M E Rothenberg

Summary

Affiliation: Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi CD44--a sticky target for asthma
    Marc E Rothenberg
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Clin Invest 111:1460-2. 2003
  2. ncbi Gastrointestinal eosinophils
    M E Rothenberg
    Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Immunol Rev 179:139-55. 2001
  3. ncbi A pathological function for eotaxin and eosinophils in eosinophilic gastrointestinal inflammation
    S P Hogan
    Division of Pulmonary Medicine, Allergy and Clinical Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Nat Immunol 2:353-60. 2001
  4. ncbi An etiological role for aeroallergens and eosinophils in experimental esophagitis
    A Mishra
    Division of Pulmonary Medicine, Allergy and Clinical Immunology, Department of Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio, USA
    J Clin Invest 107:83-90. 2001
  5. ncbi The alpha4bbeta7-integrin is dynamically expressed on murine eosinophils and involved in eosinophil trafficking to the intestine
    E B Brandt
    Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Clin Exp Allergy 36:543-53. 2006
  6. ncbi IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanism
    S M Pope
    Division of Pulmonary Medicine, Allergy and Clinical Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 108:594-601. 2001
  7. ncbi Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis
    A Munitz
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 105:7240-5. 2008
  8. ncbi Local B cells and IgE production in the oesophageal mucosa in eosinophilic oesophagitis
    M Vicario
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Gut 59:12-20. 2010
  9. ncbi A critical role for eotaxin in experimental oral antigen-induced eosinophilic gastrointestinal allergy
    S P Hogan
    Division of Pulmonary Medicine, Allergy and Clinical Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 97:6681-6. 2000
  10. ncbi Murine eotaxin-2: a constitutive eosinophil chemokine induced by allergen challenge and IL-4 overexpression
    N Zimmermann
    Division of Pulmonary Medicine, Allergy, and Clinical Immunology, Department of Pediatrics, Children s Hospital Medical Center, University of Cincinnati, OH 45229, USA
    J Immunol 165:5839-46. 2000

Collaborators

Detail Information

Publications81

  1. ncbi CD44--a sticky target for asthma
    Marc E Rothenberg
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Clin Invest 111:1460-2. 2003
  2. ncbi Gastrointestinal eosinophils
    M E Rothenberg
    Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Immunol Rev 179:139-55. 2001
    ..We propose that eosinophils are integral members of the gastrointestinal immune system and are likely to be important in innate, regulatory and inflammatory immune responses...
  3. ncbi A pathological function for eotaxin and eosinophils in eosinophilic gastrointestinal inflammation
    S P Hogan
    Division of Pulmonary Medicine, Allergy and Clinical Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Nat Immunol 2:353-60. 2001
    ..These results establish a critical pathological function for eotaxin and eosinophils in gastrointestinal allergic hypersensitivity...
  4. ncbi An etiological role for aeroallergens and eosinophils in experimental esophagitis
    A Mishra
    Division of Pulmonary Medicine, Allergy and Clinical Immunology, Department of Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio, USA
    J Clin Invest 107:83-90. 2001
    ..These results establish a pathophysiological connection between allergic hypersensitivity responses in the lung and esophagus and demonstrate an etiologic role for inhaled allergens and eosinophils in gastrointestinal inflammation...
  5. ncbi The alpha4bbeta7-integrin is dynamically expressed on murine eosinophils and involved in eosinophil trafficking to the intestine
    E B Brandt
    Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Clin Exp Allergy 36:543-53. 2006
    ..CONCLUSION: Taken together, these results identify differential expression of the alpha4beta7-integrin on eosinophils and its critical role in regulating eosinophil responses in the intestine...
  6. ncbi IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanism
    S M Pope
    Division of Pulmonary Medicine, Allergy and Clinical Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 108:594-601. 2001
    ..IL-13 induces several characteristic features of asthma, including airway eosinophilia, airway hyperresponsiveness, and mucus overproduction; however, the mechanisms involved are largely unknown...
  7. ncbi Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis
    A Munitz
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 105:7240-5. 2008
    ..Taken together, our data provide a comprehensive mechanistic analysis of the critical role by which IL-13Ralpha1 mediates allergic lung pathology and highlight unforeseen roles for the type II IL-4R...
  8. ncbi Local B cells and IgE production in the oesophageal mucosa in eosinophilic oesophagitis
    M Vicario
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Gut 59:12-20. 2010
    ....
  9. ncbi A critical role for eotaxin in experimental oral antigen-induced eosinophilic gastrointestinal allergy
    S P Hogan
    Division of Pulmonary Medicine, Allergy and Clinical Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 97:6681-6. 2000
    ..Furthermore, eotaxin is identified as a critical regulator of antigen-induced eosinophilic inflammation in the gastrointestinal tract...
  10. ncbi Murine eotaxin-2: a constitutive eosinophil chemokine induced by allergen challenge and IL-4 overexpression
    N Zimmermann
    Division of Pulmonary Medicine, Allergy, and Clinical Immunology, Department of Pediatrics, Children s Hospital Medical Center, University of Cincinnati, OH 45229, USA
    J Immunol 165:5839-46. 2000
    ..Thus, murine eotaxin-2 is a constitutively expressed eosinophil chemokine likely to be involved in homeostatic, allergen-induced, and IL-4-associated immune responses...
  11. ncbi Periostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responses
    C Blanchard
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Mucosal Immunol 1:289-96. 2008
    ....
  12. ncbi Chemokines and chemokine receptors: their role in allergic airway disease
    M E Rothenberg
    Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Clin Immunol 19:250-65. 1999
    ..In this regard, chemokines are attractive new therapeutic targets for the treatment of allergic disease. This article focuses on recently emerging data on the importance of chemokines and their receptors in allergic airway inflammation...
  13. ncbi Interleukin-5-mediated allergic airway inflammation inhibits the human surfactant protein C promoter in transgenic mice
    A Mishra
    Division of Pulmonary Medicine, Allergy and Clinical Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Biol Chem 276:8453-9. 2001
    ..These results suggest that alterations in surfactant protein levels may contribute to immune and airway dysfunction in asthma...
  14. ncbi Inhibition of human interleukin-13-induced respiratory and oesophageal inflammation by anti-human-interleukin-13 antibody (CAT-354)
    C Blanchard
    Department of Pediatrics, Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Clin Exp Allergy 35:1096-103. 2005
    ..CONCLUSION: These results demonstrate that anti-human IL-13 (CAT-354) is a potential therapeutic treatment for allergic airway and oesophageal diseases...
  15. ncbi Siglec-F antibody administration to mice selectively reduces blood and tissue eosinophils
    N Zimmermann
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center and Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, OH 45229, USA
    Allergy 63:1156-63. 2008
    ..We therefore hypothesized that Siglec-F engagement would affect levels and viability of eosinophils in vivo...
  16. ncbi MiR-375 is downregulated in epithelial cells after IL-13 stimulation and regulates an IL-13-induced epithelial transcriptome
    T X Lu
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Mucosal Immunol 5:388-96. 2012
    ..Taken together, our results support a key role of miRNAs, particularly miR-375, in regulating and fine-tuning IL-13-mediated responses...
  17. ncbi Review article: The eosinophil as a therapeutic target in gastrointestinal disease
    S P Hogan
    Cincinnati Children s Hospital Medical Center, Division of Allergy and Immunology, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Aliment Pharmacol Ther 20:1231-40. 2004
    ....
  18. ncbi Eotaxin is required for the baseline level of tissue eosinophils
    A N Matthews
    Division of Pulmonary Medicine, Allergy, and Clinical Immunology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 95:6273-8. 1998
    ..Because a variety of chemokines are constitutively expressed, their involvement in the baseline trafficking of leukocytes into nonhematopoietic tissue should now be considered...
  19. ncbi Analysis of the CC chemokine receptor 3 gene reveals a complex 5' exon organization, a functional role for untranslated exon 1, and a broadly active promoter with eosinophil-selective elements
    N Zimmermann
    Division of Pulmonary Medicine, Allergy and Clinical Immunology, Department of Pediatrics, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Blood 96:2346-54. 2000
    ..Thus, the human CCR3 gene has a complex 5' exon structure, a conserved promoter with strong activity in multiple cell types, and a functional 5' untranslated exon...
  20. ncbi Quality of life in paediatric eosinophilic oesophagitis: what is important to patients?
    J P Franciosi
    Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Child Care Health Dev 38:477-83. 2012
    ..The primary objective of this study was to identify key patient-reported and parent proxy outcome elements of EoE disease-specific HRQOL...
  21. ncbi Trefoil factor-2 is an allergen-induced gene regulated by Th2 cytokines and STAT6 in the lung
    Nikolaos M Nikolaidis
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MLC 7028 Cincinnati, OH 45229, USA
    Am J Respir Cell Mol Biol 29:458-64. 2003
    ....
  22. ncbi The role of Th2 cytokines, chemokines and parasite products in eosinophil recruitment to the gastrointestinal mucosa during helminth infection
    Helen Dixon
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Eur J Immunol 36:1753-63. 2006
    ..spiralis and T. muris products, suggest that CCL11 is the salient but not the sole eosinophil chemoattractant of biological significance during gastrointestinal helminth infection...
  23. ncbi Resistin-like molecule-beta is an allergen-induced cytokine with inflammatory and remodeling activity in the murine lung
    Anil Mishra
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Am J Physiol Lung Cell Mol Physiol 293:L305-13. 2007
    ..In vitro experiments demonstrated that RELM-beta had fibroblast motogenic activity. These results identify RELM-beta as a Th2-associated cytokine with potent inflammatory and remodeling activity...
  24. ncbi IL-17E upregulates the expression of proinflammatory cytokines in lung fibroblasts
    Severine Letuve
    Meakins Christie Laboratories, Department of Pathology and Medicine, McGill University, Montreal, Quebec, Canada
    J Allergy Clin Immunol 117:590-6. 2006
    ..IL-17E proinflammatory activity has been proposed to involve induction of cytokine and chemokine production. Recruitment of inflammatory cells may be mediated by tissue-resident cells...
  25. ncbi Interplay of adaptive th2 immunity with eotaxin-3/c-C chemokine receptor 3 in eosinophilic esophagitis
    Jennifer Z Bullock
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    J Pediatr Gastroenterol Nutr 45:22-31. 2007
    ..Although studies of esophageal tissue suggest that Th2 cytokines and eotaxin-3 may be crucial in disease pathogenesis, little is known about the systemic immunological phenotypes of children with EE...
  26. ncbi A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammation
    Patricia C Fulkerson
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45257 0524, USA
    Proc Natl Acad Sci U S A 103:16418-23. 2006
    ..In summary, we present multiple lines of independent evidence that eosinophils via CCR3 have a central role in chronic allergic airway disease...
  27. ncbi Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma
    Joerg Mattes
    Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
    J Exp Med 195:1433-44. 2002
    ....
  28. ncbi Epicutaneous antigen exposure primes for experimental eosinophilic esophagitis in mice
    Hiroko Saito Akei
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Gastroenterology 129:985-94. 2005
    ..CONCLUSIONS: These findings provide the first evidence that epicutaneous exposure to allergens potently primes for EE via a Th2-dependent mechanism...
  29. ncbi Eosinophilic gastrointestinal disorders (EGID)
    Marc E Rothenberg
    Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA
    J Allergy Clin Immunol 113:11-28; quiz 29. 2004
    ..An essential question is to determine the cellular and molecular basis for each of these clinical problems and the best treatment regimen, which is the main subject of this review...
  30. ncbi Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis
    Nives Zimmermann
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Clin Invest 111:1863-74. 2003
    ..Based on the ability of arginase to regulate generation of NO, polyamines, and collagen, these results provide a basis for pharmacologically targeting arginine metabolism in allergic disorders...
  31. ncbi Chemokines in asthma: cooperative interaction between chemokines and IL-13
    Nives Zimmermann
    Divisions of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA
    J Allergy Clin Immunol 111:227-42; quiz 243. 2003
    ....
  32. ncbi Origin, regulation and physiological function of intestinal oeosinophils
    Patricia C Fulkerson
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Best Pract Res Clin Gastroenterol 22:411-23. 2008
    ..In addition, the regulation of oeosinophil survival by inhibitory and death receptors and the expanding role for oeosinophils in health and disease are reviewed...
  33. ncbi Immunotherapy of cytotoxic T cell-resistant tumors by T helper 2 cells: an eotaxin and STAT6-dependent process
    Joerg Mattes
    Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia
    J Exp Med 197:387-93. 2003
    ..In contrast, tumor-specific CD4(+) Th1 cells, that recruited macrophages into the tumors, had no effect on tumor growth. This work provides the basis for a new approach to adoptive T cell immunotherapy of cancer...
  34. ncbi Allergen induced TFF2 is expressed by mucus-producing airway epithelial cells but is not a major regulator of inflammatory responses in the murine lung
    Nikolaos M Nikolaidis
    Department of Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Exp Lung Res 32:483-97. 2006
    ..Thus, TFF2 is an allergen-induced gene, which is expressed in mucus-positive airways, but is not a major contributor to allergen-induced goblet cell metaplasia, mucus production, or inflammatory responses in the lung...
  35. ncbi Eosinophils and CCR3 regulate interleukin-13 transgene-induced pulmonary remodeling
    Patricia C Fulkerson
    Deparmtnet of Molecular Genetics, Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Ave, MLC 7028, Cincinnati, OH 45229, USA
    Am J Pathol 169:2117-26. 2006
    ..Taken together, these data definitively identify a functional contribution by eosinophils on the effects of chronic IL-13 expression in the lung...
  36. ncbi Anti-IL-5 (mepolizumab) therapy for eosinophilic esophagitis
    Miguel L Stein
    Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
    J Allergy Clin Immunol 118:1312-9. 2006
    ..CLINICAL IMPLICATIONS: Anti-IL-5 is a promising therapeutic intervention for EE...
  37. ncbi Eosinophils in the new millennium
    Marc E Rothenberg
    J Allergy Clin Immunol 119:1321-2. 2007
  38. ncbi Crosstalk between Gi and Gq/Gs pathways in airway smooth muscle regulates bronchial contractility and relaxation
    Dennis W McGraw
    Pulmonary Division, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Clin Invest 117:1391-8. 2007
    ..By selective intervention within these multipronged signaling modules, advantageous G(s)/G(q) activities could provide new asthma therapies...
  39. ncbi Influence of cigarette smoke on the arginine pathway in asthmatic airways: increased expression of arginase I
    Celine Bergeron
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    J Allergy Clin Immunol 119:391-7. 2007
    ..We have shown that arginase I and iNOS are upregulated in asthma. Smoking asthmatic subjects are reported to have low exhaled nitric oxide levels. The effect of cigarette smoking on the expression of arginase I in asthma is unknown...
  40. ncbi Summary of the First International Gastrointestinal Eosinophil Research Symposium
    Chris A Liacouras
    J Pediatr Gastroenterol Nutr 45:370-91. 2007
  41. ncbi Mitochondrial missile defense
    Victor Nizet
    Nat Med 14:910-2. 2008
  42. ncbi FIP1L1/PDGFRalpha synergizes with SCF to induce systemic mastocytosis in a murine model of chronic eosinophilic leukemia/hypereosinophilic syndrome
    Yoshiyuki Yamada
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, OH 45229 3039, USA
    Blood 112:2500-7. 2008
    ..The increased proliferation and survival correlated with increased SCF-induced Akt activation. In summary, F/P synergistically promotes MC development, activation, and survival in vivo and in vitro in response to SCF...
  43. ncbi Clinical, pathologic, and molecular characterization of familial eosinophilic esophagitis compared with sporadic cases
    Margaret H Collins
    Division of Pathology and Laboratory Medicine, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Clin Gastroenterol Hepatol 6:621-9. 2008
    ..Eosinophilic esophagitis (EE) occurs in families...
  44. ncbi Enterocyte expression of the eotaxin and interleukin-5 transgenes induces compartmentalized dysregulation of eosinophil trafficking
    Anil Mishra
    Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Biol Chem 277:4406-12. 2002
    ....
  45. ncbi Eosinophils: biological properties and role in health and disease
    Simon P Hogan
    Clin Exp Allergy 38:709-50. 2008
    ..Finally, strategies for targeted therapeutic intervention in eosinophil-mediated mucosal diseases are conceptualized...
  46. ncbi Surfactant protein D alters allergic lung responses in mice and human subjects
    Eric B Brandt
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 121:1140-1147.e2. 2008
    ..Surfactant protein (SP) D has been proposed to be protective in allergic airway responses...
  47. ncbi Anti-IL-5 (mepolizumab) therapy reduces eosinophil activation ex vivo and increases IL-5 and IL-5 receptor levels
    Miguel L Stein
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 121:1473-83, 1483.e1-4. 2008
    ..Anti-IL-5 might be a useful therapeutic agent for eosinophilic disorders, yet its immunologic consequences have not been well characterized...
  48. ncbi Treatment of patients with the hypereosinophilic syndrome with mepolizumab
    Marc E Rothenberg
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    N Engl J Med 358:1215-28. 2008
    ..Although most patients have a response to corticosteroids, side effects are common and can lead to considerable morbidity...
  49. ncbi A dual activation and inhibition role for the paired immunoglobulin-like receptor B in eosinophils
    Ariel Munitz
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, OH 45229, USA
    Blood 111:5694-703. 2008
    ..These data change the conventional wisdom that inhibitory receptors are restricted to inhibitory signals; we therefore propose that a single receptor can have dual functionality in distinct cell types after unique cellular signals...
  50. ncbi Basic pathogenesis of eosinophilic esophagitis
    Carine Blanchard
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Gastrointest Endosc Clin N Am 18:133-43; x. 2008
    ....
  51. ncbi An eosinophil hypothesis for functional dyspepsia
    Marc E Rothenberg
    Clin Gastroenterol Hepatol 5:1147-8. 2007
  52. ncbi Gastrointestinal eosinophilia
    Li Zuo
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Immunol Allergy Clin North Am 27:443-55. 2007
    ..All three groups of gastrointestinal eosinophila are described in this article, although the focus is on primary gastrointestinal eosinophilia...
  53. ncbi Potential of blood eosinophils, eosinophil-derived neurotoxin, and eotaxin-3 as biomarkers of eosinophilic esophagitis
    Michael R Konikoff
    Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229-3039, USA
    Clin Gastroenterol Hepatol 4:1328-36. 2006
    ..CONCLUSIONS: These data show that blood levels of AEC, EDN, and eotaxin-3 may have value as noninvasive biomarkers for monitoring EE...
  54. ncbi Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness
    Ming Yang
    Division of Molecular Biosciences, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Immunol 177:5595-603. 2006
    ....
  55. ncbi Pulmonary chemokine expression is coordinately regulated by STAT1, STAT6, and IFN-gamma
    Patricia C Fulkerson
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45257, USA
    J Immunol 173:7565-74. 2004
    ..Collectively, we demonstrate that allergen-induced inflammation involves coordinate regulation by STAT1, STAT6, and IFN-gamma...
  56. ncbi Arginine in asthma and lung inflammation
    Nina E King
    Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
    J Nutr 134:2830S-2836S; discussion 2853S. 2004
    ..This review focuses on the current body of knowledge on L-arginine metabolism in asthma...
  57. ncbi Expression and regulation of a disintegrin and metalloproteinase (ADAM) 8 in experimental asthma
    Nina E King
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinatti College of Medicine, Cincinnati, OH 45229, USA
    Am J Respir Cell Mol Biol 31:257-65. 2004
    ..Taken together with the role of ADAM33 in asthma, these results suggest that allergic lung responses involve the interplay of diverse members of the ADAM family...
  58. ncbi Negative regulation of eosinophil recruitment to the lung by the chemokine monokine induced by IFN-gamma (Mig, CXCL9)
    Patricia C Fulkerson
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45257 0524, USA
    Proc Natl Acad Sci U S A 101:1987-92. 2004
    ..The identification of a naturally occurring eosinophil inhibitory chemokine pathway in vivo provides a strategic basis for future therapeutic consideration...
  59. ncbi Transcript signatures in experimental asthma: identification of STAT6-dependent and -independent pathways
    Nives Zimmermann
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Immunol 172:1815-24. 2004
    ..These results provide unprecedented insight into the complex steps involved in the pathogenesis of allergic airway responses; as such, these results have significant therapeutic and clinical implications...
  60. ncbi Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes
    Jennifer K Garrett
    Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 113:115-9. 2004
    ..As such, anti-IL-5 may have significant therapeutic potential for hypereosinophilic syndromes...
  61. ncbi Chemokines in eosinophil-associated gastrointestinal disorders
    Simon P Hogan
    Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra, Australia 0200
    Curr Allergy Asthma Rep 4:74-82. 2004
    ..In this review, we describe the role of CD4+ T cells and eosinophils in the clinical manifestations of EGDs and discuss the current understanding of the role of chemokines in the recruitment of these cells in the expression of diseases...
  62. ncbi Mast cells are required for experimental oral allergen-induced diarrhea
    Eric B Brandt
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    J Clin Invest 112:1666-77. 2003
    ..These results demonstrate that oral allergen-induced diarrhea associated with experimental Th2 intestinal inflammation is largely mast cell, IgE, serotonin, and PAF dependent...
  63. ncbi Eotaxin-2 and IL-5 cooperate in the lung to regulate IL-13 production and airway eosinophilia and hyperreactivity
    Ming Yang
    Division of Molecular Biosciences, The John Curtin School of Medical Research, Australian National University, Canberra, ACT
    J Allergy Clin Immunol 112:935-43. 2003
    ..CONCLUSION: These investigations demonstrate important cooperativity between eotaxin-2, IL-5, and IL-13 signaling systems and eosinophils for the development of hallmark features of allergic disease of the lung...
  64. ncbi Molecular analysis of human Siglec-8 orthologs relevant to mouse eosinophils: identification of mouse orthologs of Siglec-5 (mSiglec-F) and Siglec-10 (mSiglec-G)
    Hideyuki Aizawa
    Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    Genomics 82:521-30. 2003
    ....
  65. ncbi Receptor internalization is required for eotaxin-induced responses in human eosinophils
    Nives Zimmermann
    Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 111:97-105. 2003
    ..CONCLUSION: These results establish that CCR3 internalization is critically involved in select eosinophil functional responses (ie, cellular shape change and actin polymerization) but not desensitization and calcium mobilization...
  66. ncbi Constitutive overexpression of IL-5 induces extramedullary hematopoiesis in the spleen
    Sophia Khaldoyanidi
    Division of Vascular Biology, La Jolla Institute for Molecular Medicine, San Diego, CA 92121, USA
    Blood 101:863-8. 2003
    ..Overall, our results suggest that constitutive overexpression of IL-5 can potentially induce colonization of spleen with MSP cells, which provides the necessary microenvironment for establishment of hematopoiesis in extramedullary sites...
  67. ncbi Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation
    Samuel M Pope
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Biol Chem 280:13952-61. 2005
    ..Taken together, these results demonstrate a cooperative mechanism between IL-13 and eotaxin-2. In particular, IL-13 mediates allergen-induced eotaxin-2 expression, and eotaxin-2 mediates IL-13-induced airway eosinophilia...
  68. ncbi Expression and regulation of small proline-rich protein 2 in allergic inflammation
    Nives Zimmermann
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Am J Respir Cell Mol Biol 32:428-35. 2005
    ..Thus, SPRR2 is an allergen- and IL-13-induced gene in experimental allergic responses that may be involved in disease pathophysiology...
  69. ncbi Cationic amino acid transporter 2 regulates inflammatory homeostasis in the lung
    Marc E Rothenberg
    Division of Allergy and Immunology, Cincinnati Children s Hospital and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Proc Natl Acad Sci U S A 103:14895-900. 2006
    ..This process was accompanied by an increase in the number of memory T cells. Thus, our data suggest that CAT2 regulates anti-inflammatory processes in the lungs via regulation of dendritic cell activation and subsequent T cell responses...
  70. ncbi Experimental gastrointestinal allergy enhances pulmonary responses to specific and unrelated allergens
    Eric B Brandt
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    J Allergy Clin Immunol 118:420-7. 2006
    ....
  71. ncbi Epicutaneous aeroallergen exposure induces systemic TH2 immunity that predisposes to allergic nasal responses
    Hiroko Saito Akei
    Divisions of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    J Allergy Clin Immunol 118:62-9. 2006
    ..These results draw attention to the cooperative interaction between the nasal tract and skin. CLINICAL IMPLICATIONS: The skin is a potent site for antigen sensitization in the development of experimental allergic rhinitis...
  72. ncbi CD48 is an allergen and IL-3-induced activation molecule on eosinophils
    Ariel Munitz
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    J Immunol 177:77-83. 2006
    ..Additionally, anti-IL-3 reduces CD48 expression and the degree of airway inflammation. Thus, CD48 is an IL-3-induced activating receptor on eosinophils, likely involved in promoting allergic inflammation...
  73. ncbi ICAM-1-dependent pathways regulate colonic eosinophilic inflammation
    Elizabeth Forbes
    Allergy and Inflammation Research Group, Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Leukoc Biol 80:330-41. 2006
    ..These studies demonstrate that beta2 -integrin/ICAM-1-dependent pathways are integral to eosinophil recruitment into the colon during GI inflammation associated with colonic injury...
  74. ncbi Persistent effects induced by IL-13 in the lung
    Patricia C Fulkerson
    Department of Molecular Genetics, Biochemistry and Microbiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA
    Am J Respir Cell Mol Biol 35:337-46. 2006
    ..Thus, several hallmark features of IL-13-induced lung pathology persist and are dissociated from eosinophilia after IL-13 overexpression ceases...
  75. ncbi The eosinophil
    Marc E Rothenberg
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Annu Rev Immunol 24:147-74. 2006
    ..Finally, strategies for targeted therapeutic intervention in eosinophil-mediated mucosal diseases are conceptualized...
  76. ncbi The arginine-arginase balance in asthma and lung inflammation
    Nives Zimmermann
    Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, OH 45229, USA
    Eur J Pharmacol 533:253-62. 2006
    ..This review focuses on the current body of knowledge on l-arginine metabolism in asthma and lung inflammation...
  77. ncbi Transgenic expression of bean alpha-amylase inhibitor in peas results in altered structure and immunogenicity
    Vanessa E Prescott
    Division of Molecular Bioscience, The John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
    J Agric Food Chem 53:9023-30. 2005
    ..Thus, transgenic expression of non-native proteins in plants may lead to the synthesis of structural variants possessing altered immunogenicity...
  78. ncbi Suppressive effect of IL-4 on IL-13-induced genes in mouse lung
    Fred D Finkelman
    Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 174:4630-8. 2005
    ..These results provide a potential explanation for the dominant role of IL-13 in induction of goblet cell hyperplasia and airway hyperresponsiveness in asthma...
  79. ncbi Analysis of the CCR3 promoter reveals a regulatory region in exon 1 that binds GATA-1
    Nives Zimmermann
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    BMC Immunol 6:7. 2005
    ..It is therefore important to elucidate the molecular mechanisms regulating receptor expression...
  80. ncbi CXCL9 inhibits eosinophil responses by a CCR3- and Rac2-dependent mechanism
    Patricia C Fulkerson
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, OH 45229 3039, USA
    Blood 106:436-43. 2005
    ..These results establish evidence that distinct chemokines can use CCR3 to induce opposing signals in eosinophils...
  81. ncbi Experimental analysis of eosinophil-associated gastrointestinal diseases
    Simon P Hogan
    Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Curr Opin Allergy Clin Immunol 2:239-48. 2002
    ....