N L Seibel

Summary

Affiliation: Children's National Medical Center
Country: USA

Publications

  1. ncbi request reprint Phase I trial of docetaxel with filgrastim support in pediatric patients with refractory solid tumors: a collaborative Pediatric Oncology Branch, National Cancer Institute and Children's Cancer Group trial
    N L Seibel
    Department of Hematology Oncology, Children s National Medical Center, George Washington University School of Medicine, Washington, DC 20010, USA
    Clin Cancer Res 5:733-7. 1999
  2. ncbi request reprint Effect of duration of treatment on treatment outcome for patients with clear-cell sarcoma of the kidney: a report from the National Wilms' Tumor Study Group
    Nita L Seibel
    Department of Hematology Oncology, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    J Clin Oncol 22:468-73. 2004
  3. pmc Early postinduction intensification therapy improves survival for children and adolescents with high-risk acute lymphoblastic leukemia: a report from the Children's Oncology Group
    Nita L Seibel
    Hematology Oncology, Children s National Medical Center and George Washington University School of Medicine and Public Health, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Blood 111:2548-55. 2008
  4. ncbi request reprint Upfront window trial of topotecan in previously untreated children and adolescents with poor prognosis metastatic osteosarcoma: children's Cancer Group (CCG) 7943
    Nita L Seibel
    Hematology Oncology, Children s National Medical Center, George Washington University School of Medicine, Washington, DC 20010, USA
    Cancer 109:1646-53. 2007
  5. ncbi request reprint Phase I/II study of idarubicin given with continuous infusion fludarabine followed by continuous infusion cytarabine in children with acute leukemia: a report from the Children's Cancer Group
    P A Dinndorf
    Children s National Medical Center, Washington, DC, USA
    J Clin Oncol 15:2780-5. 1997
  6. pmc Phase 2 trial of recombinant tumor necrosis factor-alpha in combination with dactinomycin in children with recurrent Wilms tumor
    Holly J Meany
    Department of Pediatric Hematology Oncology, Children s National Medical Center, Washington, DC 20010, USA
    J Immunother 31:679-83. 2008
  7. ncbi request reprint Phase I study of temozolomide in children and adolescents with recurrent solid tumors: a report from the Children's Cancer Group
    H S Nicholson
    Department of Hematology Oncology, Children s National Medical Center, Washington, DC, USA
    J Clin Oncol 16:3037-43. 1998
  8. ncbi request reprint Primary cutaneous CD30-positive anaplastic large cell lymphoma in childhood: report of 4 cases and review of the literature
    Shimareet Kumar
    Department of Anatomic Pathology, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Pediatr Dev Pathol 8:52-60. 2005
  9. doi request reprint Aprepitant use in children, adolescents, and young adults for the control of chemotherapy-induced nausea and vomiting (CINV)
    Mi Rim Choi
    Division of Hematology and Oncology, Children s National Medical Center, Washington, DC, USA
    J Pediatr Hematol Oncol 32:e268-71. 2010
  10. ncbi request reprint Phase I trial of cisplatin and topotecan in children with recurrent solid tumors: Children's Cancer Group Study 0942
    Robert J Wells
    Children s Hospital Research Foundation, Cincinnati, Ohio, USA
    J Pediatr Hematol Oncol 24:89-93. 2002

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Phase I trial of docetaxel with filgrastim support in pediatric patients with refractory solid tumors: a collaborative Pediatric Oncology Branch, National Cancer Institute and Children's Cancer Group trial
    N L Seibel
    Department of Hematology Oncology, Children s National Medical Center, George Washington University School of Medicine, Washington, DC 20010, USA
    Clin Cancer Res 5:733-7. 1999
    ..The maximum tolerated dose of docetaxel with G-CSF support in children is 185 mg/m2, which is 50% higher than the maximum tolerated dose of docetaxel alone in children and 85 % higher than the recommended adult dose...
  2. ncbi request reprint Effect of duration of treatment on treatment outcome for patients with clear-cell sarcoma of the kidney: a report from the National Wilms' Tumor Study Group
    Nita L Seibel
    Department of Hematology Oncology, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    J Clin Oncol 22:468-73. 2004
    ....
  3. pmc Early postinduction intensification therapy improves survival for children and adolescents with high-risk acute lymphoblastic leukemia: a report from the Children's Oncology Group
    Nita L Seibel
    Hematology Oncology, Children s National Medical Center and George Washington University School of Medicine and Public Health, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Blood 111:2548-55. 2008
    ..Longer duration PII provided no benefit. Stronger intensity but not prolonged duration PII improved outcome for patients with higher-risk ALL. This study is registered at http://clinicaltrials.gov as NCT00002812...
  4. ncbi request reprint Upfront window trial of topotecan in previously untreated children and adolescents with poor prognosis metastatic osteosarcoma: children's Cancer Group (CCG) 7943
    Nita L Seibel
    Hematology Oncology, Children s National Medical Center, George Washington University School of Medicine, Washington, DC 20010, USA
    Cancer 109:1646-53. 2007
    ....
  5. ncbi request reprint Phase I/II study of idarubicin given with continuous infusion fludarabine followed by continuous infusion cytarabine in children with acute leukemia: a report from the Children's Cancer Group
    P A Dinndorf
    Children s National Medical Center, Washington, DC, USA
    J Clin Oncol 15:2780-5. 1997
    ..The phase I study was extended to a limited phase II study to assess the activity of this combination in children with acute myelogenous leukemia (AML)...
  6. pmc Phase 2 trial of recombinant tumor necrosis factor-alpha in combination with dactinomycin in children with recurrent Wilms tumor
    Holly J Meany
    Department of Pediatric Hematology Oncology, Children s National Medical Center, Washington, DC 20010, USA
    J Immunother 31:679-83. 2008
    ..The combination was well tolerated. Although grade 3/4 adverse events were reported, dose adjustments were not required. Toxicities resolved without significant interventions...
  7. ncbi request reprint Phase I study of temozolomide in children and adolescents with recurrent solid tumors: a report from the Children's Cancer Group
    H S Nicholson
    Department of Hematology Oncology, Children s National Medical Center, Washington, DC, USA
    J Clin Oncol 16:3037-43. 1998
    ..The Children's Cancer Group conducted a phase I trial of temozolomide stratified by prior craniospinal irradiation (CSI)...
  8. ncbi request reprint Primary cutaneous CD30-positive anaplastic large cell lymphoma in childhood: report of 4 cases and review of the literature
    Shimareet Kumar
    Department of Anatomic Pathology, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Pediatr Dev Pathol 8:52-60. 2005
    ..Recognition of this entity and its differentiation from other T-cell lymphomas that secondarily involve the skin is important to avoid unnecessarily aggressive therapy in these children...
  9. doi request reprint Aprepitant use in children, adolescents, and young adults for the control of chemotherapy-induced nausea and vomiting (CINV)
    Mi Rim Choi
    Division of Hematology and Oncology, Children s National Medical Center, Washington, DC, USA
    J Pediatr Hematol Oncol 32:e268-71. 2010
    ..However, little is known about its effect in the pediatric oncology population, with only a few reported cases in the literature...
  10. ncbi request reprint Phase I trial of cisplatin and topotecan in children with recurrent solid tumors: Children's Cancer Group Study 0942
    Robert J Wells
    Children s Hospital Research Foundation, Cincinnati, Ohio, USA
    J Pediatr Hematol Oncol 24:89-93. 2002
    ..To determine the maximum tolerated dose (MTD) and dose-limiting toxicities (DLTs) of cisplatin after a 72-hour continuous infusion of topotecan...
  11. ncbi request reprint Deamination of glutamine is a prerequisite for optimal asparagine deamination by asparaginases in vivo (CCG-1961)
    Eduard H Panosyan
    Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    Anticancer Res 24:1121-5. 2004
    ..The pharmacodynamic (PD) rationale is based on the role of Gln as the main amino group donor for Asn synthesis from aspartate by the enzyme asparagine synthetase (AS)...
  12. ncbi request reprint Changes of amino acid serum levels in pediatric patients with higher-risk acute lymphoblastic leukemia (CCG-1961)
    Rita S Grigoryan
    Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    In Vivo 18:107-12. 2004
    ..Deamination of asparagine (Asn) and glutamine (Gln) by asparaginases (ASNase) is associated with good prognosis in acute lymphoblastic leukemia (ALL). Chemotherapy drugs used for ALL may accelerate catabolism of other amino acids (AA)...
  13. ncbi request reprint Obesity and outcome in pediatric acute lymphoblastic leukemia
    Anna M Butturini
    Childrens Hospital Los Angeles and Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA
    J Clin Oncol 25:2063-9. 2007
    ..To evaluate the effect of obesity (defined as a body mass index > 95th percentile for age and sex at diagnosis) on outcome of pediatric acute lymphoblastic leukemia (ALL)...
  14. ncbi request reprint A Phase 1 and pharmacokinetic clinical trial of paclitaxel for the treatment of refractory leukemia in children: a Children's Oncology Group study
    Terzah M Horton
    Texas Children s Cancer Center Baylor College of Medicine, Houston, Texas, USA
    Pediatr Blood Cancer 50:788-92. 2008
    ....
  15. ncbi request reprint Asparaginase antibody and asparaginase activity in children with higher-risk acute lymphoblastic leukemia: Children's Cancer Group Study CCG-1961
    Eduard H Panosyan
    Childrens Hospital Los Angeles, Los Angeles, California 90027, USA
    J Pediatr Hematol Oncol 26:217-26. 2004
    ..Anti-asparaginase Ab was associated with undetectable asparaginase activity and may be correlated with adverse outcomes in HR ALL...
  16. ncbi request reprint Phase I trial and pharmacokinetics of gemcitabine in children with advanced solid tumors
    Joel M Reid
    Mayo Clinic, Rochester, MN, USA
    J Clin Oncol 22:2445-51. 2004
    ..To determine the maximum tolerated dose, toxicity, and pharmacokinetics of gemcitabine in children with refractory solid tumors...