M G Michaels
Affiliation: Children's Hospital of Pittsburgh
- Cytomegalovirus infection in pediatric immunocompromised hostsMarsha Y Russell
Children s Hospital of Pittsburgh of UPMC, One Children s Hospital Drive, Pittsburgh, PA 15224, USA
Infect Disord Drug Targets 11:437-48. 2011..The importance of CMV in these special populations of children, emphasizing epidemiology, risk factors, and preventive strategies, is reviewed...
- Infections in pediatric transplant recipients: not just small adultsMarian G Michaels
Department of Pediatrics and Surgery, Children s Hospital of Pittsburgh, One Children s Hospital Drive, 4401 Penn Avenue, Pittsburgh, PA 15224, USA
Infect Dis Clin North Am 24:307-18. 2010..This article reviews some of the major concepts regarding infections that complicate pediatric transplantation, highlighting differences in epidemiology, evaluation, treatment and prevention for children compared with adult recipients...
- Respiratory syncytial virus prophylaxis: a survey of pediatric solid organ transplant centersMarian G Michaels
Pediatrics, Children s Hospital of Pittsburgh, Pittsburgh, PA 15217, USA
Pediatr Transplant 13:451-6. 2009..Strategies varied at centers based on age and organ type. Data on RSV hospitalization and outcome are needed to refine approaches to RSV immunoprophylaxis in these high-risk patients...
- Treatment of congenital cytomegalovirus: where are we now?Marian G Michaels
University of Pittsburgh School of Medicine, Children s Hospital of Pittsburgh, Division of Infectious Diseases, Pittsburgh PA 15213, USA
Expert Rev Anti Infect Ther 5:441-8. 2007..Accordingly, researchers and clinicians have long been interested in identifying strategies to prevent or treat symptomatic congenital CMV infection. This article reviews congenital CMV with a focus on treatment strategies...
- Nonhuman primate herpesviruses: importance for xenotransplantationM G Michaels
Division of Allergy, Immunology and Infectious Diseases, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
Curr Top Microbiol Immunol 278:73-100. 2003..This chapter reviews herpesviruses of nonhuman primates and their potential implication for causing disease after xenotransplantation...
- Detection of infectious baboon cytomegalovirus after baboon-to-human liver xenotransplantationM G Michaels
Department of Pediatrics, Division of Allergy, Immunology, and Infectious Diseases, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
J Virol 75:2825-8. 2001..This is the first report of detecting a replication-competent virus from a source animal after xenotransplantation and is a concern with regard to potential zoonotic transmission to others...
- CMV-IVIG for prevention of Epstein Barr virus disease and posttransplant lymphoproliferative disease in pediatric liver transplant recipientsM Green
Department of Pediatrics, University of Pitttsburgh School of Medicine, Pennsylvania, USA
Am J Transplant 6:1906-12. 2006..20). The absence of significant effect of CMV-IVIG may be explained by a lack of efficacy of the drug or limitations of sample size...
- Safety and immunogenicity of the American Academy of Pediatrics--recommended sequential pneumococcal conjugate and polysaccharide vaccine schedule in pediatric solid organ transplant recipientsPhilana Ling Lin
Department of Pediatrics, Children s Hospital of Pittsburgh, PA 15213, USA
Pediatrics 116:160-7. 2005..Accordingly, this study was designed to evaluate the safety and immunogenicity of the recommended regimen...
- Intrathoracic disease from nontuberculous mycobacteria in children: two cases and a review of the literatureDawn Nolt
University of Pittsburgh School of Medicine, Division of Allergy, Immunology, and Infectious Diseases, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Pediatrics 112:e434. 2003..5 months vs 6 months). The most common causative organism was Mycobacterium avium complex. Pediatricians should be increasingly aware of NTM in the differential diagnosis of persistent pulmonary disease in previously healthy children...
- Survival with hypopituitarism from congenital syphilisDawn Nolt
University of Pittsburgh School of Medicine, Division of Allergy, Immunology and Infectious Diseases, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Pediatrics 109:e63. 2002..Institution of routine testing in all countries might have prevented the severe manifestations of syphilis seen in this child...
- Management of nontuberculous mycobacterial cervical lymphadenitisDavid L Mandell
Department of Pediatric Otolaryngology, Children s Hospital of Pittsburgh, PA 15213, USA
Arch Otolaryngol Head Neck Surg 129:341-4. 2003..To review the treatment and outcome of patients with nontuberculous mycobacterial (NTM) cervical lymphadenitis...
- Infectious complications in pediatric solid organ transplantationWilliam L Keough
Division of Allergy, Immunology and Infectious Diseases, Children's Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
Pediatr Clin North Am 50:1451-69, x. 2003..In addition, an approach to the pediatric transplant patient who presents with specific symptoms suggestive of infection is provided...
- Chronic high Epstein-Barr viral load state and risk for late-onset posttransplant lymphoproliferative disease/lymphoma in childrenM A Bingler
Division of Cardiology, Department of Pediatrics, Children s Hospital of Pittsburgh, Pittsburgh, PA, USA
Am J Transplant 8:442-5. 2008..4, 95% CI 2.1-74.4) and prior history of PTLD (OR = 10.7, 95% CI 1.9-60.6) independently predicted late PTLD. A chronic high EBV-load state is not benign and is a predictor of de novo or recurrent PTLD...
- Treatment of children with congenital cytomegalovirus infection with ganciclovirMarian G Michaels
Division of Allergy, Immunology, Infectious Diseases, Department of Pediatrics, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA
Pediatr Infect Dis J 22:504-9. 2003..Currently available oral analogues of ganciclovir may facilitate earlier and more prolonged therapy for children with symptomatic congenital CMV and should be subjected to randomized controlled trials...
- Infectious complications of immunosuppressive medications in organ transplant recipientsMichael Green
University of Pittsburgh School of Medicine, Division of Infectious Diseases, Children's Hospital of Pittsburgh, USA
Pediatr Infect Dis J 26:443-4. 2007
- Incidence of invasive pneumococcal disease in children 3 to 36 months of age at a tertiary care pediatric center 2 years after licensure of the pneumococcal conjugate vaccinePhilana Ling Lin
Division of Pediatric Infectious Diseases, Children's Hospital of Pittsburgh, PA 15213, USA
Pediatrics 111:896-9. 2003
- New kids on the block: an old problem for a growing pediatric populationMichael Green
Pediatr Transplant 9:138-40. 2005
- Prevention, detection, and management of early bacterial and fungal infections in a preclinical cardiac xenotransplantation model that achieves prolonged survivalSumeet S Teotia
William J von Liebig Transplant Center, Mayo Clinic College of Medicine, Rochester, MN 55902, USA
Xenotransplantation 12:127-33. 2005..Further research will determine if the viral infectious complications observed in these experiments can be reduced by optimizing blood levels of anti-viral prophylaxis and monitoring viral polymerase chain reaction levels...
- Variability in immunization guidelines in children before and after lung transplantationChristian Benden
Division of Pulmonary Medicine and Lung Transplantation, University Hospital, Zurich, Switzerland
Pediatr Transplant 11:882-7. 2007..Current vaccination practices of pediatric lung transplant centers are heterogeneous. The lung transplant community would be well served by studies designed to evaluate the efficacy of vaccinations in this population...
- Cardiac xenotransplantation: progress toward the clinicChristopher G A McGregor
The Mayo Clinic William J von Liebig Transplant Center, 220 First Street SW, Rochester, MN 55905, USA
Transplantation 78:1569-75. 2004..A median graft survival of 90 days in the life-supporting position is considered a reasonable initial standard for consideration of entry to the clinic...
- Human herpesvirus 8: Is it time for routine surveillance in pediatric solid organ transplant recipients to prevent the development of Kaposi's sarcoma?Marian G Michaels
Pediatr Transplant 7:1-3. 2003
- Variability in standard care for cytomegalovirus prevention and detection in pediatric lung transplantation: survey of eight pediatric lung transplant programsLara A Danziger-Isakov
Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, MO, USA
Pediatr Transplant 7:469-73. 2003..A retrospective analysis among these centers is being conducted to evaluate the efficacy of these approaches...
- Baboon bone-marrow xenotransplant in a patient with advanced HIV disease: case report and 8-year follow-upMarian G Michaels
University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
Transplantation 78:1582-9. 2004..Long-term improvement was not achieved; however, no adverse events occurred, and no evidence of transmission of xenogeneic infections was found...