Marisa Wong Medina
Affiliation: Children's Hospital Oakland Research Institute
Medina M. The relationship between HMGCR genetic variation, alternative splicing, and statin efficacy. Discov Med. 2010;9:495-9 pubmed
Kim K, Theusch E, Kuang Y, Dosé A, Mitchel K, Cubitt C, et al
. ZNF542P is a pseudogene associated with LDL response to simvastatin treatment. Sci Rep. 2018;8:12443 pubmed publisher
..Together, these findings imply a role for ZNF542P in LDLC response to simvastatin and, importantly, highlight the potential significance of noncoding RNAs as a contributing factor to variation in drug response. ..
Medina M, Krauss R. The role of HMGCR alternative splicing in statin efficacy. Trends Cardiovasc Med. 2009;19:173-7 pubmed publisher
Mitchel K, Theusch E, Cubitt C, Dose A, Stevens K, Naidoo D, et al
. RP1-13D10.2 Is a Novel Modulator of Statin-Induced Changes in Cholesterol. Circ Cardiovasc Genet. 2016;9:223-30 pubmed publisher
..These findings highlight the potential role of noncoding RNAs as determinants of interindividual variation in drug response. ..
Medina M, Theusch E, Naidoo D, Bauzon F, Stevens K, Mangravite L, et al
. RHOA is a modulator of the cholesterol-lowering effects of statin. PLoS Genet. 2012;8:e1003058 pubmed publisher
Medina M, Bauzon F, Naidoo D, Theusch E, Stevens K, Schilde J, et al
. Transmembrane protein 55B is a novel regulator of cellular cholesterol metabolism. Arterioscler Thromb Vasc Biol. 2014;34:1917-23 pubmed publisher
..The findings highlight the value of an integrated genomic approach for identifying genes that influence cholesterol homeostasis. ..
Kim M, Yu C, Theusch E, Naidoo D, Stevens K, Kuang Y, et al
. SUGP1 is a novel regulator of cholesterol metabolism. Hum Mol Genet. 2016;25:3106-3116 pubmed
..Our results strongly support a role for SUGP1 as a novel regulator of cholesterol metabolism and suggest that it contributes to the relationship between rs10401969 and plasma cholesterol. ..