PATRICIO ERNESTO RAY

Summary

Affiliation: Children's National Medical Center
Country: USA

Publications

  1. pmc HIV-associated nephropathy: a diagnosis in evolution
    Patricio E Ray
    Correspondence and offprint requests to Patricio E Ray E mail
    Nephrol Dial Transplant 27:3969-72. 2012
  2. pmc Can we cure HIV-1-associated nephropathy in transgenic mice?
    Patricio E Ray
    Center for Molecular Physiology Research, The George Washington University, Washington, DC, USA
    Kidney Int 81:811-3. 2012
  3. pmc Shiga-like toxins and HIV-1 'go through' glycosphingolipids and lipid rafts in renal cells
    Patricio E Ray
    Children s Research Institute, Children s National Medical Center, and Department of Pediatrics, The George Washington University, Washington, DC, USA
    Kidney Int 75:1135-7. 2009
  4. pmc Taking a hard look at the pathogenesis of childhood HIV-associated nephropathy
    Patricio E Ray
    Children s Research Institute, Children s National Medical Center, Washington, D C 20010, USA
    Pediatr Nephrol 24:2109-19. 2009
  5. ncbi request reprint Infection of human primary renal epithelial cells with HIV-1 from children with HIV-associated nephropathy
    P E Ray
    Children s Research Institute, Children s National Medical Center, Washington, D C, USA
    Kidney Int 53:1217-29. 1998
  6. ncbi request reprint Fusion of HIV-1 envelope-expressing cells to human glomerular endothelial cells through an CXCR4-mediated mechanism
    Patricio E Ray
    Division of Nephrology and Center for Genetic Medicine, Children s Research Institute, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Pediatr Nephrol 20:1401-9. 2005
  7. ncbi request reprint A 20-year history of childhood HIV-associated nephropathy
    Patricio E Ray
    Division of Nephrology, Children s National Medical Center, Washington, DC 20010, USA
    Pediatr Nephrol 19:1075-92. 2004
  8. ncbi request reprint A novel HIV-1 transgenic rat model of childhood HIV-1-associated nephropathy
    Patricio E Ray
    Children s Research Institute, Center for Genetic Medicine, Children s National Medical Center, Washington, D C 20010, USA
    Kidney Int 63:2242-53. 2003
  9. ncbi request reprint Basic fibroblast growth factor in HIV-associated hemolytic uremic syndrome
    P E Ray
    Center IV, Room R 211, Children s Research Institute, Children s National Medical Center, 111 Michigan Avenue N W, Washington, DC 20010, USA
    Pediatr Nephrol 13:586-93. 1999
  10. ncbi request reprint Pathogenesis of Shiga toxin-induced hemolytic uremic syndrome
    P E Ray
    Children s Research Institute, Research Center for Molecular Physiology, Washington, DC, USA
    Pediatr Nephrol 16:823-39. 2001

Research Grants

  1. Basic FGF Low Affinity Receptors in HIVAN
    PATRICIO ERNESTO RAY; Fiscal Year: 2010
  2. Role of heparin binding growth factors in vascular leakage and fatal bleeding
    PATRICIO ERNESTO RAY; Fiscal Year: 2010
  3. Novel Animal Model System of AIDS-Kaposi Sarcoma
    Patricio Ray; Fiscal Year: 2005
  4. Pathogenesis of HIV-Associated HUS in Children
    Patricio Ray; Fiscal Year: 2006
  5. Iron and Vitamin E in Childhood HIV-Associated Renal Disease
    Patricio Ray; Fiscal Year: 2006
  6. BFGF LOW AFFINITY RECEPTORS AND HIVAN
    Patricio Ray; Fiscal Year: 2007
  7. BFGF LOW AFFINITY RECEPTORS AND HIVAN
    Patricio Ray; Fiscal Year: 2007
  8. Pathogenesis of HIV-HUS in children
    PATRICIO ERNESTO RAY; Fiscal Year: 2010
  9. Pathogenesis of HIV-Associated HUS in Children
    Patricio Ray; Fiscal Year: 2002
  10. BFGF LOW AFFINITY RECEPTORS AND HIVAN
    Patricio Ray; Fiscal Year: 2002

Collaborators

Detail Information

Publications27

  1. pmc HIV-associated nephropathy: a diagnosis in evolution
    Patricio E Ray
    Correspondence and offprint requests to Patricio E Ray E mail
    Nephrol Dial Transplant 27:3969-72. 2012
    ....
  2. pmc Can we cure HIV-1-associated nephropathy in transgenic mice?
    Patricio E Ray
    Center for Molecular Physiology Research, The George Washington University, Washington, DC, USA
    Kidney Int 81:811-3. 2012
    ..These findings suggest that endogenous host factors play a critical role in HIVAN...
  3. pmc Shiga-like toxins and HIV-1 'go through' glycosphingolipids and lipid rafts in renal cells
    Patricio E Ray
    Children s Research Institute, Children s National Medical Center, and Department of Pediatrics, The George Washington University, Washington, DC, USA
    Kidney Int 75:1135-7. 2009
    ..They also propose that the binding of the HIV-1 glycoprotein gp120 to Gb(3) in renal tubules may play a role in HIV nephropathy...
  4. pmc Taking a hard look at the pathogenesis of childhood HIV-associated nephropathy
    Patricio E Ray
    Children s Research Institute, Children s National Medical Center, Washington, D C 20010, USA
    Pediatr Nephrol 24:2109-19. 2009
    ..More research is needed to elucidate how HIV-1 induces renal epithelial injury and proliferation in HIV-infected children...
  5. ncbi request reprint Infection of human primary renal epithelial cells with HIV-1 from children with HIV-associated nephropathy
    P E Ray
    Children s Research Institute, Children s National Medical Center, Washington, D C, USA
    Kidney Int 53:1217-29. 1998
    ..Thus, HIV-1 may directly induce degenerative changes in RTEc of children with HIVAN. Infected macrophages may play a relevant role in this process by transferring viruses to RTEc...
  6. ncbi request reprint Fusion of HIV-1 envelope-expressing cells to human glomerular endothelial cells through an CXCR4-mediated mechanism
    Patricio E Ray
    Division of Nephrology and Center for Genetic Medicine, Children s Research Institute, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Pediatr Nephrol 20:1401-9. 2005
    ..Cultured primary HGECs express CXCR4 but not CD4 or CCR5. The ability of HGECs to promote fusion by a CD4-independent HIV-1 envelope glycoprotein suggests that these cells may become a potential direct target of certain HIV-1 isolates...
  7. ncbi request reprint A 20-year history of childhood HIV-associated nephropathy
    Patricio E Ray
    Division of Nephrology, Children s National Medical Center, Washington, DC 20010, USA
    Pediatr Nephrol 19:1075-92. 2004
    ..Hopefully, in the near future, better education, prevention, and treatment programs will lead to the eradication of this fatal childhood disease...
  8. ncbi request reprint A novel HIV-1 transgenic rat model of childhood HIV-1-associated nephropathy
    Patricio E Ray
    Children s Research Institute, Center for Genetic Medicine, Children s National Medical Center, Washington, D C 20010, USA
    Kidney Int 63:2242-53. 2003
    ....
  9. ncbi request reprint Basic fibroblast growth factor in HIV-associated hemolytic uremic syndrome
    P E Ray
    Center IV, Room R 211, Children s Research Institute, Children s National Medical Center, 111 Michigan Avenue N W, Washington, DC 20010, USA
    Pediatr Nephrol 13:586-93. 1999
    ..A follow-up study in a larger sample population is required to confirm these results...
  10. ncbi request reprint Pathogenesis of Shiga toxin-induced hemolytic uremic syndrome
    P E Ray
    Children s Research Institute, Research Center for Molecular Physiology, Washington, DC, USA
    Pediatr Nephrol 16:823-39. 2001
    ..e., basic fibrobast growth factor) may play roles in this process. Measurement of the activity of a von Willebrand factor protease in plasma may help distinguish patients with thrombotic thrombocytopenic purpura from those with Stx-HUS...
  11. ncbi request reprint Chronic potassium depletion induces renal injury, salt sensitivity, and hypertension in young rats
    P E Ray
    Center for Molecular Physiology Research, Children s Research Institute, Children s National Medical Center, Washington DC 20010, USA
    Kidney Int 59:1850-8. 2001
    ..The purpose of this study was to determine the effects of severe chronic dietary K(+) depletion on blood pressure (BP) and renal structural changes in young rats...
  12. pmc Iron-related proteins: candidate urine biomarkers in childhood HIV-associated renal diseases
    Angel A Soler-García
    Division of Nephrology, Center for Cancer and Immunology Research, Children s Research Institute, NW, Washington, DC 20010, USA
    Clin J Am Soc Nephrol 4:763-71. 2009
    ..Positive findings were confirmed in HIV-infected children with (n = 20) and without (n = 10) proteinuria using commercially available assays...
  13. ncbi request reprint NF-kappaB activation plays a role in superoxide-mediated cerebral endothelial dysfunction after hypoxia/reoxygenation
    Hui Xie
    Department of Neonatology, Children s National Medical Center, The George Washington University, Washington, DC 20010, USA
    Stroke 36:1047-52. 2005
    ....
  14. ncbi request reprint Rho-kinase contributes to hypoxia/reoxygenation-induced cerebral endothelial dysfunction
    Hui Xie
    Department of Neonatology, Children s Research Institute, Children s National Medical Center, The George Washington University, Washington, DC 20010, USA
    J Cardiovasc Pharmacol 48:814-9. 2006
    ..Pretreatment with either Y27632 or the stable NO donor profoundly prevented H/R-mediated cerebral endothelial dysfunction...
  15. ncbi request reprint Fibroblast growth factor-2 increases the renal recruitment and attachment of HIV-infected mononuclear cells to renal tubular epithelial cells
    Pingtao Tang
    Center for Genetic Medicine, Children s Research Institute, Children s National Medical Center, Washington, DC, 20010, USA
    Pediatr Nephrol 20:1708-16. 2005
    ..These data suggest that FGF-2 may have an immunomodulatory role in the pathogenesis of HIVAN by recruiting HIV-infected cells in the kidney...
  16. pmc Role of sensory C fibers in hypoxia/reoxygenation-impaired myogenic constriction of cerebral arteries
    Hui Xie
    Department of Neonatology, Children s Research Institute, Children s National Medical Center, The George Washington University, Washington, DC, USA
    Neurol Res 32:487-91. 2010
    ..However, the underlying mechanisms remain poorly understood. The present study was designed to investigate the role of sensory C-fibers in myogenic responsiveness of cerebral arteries...
  17. pmc Regulation of HIV-1 transcription at 3% versus 21% oxygen concentration
    Sharroya Charles
    Center for Sickle Cell Disease, Howard University, Washington, DC 20001, USA
    J Cell Physiol 221:469-79. 2009
    ....
  18. ncbi request reprint Adenovirus-mediated gene transfer to glomerular cells in newborn mice
    Marina Jerebtsova
    Center for Genetic Medicine Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    Pediatr Nephrol 20:1395-400. 2005
    ..This study demonstrates for the first time the feasibility of using systemic intravenous injections of rAd vectors to express foreign genes in developing glomeruli of young mice...
  19. ncbi request reprint A novel role of fibroblast growth factor-2 and pentosan polysulfate in the pathogenesis of intestinal bleeding in mice
    Marina Jerebtsova
    Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    Am J Physiol Heart Circ Physiol 292:H743-50. 2007
    ..These findings might have wider clinical implications for the systemic use of PPS and other heparinoids in the treatment of patients with angiogenic diseases associated with high levels of circulating FGF-2...
  20. pmc A urinary biomarker profile for children with HIV-associated renal diseases
    Angel A Soler-García
    Center for Molecular Physiology Research, Division of Nephrology, Children s National Medical Center, Children s Research Institute, Washington, District of Columbia 20010, USA
    Kidney Int 76:207-14. 2009
    ..Our findings suggest that this urinary growth factor profile may be useful in facilitating the diagnosis of HIV-infected children at risk of developing HIVAN when interpreted in the appropriate clinical setting...
  21. ncbi request reprint Nuclear protein phosphatase-1 regulates HIV-1 transcription
    Tatyana Ammosova
    Center for Sickle Cell Disease and Department of Biochemistry and Molecular Biology, Howard University, Washington, D C 20059, USA
    J Biol Chem 278:32189-94. 2003
    ..Our results indicate that PP1 might be a host cell factor that is required for HIV-1 viral transcription. Therefore, nuclear PP1 may represent a novel target for anti-HIV-1 therapeutics...
  22. pmc Iron chelators ICL670 and 311 inhibit HIV-1 transcription
    Zufan Debebe
    Center for Sickle Cell Disease, Howard University College of Medicine, Washington, DC 20060, USA
    Virology 367:324-33. 2007
    ..Further consideration should be given to the development of iron chelators for future anti-retroviral therapeutics...
  23. ncbi request reprint Novel cystogenic role of basic fibroblast growth factor in developing rodent kidneys
    Zhuangwu Li
    Center for Genetic Medicine, Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    Am J Physiol Renal Physiol 291:F289-96. 2006
    ..To the best of our knowledge, these experiments show for the first time that overexpression of bFGF in developing rodent kidneys can induce the formation of renal cysts in vivo...
  24. ncbi request reprint Adenovirus-mediated gene transfer to renal glomeruli in rodents
    Xuehai Ye
    Centers for Genetic Medicine and Molecular Physiology, Children s Research Institute, Children s National Medical Center, and The George Washington University, Washington, DC 20010, USA
    Kidney Int 61:S16-23. 2002
    ..Here, we described our experience using rAd vectors to express foreign genes in rodent renal glomeruli in vivo and in cultured human renal glomerular cells...
  25. ncbi request reprint Angiotensin II type 1 receptor blockade ameliorates tubulointerstitial injury induced by chronic potassium deficiency
    Shin Ichi Suga
    Division of Nephrology, University of Washington Medical Center, Seattle, Washington, USA
    Kidney Int 61:951-8. 2002
    ..We tested the hypothesis that K+-deficiency-induced renal tubulointerstitial injury could be mediated by Ang II or a reduction in nitric oxide...
  26. ncbi request reprint Role of fibroblast growth factor-binding protein in the pathogenesis of HIV-associated hemolytic uremic syndrome
    Patricio E Ray
    Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Rd, Washington DC 20057, USA
    Am J Physiol Regul Integr Comp Physiol 290:R105-13. 2006
    ....
  27. ncbi request reprint Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes
    Silvia Montaner
    Cell Growth Regulation Section, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Cell 3:23-36. 2003
    ..Endothelial cells expressing vGPCR were further able to promote tumor formation by cells expressing KSHV latent genes, suggestive of a cooperative role among viral genes in the promotion of Kaposi's sarcomagenesis...

Research Grants36

  1. Basic FGF Low Affinity Receptors in HIVAN
    PATRICIO ERNESTO RAY; Fiscal Year: 2010
    ....
  2. Role of heparin binding growth factors in vascular leakage and fatal bleeding
    PATRICIO ERNESTO RAY; Fiscal Year: 2010
    ....
  3. Novel Animal Model System of AIDS-Kaposi Sarcoma
    Patricio Ray; Fiscal Year: 2005
    ....
  4. Pathogenesis of HIV-Associated HUS in Children
    Patricio Ray; Fiscal Year: 2006
    ..abstract_text> ..
  5. Iron and Vitamin E in Childhood HIV-Associated Renal Disease
    Patricio Ray; Fiscal Year: 2006
    ..The proposed studies should have a substantial impact on the goals of the National Center for Complementary and Alternative Medicine and NIH, according to the program announcement PA-02-124. ..
  6. BFGF LOW AFFINITY RECEPTORS AND HIVAN
    Patricio Ray; Fiscal Year: 2007
    ..These studies will demonstrate that growth factors release into the circulation of HIV- infected children can accelerate the progression of HIVAN, and test new therapies against this disease. ..
  7. BFGF LOW AFFINITY RECEPTORS AND HIVAN
    Patricio Ray; Fiscal Year: 2007
    ..These studies will demonstrate that growth factors release into the circulation of HIV- infected children can accelerate the progression of HIVAN, and test new therapies against this disease. ..
  8. Pathogenesis of HIV-HUS in children
    PATRICIO ERNESTO RAY; Fiscal Year: 2010
    ....
  9. Pathogenesis of HIV-Associated HUS in Children
    Patricio Ray; Fiscal Year: 2002
    ..These studies should generate new fundamental knowledge to define the role of HIV-1 in the pathogenesis of childhood HIV-HUS and other AIDS related angiogenic clinical conditions, and generate a small animal model system of HIV-HUS. ..
  10. BFGF LOW AFFINITY RECEPTORS AND HIVAN
    Patricio Ray; Fiscal Year: 2002
    ..All these studies will provide new knowledge that could be applied clinically to develop new treatments to prevent the progression of HIVAN in children. ..