Edward V Prochownik


Affiliation: Children's Hospital of Pittsburgh
Country: USA


  1. Wang H, Dolezal J, Kulkarni S, Lu J, Mandel J, Jackson L, et al. Myc and ChREBP transcription factors cooperatively regulate normal and neoplastic hepatocyte proliferation in mice. J Biol Chem. 2018;293:14740-14757 pubmed publisher
    ..Our findings define the individual and cooperative proliferative, metabolic, and transcriptional roles for the "Extended Myc Network" under both normal and neoplastic conditions. ..
  2. Wang H, Lu J, Edmunds L, Kulkarni S, Dolezal J, Tao J, et al. Coordinated Activities of Multiple Myc-dependent and Myc-independent Biosynthetic Pathways in Hepatoblastoma. J Biol Chem. 2016;291:26241-26251 pubmed
  3. Dolezal J, Wang H, Kulkarni S, Jackson L, Lu J, Ranganathan S, et al. Sequential adaptive changes in a c-Myc-driven model of hepatocellular carcinoma. J Biol Chem. 2017;292:10068-10086 pubmed publisher
    ..Collectively, these studies define the metabolic, biochemical, and molecular events accompanyingHCCevolution, regression, and recurrence in the absence of any potentially confounding therapies. ..
  4. Jackson L, Kulkarni S, Wang H, Lu J, Dolezal J, Bharathi S, et al. Genetic Dissociation of Glycolysis and the TCA Cycle Affects Neither Normal nor Neoplastic Proliferation. Cancer Res. 2017;77:5795-5807 pubmed publisher
    ..i>Cancer Res; 77(21); 5795-807. ©2017 AACR. ..