly explain the variance in reported data on the health benefits of soy...
- Variations in isoflavone levels in soy foods and soy protein isolates and issues related to isoflavone databases and food labelingKenneth D R Setchell
Division of Clinical Mass Spectrometry, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Agric Food Chem 51:4146-55. 2003....
- S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial floraKenneth D R Setchell
Division of Pathology, Clinical Mass Spectrometry, Cincinnati Children s Hospital Medical Center, and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati 45229, OH, USA
Am J Clin Nutr 81:1072-9. 2005..Equol, unlike the soy isoflavones daidzein or genistein, has a chiral center and therefore can occur as 2 distinct diastereoisomers...
- Comparing the pharmacokinetics of daidzein and genistein with the use of 13C-labeled tracers in premenopausal womenKenneth D R Setchell
Clinical Mass Spectrometry, Children s Hospital Medical Center, Cincinnati, OH, USA
Am J Clin Nutr 77:411-9. 2003..Despite significant interest in the risks and benefits of phytoestrogens to human health, few data exist on their pharmacokinetics in humans...
- Pharmacokinetics of a slow-release formulation of soybean isoflavones in healthy postmenopausal womenKenneth D R Setchell
Division of Pathology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
J Agric Food Chem 53:1938-44. 2005..These findings show that it is feasible to employ polymer matrices that slow the aqueous dissolution for preparing sustained-release formulations of soy isoflavones. Further studies to optimize such formulations are warranted...
- Genetic defects in bile acid conjugation cause fat-soluble vitamin deficiencyKenneth D R Setchell
Department of Pathology and Laboratory Medicine, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Gastroenterology 144:945-955.e6; quiz e14-5. 2013....
- Soy isoflavone phase II metabolism differs between rodents and humans: implications for the effect on breast cancer riskKenneth D R Setchell
Division of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, OH 45229, USA
Am J Clin Nutr 94:1284-94. 2011..Human and animal studies have produced conflicting results with regard to the effect of soy isoflavones on breast cancer risk. This may be due to differences in isoflavone metabolism...
- Equol: history, chemistry, and formationKenneth D R Setchell
Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Nutr 140:1355S-62S. 2010..The following review describes the history, chemistry, and factors governing the intestinal bacterial formation of equol...
- Bioavailability, disposition, and dose-response effects of soy isoflavones when consumed by healthy women at physiologically typical dietary intakesKenneth D R Setchell
Division of Clinical Mass Spectrometry, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, OH, USA
J Nutr 133:1027-35. 2003..On the basis of the pharmacokinetics, optimum steady-state serum isoflavone concentrations would be expected from modest intakes of soy foods consumed regularly throughout the day rather than from a single highly enriched product...
- Impact of perinatal exposure to equol enantiomers on reproductive development in rodentsNadine M Brown
Department of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
Reprod Toxicol 32:33-42. 2011..With R-(+)equol this stimulatory effect subsided after exposure was discontinued, but the effect of S-(-)equol was prolonged...
- Metabolism of secoisolariciresinol-diglycoside the dietary precursor to the intestinally derived lignan enterolactone in humansKenneth D R Setchell
Division of Pathology, Clinical Mass Spectrometry, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
Food Funct 5:491-501. 2014....
- Bile acid synthetic defects and liver disease: a comprehensive reviewKevin E Bove
Department of Pathology, HT 4, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Pediatr Dev Pathol 7:315-34. 2004..We hypothesize that immature hepatocytes of infants may fuse to form multinucleate hepatocytes whenever atypical or toxic bile acids are present and the pool of normal bile acids is critically reduced...
- Inborn errors of bile acid metabolismJames E Heubi
Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
Semin Liver Dis 27:282-94. 2007..This review focuses on a description of the disorders of bile acid synthesis that are directly related to single defects in the metabolic pathway, their proposed pathogenesis, treatment, and prognosis...
- The chemopreventive action of equol enantiomers in a chemically induced animal model of breast cancerNadine M Brown
Division of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, OH 45229, USA
Carcinogenesis 31:886-93. 2010..In conclusion, the novel finding that the unnatural enantiomer, R-(+)equol, was potently chemopreventive warrants investigation of its potential for breast cancer prevention and treatment...
- Multiple pathogenic proteins implicated in neuronopathic Gaucher disease miceYou Hai Xu
The Division of Human Genetics and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Hum Mol Genet 23:3943-57. 2014..These studies implicate defective GCase function and GC/GS accumulation as risk factors for mitochondrial dysfunction and the multi-proteinopathies (α-synuclein-, APP- and Aβ-aggregates) in nGD. ..
- S-(-)equol production is developmentally regulated and related to early diet compositionNadine M Brown
Division of Clinical Mass Spectrometry, Department of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH
Nutr Res 34:401-9. 2014....
- Equol: pharmacokinetics and biological actionsKenneth D R Setchell
Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Nutr 140:1363S-8S. 2010..In this review, the plasma and urinary pharmacokinetics of S-(-)equol and R-(+)equol are reviewed and summarized, and some of the more recent evidence supporting potential biological effects of S-(-)equol is considered...
- Liver disease caused by failure to racemize trihydroxycholestanoic acid: gene mutation and effect of bile acid therapyKenneth D R Setchell
Division of Clinical Mass Spectrometry, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Gastroenterology 124:217-32. 2003....
- Defects in bile acid biosynthesis--diagnosis and treatmentKenneth D R Setchell
Department of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, OH, USA
J Pediatr Gastroenterol Nutr 43:S17-22. 2006..Bile-acid therapy using oral cholic acid has proven effective in most of these bile acid synthetic defects making early diagnosis crucial to optimum clinical prognosis...
- Tissue-specific effects of saposin A and saposin B on glycosphingolipid degradation in mutant miceYing Sun
The Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Hum Mol Genet 22:2435-50. 2013..These analyses of AB-/- mice continue to delineate the tissue differential interactions of saposins in GSL metabolism...
- Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailabilityKenneth D R Setchell
Division of Clinical Mass Spectrometry, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Am J Clin Nutr 76:447-53. 2002....
- The pharmacokinetics of S-(-)equol administered as SE5-OH tablets to healthy postmenopausal womenKenneth D R Setchell
Division of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Nutr 139:2037-43. 2009..Three participants were determined to be equol-producers, representing a 25% frequency, and equol-producer status had no effect on natural S-(-)equol pharmacokinetics...
- Phytosterols promote liver injury and kupffer cell activation in parenteral nutrition-associated liver diseaseKarim C El Kasmi
Section of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA
Sci Transl Med 5:206ra137. 2013..Modification of lipid constituents in PN solutions is thus a promising strategy to reduce incidence and severity of PNALD. ..
- Biliary diversion for progressive familial intrahepatic cholestasis: improved liver morphology and bile acid profileAmethyst C Kurbegov
Pediatric Liver Center and Liver Transplantation Program, Department of Pediatrics, University of Colorado School of Medicine and The Children s Hospital, Denver, Colorado, USA
Gastroenterology 125:1227-34. 2003..Many patients require liver transplantation, but partial external biliary diversion (PEBD) has shown therapeutic promise. However, the effect of PEBD on liver morphology and bile composition has not been evaluated...
- Tauroursodeoxycholic acid (TUDCA) in the prevention of total parenteral nutrition-associated liver diseaseJames E Heubi
Division of Pediatric Gastroenterology, Department of Hepatology and Nutrition, the General Clinical Research Center, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Pediatr 141:237-42. 2002..To determine whether tauroursodeoxycholic acid (TUDCA) would prevent or ameliorate the liver injury in neonates treated with total parenteral nutrition (TPN)...
- Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbiditiesRohit Kohli
Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Ohio, USA
Am J Physiol Gastrointest Liver Physiol 299:G652-60. 2010..Changes in serum bile acids or bile acid enterohepatic recycling may mediate the metabolic benefits seen after bariatric surgery...
- Gaucher disease: chemotactic factors and immunological cell invasion in a mouse modelManoj Kumar Pandey
Division of Human Genetics, Cincinnati Children s Hospital Medical Center, USA Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Mol Genet Metab 111:163-71. 2014..These data support these chemotactic factors as causative to increased tissue infiltration of leukocytes in Gaucher disease...
- The membrane protein ATPase class I type 8B member 1 signals through protein kinase C zeta to activate the farnesoid X receptorTamara Frankenberg
Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA
Hepatology 48:1896-905. 2008..Benign recurrent intrahepatic cholestasis emanates from a partially functional FIC1 protein. Phosphorylation of FXR is an important mechanism for regulating its activity...
- Hemoglobins dioxygenate nitric oxide with high fidelityPaul R Gardner
Division of Critical Care Medicine, Children s Hospital Medical Center, 3333 Burnet Ave, MLC7006, Cincinnati, OH 45229, USA
J Inorg Biochem 100:542-50. 2006..NO(2) to form nitrate. Hb functions as a .NO dioxygenase by controlling O(2) binding and electrochemistry, guiding .NO diffusion and reaction, and shielding highly reactive intermediates from solvent water and biomolecules...
- Separation of micelles and vesicles within lumenal aspirates from healthy humans: solubilization of cholesterol after a mealLihang Yao
Departments of Pathology and Laboratory Medicine, University of Cincinnati Medical School, Cincinnati, OH 45267, USA
J Lipid Res 43:654-60. 2002....
- Neurobehavioral effects of dietary soy phytoestrogensEdwin D Lephart
Neuroscience Center, 633 WIDB, Brigham Young University, Provo, UT 86402, USA
Neurotoxicol Teratol 24:5-16. 2002....
- Method of defining equol-producer status and its frequency among vegetariansKenneth D R Setchell
Sanitarium Development and Innovation, Cooranbong, NSW 2265, Australia
J Nutr 136:2188-93. 2006....
- Effects of soy consumption on gonadotropin secretion and acute pituitary responses to gonadotropin-releasing hormone in womenJill Nicholls
Department of Nutrition, University of California Davis, CA 95616, USA
J Nutr 132:708-14. 2002..In one premenopausal woman, enhanced LH secretion was observed after soy treatment, suggesting there may be subpopulations of women who are highly sensitive to isoflavones...
- Variations in phytoestrogen content between different mill dates of the same diet produces significant differences in the time of vaginal opening in CD-1 mice and F344 rats but not in CD Sprague-Dawley ratsJulius E Thigpen
Comparative Medicine Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
Environ Health Perspect 115:1717-26. 2007..The optimum test diet and rodent species/strain for evaluating endocrine-disrupting compounds (EDCs) are critical...
- Pasta naturally enriched with isoflavone aglycons from soy germ reduces serum lipids and improves markers of cardiovascular riskCarlo Clerici
Clinica di Gastroenterologia ed Epatologia, Universita degli Studi di Perugia, Perugia, Italy 06100
J Nutr 137:2270-8. 2007..In conclusion, pasta naturally enriched with isoflavone aglycons and lacking soy protein had a significant hypocholesterolemic effect beyond a Step II diet and improved other cardiovascular risk markers...
- Soymilk or progesterone for prevention of bone loss--a 2 year randomized, placebo-controlled trialEva Lydeking-Olsen
Institute for Optimum Nutrition, Teglgaardstraede 4, 1st Floor, 1452, Copenhagen K, Denmark
Eur J Nutr 43:246-57. 2004..Progesterone has been suggested as a bone-trophic hormone, but the effect of long-term, low dose transdermal progesterone is unknown...
- Bile acids analysis: a tool to assess graft function in human liver transplantationHector Vilca Melendez
Liver Transplant Surgical Service, King s College Hospital, Denmark Hill, SE5 9RS, London, UK
Transpl Int 17:286-92. 2004..This study characterises bile acid secretion of liver grafts and remarks the potential value of bile acid analysis to assess donor liver quality and early post-transplant graft function...
- Dietary phytoestrogens accelerate the time of vaginal opening in immature CD-1 miceJulius E Thigpen
Quality Assurance Laboratory, Comparative Medicine Branch, NIEHS, 111 T W Alexander Drive, Research Triangle Park, North Carolina 27709, USA
Comp Med 53:607-15. 2003..Phytoestrogen-free diet(s) containing the same amount of ME should be used in bioassays that compare the time of VO, or increases in uterine weight as end points for evaluating the estrogenic activity of an EDC...
- 3alpha-6alpha-Dihydroxy-7alpha-fluoro-5beta-cholanoate (UPF-680), physicochemical and physiological properties of a new fluorinated bile acid that prevents 17alpha-ethynyl-estradiol-induced cholestasis in ratsCarlo Clerici
Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale Università degli Studi di Perugia, 06122 Perugia, Italy
Toxicol Appl Pharmacol 214:199-208. 2006..This novel fluorinated bile acid may have potential in the treatment of cholestatic liver disease...
- Phytoestrogens: implications in neurovascular researchEdwin D Lephart
Department of Physiology and Developmental Biology, Neuroscience Center, 633 WIDB, Brigham Young University, Provo, Utah 84602, USA
Curr Neurovasc Res 1:455-64. 2004..Because of their diverse health effects and widespread availability in soy foods, dietary phytoestrogens merit continued research into their effects on human health and cognitive function...
- Behavioral effects of endocrine-disrupting substances: phytoestrogensEdwin D Lephart
Department of Physiology and Developmental Biology, Neuroscience Center, Brigham Young University, Provo, UT, USA
ILAR J 45:443-54. 2004..Regulatory behaviors such as food and water intake, adipose deposition and leptin, and insulin levels affected by dietary isoflavones are also discussed...
- Phytoestrogens: hormonal action and brain plasticityEdwin D Lephart
The Neuroscience Center, Brigham Young University, 633 WIDB, Provo, UT 84602, USA
Brain Res Bull 65:193-8. 2005....
- Endogenous ursodeoxycholic acid and cholic acid in liver disease due to cystic fibrosisJeffery L Smith
Hepatic Fibrosis Group, The Queensland Institute of Medical Research, Brisbane, Australia
Hepatology 39:1673-82. 2004..The correlation between both cholic acid and cholic acid/chenodeoxycholic acid levels with histological liver injury and fibrosis progression suggests a potential monitoring role for these bile acids in CFLD...
- Not all soy products are created equal: caution needed in interpretation of research resultsJohn W Erdman
Department of Food Science and Human Nutrition, University of Illinois, Urbana, IL 61801, USA
J Nutr 134:1229S-1233S. 2004..Efforts are needed by all to reduce the public confusion by adapting standardized approaches to the reporting of data. This paper provides a framework for both standardization of nomenclature and appropriate interpretation of data...
- Factors affecting the bioavailability of soy isoflavones in humans after ingestion of physiologically relevant levels from different soy foodsAedin Cassidy
School of Medicine, University of East Anglia, Norwich, UK
J Nutr 136:45-51. 2006..Only 30% of the subjects were equol producers and no differences in equol production with age or gender were observed...
- Influence of breast feeding, and adapted and hydrolyzed formulas on biliary bile acids in newborn guinea pigsCarla Colombo
Institute of Pediatrics and Neonatology, School of Medicine, Ospedale San Paolo, University of Milan, Via Commenda 9, I 20122 Milan, Italy
Biol Neonate 83:36-41. 2003..The type of feeding can differently influence bile acid ontogeny during the period of physiologic cholestasis that characterizes early human development...
- Molecular genetics of 3beta-hydroxy-Delta5-C27-steroid oxidoreductase deficiency in 16 patients with loss of bile acid synthesis and liver diseaseJeffrey B Cheng
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
J Clin Endocrinol Metab 88:1833-41. 2003..We conclude that a diverse spectrum of mutations in the HSD3B7 gene underlies this rare form of neonatal cholestasis...
- Assessing risks and benefits of genistein and soyKenneth D R Setchell
Environ Health Perspect 114:A332-3. 2006
- Influences of dietary soy isoflavones on metabolism but not nociception and stress hormone responses in ovariectomized female ratsLihong Bu
Physiology and Developmental Biology Department, Neuroscience Center, Brigham Young University, Provo, Utah 84602, USA
Reprod Biol Endocrinol 3:58. 2005..Isoflavones, the most abundant phytoestrogens in soy foods, are structurally similar to 17beta-estradiol. Few studies have examined the nociception and stress hormone responses after consumption of soy isoflavones...
- Analysis of HSD3B7 knockout mice reveals that a 3alpha-hydroxyl stereochemistry is required for bile acid functionHeidi C Shea
Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 104:11526-33. 2007..We conclude that the correct stereochemistry of a single hydroxyl group at carbon 3 in bile acids is required to maintain their physiologic and regulatory functions in mammals...
- Equol is a novel anti-androgen that inhibits prostate growth and hormone feedbackTrent D Lund
Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80524, USA
Biol Reprod 70:1188-95. 2004....