Donald Reason

Summary

Affiliation: Children's Hospital Oakland Research Institute
Country: USA

Publications

  1. ncbi Mechanism of lethal toxin neutralization by a human monoclonal antibody specific for the PA(20) region of Bacillus anthracis protective antigen
    Donald Reason
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Toxins (Basel) 3:979-90. 2011
  2. ncbi Correlation of antigenic epitope and antibody gene usage in the human immune response to Streptococcus pneumoniae type 23F capsular polysaccharide
    Donald C Reason
    Research Institute, Children s Hospital Oakland, Oakland, CA 94609, USA
    Clin Immunol 111:132-6. 2004
  3. ncbi Domain specificity of the human antibody response to Bacillus anthracis protective antigen
    Donald C Reason
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Vaccine 26:4041-7. 2008
  4. ncbi Frequency and domain specificity of toxin-neutralizing paratopes in the human antibody response to anthrax vaccine adsorbed
    Donald Reason
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Infect Immun 77:2030-5. 2009
  5. ncbi Recurrent variable region gene usage and somatic mutation in the human antibody response to the capsular polysaccharide of Streptococcus pneumoniae type 23F
    Jianhui Zhou
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Infect Immun 70:4083-91. 2002
  6. ncbi Molecular ontogeny of the human antibody repertoire to the Haemophilus influenzae type B polysaccharide: expression of canonical variable regions and their variants in vaccinated infants
    Alexander H Lucas
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Clin Immunol 108:119-27. 2003
  7. ncbi Somatic hypermutation and diverse immunoglobulin gene usage in the human antibody response to the capsular polysaccharide of Streptococcus pneumoniae Type 6B
    Jianhui Zhou
    Children's Hospital Oakland Research Institute, Oakland, California 94609, USA
    Infect Immun 72:3505-14. 2004
  8. ncbi Paratope diversity in the human antibody response to Bacillus anthracis protective antigen
    Jianhui Zhou
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Mol Immunol 45:338-47. 2008

Research Grants

  1. Structural determinants of human immunity to anthrax
    Donald Reason; Fiscal Year: 2007
  2. Human monoclonal panel mimicking anthrax immune globulin
    Donald Reason; Fiscal Year: 2005
  3. MOLECULAR DETERMINANTS OF HUMAN PNEUMOCOCCAL IMMUNITY
    Donald Reason; Fiscal Year: 2004

Collaborators

Detail Information

Publications8

  1. ncbi Mechanism of lethal toxin neutralization by a human monoclonal antibody specific for the PA(20) region of Bacillus anthracis protective antigen
    Donald Reason
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Toxins (Basel) 3:979-90. 2011
    ..We also demonstrate that the epitope recognized by this human monoclonal does not encompass the (166)RKKR(169) furin recognition sequence in domain 1 of PA...
  2. ncbi Correlation of antigenic epitope and antibody gene usage in the human immune response to Streptococcus pneumoniae type 23F capsular polysaccharide
    Donald C Reason
    Research Institute, Children s Hospital Oakland, Oakland, CA 94609, USA
    Clin Immunol 111:132-6. 2004
    ....
  3. ncbi Domain specificity of the human antibody response to Bacillus anthracis protective antigen
    Donald C Reason
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Vaccine 26:4041-7. 2008
    ....
  4. ncbi Frequency and domain specificity of toxin-neutralizing paratopes in the human antibody response to anthrax vaccine adsorbed
    Donald Reason
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Infect Immun 77:2030-5. 2009
    ..A vaccine design strategy that directed a higher percentage of the antibody response toward neutralizing epitopes may result in a more efficacious vaccine for the prevention of anthrax infection...
  5. ncbi Recurrent variable region gene usage and somatic mutation in the human antibody response to the capsular polysaccharide of Streptococcus pneumoniae type 23F
    Jianhui Zhou
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Infect Immun 70:4083-91. 2002
    ..Lastly, analysis of the isolated Fabs indicate all have undergone extensive somatic mutation, as well as class switch, maturational events that presumably require the participation of T cells...
  6. ncbi Molecular ontogeny of the human antibody repertoire to the Haemophilus influenzae type B polysaccharide: expression of canonical variable regions and their variants in vaccinated infants
    Alexander H Lucas
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Clin Immunol 108:119-27. 2003
    ..These results demonstrate the establishment of canonical V regions in early ontogeny and provide a structural explanation of how canonical antibodies in the infant can vary in their affinity and protective activity against Hib...
  7. ncbi Somatic hypermutation and diverse immunoglobulin gene usage in the human antibody response to the capsular polysaccharide of Streptococcus pneumoniae Type 6B
    Jianhui Zhou
    Children's Hospital Oakland Research Institute, Oakland, California 94609, USA
    Infect Immun 72:3505-14. 2004
    ....
  8. ncbi Paratope diversity in the human antibody response to Bacillus anthracis protective antigen
    Jianhui Zhou
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Mol Immunol 45:338-47. 2008
    ..This latter finding may have implications for the rational design of future PA-based anthrax vaccines...

Research Grants12

  1. Structural determinants of human immunity to anthrax
    Donald Reason; Fiscal Year: 2007
    ..anthracis infection. In addition, the antibodies isolated will constitute a panel of fully human monoclonal binding domains with potential for therapeutic use as passive immunogens. ..
  2. Human monoclonal panel mimicking anthrax immune globulin
    Donald Reason; Fiscal Year: 2005
    ..The PA-specific panel we construct will be molecularly defined and characterized, incorporate the advantages of toxin-specific, polyclonal human sera, and lack the inherent risk associated with blood derived products. ..
  3. MOLECULAR DETERMINANTS OF HUMAN PNEUMOCOCCAL IMMUNITY
    Donald Reason; Fiscal Year: 2004
    ..Understanding the molecular mechanisms that shape the human antibody repertoire to pneumococcal polysaccharides may also suggest strategies that would facilitate the development of more efficacious vaccines. ..