Brian R Rood

Summary

Affiliation: Children's National Medical Center
Country: USA

Publications

  1. ncbi request reprint Pediatric high-grade glioma: molecular genetic clues for innovative therapeutic approaches
    Brian R Rood
    Division of Hematology Oncology, Center for Cancer and Immunology Research, Children s National Medical Center, Washington, DC 20010, USA
    J Neurooncol 75:267-72. 2005
  2. pmc Intercellular heterogeneity of expression of the MGMT DNA repair gene in pediatric medulloblastoma
    Brian R Rood
    Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    Neuro Oncol 6:200-7. 2004
  3. ncbi request reprint Current treatment of medulloblastoma: recent advances and future challenges
    Brian R Rood
    Division of Hematology Oncology, Center for Cancer Research, Children s National Medical Center, Washington, DC 20010, USA
    Semin Oncol 31:666-75. 2004
  4. ncbi request reprint The use of gene expression analysis to gain insights into signaling mechanisms of metastatic medulloblastoma
    Arun Chopra
    Department of Pediatrics, Children s National Medical Center, Washington, DC 20010, USA
    Pediatr Neurosurg 39:68-74. 2003
  5. doi request reprint Long-term efficacy and toxicity of bevacizumab-based therapy in children with recurrent low-grade gliomas
    Eugene I Hwang
    Division of Oncology, Center for Cancer and Blood Disorders, Children s National Medical Center, Washington, District of Columbia, USA
    Pediatr Blood Cancer 60:776-82. 2013
  6. pmc A novel role of HLA class I in the pathology of medulloblastoma
    Courtney Smith
    Center for Cancer and Immunology Research, Children s Research Institute, Children s National Medical Center, Washington, DC, USA
    J Transl Med 7:59. 2009
  7. ncbi request reprint Hypermethylation of HIC-1 and 17p allelic loss in medulloblastoma
    Brian R Rood
    Department of Pediatric Hematology Oncology, Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    Cancer Res 62:3794-7. 2002
  8. ncbi request reprint Medulloblastoma: present concepts of stratification into risk groups
    Roger J Packer
    Department of Neurology, Center for Neuroscience and Behavioral Medicine, Children s National Medical Center, Washington, DC 20010, USA
    Pediatr Neurosurg 39:60-7. 2003
  9. doi request reprint Durable response of intracranial cellular hemangioma to bevacizumab and temozolomide
    Kee Kiat Yeo
    Department of Pediatrics, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    J Neurosurg Pediatr 11:682-6. 2013
  10. pmc Advances in the proteomic investigation of the cell secretome
    Kristy J Brown
    Children s National Medical Center, Center for Genetic Medicine Research, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Expert Rev Proteomics 9:337-45. 2012

Research Grants

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Pediatric high-grade glioma: molecular genetic clues for innovative therapeutic approaches
    Brian R Rood
    Division of Hematology Oncology, Center for Cancer and Immunology Research, Children s National Medical Center, Washington, DC 20010, USA
    J Neurooncol 75:267-72. 2005
    ....
  2. pmc Intercellular heterogeneity of expression of the MGMT DNA repair gene in pediatric medulloblastoma
    Brian R Rood
    Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    Neuro Oncol 6:200-7. 2004
    ..Further, these findings support the use of pharmacological MGMT depletion as a rational approach for intensification of alkylator chemotherapy in the treatment of medulloblastoma...
  3. ncbi request reprint Current treatment of medulloblastoma: recent advances and future challenges
    Brian R Rood
    Division of Hematology Oncology, Center for Cancer Research, Children s National Medical Center, Washington, DC 20010, USA
    Semin Oncol 31:666-75. 2004
    ..Treatment for this disease has evolved a great deal over the preceding decades, but a great deal of work remains to be done to effect reliable cures while reducing long-term sequelae of therapy...
  4. ncbi request reprint The use of gene expression analysis to gain insights into signaling mechanisms of metastatic medulloblastoma
    Arun Chopra
    Department of Pediatrics, Children s National Medical Center, Washington, DC 20010, USA
    Pediatr Neurosurg 39:68-74. 2003
    ..We conclude that these genes may interact to promote prometastatic signaling in medulloblastoma...
  5. doi request reprint Long-term efficacy and toxicity of bevacizumab-based therapy in children with recurrent low-grade gliomas
    Eugene I Hwang
    Division of Oncology, Center for Cancer and Blood Disorders, Children s National Medical Center, Washington, District of Columbia, USA
    Pediatr Blood Cancer 60:776-82. 2013
    ..Bevacizumab-based therapy has demonstrated encouraging responses; however, longer-term toxicity, response durability and alternative dosing regimens have not been evaluated...
  6. pmc A novel role of HLA class I in the pathology of medulloblastoma
    Courtney Smith
    Center for Cancer and Immunology Research, Children s Research Institute, Children s National Medical Center, Washington, DC, USA
    J Transl Med 7:59. 2009
    ..However, in some cancer types MHC class I expression is associated with an unfavorable outcome. We explored the basis of MHC class I association with unfavorable prognostic marker expression in the case of medulloblastoma...
  7. ncbi request reprint Hypermethylation of HIC-1 and 17p allelic loss in medulloblastoma
    Brian R Rood
    Department of Pediatric Hematology Oncology, Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    Cancer Res 62:3794-7. 2002
    ..014). The results of our study show that methylation of the CpG island that contains the HIC-1 gene is common in medulloblastoma and, together with LOH of 17p, may be a critical event in the formation and aggressiveness of this tumor...
  8. ncbi request reprint Medulloblastoma: present concepts of stratification into risk groups
    Roger J Packer
    Department of Neurology, Center for Neuroscience and Behavioral Medicine, Children s National Medical Center, Washington, DC 20010, USA
    Pediatr Neurosurg 39:60-7. 2003
    ..Biologic markers, especially molecular genetic findings, have not yet been incorporated into risk classifications, but will likely add to the understanding of medulloblastoma and may significantly alter concepts of staging and treatment...
  9. doi request reprint Durable response of intracranial cellular hemangioma to bevacizumab and temozolomide
    Kee Kiat Yeo
    Department of Pediatrics, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    J Neurosurg Pediatr 11:682-6. 2013
    ..This is the first report of the successful use of chemotherapy to treat an intracranial hemangioma, a rare condition with limited therapeutic options...
  10. pmc Advances in the proteomic investigation of the cell secretome
    Kristy J Brown
    Children s National Medical Center, Center for Genetic Medicine Research, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Expert Rev Proteomics 9:337-45. 2012
    ..In this review, some of the most recent advances in secretome studies and the fields that have benefited the most from this evolving technology are highlighted...
  11. pmc Proteomic profiling of cerebrospinal fluid identifies prostaglandin D2 synthase as a putative biomarker for pediatric medulloblastoma: A pediatric brain tumor consortium study
    Meena U Rajagopal
    Center for Genetic Medicine, Children s National Medical Center, Washington, DC, USA
    Proteomics 11:935-43. 2011
    ..In addition, our results demonstrate the feasibility of performing proteomic studies on CSF samples collected from patients at multiple institutions within the consortium setting...
  12. ncbi request reprint Advances in the diagnosis, molecular genetics, and treatment of pediatric embryonal CNS tumors
    Tobey J Macdonald
    Departments of Hematology Oncology, Children s Hospital National Medical Center, Washington, DC 20010, USA
    Oncologist 8:174-86. 2003
    ..In this review, recent advances in the diagnosis, molecular genetics, and treatment of the most common pediatric embryonal CNS tumors are discussed...
  13. ncbi request reprint Handheld optical coherence tomography during sedation in young children with optic pathway gliomas
    Robert A Avery
    The Gilbert Family Neurofibromatosis Institute, Children s National Medical Center, Washington, DC2Department of Neurology, Children s National Medical Center, Washington, DC3Department of Ophthalmology, Children s National Medical Center, Washington, DC7
    JAMA Ophthalmol 132:265-71. 2014
    ..Optical coherence tomography (OCT) measures of retinal nerve fiber layer (RNFL) thickness have been proposed as a surrogate marker of vision but this technique is also limited by patient cooperation...
  14. doi request reprint Preclinical magnetic resonance imaging and systems biology in cancer research: current applications and challenges
    Chris Albanese
    Lombardi Comprehensive Cancer Center and Department of Oncology, Georgetown University Medical Center, Washington, District of Columbia 20057, USA
    Am J Pathol 182:312-8. 2013
    ..Finally, we provide new data from an ongoing preclinical drug study demonstrating how multiscale modeling can lead to a more comprehensive understanding of cancer biology and therapy...
  15. pmc Insights into pediatric diffuse intrinsic pontine glioma through proteomic analysis of cerebrospinal fluid
    Amanda M Saratsis
    Department of Neurosurgery, Georgetown University Hospital, Research Center for Genetic Medicine, Children s National Medical Center NW, Washington, DC 20010, USA
    Neuro Oncol 14:547-60. 2012
    ..Detection of secreted CypA and DDAH1 in serum and urine has potential clinical application, with implications for assessing treatment response and detecting tumor recurrence in patients with DIPG...
  16. doi request reprint Isolated extracranial recurrence of anaplastic ependymoma
    Mwe Mwe Chao
    Children s National Medical Center, Division of Pediatric Oncology, Washington, District of Columbia 20010, USA
    Pediatr Blood Cancer 56:317-8. 2011
    ..The location of tumor recurrence proximate to the surgical site suggested surgical seeding. This case demonstrates an unusual site of recurrence of anaplastic ependymoma and highlights a previously underappreciated surgical complication...
  17. pmc Deciphering HIC1 control pathways to reveal new avenues in cancer therapeutics
    Brian R Rood
    Center for Cancer and Blood Disorders, Children s National Medical Center, Division of Oncology, 111 Michigan Ave NW, Washington, DC 20010, USA
    Expert Opin Ther Targets 17:811-27. 2013
    ..An understanding of this program through identification of HIC1's target genes and their involvement in feedback loops and cell process regulation will yield the ability to leverage this knowledge for therapeutic translation...

Research Grants2

  1. Creation of a PDGF-C Autocrine Loop by HIC1 Inactivation
    Brian Rood; Fiscal Year: 2007
    ..This project seeks to investigate the biologic role of one of these potential therapeutic targets, the PDGF signaling pathway. ..