K D Setchell

Summary

Affiliation: Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi request reprint Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability
    Kenneth D R Setchell
    Division of Clinical Mass Spectrometry, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Am J Clin Nutr 76:447-53. 2002
  2. pmc Identification of a new inborn error in bile acid synthesis: mutation of the oxysterol 7alpha-hydroxylase gene causes severe neonatal liver disease
    K D Setchell
    Clinical Mass Spectrometry Center, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Clin Invest 102:1690-703. 1998
  3. ncbi request reprint Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones
    K D Setchell
    Clinical Mass Spectrometry Center, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Am J Clin Nutr 68:1333S-1346S. 1998
  4. ncbi request reprint Isoflavone content of infant formulas and the metabolic fate of these phytoestrogens in early life
    K D Setchell
    Clinical Mass Spectrometry Center, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Am J Clin Nutr 68:1453S-1461S. 1998
  5. ncbi request reprint Soy isoflavones--benefits and risks from nature's selective estrogen receptor modulators (SERMs)
    K D Setchell
    Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Am Coll Nutr 20:354S-362S; discussion 381S-383S. 2001
  6. ncbi request reprint Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements
    K D Setchell
    Division of Clinical Mass Spectrometry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Nutr 131:1362S-75S. 2001
  7. ncbi request reprint Animal models impacted by phytoestrogens in commercial chow: implications for pathways influenced by hormones
    N M Brown
    Clinical Mass Spectrometry, Children s Hospital Medical Center, Cincinnati, Ohio 45227, USA
    Lab Invest 81:735-47. 2001
  8. ncbi request reprint Dietary inclusion of whole soy foods results in significant reductions in clinical risk factors for osteoporosis and cardiovascular disease in normal postmenopausal women
    M D Scheiber
    Departments of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Cincinnati, USA
    Menopause 8:384-92. 2001
  9. ncbi request reprint Myocardial Akt activation and gender: increased nuclear activity in females versus males
    D Camper-Kirby
    Division of Molecular Cardiovascular Biology, The Children's Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    Circ Res 88:1020-7. 2001
  10. ncbi request reprint Disruption of cholesterol 7alpha-hydroxylase gene in mice. II. Bile acid deficiency is overcome by induction of oxysterol 7alpha-hydroxylase
    M Schwarz
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9046, USA
    J Biol Chem 271:18024-31. 1996

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability
    Kenneth D R Setchell
    Division of Clinical Mass Spectrometry, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Am J Clin Nutr 76:447-53. 2002
    ....
  2. pmc Identification of a new inborn error in bile acid synthesis: mutation of the oxysterol 7alpha-hydroxylase gene causes severe neonatal liver disease
    K D Setchell
    Clinical Mass Spectrometry Center, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Clin Invest 102:1690-703. 1998
    ..These findings indicate the quantitative importance of the acidic pathway in early life in humans and define a further inborn error in bile acid synthesis as a metabolic cause of severe cholestatic liver disease...
  3. ncbi request reprint Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones
    K D Setchell
    Clinical Mass Spectrometry Center, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Am J Clin Nutr 68:1333S-1346S. 1998
    ..These phytoestrogens and their metabolites have many potent hormonal and nonhormonal activities that may explain some of the biological effects of diets rich in phytoestrogens...
  4. ncbi request reprint Isoflavone content of infant formulas and the metabolic fate of these phytoestrogens in early life
    K D Setchell
    Clinical Mass Spectrometry Center, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Am J Clin Nutr 68:1453S-1461S. 1998
    ..Exposure to these phytoestrogens early in life may have long-term health benefits for hormone-dependent diseases...
  5. ncbi request reprint Soy isoflavones--benefits and risks from nature's selective estrogen receptor modulators (SERMs)
    K D Setchell
    Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Am Coll Nutr 20:354S-362S; discussion 381S-383S. 2001
    ..This article is not intended to be a comprehensive review of the literature but merely highlight recent research with key historical perspectives...
  6. ncbi request reprint Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements
    K D Setchell
    Division of Clinical Mass Spectrometry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Nutr 131:1362S-75S. 2001
    ..These studies indicate a need for improvement in quality assurance and standardization of such products...
  7. ncbi request reprint Animal models impacted by phytoestrogens in commercial chow: implications for pathways influenced by hormones
    N M Brown
    Clinical Mass Spectrometry, Children s Hospital Medical Center, Cincinnati, Ohio 45227, USA
    Lab Invest 81:735-47. 2001
    ....
  8. ncbi request reprint Dietary inclusion of whole soy foods results in significant reductions in clinical risk factors for osteoporosis and cardiovascular disease in normal postmenopausal women
    M D Scheiber
    Departments of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Cincinnati, USA
    Menopause 8:384-92. 2001
    ..Long-term, placebo-controlled clinical trials are needed to evaluate the effect of phytoestrogens on the clinical endpoints of CVD and osteoporosis in this population...
  9. ncbi request reprint Myocardial Akt activation and gender: increased nuclear activity in females versus males
    D Camper-Kirby
    Division of Molecular Cardiovascular Biology, The Children's Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    Circ Res 88:1020-7. 2001
    ..The activation of Akt in a gender-dependent manner may help explain differences observed in cardiovascular disease risk between the sexes and supports the potential beneficial effects of estrogenic stimulation...
  10. ncbi request reprint Disruption of cholesterol 7alpha-hydroxylase gene in mice. II. Bile acid deficiency is overcome by induction of oxysterol 7alpha-hydroxylase
    M Schwarz
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9046, USA
    J Biol Chem 271:18024-31. 1996
    ..In older animals, an alternate pathway of bile acid synthesis involving an inducible oxysterol 7alpha-hydroxylase plays a crucial role in lipid and bile acid metabolism...
  11. ncbi request reprint Modulation of steady-state messenger RNA levels in the regenerating rat liver with bile acid feeding
    B T Kren
    Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Liver Transpl 7:321-34. 2001
    ..These data suggest that bile acids may have a key role in liver regeneration, which is significantly altered by modulation of the bile-acid pool...
  12. ncbi request reprint Dietary soy-phytoestrogens decrease testosterone levels and prostate weight without altering LH, prostate 5alpha-reductase or testicular steroidogenic acute regulatory peptide levels in adult male Sprague-Dawley rats
    K S Weber
    Neuroscience Center, Brigham Young University, Provo, Utah 86402, USA
    J Endocrinol 170:591-9. 2001
    ....
  13. ncbi request reprint Altered sexually dimorphic nucleus of the preoptic area (SDN-POA) volume in adult Long-Evans rats by dietary soy phytoestrogens
    T D Lund
    The Neuroscience Center, Brigham Young University, Provo, UT 84602, USA
    Brain Res 914:92-9. 2001
    ..These data suggest that consumption of phytoestrogens via a soy diet, significantly: (1) decreases body and prostate weight, (2) delays puberty onset, and (3) alters SDN-POA volumes during adulthood...
  14. ncbi request reprint Maternal and perinatal brain aromatase: effects of dietary soy phytoestrogens
    K S Weber
    633 WIDB, Neuroscience Center, Brigham Young University, Provo, UT 84602, USA
    Brain Res Dev Brain Res 126:217-21. 2001
    ..Dietary phytoestrogens, however, do not alter brain aromatase during pregnancy/lactation or perinatal development...
  15. ncbi request reprint Adaptive regulation of bile salt transporters in kidney and liver in obstructive cholestasis in the rat
    J Lee
    Liver Center and Department of Medicine, Yale University School of Medicine, 1080 LMP, New Haven, CT 06520-8019, USA
    Gastroenterology 121:1473-84. 2001
    ..These responses may facilitate extrahepatic pathways for bile salt excretion during cholestasis...