Research Topics
| PATRICIO ERNESTO RAYSummaryAffiliation: Children's National Medical Center Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
HIV-associated nephropathy: a diagnosis in evolutionPatricio E Ray
Correspondence and offprint requests to Patricio E Ray E mail
Nephrol Dial Transplant 27:3969-72. 2012....- Can we cure HIV-1-associated nephropathy in transgenic mice?Patricio E Ray
Center for Molecular Physiology Research, The George Washington University, Washington, DC, USA
Kidney Int 81:811-3. 2012..These findings suggest that endogenous host factors play a critical role in HIVAN... - Shiga-like toxins and HIV-1 'go through' glycosphingolipids and lipid rafts in renal cellsPatricio E Ray
Children s Research Institute, Children s National Medical Center, and Department of Pediatrics, The George Washington University, Washington, DC, USA
Kidney Int 75:1135-7. 2009..They also propose that the binding of the HIV-1 glycoprotein gp120 to Gb(3) in renal tubules may play a role in HIV nephropathy... - Taking a hard look at the pathogenesis of childhood HIV-associated nephropathyPatricio E Ray
Children s Research Institute, Children s National Medical Center, Washington, D C 20010, USA
Pediatr Nephrol 24:2109-19. 2009..More research is needed to elucidate how HIV-1 induces renal epithelial injury and proliferation in HIV-infected children... 
Infection of human primary renal epithelial cells with HIV-1 from children with HIV-associated nephropathyP E Ray
Children s Research Institute, Children s National Medical Center, Washington, D C, USA
Kidney Int 53:1217-29. 1998..Thus, HIV-1 may directly induce degenerative changes in RTEc of children with HIVAN. Infected macrophages may play a relevant role in this process by transferring viruses to RTEc...- Fusion of HIV-1 envelope-expressing cells to human glomerular endothelial cells through an CXCR4-mediated mechanismPatricio E Ray
Division of Nephrology and Center for Genetic Medicine, Children s Research Institute, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
Pediatr Nephrol 20:1401-9. 2005..Cultured primary HGECs express CXCR4 but not CD4 or CCR5. The ability of HGECs to promote fusion by a CD4-independent HIV-1 envelope glycoprotein suggests that these cells may become a potential direct target of certain HIV-1 isolates... - A 20-year history of childhood HIV-associated nephropathyPatricio E Ray
Division of Nephrology, Children s National Medical Center, Washington, DC 20010, USA
Pediatr Nephrol 19:1075-92. 2004..Hopefully, in the near future, better education, prevention, and treatment programs will lead to the eradication of this fatal childhood disease... - A novel HIV-1 transgenic rat model of childhood HIV-1-associated nephropathyPatricio E Ray
Children s Research Institute, Center for Genetic Medicine, Children s National Medical Center, Washington, D C 20010, USA
Kidney Int 63:2242-53. 2003.... - Basic fibroblast growth factor in HIV-associated hemolytic uremic syndromeP E Ray
Center IV, Room R 211, Children s Research Institute, Children s National Medical Center, 111 Michigan Avenue N W, Washington, DC 20010, USA
Pediatr Nephrol 13:586-93. 1999..A follow-up study in a larger sample population is required to confirm these results... - Pathogenesis of Shiga toxin-induced hemolytic uremic syndromeP E Ray
Children s Research Institute, Research Center for Molecular Physiology, Washington, DC, USA
Pediatr Nephrol 16:823-39. 2001..e., basic fibrobast growth factor) may play roles in this process. Measurement of the activity of a von Willebrand factor protease in plasma may help distinguish patients with thrombotic thrombocytopenic purpura from those with Stx-HUS... - Chronic potassium depletion induces renal injury, salt sensitivity, and hypertension in young ratsP E Ray
Center for Molecular Physiology Research, Children s Research Institute, Children s National Medical Center, Washington DC 20010, USA
Kidney Int 59:1850-8. 2001..The purpose of this study was to determine the effects of severe chronic dietary K(+) depletion on blood pressure (BP) and renal structural changes in young rats... - Iron-related proteins: candidate urine biomarkers in childhood HIV-associated renal diseasesAngel A Soler-García
Division of Nephrology, Center for Cancer and Immunology Research, Children s Research Institute, NW, Washington, DC 20010, USA
Clin J Am Soc Nephrol 4:763-71. 2009..Positive findings were confirmed in HIV-infected children with (n = 20) and without (n = 10) proteinuria using commercially available assays... - NF-kappaB activation plays a role in superoxide-mediated cerebral endothelial dysfunction after hypoxia/reoxygenationHui Xie
Department of Neonatology, Children s National Medical Center, The George Washington University, Washington, DC 20010, USA
Stroke 36:1047-52. 2005.... - Rho-kinase contributes to hypoxia/reoxygenation-induced cerebral endothelial dysfunctionHui Xie
Department of Neonatology, Children s Research Institute, Children s National Medical Center, The George Washington University, Washington, DC 20010, USA
J Cardiovasc Pharmacol 48:814-9. 2006..Pretreatment with either Y27632 or the stable NO donor profoundly prevented H/R-mediated cerebral endothelial dysfunction... - Fibroblast growth factor-2 increases the renal recruitment and attachment of HIV-infected mononuclear cells to renal tubular epithelial cellsPingtao Tang
Center for Genetic Medicine, Children's Research Institute, Children's National Medical Center, Washington, DC, 20010, USA
Pediatr Nephrol 20:1708-16. 2005..These data suggest that FGF-2 may have an immunomodulatory role in the pathogenesis of HIVAN by recruiting HIV-infected cells in the kidney... - Role of sensory C fibers in hypoxia/reoxygenation-impaired myogenic constriction of cerebral arteriesHui Xie
Department of Neonatology, Children s Research Institute, Children s National Medical Center, The George Washington University, Washington, DC, USA
Neurol Res 32:487-91. 2010..However, the underlying mechanisms remain poorly understood. The present study was designed to investigate the role of sensory C-fibers in myogenic responsiveness of cerebral arteries... - Regulation of HIV-1 transcription at 3% versus 21% oxygen concentrationSharroya Charles
Center for Sickle Cell Disease, Howard University, Washington, DC 20001, USA
J Cell Physiol 221:469-79. 2009.... - Adenovirus-mediated gene transfer to glomerular cells in newborn miceMarina Jerebtsova
Center for Genetic Medicine Research, Children's Research Institute, Children's National Medical Center, Washington, DC 20010, USA
Pediatr Nephrol 20:1395-400. 2005..This study demonstrates for the first time the feasibility of using systemic intravenous injections of rAd vectors to express foreign genes in developing glomeruli of young mice... - A novel role of fibroblast growth factor-2 and pentosan polysulfate in the pathogenesis of intestinal bleeding in miceMarina Jerebtsova
Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
Am J Physiol Heart Circ Physiol 292:H743-50. 2007..These findings might have wider clinical implications for the systemic use of PPS and other heparinoids in the treatment of patients with angiogenic diseases associated with high levels of circulating FGF-2... - A urinary biomarker profile for children with HIV-associated renal diseasesAngel A Soler-García
Center for Molecular Physiology Research, Division of Nephrology, Children s National Medical Center, Children s Research Institute, Washington, District of Columbia 20010, USA
Kidney Int 76:207-14. 2009..Our findings suggest that this urinary growth factor profile may be useful in facilitating the diagnosis of HIV-infected children at risk of developing HIVAN when interpreted in the appropriate clinical setting... - Nuclear protein phosphatase-1 regulates HIV-1 transcriptionTatyana Ammosova
Center for Sickle Cell Disease and Department of Biochemistry and Molecular Biology, Howard University, Washington, D C 20059, USA
J Biol Chem 278:32189-94. 2003..Our results indicate that PP1 might be a host cell factor that is required for HIV-1 viral transcription. Therefore, nuclear PP1 may represent a novel target for anti-HIV-1 therapeutics... - Iron chelators ICL670 and 311 inhibit HIV-1 transcriptionZufan Debebe
Center for Sickle Cell Disease, Howard University College of Medicine, Washington, DC 20060, USA
Virology 367:324-33. 2007..Further consideration should be given to the development of iron chelators for future anti-retroviral therapeutics... - Novel cystogenic role of basic fibroblast growth factor in developing rodent kidneysZhuangwu Li
Center for Genetic Medicine, Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
Am J Physiol Renal Physiol 291:F289-96. 2006..To the best of our knowledge, these experiments show for the first time that overexpression of bFGF in developing rodent kidneys can induce the formation of renal cysts in vivo... - Adenovirus-mediated gene transfer to renal glomeruli in rodentsXuehai Ye
Centers for Genetic Medicine and Molecular Physiology, Children's Research Institute, Children's National Medical Center, and The George Washington University, Washington, DC 20010, USA
Kidney Int 61:S16-23. 2002.... - Angiotensin II type 1 receptor blockade ameliorates tubulointerstitial injury induced by chronic potassium deficiencyShin-ichi Suga
Division of Nephrology, University of Washington Medical Center, Seattle, Washington, USA
Kidney Int 61:951-8. 2002..Losartan may be beneficial in preventing hypokalemic tubulointerstitial injury... - Role of fibroblast growth factor-binding protein in the pathogenesis of HIV-associated hemolytic uremic syndromePatricio E Ray
Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Rd, Washington DC 20057, USA
Am J Physiol Regul Integr Comp Physiol 290:R105-13. 2006.... - Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genesSilvia Montaner
Cell Growth Regulation Section, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
Cancer Cell 3:23-36. 2003..Endothelial cells expressing vGPCR were further able to promote tumor formation by cells expressing KSHV latent genes, suggestive of a cooperative role among viral genes in the promotion of Kaposi's sarcomagenesis...
Research Grants
- Role of heparin binding growth factors in vascular leakage and fatal bleedingPATRICIO ERNESTO RAY; Fiscal Year: 2010....
- Basic FGF Low Affinity Receptors in HIVANPATRICIO ERNESTO RAY; Fiscal Year: 2010....
- Novel Animal Model System of AIDS-Kaposi SarcomaPatricio Ray; Fiscal Year: 2005....
- Pathogenesis of HIV-Associated HUS in ChildrenPatricio Ray; Fiscal Year: 2006..abstract_text> ..
- Iron and Vitamin E in Childhood HIV-Associated Renal DiseasePatricio Ray; Fiscal Year: 2006..The proposed studies should have a substantial impact on the goals of the National Center for Complementary and Alternative Medicine and NIH, according to the program announcement PA-02-124. ..
- BFGF LOW AFFINITY RECEPTORS AND HIVANPatricio Ray; Fiscal Year: 2007..These studies will demonstrate that growth factors release into the circulation of HIV- infected children can accelerate the progression of HIVAN, and test new therapies against this disease. ..
- BFGF LOW AFFINITY RECEPTORS AND HIVANPatricio Ray; Fiscal Year: 2007..These studies will demonstrate that growth factors release into the circulation of HIV- infected children can accelerate the progression of HIVAN, and test new therapies against this disease. ..
- Pathogenesis of HIV-HUS in childrenPATRICIO ERNESTO RAY; Fiscal Year: 2010....
- Pathogenesis of HIV-Associated HUS in ChildrenPatricio Ray; Fiscal Year: 2002..These studies should generate new fundamental knowledge to define the role of HIV-1 in the pathogenesis of childhood HIV-HUS and other AIDS related angiogenic clinical conditions, and generate a small animal model system of HIV-HUS. ..
- BFGF LOW AFFINITY RECEPTORS AND HIVANPatricio Ray; Fiscal Year: 2002..All these studies will provide new knowledge that could be applied clinically to develop new treatments to prevent the progression of HIVAN in children. ..