Research Topics
Genomes and GenesSpecies | Ian F PollackSummaryAffiliation: Children's Hospital of Pittsburgh Country: USA Publications
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Publications
YM-155 potentiates the effect of ABT-737 in malignant human glioma cells via survivin and Mcl-1 downregulation in an EGFR-dependent contextEsther P Jane
Department of Neurosurgery, Children s Hospital of Pittsburgh, Pittsburgh, PA 15224, USA
Mol Cancer Ther 12:326-38. 2013....- The influence of central review on outcome associations in childhood malignant gliomas: results from the CCG-945 experienceIan F Pollack
Department of Neurosurgery, University of Pittsburgh School of Medicine and the Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
Neuro Oncol 5:197-207. 2003.... - IDH1 mutations are common in malignant gliomas arising in adolescents: a report from the Children's Oncology GroupIan F Pollack
Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 4401 Penn Avenue, Pittsburgh, PA 15224, USA
Childs Nerv Syst 27:87-94. 2011..Because pediatric malignant gliomas share some molecular features with adult secondary gliomas, we questioned whether a subset of these tumors also exhibited IDH mutations... - Akt activation is a common event in pediatric malignant gliomas and a potential adverse prognostic marker: a report from the Children's Oncology GroupIan F Pollack
Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 4401 Penn Avenue, Pittsburgh, PA 15224, USA
J Neurooncol 99:155-63. 2010..In view of the frequency of Akt activation, the evaluation of molecularly targeted therapies that inhibit this pathway warrants consideration for these tumors... - Mismatch repair deficiency is an uncommon mechanism of alkylator resistance in pediatric malignant gliomas: a report from the Children's Oncology GroupIan F Pollack
Department of Neurosurgery, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Pediatr Blood Cancer 55:1066-71. 2010..However, the frequency of this abnormality as a clinical resistance mechanism in childhood malignant gliomas has not been well characterized... 
Intramedullary spinal cord astrocytomas in childrenIan F Pollack
Department of Neurosurgery, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute Brain Tumor Center, Pittsburgh, Pennsylvania 15213, USA
Pediatr Blood Cancer 43:617-8. 2004- New delivery approaches for pediatric brain tumorsIan F Pollack
Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh Brain Tumor Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Neurooncol 75:315-26. 2005.... - Phase I trial of imatinib in children with newly diagnosed brainstem and recurrent malignant gliomas: a Pediatric Brain Tumor Consortium reportIan F Pollack
Department of Neurosurgery, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
Neuro Oncol 9:145-60. 2007..Imatinib may increase the risk of ITH, although the incidence of spontaneous hemorrhages in brainstem glioma is sufficiently high that this should be considered in studies of agents in which hemorrhage is a concern... 
Diagnostic and therapeutic stratification of childhood brain tumors: implications for translational researchIan F Pollack
Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Child Neurol 23:1179-85. 2008....- P53 pathway alterations are uncommon in childhood ependymomasIan F Pollack
Department of Neurosurgery, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute Brain Tumor Center, Pittsburgh, Pennsylvania 15213, USA
Pediatr Blood Cancer 46:531-2. 2006 - Association between chromosome 1p and 19q loss and outcome in pediatric malignant gliomas: results from the CCG-945 cohortIan F Pollack
Department of Neurosurgery, University of Pittsburgh Medical Center and the Children s Hospital of Pittsburgh, Pittsburgh, PA, USA
Pediatr Neurosurg 39:114-21. 2003.... - Impact of proliferation index on outcome in childhood malignant gliomas: results in a multi-institutional cohortIan F Pollack
Departments of Neurosurgery, University of Pittsburgh Medical Center and the Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
Neurosurgery 50:1238-44; discussion 1244-5. 2002.... - Rarity of PTEN deletions and EGFR amplification in malignant gliomas of childhood: results from the Children's Cancer Group 945 cohortIan F Pollack
Departments of Neurosurgery, University of Pittsburgh Medical Center, Children s Hospital of Pittsburgh, Pennsylvania 15213, USA
J Neurosurg 105:418-24. 2006..To address this issue, we examined tumor samples from the Children's Cancer Group 945 study, a large randomized trial of treatment for childhood malignant gliomas... - O6-methylguanine-DNA methyltransferase expression strongly correlates with outcome in childhood malignant gliomas: results from the CCG-945 CohortIan F Pollack
Department of Neurosurgery, University of Pittsburgh Cancer Institute, University of Pittsburgh Medical Center and the Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
J Clin Oncol 24:3431-7. 2006..Epigenetic silencing of MGMT has been associated with prolonged survival in adults with malignant gliomas, although the association between MGMT expression status and outcome in pediatric malignant gliomas has not been defined... - Childhood brain tumors: epidemiology, current management and future directionsIan F Pollack
Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 4401 Penn Avenue, Pittsburgh, PA 15224, USA
Nat Rev Neurol 7:495-506. 2011..The latest insights from molecular correlative studies that hold potential for future refinements in therapy will also be discussed... - Multidisciplinary management of childhood brain tumors: a review of outcomes, recent advances, and challengesIan F Pollack
Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
J Neurosurg Pediatr 8:135-48. 2011..The goal of this report is to provide an overview of recent progress in the field... - Ataxia resulting from posterior fossa tumors of childhood and other mass lesionsIan F Pollack
Department of Neurosurgery, Children s Hospital of Pittsburgh and University of Pittsburgh Cancer Institute Brain Tumor Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Handb Clin Neurol 103:161-73. 2012..In most modern centers, children with such tumors are treated in cooperative group studies, which are designed to increase the percentage of children who achieve long-term survival as well as their functional outcome... - Identification of ATP citrate lyase as a positive regulator of glycolytic function in glioblastomasMarie E Beckner
Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
Int J Cancer 126:2282-95. 2010..In summary, gene expression data, proteomics and functional assays support ACLY as a positive regulator of glycolysis in glioblastomas... - Delivery of dendritic cells engineered to secrete IFN-alpha into central nervous system tumors enhances the efficacy of peripheral tumor cell vaccines: dependence on apoptotic pathwaysNaruo Kuwashima
Department of Neurological Surgery, University of Pittsburgh School of Medicine, PA 15213, USA
J Immunol 175:2730-40. 2005.... - Identification of interleukin-13 receptor alpha2 peptide analogues capable of inducing improved antiglioma CTL responsesJunichi Eguchi
Department of Neurological Surgery, University of Pittsburgh School of Medicine, USA
Cancer Res 66:5883-91. 2006..These findings indicate highly immunogenic IL-13Ralpha2 peptide analogues may be useful for the development of vaccines capable of effectively expanding IL-13Ralpha2-specific, tumor-reactive CTLs in glioma patients... - Identification of survival genes in human glioblastoma cells by small interfering RNA screeningNikhil G Thaker
Department of Pharmacology and Chemical Biology, Biomedical Science Tower 3, 3501 Fifth Avenue, University of Pittsburgh, Pittsburgh, PA 15260, USA
Mol Pharmacol 76:1246-55. 2009.... - Inhibition of STAT3 promotes the efficacy of adoptive transfer therapy using type-1 CTLs by modulation of the immunological microenvironment in a murine intracranial gliomaMitsugu Fujita
Department of Neurological Surgery and Brain Tumor Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA
J Immunol 180:2089-98. 2008.... - Coadministration of sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cellsEsther P Jane
Department of Neurosurgery, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute Brain Tumor Center, Pennsylvania, USA
J Pharmacol Exp Ther 319:1070-80. 2006.... - Tumor cells from ultrasonic aspirations of glioblastomas migrate and form spheres with radial outgrowthMarie E Beckner
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Cancer Lett 255:135-44. 2007..Cultures were maintained for more than six weeks without fibroblastic overgrowth. Our observations show that ultrasonically aspirated specimens contain cells useful for studies of tumor migration and growth of tumorspheres... - Outcome of children with metastatic medulloblastoma treated with carboplatin during craniospinal radiotherapy: a Children's Oncology Group Phase I/II studyRegina I Jakacki
Children s Hospital of Pittsburgh, 4401 Penn Ave, Pittsburgh, PA 15224, USA
J Clin Oncol 30:2648-53. 2012.... - EphA2 as a glioma-associated antigen: a novel target for glioma vaccinesManabu Hatano
Department of Neurological Surgery, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
Neoplasia 7:717-22. 2005..Taken together, these data suggest that EphA2883-891 may be an attractive antigen epitope for molecularly targeted glioma vaccines... - Epidermal growth factor receptor-transfected bone marrow stromal cells exhibit enhanced migratory response and therapeutic potential against murine brain tumorsHidemitsu Sato
Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213-1863, USA
Cancer Gene Ther 12:757-68. 2005..These data indicate that EGFR-MSCs may serve as attractive vehicles for infiltrating brain malignancies such as malignant gliomas... - The characterization of tumor apoptosis after experimental radiosurgeryTimothy F Witham
Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213-2582, USA
Stereotact Funct Neurosurg 83:17-24. 2005..The time course of this radiobiologic phenomenon begins at approximately 6 h following radiosurgery, continues up to 48 h, and begins to decline by 72 h... - Cooperative inhibitory effect of ZD1839 (Iressa) in combination with 17-AAG on glioma cell growthDaniel R Premkumar
Department of Neurosurgery, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute Brain Tumor Center, Pittsburgh, Pennsylvania 15213, USA
Mol Carcinog 45:288-301. 2006.... - ABT-737 synergizes with bortezomib to induce apoptosis, mediated by Bid cleavage, Bax activation, and mitochondrial dysfunction in an Akt-dependent context in malignant human glioma cell linesDaniel R Premkumar
Department of Neurosurgery, Children s Hospital of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA 15224, USA
J Pharmacol Exp Ther 341:859-72. 2012.... - Autologous glioma cell vaccine admixed with interleukin-4 gene transfected fibroblasts in the treatment of patients with malignant gliomasHideho Okada
Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Transl Med 5:67. 2007..The prognosis for malignant gliomas remains dismal. We addressed the safety, feasibility and preliminary clinical activity of the vaccinations using autologous glioma cells and interleukin (IL)-4 gene transfected fibroblasts... - Co-administration of NVP-AEW541 and dasatinib induces mitochondrial-mediated apoptosis through Bax activation in malignant human glioma cell linesDaniel R Premkumar
Department of Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15201, USA
Int J Oncol 37:633-43. 2010.... - Glycolytic glioma cells with active glycogen synthase are sensitive to PTEN and inhibitors of PI3K and gluconeogenesisMarie E Beckner
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Lab Invest 85:1457-70. 2005..These findings confirm that glycolytic glioma cells can migrate invasively and that the loss of PTEN is supportive, with activated glycogenic potential included among the relevant downstream effects... - Expression of p53 and prognosis in children with malignant gliomasIan F Pollack
Department of Neurosurgery, University of Pittsburgh Medical Center and Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
N Engl J Med 346:420-7. 2002..We investigated whether mutations in the TP53 gene or the degree of expression of p53 protein in high-grade gliomas is associated with progression-free survival in children with these tumors... - Catalyst-dependent drug loading of LDI-glycerol polyurethane foams leads to differing controlled release profilesWesley N Sivak
Department of Bioengineering, School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA
Acta Biomater 4:1263-74. 2008..0x10(-8)). These results clearly demonstrate the long-term, catalyst-dependent release of DB-67 from LDI-glycerol polyurethane foams, indicating their potential for use in implantable drug-delivery devices... - Identification of chemosensitivity nodes for vinblastine through small interfering RNA high-throughput screensCarolyn A Kitchens
Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Pharmacol Exp Ther 339:851-8. 2011..These results illustrate the usefulness of unbiased siRNA screens as a method for identifying potential novel anticancer therapeutic combinations... - Enzastaurin induces H2AX phosphorylation to regulate apoptosis via MAPK signalling in malignant glioma cellsEsther P Jane
Department of Neurosurgery, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute Brain Tumor Center, Pittsburgh, PA 15213, USA
Eur J Cancer 46:412-9. 2010..These data call attention to a novel signalling pathway (MAPK/H2AX) to regulate apoptosis in malignant glioma cells... - A phase 1 study of vinblastine in combination with carboplatin for children with low-grade gliomas: a Children's Oncology Group phase 1 consortium studyRegina I Jakacki
Children s Hospital of Pittsburgh, Pittsburgh, PA 15224, USA
Neuro Oncol 13:910-5. 2011..The recommended phase 2 dose and schedule is carboplatin, 400 mg/m(2)/dose on day 1, and vinblastine, 4 mg/m(2)/dose, weekly × 3, repeated every 4 weeks. Further study of this regimen in patients with low-grade glioma is warranted... - A phase II study of gefitinib and irradiation in children with newly diagnosed brainstem gliomas: a report from the Pediatric Brain Tumor ConsortiumIan F Pollack
Department of Neurosurgery, Children s Hospital of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA 15224, USA
Neuro Oncol 13:290-7. 2011.... - Abrogation of mitogen-activated protein kinase and Akt signaling by vandetanib synergistically potentiates histone deacetylase inhibitor-induced apoptosis in human glioma cellsEsther P Jane
Department of Neurosurgery, University of Pittsburgh School of Medicine, Pennsylvania, USA
J Pharmacol Exp Ther 331:327-37. 2009.... - AG490 influences UCN-01-induced cytotoxicity in glioma cells in a p53-dependent fashion, correlating with effects on BAX cleavage and BAD phosphorylationEsther P Jane
Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Cancer Lett 257:36-46. 2007.... - Albumin marks pseudopodia of astrocytoma cells responding to hepatocyte growth factor or serumMarie E Beckner
Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
Lab Invest 86:1103-14. 2006..Thus, albumin potentially aids and marks invasion as it accumulates in these tumors... - Expression of a soluble transforming growth factor-beta (TGFbeta) receptor reduces tumorigenicity by regulating natural killer (NK) cell activity against 9L gliosarcoma in vivoTimothy F Witham
Brain Tumor Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213-1863, USA
J Neurooncol 64:63-9. 2003..Finally, we determined that elimination of CD161+ cells resulted in comparable growth of 9L-neo and 9L-TGFbeta sr in vivo, indicating that NK or NK-like cells were responsible for the anti-tumor effects in this model... - A phase I trial of temozolomide and lomustine in newly diagnosed high-grade gliomas of childhoodRegina I Jakacki
Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
Neuro Oncol 10:569-76. 2008..Radiographic changes following RT make determination of early tumor progression difficult. Metastatic disease is common prior to death... - The heat shock protein antagonist 17-AAG potentiates the activity of enzastaurin against malignant human glioma cellsEsther P Jane
Department of Neurosurgery, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute Brain Tumor Center, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
Cancer Lett 268:46-55. 2008.... - Expression of glioma-associated antigens in pediatric brain stem and non-brain stem gliomasHideho Okada
Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Neurooncol 88:245-50. 2008..These results suggest that EphA2, IL-13Ralpha2 and Survivin are suitable targets for developing vaccine strategies for pediatric glioma... - Stereotactic radiosurgery for pilocytic astrocytomas part 2: outcomes in pediatric patientsHideyuki Kano
Department of Neurological Surgery, University of Pittsburgh School of Medicine, Suite B 400, UPMC Presbyterian, 200 Lothrop Street, Pittsburgh, PA 15213, USA
J Neurooncol 95:219-29. 2009..Stereotactic radiosurgery for pediatric pilocytic astrocytomas should be considered when resection is not feasible, or if there is an early recurrence. The best response was observed in small volume residual solid tumors... - Cytokine gene therapy for malignant gliomaHideho Okada
University of Pittsburgh Medical Center Cancer Institute, Department of Neurological Surgery, Brain Tumor Program, G12 a Research Pavilion at the Hillman Cancer Center, 5117 Centre Ave, Pittsburgh, PA 15213 1863, USA
Expert Opin Biol Ther 4:1609-20. 2004..Successful immunogene therapy for brain tumours requires detailed understanding of cytokine functions and the use of them at the appropriate stages/sites of the immunological milieu... - Induction of CD8+ T-cell responses against novel glioma-associated antigen peptides and clinical activity by vaccinations with {alpha}-type 1 polarized dendritic cells and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose in Hideho Okada
G12 a Research Pavilion at the Hillman Cancer Center, 5117 Centre Ave, Pittsburgh, PA 15213 1863, USA
J Clin Oncol 29:330-6. 2011..GAAs for these peptides are EphA2, interleukin (IL)-13 receptor-α2, YKL-40, and gp100... - Molecular abnormalities and correlations with tumor response and outcome in glioma patientsIan F Pollack
Department of Neurosurgery, University of Pittsburgh Medical Center and the Children's Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
Neuroimaging Clin N Am 12:627-39. 2002.... - Bortezomib sensitizes malignant human glioma cells to TRAIL, mediated by inhibition of the NF-{kappa}B signaling pathwayEsther P Jane
Department of Neurosurgery, Children s Hospital of Pittsburgh, 3705 Fifth Ave, Pittsburgh, PA 15213, USA
Mol Cancer Ther 10:198-208. 2011.... - 7-Hydroxystaurosporine-induced apoptosis in 9L glioma cells provides an effective antigen source for dendritic cells and yields a potent vaccine strategy in an intracranial glioma modelTimothy F Witham
Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pennsylvania, USA
Neurosurgery 50:1327-34; discussion 1334-5. 2002.... - Pegylated interferon-α-2b for children with recurrent craniopharyngiomaJacky T Yeung
Department of Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
J Neurosurg Pediatr 10:498-503. 2012..Pegylaion of interferon-α-2b (PI) prolongs the half-life, allowing sustained exposure of the drug over time, and enhances efficacy. The authors report the results of the use of PI in 5 children with recurrent craniopharyngiomas... - Delivery of interferon-alpha transfected dendritic cells into central nervous system tumors enhances the antitumor efficacy of peripheral peptide-based vaccinesHideho Okada
Departments of Neurological Surgery, University of Pittsburgh School of Medicine, PA 15213, USA
Cancer Res 64:5830-8. 2004..On the basis of these results, we believe that local expression of IFN-alpha by DCs within the intracranial tumor site may enhance the clinical efficacy of peripheral vaccine approaches for brain tumors... - Molecularly targeted therapies for malignant glioma: rationale for combinatorial strategiesNikhil G Thaker
Doris Duke Clinical Research Fellow, Departments of Neurosurgery, Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA
Expert Rev Neurother 9:1815-36. 2009..This review summarizes the currently implemented single-agent and combination molecularly targeted therapies for MG... - Identification of a novel HLA-A*0201-restricted, cytotoxic T lymphocyte epitope in a human glioma-associated antigen, interleukin 13 receptor alpha2 chainFumiyoshi Okano
Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Clin Cancer Res 8:2851-5. 2002..Interleukin 13 receptor alpha2-chain (IL-13Ralpha2) has been reported to be abundantly and specifically overexpressed in glioblastoma multiforme. Here we report the identification of a CTL epitope derived from the IL-13Ralpha2... - Endoscopic port surgery for resection of lesions of the cerebellar peduncles: technical notePawel G Ochalski
Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Neurosurgery 68:1444-50; discussion 1450-1. 2011..Success has been achieved through multiple approaches, but complications can be severe... - Synergistic interaction between 17-AAG and phosphatidylinositol 3-kinase inhibition in human malignant glioma cellsDaniel R Premkumar
Department of Neurosurgery, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute Brain Tumor Center, Pittsburgh, Pennsylvania, USA
Mol Carcinog 45:47-59. 2006.... - A novel SNP analysis method to detect copy number alterations with an unbiased reference signal directly from tumor samplesAlex Lisovich
Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
BMC Med Genomics 4:14. 2011.... - Autologous glioma cell vaccine admixed with interleukin-4 gene transfected fibroblasts in the treatment of recurrent glioblastoma: preliminary observations in a patient with a favorable response to therapyHideho Okada
Department of Neurological Surgery, University of Pittsburgh School of Medicine, PA, USA
J Neurooncol 64:13-20. 2003..While it is premature to assess effectiveness of the vaccine, this initial patient's course suggested a transient response to the vaccine, and he survived 10 months after treatment... - Proteomic characterization of harvested pseudopodia with differential gel electrophoresis and specific antibodiesMarie E Beckner
Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
Lab Invest 85:316-27. 2005.... - Loss of heterozygosity reveals non-VHL allelic loss in hemangioblastomas at 22q13Marie E Beckner
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Hum Pathol 35:1105-11. 2004..LOH for the 22q13.2 region in HBs suggests that the loss of another tumor suppressor gene is involved in the pathogenesis of HBs in addition to VHL. Absence of LOH for glioma markers is consistent with the low-grade behavior of HBs... - Effect of trichostatin A, a histone deacetylase inhibitor, on glioma proliferation in vitro by inducing cell cycle arrest and apoptosisMatthew Wetzel
Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pennsylvania, USA
J Neurosurg 103:549-56. 2005..Because of the differential effects in glioma cells compared with nonneoplastic cells, TSA may provide a novel strategy for achieving tumor growth inhibition and cytotoxicity. Further investigation is warranted... - Designing, optimizing, and implementing high-throughput siRNA genomic screening with glioma cells for the discovery of survival genes and novel drug targetsNikhil G Thaker
Doris Duke Clinical Research Fellowship, University of Pittsburgh, Pittsburgh, PA 15260, United States Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15260, United States Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15224, United States Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15260, United States
J Neurosci Methods 185:204-12. 2010..Successful implementation and analysis of this siRNA screen validates our transfection optimization approach and provides guidance for the rapid development of high-throughput siRNA screens in human glioma cells... - Risk assignment in childhood brain tumors: the emerging role of molecular and biologic classificationIan F Pollack
Department of Neurosurgery, Childrens Hospital of Pittsburgh, Main Tower, Floor 3, Room 3705, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
Curr Oncol Rep 4:114-22. 2002..This paper summarizes these observations and discusses how they are being applied in a preliminary fashion as a foundation for risk-adapted stratification of childhood brain tumor therapy... - Cranial vault remodeling for sagittal craniosynostosis in older childrenS Alex Rottgers
Children s Hospital of Pittsburgh of UPMC, PA, USA
Neurosurg Focus 31:E3. 2011.... - Individualized treatment of pediatric craniopharyngiomasA Leland Albright
Department of Neurosurgery, Childrens Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
Childs Nerv Syst 21:649-54. 2005..We performed this study to correlate the clinical and radiographic features at the time of presentation with the multimodality treatments the children received... - Fractures of the clivus and traumatic diastasis of the central skull base in the pediatric populationPawel G Ochalski
Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
J Neurosurg Pediatr 7:261-7. 2011..The incidence, outcome, and biomechanics associated with these fractures have been difficult to ascertain secondary to the lack of literature pertaining to their occurrence... - Fully endoscopic expanded endonasal approach treating skull base lesions in pediatric patientsAmin Kassam
Minimally Invasive endoNeurosurgery Center, University of Pittsburgh School of Medicine, Pennsylvania, USA
J Neurosurg 106:75-86. 2007.... - Parasagittal suture after strip craniectomyChristopher R Kinsella
Divisions of Pediatric Plastic Surgery, Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Craniofac Surg 22:66-7. 2011.... - Extraventricular neurocytoma in neurofibromatosis Type 1: case reportAli I Raja
Department of Neurosurgery, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
J Neurosurg Pediatr 2:63-7. 2008..The importance of obtaining a biopsy in lesions that have atypical imaging features is highlighted... - LDI-glycerol polyurethane implants exhibit controlled release of DB-67 and anti-tumor activity in vitro against malignant gliomasWesley N Sivak
Department of Bioengineering, School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA
Acta Biomater 4:852-62. 2008..These results clearly demonstrate the long-term, slow release of DB-67 from LDI-glycerol polyurethane discs and their potential for postoperative intracranial chemotherapy of cancers... - Expanded endoscopic endonasal resection of an olfactory schwannomaHilal A Kanaan
Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Neurosurg Pediatr 2:261-5. 2008.... - Glioma-associated hyaluronan induces apoptosis in dendritic cells via inducible nitric oxide synthase: implications for the use of dendritic cells for therapy of gliomasTianbing Yang
Brain Tumor Center, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Cancer Res 62:2583-91. 2002..These data indicate that HA expressed by gliomas may contribute to their immunosuppressive effects by promoting apoptosis among professional antigen-presenting cells such as DCs via iNOS induction after CD44-HA interactions... - DNA topoisomerase IIalpha predicts progression-free and overall survival in pediatric malignant non-brainstem gliomasMarkus Bredel
Department of General Neurosurgery, Neurocenter, University of Freiburg, Freiburg, Germany
Int J Cancer 99:817-20. 2002.... - Preradiation chemotherapy in primary high-risk brainstem tumors: phase II study CCG-9941 of the Children's Cancer GroupMark T Jennings
Vanderbilt Cancer Center, Nashville, TN, USA
J Clin Oncol 20:3431-7. 2002..This Children's Cancer Group group-wide phase II trial evaluated the efficacy and toxicity of two chemotherapy arms administered before hyperfractionated external-beam radiotherapy (HFEBRT)... - Phase I and pharmacokinetic study of the oral farnesyltransferase inhibitor lonafarnib administered twice daily to pediatric patients with advanced central nervous system tumors using a modified continuous reassessment method: a Pediatric Brain Tumor ConsMark W Kieran
Dana Farber Cancer Institute and Children s Hospital Boston, Boston, MA 02115, USA
J Clin Oncol 25:3137-43. 2007..Primary objectives were to estimate the maximum-tolerated dose (MTD) and to describe the dose-limiting toxicities (DLTs) and pharmacokinetics of lonafarnib. Farnesylation inhibition of HDJ-2 in peripheral blood was also measured... - Phase II evaluation of temozolomide and 13-cis-retinoic acid for the treatment of recurrent and progressive malignant glioma: a North American Brain Tumor Consortium studyKurt A Jaeckle
University of Texas M D Anderson Cancer Center, Houston, USA
J Clin Oncol 21:2305-11. 2003..This phase II trial evaluated efficacy and toxicity of combination temozolomide and cRA treatment in recurrent MG... - Outcome of children with centrally reviewed low-grade gliomas treated with chemotherapy with or without radiotherapy on Children's Cancer Group high-grade glioma study CCG-945Maryam Fouladi
Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
Cancer 98:1243-52. 2003.... - Progression-associated genes in astrocytoma identified by novel microarray gene expression data reanalysisTobey J Macdonald
Center for Cancer and Immunology Research, Children s Research Institute, Department of Hematology Oncology, Children s National Medical Center, Washington, DC, USA
Methods Mol Biol 377:203-22. 2007..Further investigation is needed to evaluate the role of APOD, as well as the other genes identified, in malignant astrocytoma development... - A phase II study of the farnesyl transferase inhibitor, tipifarnib, in children with recurrent or progressive high-grade glioma, medulloblastoma/primitive neuroectodermal tumor, or brainstem glioma: a Children's Oncology Group studyMaryam Fouladi
Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
Cancer 110:2535-41. 2007.... - DNA topoisomerase IIalpha and Her-2/neu gene dosages in pediatric malignant gliomasClaudia Bredel
Department of General Neurosurgery, Neurocenter, University of Freiburg, D 79106 Freiburg, Germany
Int J Oncol 26:1187-92. 2005..The observed intratumor genetic heterogeneity for TIIalpha in PMNBGs may have an impact on the relevance of TIIalpha as a biological constituent of outcome in these neoplasms... - Phase I clinical trial of mafosfamide in infants and children aged 3 years or younger with newly diagnosed embryonal tumors: a pediatric brain tumor consortium study (PBTC-001)Susan M Blaney
Texas Children s Cancer Center, 6621 Fannin, CC 1410 00, Houston, TX 77030, USA
J Clin Oncol 23:525-31. 2005.... - Phase I trial of VNP40101M (Cloretazine) in children with recurrent brain tumors: a pediatric brain tumor consortium studySridharan Gururangan
The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA
Clin Cancer Res 14:1124-30. 2008..VNP40101M (Cloretazine), a novel DNA alkylating agent, was evaluated in a phase I study in children with recurrent brain tumors... - Metastatic ependymoma: a multi-institutional retrospective analysis of prognostic factorsStergios Zacharoulis
Department of Pediatrics, The Royal Marsden Hospital, Sutton, Surrey, UK
Pediatr Blood Cancer 50:231-5. 2008..Metastatic ependymoma is exceedingly rare at diagnosis with variable prognosis reported in the literature. The purpose of this study was to identify prognostic factors in children with metastatic ependymoma... - Motexafin gadolinium and involved field radiation therapy for intrinsic pontine glioma of childhood: a Children's Oncology Group phase I studyKristin A Bradley
University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
Neuro Oncol 10:752-8. 2008..The maximum tolerated dose of MGd and the recommended phase II dose was 4.4 mg/kg when administered as a daily intravenous bolus in conjunction with 6 weeks of involved field radiation therapy for pediatric intrinsic pontine gliomas... - Molecular analysis of pediatric brain tumorsJaclyn A Biegel
Division of Human Genetics, Department of Pediatrics, University of Pennsylvania School of Medicine, The Children s Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA
Curr Oncol Rep 6:445-52. 2004..Advances in this area will depend on the ability to identify new disease genes, validate prognostic markers, and develop biologically based therapeutic strategies to tailor treatment... - Dose intensive melphalan and cyclophosphamide with autologous hematopoietic stem cells for recurrent medulloblastoma or germinomaRichard P Kadota
Rady Children s Hospital, San Diego, California, USA
Pediatr Blood Cancer 51:675-8. 2008..To determine the response, toxicity, and survival for children with progressive or recurrent medulloblastoma and germinoma using a single myeloablative course of chemotherapy supported by autologous hematopoietic stem cells... - ERBB1 is amplified and overexpressed in high-grade diffusely infiltrative pediatric brain stem gliomaRichard J Gilbertson
Brain Tumor Program, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Clin Cancer Res 9:3620-4. 2003.... - Anaplastic mixed gliomas and anaplastic oligodendroglioma in children: results from the CCG 945 experienceDouglas J Hyder
Department of Pediatrics, Children s Hospital at Dartmouth, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
J Neurooncol 83:1-8. 2007..To review interpathologist diagnosis variability and survival of children treated for either anaplastic mixed glioma (AMG) or anaplastic oligodendroglioma (AO) with surgery, irradiation and chemotherapy... - Effective induction of antiglioma cytotoxic T cells by coadministration of interferon-beta gene vector and dendritic cellsNorimoto Nakahara
Department of Bio-Medicine, Nagoya University School of Medicine, Nagoya, Japan
Cancer Gene Ther 10:549-58. 2003..Suppression of the tumor growth by this combinational therapy was superior to treatment with DC or IFN-beta gene solely. This combination may constitute a new therapeutic strategy to induce potent antiglioma immune responses... - Pathologist interobserver variability of histologic features in childhood brain tumors: results from the CCG-945 studyFloyd H Gilles
Neuropathology, Childrens Hospital, Los Angeles, CA 90027, USA
Pediatr Dev Pathol 11:108-17. 2008..Agreement and strict adherence to improved nonsubjective diagnostic criteria would improve histologic feature reliability and, consequently, their usefulness in studies... - Parental heat exposure and risk of childhood brain tumor: a Children's Oncology Group studyGreta R Bunin
Division of Oncology, Children s Hospital of Philadelphia, PA 19104, USA
Am J Epidemiol 164:222-31. 2006..4, 95% CI: 1.2, 9.7, and odds ratio = 2.1, 95% CI: 1.1, 4.3, respectively). This new observation regarding paternal exposure to heat just prior to the index pregnancy deserves consideration in future animal and human studies of MB/PNET...