DAVID IK MARTIN

Summary

Affiliation: Children's Hospital Oakland Research Institute
Country: USA

Publications

  1. ncbi Identification and correction of systematic error in high-throughput sequence data
    Frazer Meacham
    Department of Mathematics, University of California, Berkeley, 970 Evans Hall 3840, Berkeley, CA 94720, USA
    BMC Bioinformatics 12:451. 2011
  2. ncbi Germline epimutation: A basis for epigenetic disease in humans
    David I K Martin
    Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia
    Ann N Y Acad Sci 1054:68-77. 2005
  3. ncbi Phyloepigenomic comparison of great apes reveals a correlation between somatic and germline methylation states
    David I K Martin
    Center for Genetics, Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Genome Res 21:2049-57. 2011
  4. ncbi Germline epimutation of MLH1 in individuals with multiple cancers
    Catherine M Suter
    Department of Medical Oncology, St Vincent s Hospital, Sydney, New South Wales, Australia
    Nat Genet 36:497-501. 2004
  5. ncbi Germline epimutation in humans
    Jennifer E Cropley
    Molecular Genetics Division, Victor Chang Cardiac Research Institute, Sydney, Australia
    Pharmacogenomics 9:1861-8. 2008
  6. ncbi CpG methylation of a silent controlling element in the murine Avy allele is incomplete and unresponsive to methyl donor supplementation
    Jennifer E Cropley
    Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia
    PLoS ONE 5:e9055. 2010
  7. ncbi Controlling elements are wild cards in the epigenomic deck
    Jennifer E Cropley
    Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst, Sydney NSW 2010, Australia
    Proc Natl Acad Sci U S A 104:18879-80. 2007
  8. ncbi Germ-line epigenetic modification of the murine A vy allele by nutritional supplementation
    Jennifer E Cropley
    Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst 2010, Sydney, Australia
    Proc Natl Acad Sci U S A 103:17308-12. 2006
  9. ncbi Paramutation: the tip of an epigenetic iceberg?
    Catherine M Suter
    Victor Chang Cardiac Research Institute, 405 Liverpool St, Darlinghurst, Sydney, NSW 2010, Australia
    Trends Genet 26:9-14. 2010
  10. ncbi CpG hypomethylation in a large domain encompassing the embryonic beta-like globin genes in primitive erythrocytes
    Mei Hsu
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, New Hampshire, USA
    Mol Cell Biol 27:5047-54. 2007

Research Grants

  1. Germline epimutation of hMLH1 as a factor in HNPCC
    David Martin; Fiscal Year: 2006
  2. Diet, Epigenetic Events, And Cancer Prevention
    David Martin; Fiscal Year: 2009

Collaborators

  • Robyn Lynne Ward
  • Catherine M Suter
  • Jennifer E Cropley
  • Frazer Meacham
  • Kenneth B Beckman
  • Mei Hsu
  • Megan P Hitchins
  • Lior Pachter
  • Meromit Singer
  • Joseph Dhahbi
  • Dario Boffelli
  • Justin J L Wong
  • Christopher H Lowrey
  • Rodwell Mabaera
  • Nicholas J Hawkins
  • Graeme Suthers
  • Steven Fiering

Detail Information

Publications14

  1. ncbi Identification and correction of systematic error in high-throughput sequence data
    Frazer Meacham
    Department of Mathematics, University of California, Berkeley, 970 Evans Hall 3840, Berkeley, CA 94720, USA
    BMC Bioinformatics 12:451. 2011
    ..We describe a new type of systematic error that manifests as statistically unlikely accumulations of errors at specific genome (or transcriptome) locations...
  2. ncbi Germline epimutation: A basis for epigenetic disease in humans
    David I K Martin
    Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia
    Ann N Y Acad Sci 1054:68-77. 2005
    ..The application of this principle to the thalassemias is discussed...
  3. ncbi Phyloepigenomic comparison of great apes reveals a correlation between somatic and germline methylation states
    David I K Martin
    Center for Genetics, Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Genome Res 21:2049-57. 2011
    ..These results provide evidence for epigenetic changes that occur in the germline and distinguish closely related species and suggest that germline epigenetic states might constrain somatic states...
  4. ncbi Germline epimutation of MLH1 in individuals with multiple cancers
    Catherine M Suter
    Department of Medical Oncology, St Vincent s Hospital, Sydney, New South Wales, Australia
    Nat Genet 36:497-501. 2004
    ..The mosaicism and nonmendelian inheritance that are characteristic of epigenetic states could produce patterns of disease risk that resemble those of polygenic or complex traits...
  5. ncbi Germline epimutation in humans
    Jennifer E Cropley
    Molecular Genetics Division, Victor Chang Cardiac Research Institute, Sydney, Australia
    Pharmacogenomics 9:1861-8. 2008
    ..In this article, we will review the recent findings with germline epimutation at the tumor suppressor gene MLH1, discuss the possible etiology of this phenomenon, and the implications of germline epimutation in humans...
  6. ncbi CpG methylation of a silent controlling element in the murine Avy allele is incomplete and unresponsive to methyl donor supplementation
    Jennifer E Cropley
    Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia
    PLoS ONE 5:e9055. 2010
    ..Phenotypic variation between A(vy) mice indicates that the epigenetic state of the IAP is unstable in the germline...
  7. ncbi Controlling elements are wild cards in the epigenomic deck
    Jennifer E Cropley
    Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst, Sydney NSW 2010, Australia
    Proc Natl Acad Sci U S A 104:18879-80. 2007
  8. ncbi Germ-line epigenetic modification of the murine A vy allele by nutritional supplementation
    Jennifer E Cropley
    Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst 2010, Sydney, Australia
    Proc Natl Acad Sci U S A 103:17308-12. 2006
    ..Although other reports have suggested such heritable epigenetic changes, this study demonstrates that a specific mammalian gene can be subjected to germ-line epigenetic change...
  9. ncbi Paramutation: the tip of an epigenetic iceberg?
    Catherine M Suter
    Victor Chang Cardiac Research Institute, 405 Liverpool St, Darlinghurst, Sydney, NSW 2010, Australia
    Trends Genet 26:9-14. 2010
    ..When viewed in this context, paramutation is only one aspect of a common and broadly distributed form of inheritance based on epigenetic states...
  10. ncbi CpG hypomethylation in a large domain encompassing the embryonic beta-like globin genes in primitive erythrocytes
    Mei Hsu
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, New Hampshire, USA
    Mol Cell Biol 27:5047-54. 2007
    ..The existence of this large developmentally regulated domain of hypomethylation supports a mechanistic role for DNA methylation in developmental regulation of globin genes...
  11. ncbi Inheritance of a cancer-associated MLH1 germ-line epimutation
    Megan P Hitchins
    Department of Medical Oncology, St Vincent s Hospital, Sydney, Australia
    N Engl J Med 356:697-705. 2007
    ..These findings demonstrate a novel pattern of inheritance of cancer susceptibility and are consistent with transgenerational epigenetic inheritance...
  12. ncbi Inherited epimutation or a haplotypic basis for the propensity to silence?
    Catherine M Suter
    Nat Genet 39:573; author reply 576. 2007
  13. ncbi Methyl donors change the germline epigenetic state of the A(vy) allele
    Jennifer E Cropley
    FASEB J 21:3021; author reply 3021-2. 2007
  14. ncbi Activators antagonize heterochromatic silencing: reply to Eissenberg
    David I K Martin
    Bioessays 24:102; author reply 103. 2002

Research Grants7

  1. Germline epimutation of hMLH1 as a factor in HNPCC
    David Martin; Fiscal Year: 2006
    ..They may also produce the first clear evidence that epigenetic silencing can be inherited to produce a familial disorder such as HNPCC. ..
  2. Diet, Epigenetic Events, And Cancer Prevention
    David Martin; Fiscal Year: 2009
    ..3. Investigate effects of methyl donor supplementation on CpG methylation of the A-vy allele We will use bisulphite allelic sequencing to obtain a detailed picture of the methylation status of the allele in mice bred for Aims 1 and 2. ..