Janelle Noble

Summary

Affiliation: Children's Hospital Oakland Research Institute
Country: USA

Publications

  1. ncbi request reprint Research profile. the genetics of type 1. Uncovering the secrets
    Terri Kordella
    Diabetes Forecast 55:122-4. 2002
  2. pmc HLA class II genotyping of African American type 1 diabetic patients reveals associations unique to African haplotypes
    Janelle A Noble
    Children s Hospital Oakland Research Institute, Oakland, California, USA
    Diabetes 62:3292-9. 2013
  3. pmc Genetics of type 1 diabetes
    Janelle A Noble
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Cold Spring Harb Perspect Med 2:a007732. 2012
  4. pmc Anticitrullinated protein antibody (ACPA) in rheumatoid arthritis: influence of an interaction between HLA-DRB1 shared epitope and a deletion polymorphism in glutathione S-transferase in a cross-sectional study
    Ted R Mikuls
    Omaha Veterans Affairs Medical Center and Nebraska Arthritis Outcomes Research Center, University of Nebraska Medical Center, 986270 Nebraska Medical Center, Omaha, NE 68198 6270, USA
    Arthritis Res Ther 12:R213. 2010
  5. pmc Type 1 diabetes risk for human leukocyte antigen (HLA)-DR3 haplotypes depends on genotypic context: association of DPB1 and HLA class I loci among DR3- and DR4-matched Italian patients and controls
    Janelle A Noble
    Childrens Hospital Oakland Research Institute, Oakland, CA, USA
    Hum Immunol 69:291-300. 2008
  6. pmc Linkage disequilibrium with predisposing DR3 haplotypes accounts for apparent effects of tumor necrosis factor and lymphotoxin-alpha polymorphisms on type 1 diabetes susceptibility
    Janelle A Noble
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Hum Immunol 67:999-1004. 2006
  7. pmc HLA class I and genetic susceptibility to type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium
    Janelle A Noble
    Children s Hospital Oakland Research Institute, Oakland, California, USA
    Diabetes 59:2972-9. 2010
  8. pmc Genetics of the HLA region in the prediction of type 1 diabetes
    Janelle A Noble
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Curr Diab Rep 11:533-42. 2011
  9. ncbi request reprint The HLA class I A locus affects susceptibility to type 1 diabetes
    Janelle A Noble
    Children s Hospital, Oakland Research Institute, Oakland, CA 94609, USA
    Hum Immunol 63:657-64. 2002
  10. ncbi request reprint A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes
    Janelle A Noble
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Diabetes 52:1579-82. 2003

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Research profile. the genetics of type 1. Uncovering the secrets
    Terri Kordella
    Diabetes Forecast 55:122-4. 2002
  2. pmc HLA class II genotyping of African American type 1 diabetic patients reveals associations unique to African haplotypes
    Janelle A Noble
    Children s Hospital Oakland Research Institute, Oakland, California, USA
    Diabetes 62:3292-9. 2013
    ....
  3. pmc Genetics of type 1 diabetes
    Janelle A Noble
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Cold Spring Harb Perspect Med 2:a007732. 2012
    ..Even after decades of study, the complete story has yet to unfold, and exact mechanisms by which HLA and other associated loci confer T1D susceptibility remain elusive...
  4. pmc Anticitrullinated protein antibody (ACPA) in rheumatoid arthritis: influence of an interaction between HLA-DRB1 shared epitope and a deletion polymorphism in glutathione S-transferase in a cross-sectional study
    Ted R Mikuls
    Omaha Veterans Affairs Medical Center and Nebraska Arthritis Outcomes Research Center, University of Nebraska Medical Center, 986270 Nebraska Medical Center, Omaha, NE 68198 6270, USA
    Arthritis Res Ther 12:R213. 2010
    ..The purpose of this study was to examine the associations of GSTM1-null with ACPA positivity in RA and to assess for evidence of interaction between GSTM1 and HLA-DRB1 shared epitope (SE)...
  5. pmc Type 1 diabetes risk for human leukocyte antigen (HLA)-DR3 haplotypes depends on genotypic context: association of DPB1 and HLA class I loci among DR3- and DR4-matched Italian patients and controls
    Janelle A Noble
    Childrens Hospital Oakland Research Institute, Oakland, CA, USA
    Hum Immunol 69:291-300. 2008
    ..These data indicate that T1D risk conferred by the 8.1 haplotype is genotype dependent...
  6. pmc Linkage disequilibrium with predisposing DR3 haplotypes accounts for apparent effects of tumor necrosis factor and lymphotoxin-alpha polymorphisms on type 1 diabetes susceptibility
    Janelle A Noble
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Hum Immunol 67:999-1004. 2006
    ..Thus, variation at TNF does not affect the T1D risk for B18-DR3 haplotypes, and the apparent association of TNF(-238)A with T1D may simply reflect its presence on a high-risk haplotype...
  7. pmc HLA class I and genetic susceptibility to type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium
    Janelle A Noble
    Children s Hospital Oakland Research Institute, Oakland, California, USA
    Diabetes 59:2972-9. 2010
    ..We report here genotyping data and type 1 diabetes association analyses for HLA class I loci (A, B, and C) on 1,753 multiplex pedigrees from the Type 1 Diabetes Genetics Consortium (T1DGC), a large international collaborative study...
  8. pmc Genetics of the HLA region in the prediction of type 1 diabetes
    Janelle A Noble
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Curr Diab Rep 11:533-42. 2011
    ..Inclusion of additional moderate HLA risk haplotypes may help identify the majority of children with T1D before the onset of the disease...
  9. ncbi request reprint The HLA class I A locus affects susceptibility to type 1 diabetes
    Janelle A Noble
    Children s Hospital, Oakland Research Institute, Oakland, CA 94609, USA
    Hum Immunol 63:657-64. 2002
    ..Our results suggest an important role for class I antigens in modulating susceptibility to type 1 diabetes...
  10. ncbi request reprint A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes
    Janelle A Noble
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Diabetes 52:1579-82. 2003
    ..04). These data also suggest that TCF7 C883A may affect age of disease onset. Analysis of genotype data from surrounding SNPs suggests that this TCF7 polymorphism may itself represent a risk factor for type 1 diabetes...
  11. pmc Race-specific type 1 diabetes risk of HLA-DR7 haplotypes
    J A Noble
    Children s Hospital Oakland Research Institute, Oakland, CA, USA
    Tissue Antigens 78:348-51. 2011
    ..These data underscore the importance of assessing genetic effects within ethnic context...
  12. ncbi request reprint Confirmation of an association between the TNF(-308) promoter polymorphism and stroke risk in children with sickle cell anemia
    Carolyn Hoppe
    Department of Hematology Oncology, Children s Hospital and Research Center Oakland, Oakland, CA 94609, USA
    Stroke 38:2241-6. 2007
    ..The aim of this replication study was to confirm our previous findings of associations between the TNF(-308) G/A, IL4R 503 S/P, and ADRB2 27 Q/E polymorphisms and large vessel stroke risk...
  13. ncbi request reprint Human leukocyte antigen class I B and C loci contribute to Type 1 Diabetes (T1D) susceptibility and age at T1D onset
    Ana M Valdes
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Hum Immunol 66:301-13. 2005
    ..5 years, p < 0.001; and 7.8 years, p < 0.002, respectively). These data support a role for HLA class I alleles in susceptibility to and age at onset of T1D...
  14. ncbi request reprint Distinct HLA associations by stroke subtype in children with sickle cell anemia
    Carolyn Hoppe
    Department of Hematology Oncology, Children s Hospital Oakland, CA 94609, USA
    Blood 101:2865-9. 2003
    ..If these results are confirmed in a larger study, HLA type may serve as a useful marker for the early identification of SCA patients at high risk for stroke...
  15. ncbi request reprint DPB1 alleles are associated with type 1 diabetes susceptibility in multiple ethnic groups
    Thomas D Cruz
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Diabetes 53:2158-63. 2004
    ..This supports the concept that multiple genes in the HLA region can affect type 1 diabetes susceptibility...
  16. pmc High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions
    Lisa F Barcellos
    Division of Epidemiology, School of Public Health, University of California Berkeley, Berkeley, California, USA
    PLoS Genet 5:e1000696. 2009
    ..We provide a list of candidate variants based on biologic and functional considerations that may be causally related to SLE risk and warrant further investigation...
  17. doi request reprint HLA on chromosome 6: the story gets longer and longer
    Leslie J Raffel
    Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Diabetes 57:527-8. 2008
  18. ncbi request reprint Association of the single nucleotide polymorphism C1858T of the PTPN22 gene with type 1 diabetes
    Martha B Ladner
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Hum Immunol 66:60-4. 2005
    ..These results are consistent with the hypothesis that individuals lacking the C allele of PTPN22 may have reduced capacity to downregulate T-cell responses and may therefore be more susceptible to autoimmunity...
  19. pmc Maximizing deoxyribonucleic acid yield from dried blood spots
    Julie A Lane
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    J Diabetes Sci Technol 4:250-4. 2010
    ..Extraction of DNA from these cards can lead to variable amounts of recovered DNA. We report here results of our efforts to maximize yield from this valuable, but nonrenewable, resource...
  20. ncbi request reprint HLA-DPB1*0402 protects against type 1A diabetes autoimmunity in the highest risk DR3-DQB1*0201/DR4-DQB1*0302 DAISY population
    Erin E Baschal
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045 6511, USA
    Diabetes 56:2405-9. 2007
    ....
  21. ncbi request reprint Association of IL4R haplotypes with type 1 diabetes
    Daniel B Mirel
    Department of Human Genetics, Roche Molecular Systems, Alameda, California 94501, USA
    Diabetes 51:3336-41. 2002
    ..These findings suggest an important role for the IL4R gene in immune-related disease susceptibility and illustrate the value of using multi-SNP haplotype information in association studies...
  22. ncbi request reprint ICA+ relatives with DQA1*0102/DQB1*0602 have expected 0602 sequence and DR types
    Carla J Greenbaum
    Benaroya Research Institute at Virginia Mason Research Center, Seattle, WA 98101, USA
    J Autoimmun 18:67-70. 2002
    ....
  23. ncbi request reprint Haplotype frequency estimation in patient populations: the effect of departures from Hardy-Weinberg proportions and collapsing over a locus in the HLA region
    Richard M Single
    Department of Integrative Biology, University of California, Berkeley, USA
    Genet Epidemiol 22:186-95. 2002
    ..The collapsing procedure is most beneficial when one of the loci in the two-locus haplotype of interest deviates significantly from HWP and the locus collapsed over is in linkage disequilibrium with the other loci...

Research Grants10

  1. The genetic basis of type 1 diabetes autoimmunity
    Janelle Noble; Fiscal Year: 2003
    ..These experiments are expected to generate data that will help elucidate the multiple genetic factors that contribute to T1DM susceptibility. ..
  2. The genetic basis of type 1 diabetes autoimmunity
    Janelle Noble; Fiscal Year: 2007
    ..These experiments are expected to generate data that will help elucidate the multiple genetic factors that contribute to T1DM susceptibility. ..
  3. The genetic basis of type 1 diabetes autoimmunity
    Janelle Noble; Fiscal Year: 2005
    ..These experiments are expected to generate data that will help elucidate the multiple genetic factors that contribute to T1DM susceptibility. ..
  4. The genetic basis of type 1 diabetes autoimmunity
    Janelle Noble; Fiscal Year: 2006
    ..These experiments are expected to generate data that will help elucidate the multiple genetic factors that contribute to T1DM susceptibility. ..
  5. The genetic basis of type 1 diabetes autoimmunity
    Janelle Noble; Fiscal Year: 2004
    ..These experiments are expected to generate data that will help elucidate the multiple genetic factors that contribute to T1DM susceptibility. ..
  6. The genetic basis of type 1 diabetes autoimmunity
    Janelle Noble; Fiscal Year: 2005
    ..These experiments are expected to generate data that will help elucidate the multiple genetic factors that contribute to T1DM susceptibility. ..
  7. The genetic basis of type 1 diabetes autoimmunity
    Janelle Noble; Fiscal Year: 2004
    ..These experiments are expected to generate data that will help elucidate the multiple genetic factors that contribute to T1DM susceptibility. ..
  8. The genetic basis of type 1 diabetes autoimmunity in African Americans
    Janelle A Noble; Fiscal Year: 2010
    ....