Ian F Pollack

Summary

Affiliation: Children's Hospital of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Intramedullary spinal cord astrocytomas in children
    Ian F Pollack
    Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute Brain Tumor Center, Pittsburgh, Pennsylvania 15213, USA
    Pediatr Blood Cancer 43:617-8. 2004
  2. pmc Antigen-specific immune responses and clinical outcome after vaccination with glioma-associated antigen peptides and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose in children with newly diagnosed malignant brainstem and n
    Ian F Pollack
    All authors University of Pittsburgh, Pittsburgh, PA
    J Clin Oncol 32:2050-8. 2014
  3. ncbi request reprint Association between chromosome 1p and 19q loss and outcome in pediatric malignant gliomas: results from the CCG-945 cohort
    Ian F Pollack
    Department of Neurosurgery, University of Pittsburgh Medical Center and the Children s Hospital of Pittsburgh, Pittsburgh, PA, USA
    Pediatr Neurosurg 39:114-21. 2003
  4. doi request reprint Multidisciplinary management of childhood brain tumors: a review of outcomes, recent advances, and challenges
    Ian F Pollack
    Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neurosurg Pediatr 8:135-48. 2011
  5. pmc Diagnostic and therapeutic stratification of childhood brain tumors: implications for translational research
    Ian F Pollack
    Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Child Neurol 23:1179-85. 2008
  6. ncbi request reprint Rarity of PTEN deletions and EGFR amplification in malignant gliomas of childhood: results from the Children's Cancer Group 945 cohort
    Ian F Pollack
    Departments of Neurosurgery, University of Pittsburgh Medical Center, Children s Hospital of Pittsburgh, Pennsylvania 15213, USA
    J Neurosurg 105:418-24. 2006
  7. pmc Phase I trial of imatinib in children with newly diagnosed brainstem and recurrent malignant gliomas: a Pediatric Brain Tumor Consortium report
    Ian F Pollack
    Department of Neurosurgery, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Neuro Oncol 9:145-60. 2007
  8. ncbi request reprint O6-methylguanine-DNA methyltransferase expression strongly correlates with outcome in childhood malignant gliomas: results from the CCG-945 Cohort
    Ian F Pollack
    Department of Neurosurgery, University of Pittsburgh Cancer Institute, University of Pittsburgh Medical Center and the Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    J Clin Oncol 24:3431-7. 2006
  9. ncbi request reprint New delivery approaches for pediatric brain tumors
    Ian F Pollack
    Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh Brain Tumor Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Neurooncol 75:315-26. 2005
  10. pmc Mismatch repair deficiency is an uncommon mechanism of alkylator resistance in pediatric malignant gliomas: a report from the Children's Oncology Group
    Ian F Pollack
    Department of Neurosurgery, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Pediatr Blood Cancer 55:1066-71. 2010

Detail Information

Publications100

  1. ncbi request reprint Intramedullary spinal cord astrocytomas in children
    Ian F Pollack
    Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute Brain Tumor Center, Pittsburgh, Pennsylvania 15213, USA
    Pediatr Blood Cancer 43:617-8. 2004
  2. pmc Antigen-specific immune responses and clinical outcome after vaccination with glioma-associated antigen peptides and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose in children with newly diagnosed malignant brainstem and n
    Ian F Pollack
    All authors University of Pittsburgh, Pittsburgh, PA
    J Clin Oncol 32:2050-8. 2014
    ....
  3. ncbi request reprint Association between chromosome 1p and 19q loss and outcome in pediatric malignant gliomas: results from the CCG-945 cohort
    Ian F Pollack
    Department of Neurosurgery, University of Pittsburgh Medical Center and the Children s Hospital of Pittsburgh, Pittsburgh, PA, USA
    Pediatr Neurosurg 39:114-21. 2003
    ....
  4. doi request reprint Multidisciplinary management of childhood brain tumors: a review of outcomes, recent advances, and challenges
    Ian F Pollack
    Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neurosurg Pediatr 8:135-48. 2011
    ..The goal of this report is to provide an overview of recent progress in the field...
  5. pmc Diagnostic and therapeutic stratification of childhood brain tumors: implications for translational research
    Ian F Pollack
    Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Child Neurol 23:1179-85. 2008
    ....
  6. ncbi request reprint Rarity of PTEN deletions and EGFR amplification in malignant gliomas of childhood: results from the Children's Cancer Group 945 cohort
    Ian F Pollack
    Departments of Neurosurgery, University of Pittsburgh Medical Center, Children s Hospital of Pittsburgh, Pennsylvania 15213, USA
    J Neurosurg 105:418-24. 2006
    ..To address this issue, we examined tumor samples from the Children's Cancer Group 945 study, a large randomized trial of treatment for childhood malignant gliomas...
  7. pmc Phase I trial of imatinib in children with newly diagnosed brainstem and recurrent malignant gliomas: a Pediatric Brain Tumor Consortium report
    Ian F Pollack
    Department of Neurosurgery, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Neuro Oncol 9:145-60. 2007
    ..Imatinib may increase the risk of ITH, although the incidence of spontaneous hemorrhages in brainstem glioma is sufficiently high that this should be considered in studies of agents in which hemorrhage is a concern...
  8. ncbi request reprint O6-methylguanine-DNA methyltransferase expression strongly correlates with outcome in childhood malignant gliomas: results from the CCG-945 Cohort
    Ian F Pollack
    Department of Neurosurgery, University of Pittsburgh Cancer Institute, University of Pittsburgh Medical Center and the Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    J Clin Oncol 24:3431-7. 2006
    ..Epigenetic silencing of MGMT has been associated with prolonged survival in adults with malignant gliomas, although the association between MGMT expression status and outcome in pediatric malignant gliomas has not been defined...
  9. ncbi request reprint New delivery approaches for pediatric brain tumors
    Ian F Pollack
    Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh Brain Tumor Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Neurooncol 75:315-26. 2005
    ....
  10. pmc Mismatch repair deficiency is an uncommon mechanism of alkylator resistance in pediatric malignant gliomas: a report from the Children's Oncology Group
    Ian F Pollack
    Department of Neurosurgery, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Pediatr Blood Cancer 55:1066-71. 2010
    ..However, the frequency of this abnormality as a clinical resistance mechanism in childhood malignant gliomas has not been well characterized...
  11. pmc The influence of central review on outcome associations in childhood malignant gliomas: results from the CCG-945 experience
    Ian F Pollack
    Department of Neurosurgery, University of Pittsburgh School of Medicine and the Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuro Oncol 5:197-207. 2003
    ....
  12. pmc IDH1 mutations are common in malignant gliomas arising in adolescents: a report from the Children's Oncology Group
    Ian F Pollack
    Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 4401 Penn Avenue, Pittsburgh, PA 15224, USA
    Childs Nerv Syst 27:87-94. 2011
    ..Because pediatric malignant gliomas share some molecular features with adult secondary gliomas, we questioned whether a subset of these tumors also exhibited IDH mutations...
  13. ncbi request reprint Impact of proliferation index on outcome in childhood malignant gliomas: results in a multi-institutional cohort
    Ian F Pollack
    Departments of Neurosurgery, University of Pittsburgh Medical Center and the Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Neurosurgery 50:1238-44; discussion 1244-5. 2002
    ....
  14. ncbi request reprint P53 pathway alterations are uncommon in childhood ependymomas
    Ian F Pollack
    Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute Brain Tumor Center, Pittsburgh, Pennsylvania 15213, USA
    Pediatr Blood Cancer 46:531-2. 2006
  15. doi request reprint Ataxia resulting from posterior fossa tumors of childhood and other mass lesions
    Ian F Pollack
    Department of Neurosurgery, Children s Hospital of Pittsburgh and University of Pittsburgh Cancer Institute Brain Tumor Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Handb Clin Neurol 103:161-73. 2012
    ..In most modern centers, children with such tumors are treated in cooperative group studies, which are designed to increase the percentage of children who achieve long-term survival as well as their functional outcome...
  16. pmc Akt activation is a common event in pediatric malignant gliomas and a potential adverse prognostic marker: a report from the Children's Oncology Group
    Ian F Pollack
    Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 4401 Penn Avenue, Pittsburgh, PA 15224, USA
    J Neurooncol 99:155-63. 2010
    ..In view of the frequency of Akt activation, the evaluation of molecularly targeted therapies that inhibit this pathway warrants consideration for these tumors...
  17. doi request reprint Childhood brain tumors: epidemiology, current management and future directions
    Ian F Pollack
    Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 4401 Penn Avenue, Pittsburgh, PA 15224, USA
    Nat Rev Neurol 7:495-506. 2011
    ..The latest insights from molecular correlative studies that hold potential for future refinements in therapy will also be discussed...
  18. pmc Identification of ATP citrate lyase as a positive regulator of glycolytic function in glioblastomas
    Marie E Beckner
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
    Int J Cancer 126:2282-95. 2010
    ..In summary, gene expression data, proteomics and functional assays support ACLY as a positive regulator of glycolysis in glioblastomas...
  19. pmc Bortezomib-induced sensitization of malignant human glioma cells to vorinostat-induced apoptosis depends on reactive oxygen species production, mitochondrial dysfunction, Noxa upregulation, Mcl-1 cleavage, and DNA damage
    Daniel R Premkumar
    Department of Neurosurgery, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15223, USA
    Mol Carcinog 52:118-33. 2013
    ..The significantly enhanced antitumor activity that results from the combination of bortezomib and HDACIs offers promise as a novel treatment for glioma patients...
  20. ncbi request reprint Delivery of dendritic cells engineered to secrete IFN-alpha into central nervous system tumors enhances the efficacy of peripheral tumor cell vaccines: dependence on apoptotic pathways
    Naruo Kuwashima
    Department of Neurological Surgery, University of Pittsburgh School of Medicine, PA 15213, USA
    J Immunol 175:2730-40. 2005
    ....
  21. ncbi request reprint Identification of interleukin-13 receptor alpha2 peptide analogues capable of inducing improved antiglioma CTL responses
    Junichi Eguchi
    Department of Neurological Surgery, University of Pittsburgh School of Medicine, USA
    Cancer Res 66:5883-91. 2006
    ..These findings indicate highly immunogenic IL-13Ralpha2 peptide analogues may be useful for the development of vaccines capable of effectively expanding IL-13Ralpha2-specific, tumor-reactive CTLs in glioma patients...
  22. pmc EphA2 as a glioma-associated antigen: a novel target for glioma vaccines
    Manabu Hatano
    Department of Neurological Surgery, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Neoplasia 7:717-22. 2005
    ..Taken together, these data suggest that EphA2883-891 may be an attractive antigen epitope for molecularly targeted glioma vaccines...
  23. ncbi request reprint Inhibition of STAT3 promotes the efficacy of adoptive transfer therapy using type-1 CTLs by modulation of the immunological microenvironment in a murine intracranial glioma
    Mitsugu Fujita
    Department of Neurological Surgery and Brain Tumor Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA
    J Immunol 180:2089-98. 2008
    ....
  24. ncbi request reprint Coadministration of sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells
    Esther P Jane
    Department of Neurosurgery, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute Brain Tumor Center, Pennsylvania, USA
    J Pharmacol Exp Ther 319:1070-80. 2006
    ....
  25. pmc Identification of survival genes in human glioblastoma cells by small interfering RNA screening
    Nikhil G Thaker
    Department of Pharmacology and Chemical Biology, Biomedical Science Tower 3, 3501 Fifth Avenue, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Mol Pharmacol 76:1246-55. 2009
    ....
  26. pmc Tumor cells from ultrasonic aspirations of glioblastomas migrate and form spheres with radial outgrowth
    Marie E Beckner
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Cancer Lett 255:135-44. 2007
    ..Cultures were maintained for more than six weeks without fibroblastic overgrowth. Our observations show that ultrasonically aspirated specimens contain cells useful for studies of tumor migration and growth of tumorspheres...
  27. doi request reprint Outcome of children with metastatic medulloblastoma treated with carboplatin during craniospinal radiotherapy: a Children's Oncology Group Phase I/II study
    Regina I Jakacki
    Children s Hospital of Pittsburgh, 4401 Penn Ave, Pittsburgh, PA 15224, USA
    J Clin Oncol 30:2648-53. 2012
    ....
  28. ncbi request reprint Cooperative inhibitory effect of ZD1839 (Iressa) in combination with 17-AAG on glioma cell growth
    Daniel R Premkumar
    Department of Neurosurgery, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute Brain Tumor Center, Pittsburgh, Pennsylvania 15213, USA
    Mol Carcinog 45:288-301. 2006
    ....
  29. ncbi request reprint The characterization of tumor apoptosis after experimental radiosurgery
    Timothy F Witham
    Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2582, USA
    Stereotact Funct Neurosurg 83:17-24. 2005
    ..The time course of this radiobiologic phenomenon begins at approximately 6 h following radiosurgery, continues up to 48 h, and begins to decline by 72 h...
  30. ncbi request reprint Epidermal growth factor receptor-transfected bone marrow stromal cells exhibit enhanced migratory response and therapeutic potential against murine brain tumors
    Hidemitsu Sato
    Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 1863, USA
    Cancer Gene Ther 12:757-68. 2005
    ..These data indicate that EGFR-MSCs may serve as attractive vehicles for infiltrating brain malignancies such as malignant gliomas...
  31. pmc Autologous glioma cell vaccine admixed with interleukin-4 gene transfected fibroblasts in the treatment of patients with malignant gliomas
    Hideho Okada
    Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Transl Med 5:67. 2007
    ..The prognosis for malignant gliomas remains dismal. We addressed the safety, feasibility and preliminary clinical activity of the vaccinations using autologous glioma cells and interleukin (IL)-4 gene transfected fibroblasts...
  32. ncbi request reprint Co-administration of NVP-AEW541 and dasatinib induces mitochondrial-mediated apoptosis through Bax activation in malignant human glioma cell lines
    Daniel R Premkumar
    Department of Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15201, USA
    Int J Oncol 37:633-43. 2010
    ....
  33. pmc ABT-737 synergizes with bortezomib to induce apoptosis, mediated by Bid cleavage, Bax activation, and mitochondrial dysfunction in an Akt-dependent context in malignant human glioma cell lines
    Daniel R Premkumar
    Department of Neurosurgery, Children s Hospital of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA 15224, USA
    J Pharmacol Exp Ther 341:859-72. 2012
    ....
  34. ncbi request reprint Glycolytic glioma cells with active glycogen synthase are sensitive to PTEN and inhibitors of PI3K and gluconeogenesis
    Marie E Beckner
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Lab Invest 85:1457-70. 2005
    ..These findings confirm that glycolytic glioma cells can migrate invasively and that the loss of PTEN is supportive, with activated glycogenic potential included among the relevant downstream effects...
  35. ncbi request reprint Catalyst-dependent drug loading of LDI-glycerol polyurethane foams leads to differing controlled release profiles
    Wesley N Sivak
    Department of Bioengineering, School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA
    Acta Biomater 4:1263-74. 2008
    ..0x10(-8)). These results clearly demonstrate the long-term, catalyst-dependent release of DB-67 from LDI-glycerol polyurethane foams, indicating their potential for use in implantable drug-delivery devices...
  36. ncbi request reprint Expression of p53 and prognosis in children with malignant gliomas
    Ian F Pollack
    Department of Neurosurgery, University of Pittsburgh Medical Center and Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    N Engl J Med 346:420-7. 2002
    ..We investigated whether mutations in the TP53 gene or the degree of expression of p53 protein in high-grade gliomas is associated with progression-free survival in children with these tumors...
  37. pmc Induction of CD8+ T-cell responses against novel glioma-associated antigen peptides and clinical activity by vaccinations with {alpha}-type 1 polarized dendritic cells and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose in
    Hideho Okada
    G12 a Research Pavilion at the Hillman Cancer Center, 5117 Centre Ave, Pittsburgh, PA 15213 1863, USA
    J Clin Oncol 29:330-6. 2011
    ..GAAs for these peptides are EphA2, interleukin (IL)-13 receptor-α2, YKL-40, and gp100...
  38. pmc LOH in the HLA class I region at 6p21 is associated with shorter survival in newly diagnosed adult glioblastoma
    Jacky T Yeung
    Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Clin Cancer Res 19:1816-26. 2013
    ..In this study, we examined the prevalence of these LOH events and their relations with overall survival in GBM...
  39. pmc Identification of chemosensitivity nodes for vinblastine through small interfering RNA high-throughput screens
    Carolyn A Kitchens
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Pharmacol Exp Ther 339:851-8. 2011
    ..These results illustrate the usefulness of unbiased siRNA screens as a method for identifying potential novel anticancer therapeutic combinations...
  40. ncbi request reprint Albumin marks pseudopodia of astrocytoma cells responding to hepatocyte growth factor or serum
    Marie E Beckner
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Lab Invest 86:1103-14. 2006
    ..Thus, albumin potentially aids and marks invasion as it accumulates in these tumors...
  41. pmc A phase 1 study of vinblastine in combination with carboplatin for children with low-grade gliomas: a Children's Oncology Group phase 1 consortium study
    Regina I Jakacki
    Children s Hospital of Pittsburgh, Pittsburgh, PA 15224, USA
    Neuro Oncol 13:910-5. 2011
    ..The recommended phase 2 dose and schedule is carboplatin, 400 mg/m(2)/dose on day 1, and vinblastine, 4 mg/m(2)/dose, weekly × 3, repeated every 4 weeks. Further study of this regimen in patients with low-grade glioma is warranted...
  42. pmc AG490 influences UCN-01-induced cytotoxicity in glioma cells in a p53-dependent fashion, correlating with effects on BAX cleavage and BAD phosphorylation
    Esther P Jane
    Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Cancer Lett 257:36-46. 2007
    ....
  43. ncbi request reprint Expression of a soluble transforming growth factor-beta (TGFbeta) receptor reduces tumorigenicity by regulating natural killer (NK) cell activity against 9L gliosarcoma in vivo
    Timothy F Witham
    Brain Tumor Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213 1863, USA
    J Neurooncol 64:63-9. 2003
    ..Finally, we determined that elimination of CD161+ cells resulted in comparable growth of 9L-neo and 9L-TGFbeta sr in vivo, indicating that NK or NK-like cells were responsible for the anti-tumor effects in this model...
  44. pmc Abrogation of mitogen-activated protein kinase and Akt signaling by vandetanib synergistically potentiates histone deacetylase inhibitor-induced apoptosis in human glioma cells
    Esther P Jane
    Department of Neurosurgery, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Pharmacol Exp Ther 331:327-37. 2009
    ....
  45. pmc Enzastaurin induces H2AX phosphorylation to regulate apoptosis via MAPK signalling in malignant glioma cells
    Esther P Jane
    Department of Neurosurgery, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute Brain Tumor Center, Pittsburgh, PA 15213, USA
    Eur J Cancer 46:412-9. 2010
    ..These data call attention to a novel signalling pathway (MAPK/H2AX) to regulate apoptosis in malignant glioma cells...
  46. pmc A phase II study of gefitinib and irradiation in children with newly diagnosed brainstem gliomas: a report from the Pediatric Brain Tumor Consortium
    Ian F Pollack
    Department of Neurosurgery, Children s Hospital of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA 15224, USA
    Neuro Oncol 13:290-7. 2011
    ....
  47. pmc YM-155 potentiates the effect of ABT-737 in malignant human glioma cells via survivin and Mcl-1 downregulation in an EGFR-dependent context
    Esther P Jane
    Department of Neurosurgery, Children s Hospital of Pittsburgh, Pittsburgh, PA 15224, USA
    Mol Cancer Ther 12:326-38. 2013
    ....
  48. pmc Survivin inhibitor YM-155 sensitizes tumor necrosis factor- related apoptosis-inducing ligand-resistant glioma cells to apoptosis through Mcl-1 downregulation and by engaging the mitochondrial death pathway
    Daniel R Premkumar
    Department of Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    J Pharmacol Exp Ther 346:201-10. 2013
    ..The significantly enhanced antitumor activity of the combination of YM-155 and TRAIL may have applications for therapy of malignant glioma. ..
  49. pmc A phase I trial of temozolomide and lomustine in newly diagnosed high-grade gliomas of childhood
    Regina I Jakacki
    Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuro Oncol 10:569-76. 2008
    ..Radiographic changes following RT make determination of early tumor progression difficult. Metastatic disease is common prior to death...
  50. pmc The heat shock protein antagonist 17-AAG potentiates the activity of enzastaurin against malignant human glioma cells
    Esther P Jane
    Department of Neurosurgery, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute Brain Tumor Center, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Cancer Lett 268:46-55. 2008
    ....
  51. pmc Expression of glioma-associated antigens in pediatric brain stem and non-brain stem gliomas
    Hideho Okada
    Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Neurooncol 88:245-50. 2008
    ..These results suggest that EphA2, IL-13Ralpha2 and Survivin are suitable targets for developing vaccine strategies for pediatric glioma...
  52. ncbi request reprint Stereotactic radiosurgery for pilocytic astrocytomas part 2: outcomes in pediatric patients
    Hideyuki Kano
    Department of Neurological Surgery, University of Pittsburgh School of Medicine, Suite B 400, UPMC Presbyterian, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    J Neurooncol 95:219-29. 2009
    ..Stereotactic radiosurgery for pediatric pilocytic astrocytomas should be considered when resection is not feasible, or if there is an early recurrence. The best response was observed in small volume residual solid tumors...
  53. ncbi request reprint 7-Hydroxystaurosporine-induced apoptosis in 9L glioma cells provides an effective antigen source for dendritic cells and yields a potent vaccine strategy in an intracranial glioma model
    Timothy F Witham
    Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Neurosurgery 50:1327-34; discussion 1334-5. 2002
    ....
  54. pmc Increased expression of tumor-associated antigens in pediatric and adult ependymomas: implication for vaccine therapy
    Jacky T Yeung
    Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Neurooncol 111:103-11. 2013
    ..Pediatric and adult ependymomas frequently express EphA2, IL-13Rα2, and Survivin. This provides the basis for the utilization of an established multiple peptide vaccine for ependymoma in a clinical trial setting...
  55. ncbi request reprint Cytokine gene therapy for malignant glioma
    Hideho Okada
    University of Pittsburgh Medical Center Cancer Institute, Department of Neurological Surgery, Brain Tumor Program, G12 a Research Pavilion at the Hillman Cancer Center, 5117 Centre Ave, Pittsburgh, PA 15213 1863, USA
    Expert Opin Biol Ther 4:1609-20. 2004
    ..Successful immunogene therapy for brain tumours requires detailed understanding of cytokine functions and the use of them at the appropriate stages/sites of the immunological milieu...
  56. ncbi request reprint Identification of a novel HLA-A*0201-restricted, cytotoxic T lymphocyte epitope in a human glioma-associated antigen, interleukin 13 receptor alpha2 chain
    Fumiyoshi Okano
    Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Clin Cancer Res 8:2851-5. 2002
    ..Interleukin 13 receptor alpha2-chain (IL-13Ralpha2) has been reported to be abundantly and specifically overexpressed in glioblastoma multiforme. Here we report the identification of a CTL epitope derived from the IL-13Ralpha2...
  57. pmc Ependymomas: development of immunotherapeutic strategies
    Ian F Pollack
    Department of Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Expert Rev Neurother 13:1089-98. 2013
    ....
  58. doi request reprint Pegylated interferon-α-2b for children with recurrent craniopharyngioma
    Jacky T Yeung
    Department of Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    J Neurosurg Pediatr 10:498-503. 2012
    ..Pegylaion of interferon-α-2b (PI) prolongs the half-life, allowing sustained exposure of the drug over time, and enhances efficacy. The authors report the results of the use of PI in 5 children with recurrent craniopharyngiomas...
  59. pmc Bortezomib sensitizes malignant human glioma cells to TRAIL, mediated by inhibition of the NF-{kappa}B signaling pathway
    Esther P Jane
    Department of Neurosurgery, Children s Hospital of Pittsburgh, 3705 Fifth Ave, Pittsburgh, PA 15213, USA
    Mol Cancer Ther 10:198-208. 2011
    ....
  60. ncbi request reprint Molecular abnormalities and correlations with tumor response and outcome in glioma patients
    Ian F Pollack
    Department of Neurosurgery, University of Pittsburgh Medical Center and the Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Neuroimaging Clin N Am 12:627-39. 2002
    ....
  61. ncbi request reprint Autologous glioma cell vaccine admixed with interleukin-4 gene transfected fibroblasts in the treatment of recurrent glioblastoma: preliminary observations in a patient with a favorable response to therapy
    Hideho Okada
    Department of Neurological Surgery, University of Pittsburgh School of Medicine, PA, USA
    J Neurooncol 64:13-20. 2003
    ..While it is premature to assess effectiveness of the vaccine, this initial patient's course suggested a transient response to the vaccine, and he survived 10 months after treatment...
  62. pmc Molecularly targeted therapies for malignant glioma: rationale for combinatorial strategies
    Nikhil G Thaker
    Doris Duke Clinical Research Fellow, Departments of Neurosurgery, Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA
    Expert Rev Neurother 9:1815-36. 2009
    ..This review summarizes the currently implemented single-agent and combination molecularly targeted therapies for MG...
  63. ncbi request reprint Delivery of interferon-alpha transfected dendritic cells into central nervous system tumors enhances the antitumor efficacy of peripheral peptide-based vaccines
    Hideho Okada
    Departments of Neurological Surgery, University of Pittsburgh School of Medicine, PA 15213, USA
    Cancer Res 64:5830-8. 2004
    ..On the basis of these results, we believe that local expression of IFN-alpha by DCs within the intracranial tumor site may enhance the clinical efficacy of peripheral vaccine approaches for brain tumors...
  64. doi request reprint Endoscopic port surgery for resection of lesions of the cerebellar peduncles: technical note
    Pawel G Ochalski
    Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Neurosurgery 68:1444-50; discussion 1450-1. 2011
    ..Success has been achieved through multiple approaches, but complications can be severe...
  65. ncbi request reprint Synergistic interaction between 17-AAG and phosphatidylinositol 3-kinase inhibition in human malignant glioma cells
    Daniel R Premkumar
    Department of Neurosurgery, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute Brain Tumor Center, Pittsburgh, Pennsylvania, USA
    Mol Carcinog 45:47-59. 2006
    ....
  66. pmc A novel SNP analysis method to detect copy number alterations with an unbiased reference signal directly from tumor samples
    Alex Lisovich
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    BMC Med Genomics 4:14. 2011
    ....
  67. doi request reprint Designing, optimizing, and implementing high-throughput siRNA genomic screening with glioma cells for the discovery of survival genes and novel drug targets
    Nikhil G Thaker
    Doris Duke Clinical Research Fellowship, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Neurosci Methods 185:204-12. 2010
    ..Successful implementation and analysis of this siRNA screen validates our transfection optimization approach and provides guidance for the rapid development of high-throughput siRNA screens in human glioma cells...
  68. ncbi request reprint Loss of heterozygosity reveals non-VHL allelic loss in hemangioblastomas at 22q13
    Marie E Beckner
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Hum Pathol 35:1105-11. 2004
    ..LOH for the 22q13.2 region in HBs suggests that the loss of another tumor suppressor gene is involved in the pathogenesis of HBs in addition to VHL. Absence of LOH for glioma markers is consistent with the low-grade behavior of HBs...
  69. ncbi request reprint Risk assignment in childhood brain tumors: the emerging role of molecular and biologic classification
    Ian F Pollack
    Department of Neurosurgery, Children s Hospital of Pittsburgh, Main Tower, Floor 3, Room 3705, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Curr Oncol Rep 4:114-22. 2002
    ..This paper summarizes these observations and discusses how they are being applied in a preliminary fashion as a foundation for risk-adapted stratification of childhood brain tumor therapy...
  70. ncbi request reprint Effect of trichostatin A, a histone deacetylase inhibitor, on glioma proliferation in vitro by inducing cell cycle arrest and apoptosis
    Matthew Wetzel
    Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Neurosurg 103:549-56. 2005
    ..The authors' goal was to evaluate its effect on cell growth and cell cycle regulation in a large panel of glioma cell lines, as well as in human astrocytes, fibroblasts, and endothelial cells...
  71. ncbi request reprint Proteomic characterization of harvested pseudopodia with differential gel electrophoresis and specific antibodies
    Marie E Beckner
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Lab Invest 85:316-27. 2005
    ....
  72. doi request reprint Cranial vault remodeling for sagittal craniosynostosis in older children
    S Alex Rottgers
    Children s Hospital of Pittsburgh of UPMC, PA, USA
    Neurosurg Focus 31:E3. 2011
    ....
  73. ncbi request reprint Individualized treatment of pediatric craniopharyngiomas
    A Leland Albright
    Department of Neurosurgery, Childrens Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Childs Nerv Syst 21:649-54. 2005
    ..We performed this study to correlate the clinical and radiographic features at the time of presentation with the multimodality treatments the children received...
  74. doi request reprint Fractures of the clivus and traumatic diastasis of the central skull base in the pediatric population
    Pawel G Ochalski
    Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Neurosurg Pediatr 7:261-7. 2011
    ..The incidence, outcome, and biomechanics associated with these fractures have been difficult to ascertain secondary to the lack of literature pertaining to their occurrence...
  75. ncbi request reprint Fully endoscopic expanded endonasal approach treating skull base lesions in pediatric patients
    Amin Kassam
    Minimally Invasive endoNeurosurgery Center, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Neurosurg 106:75-86. 2007
    ....
  76. doi request reprint Parasagittal suture after strip craniectomy
    Christopher R Kinsella
    Divisions of Pediatric Plastic Surgery, Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Craniofac Surg 22:66-7. 2011
    ....
  77. doi request reprint LDI-glycerol polyurethane implants exhibit controlled release of DB-67 and anti-tumor activity in vitro against malignant gliomas
    Wesley N Sivak
    Department of Bioengineering, School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA
    Acta Biomater 4:852-62. 2008
    ..These results clearly demonstrate the long-term, slow release of DB-67 from LDI-glycerol polyurethane discs and their potential for postoperative intracranial chemotherapy of cancers...
  78. doi request reprint Extraventricular neurocytoma in neurofibromatosis Type 1: case report
    Ali I Raja
    Department of Neurosurgery, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    J Neurosurg Pediatr 2:63-7. 2008
    ..The importance of obtaining a biopsy in lesions that have atypical imaging features is highlighted...
  79. doi request reprint Expanded endoscopic endonasal resection of an olfactory schwannoma
    Hilal A Kanaan
    Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurosurg Pediatr 2:261-5. 2008
    ....
  80. ncbi request reprint Glioma-associated hyaluronan induces apoptosis in dendritic cells via inducible nitric oxide synthase: implications for the use of dendritic cells for therapy of gliomas
    Tianbing Yang
    Brain Tumor Center, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 62:2583-91. 2002
    ..These data indicate that HA expressed by gliomas may contribute to their immunosuppressive effects by promoting apoptosis among professional antigen-presenting cells such as DCs via iNOS induction after CD44-HA interactions...
  81. ncbi request reprint Molecular analysis of pediatric brain tumors
    Jaclyn A Biegel
    Division of Human Genetics, Department of Pediatrics, University of Pennsylvania School of Medicine, The Children s Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA
    Curr Oncol Rep 6:445-52. 2004
    ..Advances in this area will depend on the ability to identify new disease genes, validate prognostic markers, and develop biologically based therapeutic strategies to tailor treatment...
  82. pmc Dose intensive melphalan and cyclophosphamide with autologous hematopoietic stem cells for recurrent medulloblastoma or germinoma
    Richard P Kadota
    Rady Children s Hospital, San Diego, California, USA
    Pediatr Blood Cancer 51:675-8. 2008
    ..To determine the response, toxicity, and survival for children with progressive or recurrent medulloblastoma and germinoma using a single myeloablative course of chemotherapy supported by autologous hematopoietic stem cells...
  83. ncbi request reprint Phase I clinical trial of mafosfamide in infants and children aged 3 years or younger with newly diagnosed embryonal tumors: a pediatric brain tumor consortium study (PBTC-001)
    Susan M Blaney
    Texas Children s Cancer Center, 6621 Fannin, CC 1410 00, Houston, TX 77030, USA
    J Clin Oncol 23:525-31. 2005
    ....
  84. ncbi request reprint Phase I and pharmacokinetic study of the oral farnesyltransferase inhibitor lonafarnib administered twice daily to pediatric patients with advanced central nervous system tumors using a modified continuous reassessment method: a Pediatric Brain Tumor Cons
    Mark W Kieran
    Dana Farber Cancer Institute and Children s Hospital Boston, Boston, MA 02115, USA
    J Clin Oncol 25:3137-43. 2007
    ..Primary objectives were to estimate the maximum-tolerated dose (MTD) and to describe the dose-limiting toxicities (DLTs) and pharmacokinetics of lonafarnib. Farnesylation inhibition of HDJ-2 in peripheral blood was also measured...
  85. ncbi request reprint Progression-associated genes in astrocytoma identified by novel microarray gene expression data reanalysis
    Tobey J Macdonald
    Center for Cancer and Immunology Research, Children s Research Institute, Department of Hematology Oncology, Children s National Medical Center, Washington, DC, USA
    Methods Mol Biol 377:203-22. 2007
    ..Further investigation is needed to evaluate the role of APOD, as well as the other genes identified, in malignant astrocytoma development...
  86. doi request reprint Phase I trial of VNP40101M (Cloretazine) in children with recurrent brain tumors: a pediatric brain tumor consortium study
    Sridharan Gururangan
    The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Cancer Res 14:1124-30. 2008
    ..VNP40101M (Cloretazine), a novel DNA alkylating agent, was evaluated in a phase I study in children with recurrent brain tumors...
  87. ncbi request reprint DNA topoisomerase IIalpha predicts progression-free and overall survival in pediatric malignant non-brainstem gliomas
    Markus Bredel
    Department of General Neurosurgery, Neurocenter, University of Freiburg, Freiburg, Germany
    Int J Cancer 99:817-20. 2002
    ....
  88. ncbi request reprint A phase II study of the farnesyl transferase inhibitor, tipifarnib, in children with recurrent or progressive high-grade glioma, medulloblastoma/primitive neuroectodermal tumor, or brainstem glioma: a Children's Oncology Group study
    Maryam Fouladi
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Cancer 110:2535-41. 2007
    ....
  89. ncbi request reprint Phase II evaluation of temozolomide and 13-cis-retinoic acid for the treatment of recurrent and progressive malignant glioma: a North American Brain Tumor Consortium study
    Kurt A Jaeckle
    University of Texas M D Anderson Cancer Center, Houston, USA
    J Clin Oncol 21:2305-11. 2003
    ..This phase II trial evaluated efficacy and toxicity of combination temozolomide and cRA treatment in recurrent MG...
  90. ncbi request reprint Anaplastic mixed gliomas and anaplastic oligodendroglioma in children: results from the CCG 945 experience
    Douglas J Hyder
    Department of Pediatrics, Children s Hospital at Dartmouth, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    J Neurooncol 83:1-8. 2007
    ..To review interpathologist diagnosis variability and survival of children treated for either anaplastic mixed glioma (AMG) or anaplastic oligodendroglioma (AO) with surgery, irradiation and chemotherapy...
  91. ncbi request reprint Metastatic ependymoma: a multi-institutional retrospective analysis of prognostic factors
    Stergios Zacharoulis
    Department of Pediatrics, The Royal Marsden Hospital, Sutton, Surrey, UK
    Pediatr Blood Cancer 50:231-5. 2008
    ..Metastatic ependymoma is exceedingly rare at diagnosis with variable prognosis reported in the literature. The purpose of this study was to identify prognostic factors in children with metastatic ependymoma...
  92. ncbi request reprint Outcome of children with centrally reviewed low-grade gliomas treated with chemotherapy with or without radiotherapy on Children's Cancer Group high-grade glioma study CCG-945
    Maryam Fouladi
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Cancer 98:1243-52. 2003
    ....
  93. ncbi request reprint ERBB1 is amplified and overexpressed in high-grade diffusely infiltrative pediatric brain stem glioma
    Richard J Gilbertson
    Brain Tumor Program, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Clin Cancer Res 9:3620-4. 2003
    ....
  94. ncbi request reprint Preradiation chemotherapy in primary high-risk brainstem tumors: phase II study CCG-9941 of the Children's Cancer Group
    Mark T Jennings
    Vanderbilt Cancer Center, Nashville, TN, USA
    J Clin Oncol 20:3431-7. 2002
    ..This Children's Cancer Group group-wide phase II trial evaluated the efficacy and toxicity of two chemotherapy arms administered before hyperfractionated external-beam radiotherapy (HFEBRT)...
  95. pmc Motexafin gadolinium and involved field radiation therapy for intrinsic pontine glioma of childhood: a Children's Oncology Group phase I study
    Kristin A Bradley
    University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Neuro Oncol 10:752-8. 2008
    ..The maximum tolerated dose of MGd and the recommended phase II dose was 4.4 mg/kg when administered as a daily intravenous bolus in conjunction with 6 weeks of involved field radiation therapy for pediatric intrinsic pontine gliomas...
  96. ncbi request reprint DNA topoisomerase IIalpha and Her-2/neu gene dosages in pediatric malignant gliomas
    Claudia Bredel
    Department of General Neurosurgery, Neurocenter, University of Freiburg, D 79106 Freiburg, Germany
    Int J Oncol 26:1187-92. 2005
    ..The observed intratumor genetic heterogeneity for TIIalpha in PMNBGs may have an impact on the relevance of TIIalpha as a biological constituent of outcome in these neoplasms...
  97. ncbi request reprint Parental heat exposure and risk of childhood brain tumor: a Children's Oncology Group study
    Greta R Bunin
    Division of Oncology, Children s Hospital of Philadelphia, PA 19104, USA
    Am J Epidemiol 164:222-31. 2006
    ..4, 95% CI: 1.2, 9.7, and odds ratio = 2.1, 95% CI: 1.1, 4.3, respectively). This new observation regarding paternal exposure to heat just prior to the index pregnancy deserves consideration in future animal and human studies of MB/PNET...
  98. ncbi request reprint Effective induction of antiglioma cytotoxic T cells by coadministration of interferon-beta gene vector and dendritic cells
    Norimoto Nakahara
    Department of Bio Medicine, Nagoya University School of Medicine, Nagoya, Japan
    Cancer Gene Ther 10:549-58. 2003
    ..Suppression of the tumor growth by this combinational therapy was superior to treatment with DC or IFN-beta gene solely. This combination may constitute a new therapeutic strategy to induce potent antiglioma immune responses...
  99. ncbi request reprint Pathologist interobserver variability of histologic features in childhood brain tumors: results from the CCG-945 study
    Floyd H Gilles
    Neuropathology, Childrens Hospital, Los Angeles, CA 90027, USA
    Pediatr Dev Pathol 11:108-17. 2008
    ..Agreement and strict adherence to improved nonsubjective diagnostic criteria would improve histologic feature reliability and, consequently, their usefulness in studies...