Roger Packer

Summary

Affiliation: Children's National Medical Center
Country: USA

Publications

  1. ncbi request reprint Treatment of children with medulloblastomas with reduced-dose craniospinal radiation therapy and adjuvant chemotherapy: A Children's Cancer Group Study
    R J Packer
    Departments of Neurology and Radiology, Children s National Medical Center, Washington, DC, USA
    J Clin Oncol 17:2127-36. 1999
  2. ncbi request reprint Germinoma: unusual imaging and pathological characteristics. Report of two cases
    Elisabeth J Rushing
    Department of Neuropathology and Ophthalmic Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    J Neurosurg 104:143-8. 2006
  3. doi request reprint Medulloblastoma and primitive neuroectodermal tumors
    Roger J Packer
    The George Washington University, Washington, DC, USA
    Handb Clin Neurol 105:529-48. 2012
  4. ncbi request reprint Therapy for plexiform neurofibromas in children with neurofibromatosis 1: an overview
    Roger J Packer
    Department of Neurology and Pediatrics, Center for Neuroscience and Behavioral Medicine, Children s National Medical Center, The George Washington University, Washington, DC 20010, USA
    J Child Neurol 17:638-41; discussion 646-51. 2002
  5. ncbi request reprint Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma
    Roger J Packer
    Division of Neurology, Children s National Medical Center, Washington, DC 20010, USA
    J Clin Oncol 24:4202-8. 2006
  6. ncbi request reprint Gene expression profiling to analyze embryonal tumors of the central nervous system
    Roger J Packer
    Department of Neurology, Children s National Medical Center, Washington, DC 20010, USA
    Curr Neurol Neurosci Rep 3:117-9. 2003
  7. ncbi request reprint Medulloblastoma: present concepts of stratification into risk groups
    Roger J Packer
    Department of Neurology, Center for Neuroscience and Behavioral Medicine, Children s National Medical Center, Washington, DC 20010, USA
    Pediatr Neurosurg 39:60-7. 2003
  8. ncbi request reprint A Phase I study of concurrent RMP-7 and carboplatin with radiation therapy for children with newly diagnosed brainstem gliomas
    Roger J Packer
    Center for Neuroscience and Behavioral Medicine, Division of Neurology, Children s National Medical Center, Washington, DC 20010, USA
    Cancer 104:1968-74. 2005
  9. ncbi request reprint Long-term neurologic and neurosensory sequelae in adult survivors of a childhood brain tumor: childhood cancer survivor study
    Roger J Packer
    Department of Neurology, Center for Neuroscience and Behavioral Medicine, Children s National Medical Center, Washington, DC, USA
    J Clin Oncol 21:3255-61. 2003
  10. ncbi request reprint Proceedings of the conference on the effects of radiotherapy on the brain and on behavior through the life span
    Roger J Packer
    Center for Neuroscience and Behavioral Medicine, Department of Neurology, Children s National Medical Center, Washington, DC 20010 2916, USA
    Med Pediatr Oncol 41:448-9. 2003

Research Grants

  1. CHILDRENS NATIONAL MEDICAL CENTER
    Roger Packer; Fiscal Year: 2003
  2. Pirfenidone in Children with PNs in NF1
    Roger Packer; Fiscal Year: 2006
  3. Neurological Sciences Academic Development at CNMC
    Roger Packer; Fiscal Year: 2007

Detail Information

Publications67

  1. ncbi request reprint Treatment of children with medulloblastomas with reduced-dose craniospinal radiation therapy and adjuvant chemotherapy: A Children's Cancer Group Study
    R J Packer
    Departments of Neurology and Radiology, Children s National Medical Center, Washington, DC, USA
    J Clin Oncol 17:2127-36. 1999
    ..This study was undertaken to determine the feasibility and efficacy of treating children with nondisseminated medulloblastoma with reduced-dose craniospinal radiotherapy plus adjuvant chemotherapy...
  2. ncbi request reprint Germinoma: unusual imaging and pathological characteristics. Report of two cases
    Elisabeth J Rushing
    Department of Neuropathology and Ophthalmic Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    J Neurosurg 104:143-8. 2006
    ..The diagnosis of diffuse germinoma was confirmed, and the patient was treated with adjunctive chemotherapy. Although uncommon, germ cell tumors can present outside the midline and exhibit a multifocal growth pattern...
  3. doi request reprint Medulloblastoma and primitive neuroectodermal tumors
    Roger J Packer
    The George Washington University, Washington, DC, USA
    Handb Clin Neurol 105:529-48. 2012
    ..For further improvements,the recent impressive discoveries concerning molecular mechanisms of embryonal tumor origin, development,and growth will need to be translated into molecularly based, risk-adapted therapy...
  4. ncbi request reprint Therapy for plexiform neurofibromas in children with neurofibromatosis 1: an overview
    Roger J Packer
    Department of Neurology and Pediatrics, Center for Neuroscience and Behavioral Medicine, Children s National Medical Center, The George Washington University, Washington, DC 20010, USA
    J Child Neurol 17:638-41; discussion 646-51. 2002
    ..The use of innovative neuroimaging techniques and other outcome measures may greatly improve the design of trials and evaluation of potential effective agents...
  5. ncbi request reprint Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma
    Roger J Packer
    Division of Neurology, Children s National Medical Center, Washington, DC 20010, USA
    J Clin Oncol 24:4202-8. 2006
    ..To determine the event-free survival (EFS) and overall survival of children with average-risk medulloblastoma and treated with reduced-dose craniospinal radiotherapy (CSRT) and one of two postradiotherapy chemotherapies...
  6. ncbi request reprint Gene expression profiling to analyze embryonal tumors of the central nervous system
    Roger J Packer
    Department of Neurology, Children s National Medical Center, Washington, DC 20010, USA
    Curr Neurol Neurosci Rep 3:117-9. 2003
  7. ncbi request reprint Medulloblastoma: present concepts of stratification into risk groups
    Roger J Packer
    Department of Neurology, Center for Neuroscience and Behavioral Medicine, Children s National Medical Center, Washington, DC 20010, USA
    Pediatr Neurosurg 39:60-7. 2003
    ..Biologic markers, especially molecular genetic findings, have not yet been incorporated into risk classifications, but will likely add to the understanding of medulloblastoma and may significantly alter concepts of staging and treatment...
  8. ncbi request reprint A Phase I study of concurrent RMP-7 and carboplatin with radiation therapy for children with newly diagnosed brainstem gliomas
    Roger J Packer
    Center for Neuroscience and Behavioral Medicine, Division of Neurology, Children s National Medical Center, Washington, DC 20010, USA
    Cancer 104:1968-74. 2005
    ..The objective of this Phase I study was to determine the toxicity and feasibility of delivering RMP-7 and carboplatin for 5 successive days during radiotherapy to children with newly diagnosed, diffuse, intrinsic brainstem gliomas...
  9. ncbi request reprint Long-term neurologic and neurosensory sequelae in adult survivors of a childhood brain tumor: childhood cancer survivor study
    Roger J Packer
    Department of Neurology, Center for Neuroscience and Behavioral Medicine, Children s National Medical Center, Washington, DC, USA
    J Clin Oncol 21:3255-61. 2003
    ..To describe the neurologic and neurosensory deficits in children with brain tumors (BTs), compare incidence of these deficits with that of a sibling control group, and evaluate the factors associated with the development of these deficits...
  10. ncbi request reprint Proceedings of the conference on the effects of radiotherapy on the brain and on behavior through the life span
    Roger J Packer
    Center for Neuroscience and Behavioral Medicine, Department of Neurology, Children s National Medical Center, Washington, DC 20010 2916, USA
    Med Pediatr Oncol 41:448-9. 2003
  11. ncbi request reprint Phase 1 study of concurrent RMP-7 and carboplatin with radiotherapy for children with newly diagnosed brainstem gliomas
    Roger J Packer
    Division of Neurology, Children s National Medical Center, Washington, DC 20010, USA
    Cancer 104:1281-7. 2005
    ..The goal of the current Phase I study was to determine the toxicity and feasibility of delivering RMP-7 and carboplatin for 5 successive days during radiotherapy...
  12. ncbi request reprint New insights into childhood ependymomas
    Roger J Packer
    Division of Neurology, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Curr Neurol Neurosci Rep 5:107-9. 2005
    ..Relapse-free survival rates vary significantly in contemporary series, and therapeutic approaches remain unsettled...
  13. doi request reprint Objective response of multiply recurrent low-grade gliomas to bevacizumab and irinotecan
    Roger J Packer
    Division of Neurology, Children s National Medical Center, Washington, District of Columbia 20010, USA
    Pediatr Blood Cancer 52:791-5. 2009
    ..Bevacizumab, a humanized immunoglobulin, monoclonal antibody that inhibits the activity of vascular endothelial growth factor and irinotecan have been used with some success in adults with malignant gliomas...
  14. doi request reprint Central nervous system tumors
    Roger J Packer
    Center for Neuroscience and Behavioral Medicine, Children s National Medical Center, Washington, DC 20010, USA
    Pediatr Clin North Am 55:121-45, xi. 2008
    ..Symptoms and signs depend on the growth rate of the tumor, its location in the central nervous system (CNS), and the age of the child. This article describes the presentation, diagnosis and management of these tumors...
  15. ncbi request reprint Alternative treatments for childhood brain tumors
    R J Packer
    Department of Neurology, Children s National Medical Center, 111 Michigan Avenue N W, Washington, DC 20010, USA
    Childs Nerv Syst 15:789-94. 1999
    ..Such innovative treatments will be more widely employed in the years ahead and may improve outcome for children with brain tumors...
  16. ncbi request reprint Treatment of progressive or recurrent pediatric malignant supratentorial brain tumors with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administration
    R J Packer
    Department of Neurology, Children s National Medical Center, Washington, DC 20010, USA
    J Neurosurg 92:249-54. 2000
    ..The goal of this Phase I study was to evaluate the safety of in vivo suicide gene therapy in 12 children with recurrent, malignant, supratentorial brain tumors...
  17. ncbi request reprint Intracranial germ cell tumors
    R J Packer
    Department of Neurology, Children s National Medical Center Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Oncologist 5:312-20. 2000
    ..Radiation therapy alone will result in disease control in 40%-60% of patients. The addition of chemotherapy to radiation therapy may improve the rate of survival...
  18. ncbi request reprint Chemotherapy: low-grade gliomas of the hypothalamus and thalamus
    R J Packer
    Center for Neuroscience and Behavioral Medicine, Department of Neurology, Children s National Medical Center, Washington, DC, USA
    Pediatr Neurosurg 32:259-63. 2000
    ..The erratic natural history of diencephalic tumors confounds evaluation of efficacy of the regimen chosen...
  19. doi request reprint Center for Neuroscience and Behavioral Medicine: an innovative administrative structure and possible paradigm for the future
    Roger J Packer
    Center for Neuroscience and Behavioral Medicine, Children s National Medical Center, Washington, DC 20010, USA
    Pediatr Neurol 44:1-9. 2011
    ..The strengths, limitations, and challenges of this structure in terms of child neurology are reviewed. This administrative structure has been successful and may act as a model for other programs...
  20. doi request reprint Management of and prognosis with medulloblastoma: therapy at a crossroads
    Roger J Packer
    Division of Neurology, Children s National Medical Center, Washington, DC 20010, USA
    Arch Neurol 65:1419-24. 2008
    ..However, these biological advances have yet to be integrated into the treatment of medulloblastoma in children or adults...
  21. ncbi request reprint Plexiform neurofibromas in NF1: toward biologic-based therapy
    R J Packer
    Department of Neurology, Children s National Medical Center, George Washington University, Washington, DC 20010, USA
    Neurology 58:1461-70. 2002
    ..The ability to design more rational therapies for NF1-associated neurofibromas is heavily predicated on an improved understanding of the molecular and cellular biology of the cells involved in neurofibroma formation and growth...
  22. pmc Childhood brain tumors: accomplishments and ongoing challenges
    Roger J Packer
    Division of Child Neurology, Center of Excellence for Neuroscience and Behavioral Medicine, Children s National Medical Center, Washington, DC 20010, USA
    J Child Neurol 23:1122-7. 2008
    ..Because of advances in our understanding of the biology underlying childhood brain tumors, treatments may change dramatically in the years ahead. Accordingly, survival rates may improve and long-term sequelae lessen...
  23. ncbi request reprint Atypical teratoid/rhabdoid tumor of the central nervous system: report on workshop
    Roger J Packer
    Department of Neurology, Children s National Medical Center, The George Washington University Medical Center, Washington, DC 20010, USA
    J Pediatr Hematol Oncol 24:337-42. 2002
    ..Therapeutic approached have included surgery, chemotherapy, and radiotherapy. Prospective clinical trials are needed for children with AT/RTs...
  24. ncbi request reprint Progress and challenges in childhood brain tumors
    Roger J Packer
    Center for Neuroscience and Behavioral Medicine, USA
    J Neurooncol 75:239-42. 2005
    ....
  25. ncbi request reprint Feasibility of metronomic maintenance chemotherapy following high-dose chemotherapy for malignant central nervous system tumors
    L Mi Rim Choi
    Division of Hematology and Oncology, Children s National Medical Center, Washington, District of Columbia, USA
    Pediatr Blood Cancer 50:970-5. 2008
    ..Metronomic chemotherapy has also been reported as a potential new treatment strategy in solid tumors, particularly in adults...
  26. ncbi request reprint Outcome for children <4 years of age with malignant central nervous system tumors treated with high-dose chemotherapy and autologous stem cell rescue
    Halldora K Thorarinsdottir
    Division of Hematology and Oncology, Children s National Medical Center, Washington, District of Columbia, USA
    Pediatr Blood Cancer 48:278-84. 2007
    ....
  27. ncbi request reprint Phase II study of high-dose chemotherapy before radiation in children with newly diagnosed high-grade astrocytoma: final analysis of Children's Cancer Group Study 9933
    Tobey J Macdonald
    Department of Hematology Oncology, Children s National Medical Center, Washington, DC 20010, USA
    Cancer 104:2862-71. 2005
    ..High-grade astrocytomas (HGA) carry a dismal prognosis and compose nearly 20% of all childhood brain tumors. The role of high-dose chemotherapy (HDCT) in the treatment of HGA remains unclear...
  28. pmc Proteomic profiling of cerebrospinal fluid identifies prostaglandin D2 synthase as a putative biomarker for pediatric medulloblastoma: A pediatric brain tumor consortium study
    Meena U Rajagopal
    Center for Genetic Medicine, Children s National Medical Center, Washington, DC, USA
    Proteomics 11:935-43. 2011
    ..In addition, our results demonstrate the feasibility of performing proteomic studies on CSF samples collected from patients at multiple institutions within the consortium setting...
  29. ncbi request reprint Advances in the diagnosis, molecular genetics, and treatment of pediatric embryonal CNS tumors
    Tobey J Macdonald
    Departments of Hematology Oncology, Children s Hospital National Medical Center, Washington, DC 20010, USA
    Oncologist 8:174-86. 2003
    ..In this review, recent advances in the diagnosis, molecular genetics, and treatment of the most common pediatric embryonal CNS tumors are discussed...
  30. ncbi request reprint Neurocognitive dysfunction in children with neurofibromatosis type 1
    Tena L Rosser
    Department of Neurology, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Curr Neurol Neurosci Rep 3:129-36. 2003
    ..The development of NF1 animal models with learning and memory difficulties similar to those seen in humans demonstrates promising preliminary evidence that medical treatment of cognitive abnormalities may one day be possible...
  31. ncbi request reprint Neurotoxicity of chemotherapeutic and biologic agents in children with cancer
    Kevin C De Braganca
    Division of Neurology, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Curr Neurol Neurosci Rep 8:114-22. 2008
    ..The earlier recognition of these neurotoxicities could possibly alter the course of a treatment or facilitate interventions to improve quality of life...
  32. ncbi request reprint Medulloblastoma in childhood: new biological advances
    John R Crawford
    Center for Neuroscience and Behavioral Medicine, Children s National Medical Center, Washington DC 20010, USA
    Lancet Neurol 6:1073-85. 2007
    ..Greater understanding of the molecular biology of medulloblastoma is needed so that more children can be cured or have an improved quality of life...
  33. ncbi request reprint Cerebrovascular abnormalities in a population of children with neurofibromatosis type 1
    Tena L Rosser
    Department of Neurology, Center for Neuroscience and Behavioral Medicine, Children s National Medical Center, The George Washington University, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Neurology 64:553-5. 2005
    ..Of 316 patients with NF1 who underwent brain MRI, 8 (2.5%) children were reported to have an abnormality of the cerebrovascular system, including narrowed or ectatic vessels, vascular stenoses, aneurysm, and moyamoya...
  34. ncbi request reprint Current treatment of medulloblastoma: recent advances and future challenges
    Brian R Rood
    Division of Hematology Oncology, Center for Cancer Research, Children s National Medical Center, Washington, DC 20010, USA
    Semin Oncol 31:666-75. 2004
    ..Treatment for this disease has evolved a great deal over the preceding decades, but a great deal of work remains to be done to effect reliable cures while reducing long-term sequelae of therapy...
  35. doi request reprint Isolated extracranial recurrence of anaplastic ependymoma
    Mwe Mwe Chao
    Children s National Medical Center, Division of Pediatric Oncology, Washington, District of Columbia 20010, USA
    Pediatr Blood Cancer 56:317-8. 2011
    ..The location of tumor recurrence proximate to the surgical site suggested surgical seeding. This case demonstrates an unusual site of recurrence of anaplastic ependymoma and highlights a previously underappreciated surgical complication...
  36. doi request reprint The cerebellar mutism syndrome and its relation to cerebellar cognitive function and the cerebellar cognitive affective disorder
    Elizabeth M Wells
    Division of Neurology, Brain Tumor Institute, Children s National Medical Center, The George Washington University School of Medicine and Health Sciences, Washington DC 20010, USA
    Dev Disabil Res Rev 14:221-8. 2008
    ..Future directions include more thorough neuropsychological characterization, functional and diffusion tensor imaging studies, and investigations into the underlying differences that may make some patients more vulnerable to CMS...
  37. ncbi request reprint Intracranial neoplasms in children with neurofibromatosis 1
    Tena Rosser
    Department of Neurology and Pediatrics, Center for Neuroscience and Behavioral Medicine, Children s National Medical Center, The George Washington University, Washington, DC 20010, USA
    J Child Neurol 17:630-7; discussion 646-51. 2002
    ....
  38. ncbi request reprint The use of gene expression analysis to gain insights into signaling mechanisms of metastatic medulloblastoma
    Arun Chopra
    Department of Pediatrics, Children s National Medical Center, Washington, DC 20010, USA
    Pediatr Neurosurg 39:68-74. 2003
    ..We conclude that these genes may interact to promote prometastatic signaling in medulloblastoma...
  39. pmc Secretome Survey of Human Plexiform Neurofibroma Derived Schwann Cells Reveals a Secreted form of the RARRES1 Protein
    Hui Ling Chen
    Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA E Mails H L C H S K J B H G D A H V G R P
    Int J Mol Sci 13:9380-99. 2012
    ..This study shows altered secretion of key proteins in NF1 derived Schwann cells. The potential implication of these proteins in neurofibroma biology is discussed...
  40. ncbi request reprint Central nervous system meningiomas in the first two decades of life: a clinicopathological analysis of 87 patients
    Elisabeth J Rushing
    Department of Neuropathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    J Neurosurg 103:489-95. 2005
    ..The authors of this study sought to add to the limited available information regarding clinicopathological factors that influence outcome, disease progression, and survival in children with meningiomas...
  41. doi request reprint Central nervous system tumors
    Roger J Packer
    Center for Neuroscience and Behavioral Medicine, Children s National Medical Center, 111 Michigan Avenue, Washington, DC 20010, USA
    Hematol Oncol Clin North Am 24:87-108. 2010
    ..Symptoms and signs depend on the growth rate of the tumor, its location in the central nervous system (CNS), and the age of the child. This article describes the presentation, diagnosis, and management of these tumors...
  42. pmc Primary spinal cord tumors of childhood: effects of clinical presentation, radiographic features, and pathology on survival
    John R Crawford
    Department of Neurology, Children s National Medical Center, The George Washington University, Washington, DC, USA
    J Neurooncol 95:259-69. 2009
    ..While tumor grade and gross total resection rather than duration of symptoms correlated with survival in our series, greater than one-third of patients had reported symptoms greater than 6 months duration prior to diagnosis...
  43. ncbi request reprint Neurofibromas in children with neurofibromatosis 1
    Tena Rosser
    Department of Neurology and Pediatrics, Center for Neuroscience and Behavioral Medicine, Children s National Medical Center, The George Washington University, Washington, DC 20010, USA
    J Child Neurol 17:585-91; discussion 602-4, 646-51. 2002
    ..The purpose of this review is to summarize the defining characteristics, incidence, clinical course, management options, and outcome of neurofibromas in children with neurofibromatosis 1...
  44. doi request reprint Postoperative cerebellar mutism syndrome following treatment of medulloblastoma: neuroradiographic features and origin
    Elizabeth M Wells
    Division of Neurology, Children s National Medical Center, Washington, DC 20010, USA
    J Neurosurg Pediatr 5:329-34. 2010
    ..The current study was undertaken to determine factors associated with development of CMS, a means to determine its severity or cause, and outcomes of patients with this syndrome...
  45. ncbi request reprint The role of INI1 and the SWI/SNF complex in the development of rhabdoid tumors: meeting summary from the workshop on childhood atypical teratoid/rhabdoid tumors
    Jaclyn A Biegel
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 62:323-8. 2002
    ..Drs. Malcolm Smith, Jaclyn Biegel, and Roger Packer hosted the meeting. There were 22 participants from 14 institutions...
  46. ncbi request reprint Radiation-induced neurocognitive decline: the risks and benefits of reducing the amount of whole-brain irradiation
    Roger J Packer
    Curr Neurol Neurosci Rep 2:131-3. 2002
  47. ncbi request reprint Study design and cohort characteristics of the Childhood Cancer Survivor Study: a multi-institutional collaborative project
    Leslie L Robison
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota
    Med Pediatr Oncol 38:229-39. 2002
    ..To facilitate such research, a multi-institutional consortium established the Childhood Cancer Survivor Study (CCSS), a large, diverse, and well-characterized cohort of 5-year survivors of childhood and adolescent cancer...
  48. ncbi request reprint Neurocognitive deficits in children with neurofibromatosis type 1
    Roger J Packer
    Curr Neurol Neurosci Rep 6:119-20. 2006
  49. ncbi request reprint Long-term outcomes of adult survivors of childhood cancer
    Leslie L Robison
    Department of Pediatrics, University of Minnesota Medical School and Cancer Center, Minneapolis, USA
    Cancer 104:2557-64. 2005
    ..The ongoing evaluation of large and diverse cohorts of cancer survivors will aid in further identifying individuals who should be the target of innovative intervention strategies...
  50. ncbi request reprint Neurocognitive sequelae of cancer treatment
    Roger J Packer
    Neurology 59:8-10. 2002
  51. ncbi request reprint Phase I and pharmacokinetic study of the oral farnesyltransferase inhibitor lonafarnib administered twice daily to pediatric patients with advanced central nervous system tumors using a modified continuous reassessment method: a Pediatric Brain Tumor Cons
    Mark W Kieran
    Dana Farber Cancer Institute and Children s Hospital Boston, Boston, MA 02115, USA
    J Clin Oncol 25:3137-43. 2007
    ..Primary objectives were to estimate the maximum-tolerated dose (MTD) and to describe the dose-limiting toxicities (DLTs) and pharmacokinetics of lonafarnib. Farnesylation inhibition of HDJ-2 in peripheral blood was also measured...
  52. ncbi request reprint Preradiation chemotherapy versus radiotherapy alone for nonmetastatic medulloblastoma
    Roger J Packer
    Curr Neurol Neurosci Rep 4:127-8. 2004
  53. ncbi request reprint Current approaches to CNS tumors in infants and very young children
    Katherine E Warren
    Neuro Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Expert Rev Neurother 4:681-90. 2004
    ..Achieving successful tumor control while optimizing quality of life for survivors is the major goal of recent research...
  54. ncbi request reprint Stroke as a late treatment effect of Hodgkin's Disease: a report from the Childhood Cancer Survivor Study
    Daniel C Bowers
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9063, USA
    J Clin Oncol 23:6508-15. 2005
    ..The objectives of this report are to examine the incidence of and risk factors for stroke among childhood Hodgkin's disease (HD) survivors...
  55. ncbi request reprint Phase I study of O6-benzylguanine and temozolomide administered daily for 5 days to pediatric patients with solid tumors
    Katherine E Warren
    National Cancer Institute Neuro Oncology Branch, Building 82, Room 219, 9030 Old Georgetown Rd, Bethesda, MD 20892 8200, USA
    J Clin Oncol 23:7646-53. 2005
    ....
  56. ncbi request reprint Phase I trial of single-dose temozolomide and continuous administration of o6-benzylguanine in children with brain tumors: a pediatric brain tumor consortium report
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Clin Cancer Res 13:6712-8. 2007
    ..To estimate the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of escalating doses of temozolomide combined with O(6)-benzylguanine in patients < or =21 years with recurrent brain tumors...
  57. ncbi request reprint Endocrine and cardiovascular late effects among adult survivors of childhood brain tumors: Childhood Cancer Survivor Study
    James G Gurney
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
    Cancer 97:663-73. 2003
    ....
  58. ncbi request reprint Phase II study of thalidomide and radiation in children with newly diagnosed brain stem gliomas and glioblastoma multiforme
    Christopher D Turner
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Neurooncol 82:95-101. 2007
    ..In this small patient sample adding thalidomide to radiation did not improve TTP or TTD from historical controls, however, toxicity appeared to be increased...
  59. ncbi request reprint New primary neoplasms of the central nervous system in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study
    Joseph P Neglia
    Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, MN, USA
    J Natl Cancer Inst 98:1528-37. 2006
    ..However, the details of the dose-response relationships, the expression of excess risk over time, and the modifying effects of other host and treatment factors have not been well defined...
  60. ncbi request reprint Late-occurring stroke among long-term survivors of childhood leukemia and brain tumors: a report from the Childhood Cancer Survivor Study
    Daniel C Bowers
    Department of Pediatrics, The University of Texas Southwestern Medical School, Dallas, TX 75390 9063, USA
    J Clin Oncol 24:5277-82. 2006
    ..This report examines the incidence of and risk factors for strokes that occur in > or = 5-year survivors of childhood leukemia and brain tumors...
  61. ncbi request reprint Progress in the treatment of childhood brain tumors: no room for complacency
    Jonathan L Finlay
    Department of Hematology Oncology, Children s Hospital, Los Angeles, California 90027, USA
    Pediatr Hematol Oncol 24:79-84. 2007
  62. ncbi request reprint Incidence and severity of postoperative cerebellar mutism syndrome in children with medulloblastoma: a prospective study by the Children's Oncology Group
    Patricia L Robertson
    Department of Pediatrics, University of Michigan Health System, Ann Arbor, Michigan 48109 0203, USA
    J Neurosurg 105:444-51. 2006
    ..Most descriptions have been limited to small institutional series using a retrospective chart review methodology...
  63. ncbi request reprint Phase I trial of pirfenidone in children with neurofibromatosis 1 and plexiform neurofibromas
    Dusica Babovic-Vuksanovic
    Department of Medical Genetics, Mayo College of Medicine, Rochester, MN, USA
    Pediatr Neurol 36:293-300. 2007
    ..The second dose level was the pharmacokinetically comparable dose and is being used in an ongoing phase II trial of pirfenidone for children with neurofibromatosis 1 and progressive plexiform neurofibroma...
  64. ncbi request reprint Psychological outcomes in long-term survivors of childhood brain cancer: a report from the childhood cancer survivor study
    Brad J Zebrack
    University of Southern California School of Social Work, 669 W 34th St, Los Angeles, CA 90089 0411, USA
    J Clin Oncol 22:999-1006. 2004
    ..To evaluate and compare psychological outcomes in long-term survivors of pediatric brain cancer and siblings of childhood cancer survivors, and to identify significant correlates of psychological distress...
  65. ncbi request reprint Medulloblastoma
    Roger J Packer
    J Neurosurg 103:299-300; discussion 300-1. 2005
  66. ncbi request reprint Final height and body mass index among adult survivors of childhood brain cancer: childhood cancer survivor study
    James G Gurney
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Clin Endocrinol Metab 88:4731-9. 2003
    ..We did not find a corresponding elevated risk for obesity...
  67. pmc Endocrine outcome in children with medulloblastoma treated with 18 Gy of craniospinal radiation therapy
    Weizhen Xu
    Division of Endocrinology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Neuro Oncol 6:113-8. 2004
    ..In contrast, within group 18 Gy, only 1 was hypothyroid (P = 0.006) and 1 had early puberty. We conclude that endocrine morbidity was significantly reduced with 18 Gy CSRT in young children with medulloblastoma...

Research Grants5

  1. CHILDRENS NATIONAL MEDICAL CENTER
    Roger Packer; Fiscal Year: 2003
    ....
  2. Pirfenidone in Children with PNs in NF1
    Roger Packer; Fiscal Year: 2006
    ..Abstract Not Provided ..
  3. Neurological Sciences Academic Development at CNMC
    Roger Packer; Fiscal Year: 2007
    ....