Claudia R Morris

Summary

Affiliation: Children's Hospital and Research Center
Country: USA

Publications

  1. ncbi Arginine therapy: a new treatment for pulmonary hypertension in sickle cell disease?
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital Oakland, 747 52nd Street, Oakland, CA 94609, USA
    Am J Respir Crit Care Med 168:63-9. 2003
  2. ncbi Hydroxyurea and arginine therapy: impact on nitric oxide production in sickle cell disease
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center at Oakland, Oakland, California 94609, USA
    J Pediatr Hematol Oncol 25:629-34. 2003
  3. ncbi Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center at Oakland, CA 94609, USA
    JAMA 294:81-90. 2005
  4. ncbi Hemolysis-associated pulmonary hypertension in thalassemia
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center at Oakland, 747 52nd Street, Oakland, California 94609, USA
    Ann N Y Acad Sci 1054:481-5. 2005
  5. ncbi Erythrocyte glutamine depletion, altered redox environment, and pulmonary hypertension in sickle cell disease
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center Oakland, 747 52nd St, Oakland, CA 94609, USA
    Blood 111:402-10. 2008
  6. ncbi Decreased arginine bioavailability and increased serum arginase activity in asthma
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center at Oakland, Oakland, CA 94609, USA
    Am J Respir Crit Care Med 170:148-53. 2004
  7. ncbi Asthma management: reinventing the wheel in sickle cell disease
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center Oakland, Oakland, California 94609, USA
    Am J Hematol 84:234-41. 2009
  8. ncbi Nitric oxide and arginine dysregulation: a novel pathway to pulmonary hypertension in hemolytic disorders
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center Oakland, Oakland, CA 94609, USA
    Curr Mol Med 8:620-32. 2008
  9. ncbi A randomized, placebo-controlled study of intravenous montelukast in children with acute asthma
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center, Oakland, California 94609, USA
    Ann Allergy Asthma Immunol 104:161-71. 2010
  10. ncbi Clinical differences between children and adults with pulmonary hypertension and sickle cell disease
    R Ward Hagar
    Hematology Oncology, Children s Hospital and Research Center Oakland, Oakland, CA 94609, USA
    Br J Haematol 140:104-12. 2008

Research Grants

  1. ARGININE THERAPY IN SICKLE CELL DISEASE
    CLAUDIA MORRIS; Fiscal Year: 2004

Detail Information

Publications19

  1. ncbi Arginine therapy: a new treatment for pulmonary hypertension in sickle cell disease?
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital Oakland, 747 52nd Street, Oakland, CA 94609, USA
    Am J Respir Crit Care Med 168:63-9. 2003
    ..With limited treatment options and a high mortality rate for patients with sickle cell disease who develop pulmonary hypertension, arginine is a promising new therapy that warrants further investigation...
  2. ncbi Hydroxyurea and arginine therapy: impact on nitric oxide production in sickle cell disease
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center at Oakland, Oakland, California 94609, USA
    J Pediatr Hematol Oncol 25:629-34. 2003
    ..The authors have previously shown that Arg supplementation alone induces a paradoxical decrease in NO metabolite (NO(x)) production...
  3. ncbi Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center at Oakland, CA 94609, USA
    JAMA 294:81-90. 2005
    ..We hypothesized that increased arginase activity and dysregulated arginine metabolism contribute to endothelial dysfunction, pulmonary hypertension, and patient outcomes...
  4. ncbi Hemolysis-associated pulmonary hypertension in thalassemia
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center at Oakland, 747 52nd Street, Oakland, California 94609, USA
    Ann N Y Acad Sci 1054:481-5. 2005
    ..Erythrocyte release of arginase during hemolysis contributes to the development of PHT. Therapies that maximize arginine and nitric oxide bioavailability may benefit patients with thalassemia...
  5. ncbi Erythrocyte glutamine depletion, altered redox environment, and pulmonary hypertension in sickle cell disease
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center Oakland, 747 52nd St, Oakland, CA 94609, USA
    Blood 111:402-10. 2008
    ..Decreased erythrocyte glutathione and glutamine levels contribute to alterations in the erythrocyte redox environment, which may compromise erythrocyte integrity, contribute to hemolysis, and play a role in the pathogenesis of PH of SCD...
  6. ncbi Decreased arginine bioavailability and increased serum arginase activity in asthma
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center at Oakland, Oakland, CA 94609, USA
    Am J Respir Crit Care Med 170:148-53. 2004
    ..Addressing the alterations in arginine metabolism may result in new strategies for treatment of asthma...
  7. ncbi Asthma management: reinventing the wheel in sickle cell disease
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center Oakland, Oakland, California 94609, USA
    Am J Hematol 84:234-41. 2009
    ..Barriers to appropriate asthma management in SCD are discussed as well as strategies to overcome these obstacles in order to provide optimal care...
  8. ncbi Nitric oxide and arginine dysregulation: a novel pathway to pulmonary hypertension in hemolytic disorders
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center Oakland, Oakland, CA 94609, USA
    Curr Mol Med 8:620-32. 2008
    ....
  9. ncbi A randomized, placebo-controlled study of intravenous montelukast in children with acute asthma
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center, Oakland, California 94609, USA
    Ann Allergy Asthma Immunol 104:161-71. 2010
    ..In adults, intravenous montelukast added to standard therapy significantly improved forced expiratory volume in 1 second (FEV1) and reduced hospital admissions compared with standard therapy alone...
  10. ncbi Clinical differences between children and adults with pulmonary hypertension and sickle cell disease
    R Ward Hagar
    Hematology Oncology, Children s Hospital and Research Center Oakland, Oakland, CA 94609, USA
    Br J Haematol 140:104-12. 2008
    ..3 (95% confidence interval 4.9-60.4). The divergent clinical spectrum for PHT between adults and children may point to different age-specific mechanisms or biological expression of PHT...
  11. ncbi Asthma in sickle cell disease
    Manisha Newaskar
    Bay Area Pediatric Pulmonary Medical Corporation, Oakland, CA, USA
    ScientificWorldJournal 11:1138-52. 2011
    ..Early recognition and aggressive management of asthma based on established National Institutes of Health asthma guidelines is recommended in order to minimize morbidity and mortality...
  12. ncbi Pulmonary hypertension in thalassemia
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center Oakland, Oakland, California, USA
    Ann N Y Acad Sci 1202:205-13. 2010
    ..Guidelines for the management of PH in thalassemia have not yet been established; however, clinical trials are ongoing in an effort to guide future therapy...
  13. ncbi Risk factors and mortality associated with an elevated tricuspid regurgitant jet velocity measured by Doppler-echocardiography in thalassemia: a Thalassemia Clinical Research Network report
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center Oakland, Oakland, CA, USA
    Blood 118:3794-802. 2011
    ..Mortality was low in this cohort. Prospective longitudinal studies are needed. This study is registered at http://www.clinicaltrials.gov as NCT00661804...
  14. ncbi Clinical hemoglobinopathies: iron, lungs and new blood
    Claudia R Morris
    Children's Hospital and Research Center Oakland, Oakland, CA 94609, USA
    Curr Opin Hematol 13:407-18. 2006
    ..SUMMARY: In this review, several areas that are very likely to have a significant impact in the management of patients who inherit these disorders are discussed...
  15. ncbi Secretory phospholipase A2: a marker of infection in febrile children presenting to a pediatric ED
    Karim M Mansour
    Children s Hospital and Research Center, Department of Emergency Medicine, Oakland, CA 94618, USA
    Am J Emerg Med 29:1163-8. 2011
    ..Fever is a common presenting complaint to the emergency department (ED), and the evaluation of the febrile child remains a challenging task...
  16. ncbi L-arginine levels are diminished in adult acute vaso-occlusive sickle cell crisis in the emergency department
    Bernard L Lopez
    Department of Emergency Medicine, Jefferson Medical College, Philadelphia, PA, USA
    Br J Haematol 120:532-4. 2003
    ..16 micromol/l +/- 5.04) and significantly low plasma NOx (12.33 micromol/l +/- 10.28, P < 0.05 vs steady-state control = 25.2 +/- 2.6 micro mol/l). Neither l-arg nor NOx levels could predict VOC clinical course...
  17. ncbi Syndrome of allergy, apraxia, and malabsorption: characterization of a neurodevelopmental phenotype that responds to omega 3 and vitamin E supplementation
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center Oakland, California, USA
    Altern Ther Health Med 15:34-43. 2009
    ..The goal of this investigation was to characterize symptoms and metabolic anomalies of a subset of children with verbal apraxia who may respond to nutritional interventions...
  18. ncbi Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease
    Gregory J Kato
    Vascular Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Dr, MSC 1476, Bldg 10CRC, Rm 5 5140, Bethesda, MD 20892, USA
    Blood 107:2279-85. 2006
    ..We propose that LDH elevation identifies patients with a syndrome of hemolysis-associated NO resistance, endothelial dysfunction, and end-organ vasculopathy...
  19. ncbi Evaluation of a novel, integrated approach using functionalized magnetic beads, bench-top MALDI-TOF-MS with prestructured sample supports, and pattern recognition software for profiling potential biomarkers in human plasma
    Xinyi Zhang
    Bruker Daltonics, Inc, 2859 Bayview Drive, Fremont, CA 94538, USA
    J Biomol Tech 15:167-75. 2004
    ..The results show that the novel and facile approach with manual magnetic-bead sample preparation and a low-cost bench-top MALDI-TOF mass spectrometer is suitable for preliminary biomarker discovery studies...

Research Grants1

  1. ARGININE THERAPY IN SICKLE CELL DISEASE
    CLAUDIA MORRIS; Fiscal Year: 2004
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