Claudia R Morris

Summary

Affiliation: Children's Hospital and Research Center
Country: USA

Publications

  1. ncbi request reprint Arginine therapy: a new treatment for pulmonary hypertension in sickle cell disease?
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital Oakland, 747 52nd Street, Oakland, CA 94609, USA
    Am J Respir Crit Care Med 168:63-9. 2003
  2. ncbi request reprint Hydroxyurea and arginine therapy: impact on nitric oxide production in sickle cell disease
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center at Oakland, Oakland, California 94609, USA
    J Pediatr Hematol Oncol 25:629-34. 2003
  3. pmc Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center at Oakland, CA 94609, USA
    JAMA 294:81-90. 2005
  4. pmc Hemolysis-associated pulmonary hypertension in thalassemia
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center at Oakland, 747 52nd Street, Oakland, California 94609, USA
    Ann N Y Acad Sci 1054:481-5. 2005
  5. pmc Erythrocyte glutamine depletion, altered redox environment, and pulmonary hypertension in sickle cell disease
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center Oakland, 747 52nd St, Oakland, CA 94609, USA
    Blood 111:402-10. 2008
  6. ncbi request reprint Decreased arginine bioavailability and increased serum arginase activity in asthma
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center at Oakland, Oakland, CA 94609, USA
    Am J Respir Crit Care Med 170:148-53. 2004
  7. doi request reprint Asthma management: reinventing the wheel in sickle cell disease
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center Oakland, Oakland, California 94609, USA
    Am J Hematol 84:234-41. 2009
  8. pmc Nitric oxide and arginine dysregulation: a novel pathway to pulmonary hypertension in hemolytic disorders
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center Oakland, Oakland, CA 94609, USA
    Curr Mol Med 8:620-32. 2008
  9. ncbi request reprint A randomized, placebo-controlled study of intravenous montelukast in children with acute asthma
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center, Oakland, California 94609, USA
    Ann Allergy Asthma Immunol 104:161-71. 2010
  10. ncbi request reprint Clinical differences between children and adults with pulmonary hypertension and sickle cell disease
    R Ward Hagar
    Hematology Oncology, Children s Hospital and Research Center Oakland, Oakland, CA 94609, USA
    Br J Haematol 140:104-12. 2008

Research Grants

  1. ARGININE THERAPY IN SICKLE CELL DISEASE
    CLAUDIA MORRIS; Fiscal Year: 2004

Detail Information

Publications20

  1. ncbi request reprint Arginine therapy: a new treatment for pulmonary hypertension in sickle cell disease?
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital Oakland, 747 52nd Street, Oakland, CA 94609, USA
    Am J Respir Crit Care Med 168:63-9. 2003
    ..With limited treatment options and a high mortality rate for patients with sickle cell disease who develop pulmonary hypertension, arginine is a promising new therapy that warrants further investigation...
  2. ncbi request reprint Hydroxyurea and arginine therapy: impact on nitric oxide production in sickle cell disease
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center at Oakland, Oakland, California 94609, USA
    J Pediatr Hematol Oncol 25:629-34. 2003
    ..The authors have previously shown that Arg supplementation alone induces a paradoxical decrease in NO metabolite (NO(x)) production...
  3. pmc Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center at Oakland, CA 94609, USA
    JAMA 294:81-90. 2005
    ..We hypothesized that increased arginase activity and dysregulated arginine metabolism contribute to endothelial dysfunction, pulmonary hypertension, and patient outcomes...
  4. pmc Hemolysis-associated pulmonary hypertension in thalassemia
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center at Oakland, 747 52nd Street, Oakland, California 94609, USA
    Ann N Y Acad Sci 1054:481-5. 2005
    ..Erythrocyte release of arginase during hemolysis contributes to the development of PHT. Therapies that maximize arginine and nitric oxide bioavailability may benefit patients with thalassemia...
  5. pmc Erythrocyte glutamine depletion, altered redox environment, and pulmonary hypertension in sickle cell disease
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center Oakland, 747 52nd St, Oakland, CA 94609, USA
    Blood 111:402-10. 2008
    ..Decreased erythrocyte glutathione and glutamine levels contribute to alterations in the erythrocyte redox environment, which may compromise erythrocyte integrity, contribute to hemolysis, and play a role in the pathogenesis of PH of SCD...
  6. ncbi request reprint Decreased arginine bioavailability and increased serum arginase activity in asthma
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center at Oakland, Oakland, CA 94609, USA
    Am J Respir Crit Care Med 170:148-53. 2004
    ..Addressing the alterations in arginine metabolism may result in new strategies for treatment of asthma...
  7. doi request reprint Asthma management: reinventing the wheel in sickle cell disease
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center Oakland, Oakland, California 94609, USA
    Am J Hematol 84:234-41. 2009
    ..Barriers to appropriate asthma management in SCD are discussed as well as strategies to overcome these obstacles in order to provide optimal care...
  8. pmc Nitric oxide and arginine dysregulation: a novel pathway to pulmonary hypertension in hemolytic disorders
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center Oakland, Oakland, CA 94609, USA
    Curr Mol Med 8:620-32. 2008
    ....
  9. ncbi request reprint A randomized, placebo-controlled study of intravenous montelukast in children with acute asthma
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center, Oakland, California 94609, USA
    Ann Allergy Asthma Immunol 104:161-71. 2010
    ..In adults, intravenous montelukast added to standard therapy significantly improved forced expiratory volume in 1 second (FEV1) and reduced hospital admissions compared with standard therapy alone...
  10. ncbi request reprint Clinical differences between children and adults with pulmonary hypertension and sickle cell disease
    R Ward Hagar
    Hematology Oncology, Children s Hospital and Research Center Oakland, Oakland, CA 94609, USA
    Br J Haematol 140:104-12. 2008
    ..3 (95% confidence interval 4.9-60.4). The divergent clinical spectrum for PHT between adults and children may point to different age-specific mechanisms or biological expression of PHT...
  11. pmc Asthma management in sickle cell disease
    Esteban Gómez
    Department of Hematology Oncology, Children s Hospital and Research Center Oakland, Oakland, CA 94609, USA
    Biomed Res Int 2013:604140. 2013
    ..Clinical trials are needed to evaluate the effectiveness of current asthma therapy in patients with SCD and coincident asthma, while mechanistic studies are needed to delineate the underlying pathophysiology. ..
  12. ncbi request reprint Asthma in sickle cell disease
    Manisha Newaskar
    Bay Area Pediatric Pulmonary Medical Corporation, Oakland, CA, USA
    ScientificWorldJournal 11:1138-52. 2011
    ..Early recognition and aggressive management of asthma based on established National Institutes of Health asthma guidelines is recommended in order to minimize morbidity and mortality...
  13. ncbi request reprint Clinical hemoglobinopathies: iron, lungs and new blood
    Claudia R Morris
    Children s Hospital and Research Center Oakland, Oakland, CA 94609, USA
    Curr Opin Hematol 13:407-18. 2006
    ..As a result, chronic health impairments that significantly reduce the quality of life such as pulmonary hypertension and the consequences of transfusional iron overload have become principal challenges...
  14. doi request reprint Pulmonary hypertension in thalassemia
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center Oakland, Oakland, California, USA
    Ann N Y Acad Sci 1202:205-13. 2010
    ..Guidelines for the management of PH in thalassemia have not yet been established; however, clinical trials are ongoing in an effort to guide future therapy...
  15. pmc Risk factors and mortality associated with an elevated tricuspid regurgitant jet velocity measured by Doppler-echocardiography in thalassemia: a Thalassemia Clinical Research Network report
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center Oakland, Oakland, CA, USA
    Blood 118:3794-802. 2011
    ..Mortality was low in this cohort. Prospective longitudinal studies are needed. This study is registered at http://www.clinicaltrials.gov as NCT00661804...
  16. pmc Secretory phospholipase A2: a marker of infection in febrile children presenting to a pediatric ED
    Karim M Mansour
    Children s Hospital and Research Center, Department of Emergency Medicine, Oakland, CA 94618, USA
    Am J Emerg Med 29:1163-8. 2011
    ..Fever is a common presenting complaint to the emergency department (ED), and the evaluation of the febrile child remains a challenging task...
  17. ncbi request reprint L-arginine levels are diminished in adult acute vaso-occlusive sickle cell crisis in the emergency department
    Bernard L Lopez
    Department of Emergency Medicine, Jefferson Medical College, Philadelphia, PA, USA
    Br J Haematol 120:532-4. 2003
    ..16 micromol/l +/- 5.04) and significantly low plasma NOx (12.33 micromol/l +/- 10.28, P < 0.05 vs steady-state control = 25.2 +/- 2.6 micro mol/l). Neither l-arg nor NOx levels could predict VOC clinical course...
  18. ncbi request reprint Syndrome of allergy, apraxia, and malabsorption: characterization of a neurodevelopmental phenotype that responds to omega 3 and vitamin E supplementation
    Claudia R Morris
    Department of Emergency Medicine, Children s Hospital and Research Center Oakland, California, USA
    Altern Ther Health Med 15:34-43. 2009
    ..The goal of this investigation was to characterize symptoms and metabolic anomalies of a subset of children with verbal apraxia who may respond to nutritional interventions...
  19. pmc Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease
    Gregory J Kato
    Vascular Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Dr, MSC 1476, Bldg 10CRC, Rm 5 5140, Bethesda, MD 20892, USA
    Blood 107:2279-85. 2006
    ..We propose that LDH elevation identifies patients with a syndrome of hemolysis-associated NO resistance, endothelial dysfunction, and end-organ vasculopathy...
  20. pmc Evaluation of a novel, integrated approach using functionalized magnetic beads, bench-top MALDI-TOF-MS with prestructured sample supports, and pattern recognition software for profiling potential biomarkers in human plasma
    Xinyi Zhang
    Bruker Daltonics, Inc, 2859 Bayview Drive, Fremont, CA 94538, USA
    J Biomol Tech 15:167-75. 2004
    ..The results show that the novel and facile approach with manual magnetic-bead sample preparation and a low-cost bench-top MALDI-TOF mass spectrometer is suitable for preliminary biomarker discovery studies...

Research Grants1

  1. ARGININE THERAPY IN SICKLE CELL DISEASE
    CLAUDIA MORRIS; Fiscal Year: 2004
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