Philana Ling Lin

Summary

Affiliation: Children's Hospital of Pittsburgh
Country: USA

Publications

  1. pmc The mutation rate of mycobacterial repetitive unit loci in strains of M. tuberculosis from cynomolgus macaque infection
    Mark N Ragheb
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA
    BMC Genomics 14:145. 2013
  2. ncbi request reprint Safety and immunogenicity of the American Academy of Pediatrics--recommended sequential pneumococcal conjugate and polysaccharide vaccine schedule in pediatric solid organ transplant recipients
    Philana Ling Lin
    Department of Pediatrics, Children s Hospital of Pittsburgh, PA 15213, USA
    Pediatrics 116:160-7. 2005
  3. ncbi request reprint Tumor necrosis factor and tuberculosis
    Philana Ling Lin
    Department of Pediatrics, Children s Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Investig Dermatol Symp Proc 12:22-5. 2007
  4. doi request reprint Immunological concepts in tuberculosis diagnostics for non-human primates: a review
    Philana Ling Lin
    Department of Pediatrics, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    J Med Primatol 37:44-51. 2008
  5. pmc Tumor necrosis factor neutralization results in disseminated disease in acute and latent Mycobacterium tuberculosis infection with normal granuloma structure in a cynomolgus macaque model
    Philana Ling Lin
    Children s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Arthritis Rheum 62:340-50. 2010
  6. pmc Simian immunodeficiency virus-induced changes in T cell cytokine responses in cynomolgus macaques with latent Mycobacterium tuberculosis infection are associated with timing of reactivation
    Joshua T Mattila
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Immunol 186:3527-37. 2011
  7. pmc Quantitative comparison of active and latent tuberculosis in the cynomolgus macaque model
    Philana Ling Lin
    Department of Pediatrics, Children s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15224, USA
    Infect Immun 77:4631-42. 2009
  8. pmc Reactivation of latent tuberculosis in cynomolgus macaques infected with SIV is associated with early peripheral T cell depletion and not virus load
    Collin R Diedrich
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 5:e9611. 2010
  9. pmc CD4 T cell depletion exacerbates acute Mycobacterium tuberculosis while reactivation of latent infection is dependent on severity of tissue depletion in cynomolgus macaques
    Philana Ling Lin
    Department of Pediatrics, Children s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    AIDS Res Hum Retroviruses 28:1693-702. 2012
  10. pmc Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms
    Joshua T Mattila
    Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Immunol 191:773-84. 2013

Research Grants

  1. TNF and Granuloma Formation in Tuberculosis
    PHILANA LIN; Fiscal Year: 2007

Collaborators

Detail Information

Publications21

  1. pmc The mutation rate of mycobacterial repetitive unit loci in strains of M. tuberculosis from cynomolgus macaque infection
    Mark N Ragheb
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA
    BMC Genomics 14:145. 2013
    ..From these data, we have estimated the rate of MIRU variation in the host environment, providing a benchmark rate for future epidemiologic work...
  2. ncbi request reprint Safety and immunogenicity of the American Academy of Pediatrics--recommended sequential pneumococcal conjugate and polysaccharide vaccine schedule in pediatric solid organ transplant recipients
    Philana Ling Lin
    Department of Pediatrics, Children s Hospital of Pittsburgh, PA 15213, USA
    Pediatrics 116:160-7. 2005
    ..Accordingly, this study was designed to evaluate the safety and immunogenicity of the recommended regimen...
  3. ncbi request reprint Tumor necrosis factor and tuberculosis
    Philana Ling Lin
    Department of Pediatrics, Children s Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Investig Dermatol Symp Proc 12:22-5. 2007
    ..We are using animal models to understand how TNF neutralization by these drugs can lead to reactivation of tuberculosis...
  4. doi request reprint Immunological concepts in tuberculosis diagnostics for non-human primates: a review
    Philana Ling Lin
    Department of Pediatrics, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    J Med Primatol 37:44-51. 2008
    ..Lastly, the risk and benefits to the primate colony, staff and resources must be carefully weighed when deciding to euthanize monkeys to make the diagnosis of tuberculosis...
  5. pmc Tumor necrosis factor neutralization results in disseminated disease in acute and latent Mycobacterium tuberculosis infection with normal granuloma structure in a cynomolgus macaque model
    Philana Ling Lin
    Children s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Arthritis Rheum 62:340-50. 2010
    ..This study was undertaken to investigate immune modulation in the setting of TNF neutralization in primary and latent tuberculosis in a non-human primate model...
  6. pmc Simian immunodeficiency virus-induced changes in T cell cytokine responses in cynomolgus macaques with latent Mycobacterium tuberculosis infection are associated with timing of reactivation
    Joshua T Mattila
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Immunol 186:3527-37. 2011
    ..Moreover, it appears that mycobacteria-specific multifunctional T cells are better correlates of Ag load (i.e., disease status) than of protection...
  7. pmc Quantitative comparison of active and latent tuberculosis in the cynomolgus macaque model
    Philana Ling Lin
    Department of Pediatrics, Children s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15224, USA
    Infect Immun 77:4631-42. 2009
    ..Finally, we have observed a spectrum of disease not only in monkeys with active disease but also in those with latent infection that provides insight into human latent tuberculosis...
  8. pmc Reactivation of latent tuberculosis in cynomolgus macaques infected with SIV is associated with early peripheral T cell depletion and not virus load
    Collin R Diedrich
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 5:e9611. 2010
    ..Granulomas from these animals demonstrated histopathologic characteristics consistent with a chronically active disease process. These results suggest initial T cell depletion may strongly influence outcomes of HIV-Mtb co-infection...
  9. pmc CD4 T cell depletion exacerbates acute Mycobacterium tuberculosis while reactivation of latent infection is dependent on severity of tissue depletion in cynomolgus macaques
    Philana Ling Lin
    Department of Pediatrics, Children s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    AIDS Res Hum Retroviruses 28:1693-702. 2012
    ..CD4 depletion influences CD8 T cell function. This study has important implications for human HIV-M. tuberculosis coinfection...
  10. pmc Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms
    Joshua T Mattila
    Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Immunol 191:773-84. 2013
    ..Together, these data support the concept that granulomas have organized microenvironments that balance antimicrobial anti-inflammatory responses to limit pathology in the lungs. ..
  11. pmc The multistage vaccine H56 boosts the effects of BCG to protect cynomolgus macaques against active tuberculosis and reactivation of latent Mycobacterium tuberculosis infection
    Philana Ling Lin
    Department of Pediatrics, Children s Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Clin Invest 122:303-14. 2012
    ..Our results indicate that H56/IC31 boosting is able to control late-stage infection with M. tuberculosis and contain latent tuberculosis, providing a rationale for the clinical development of H56...
  12. pmc Early events in Mycobacterium tuberculosis infection in cynomolgus macaques
    Philana Ling Lin
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, W1157 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    Infect Immun 74:3790-803. 2006
    ..From these studies, we conclude that immune responses to M. tuberculosis are relatively slow in the local and peripheral compartments and that necrosis occurs surprisingly quickly during granuloma formation...
  13. ncbi request reprint Tumor necrosis factor and chemokine interactions in the formation and maintenance of granulomas in tuberculosis
    Holly M Scott Algood
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Clin Infect Dis 41:S189-93. 2005
    ..Chemokines are small molecules that direct the migration of cells within the body. Our data support the notion that TNF is required for appropriate chemokine expression by M. tuberculosis-infected macrophages, both in vitro and in vivo...
  14. pmc Metronidazole prevents reactivation of latent Mycobacterium tuberculosis infection in macaques
    Philana Ling Lin
    Division of Infectious Diseases, Department of Pediatrics, Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Proc Natl Acad Sci U S A 109:14188-93. 2012
    ..Our data in the nonhuman primate model of active and latent TB supports targeting bacteria in hypoxic environments for preventing reactivation of latent infection and possibly shortening the duration of therapy in active TB...
  15. ncbi request reprint TNF influences chemokine expression of macrophages in vitro and that of CD11b+ cells in vivo during Mycobacterium tuberculosis infection
    Holly M Scott Algood
    Department of Molecular Genetics and Biochemistry and Molecular Virology and Microbiology Graduate Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Immunol 172:6846-57. 2004
    ..Therefore, TNF affects the expression of chemokines by macrophages in vitro and CD11b(+) cells in vivo, which probably influences the local chemokine gradients and granuloma formation...
  16. pmc Understanding latent tuberculosis: a moving target
    Philana Ling Lin
    Department of Pediatrics, Children s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA
    J Immunol 185:15-22. 2010
    ..The immunology of TB is complex and multifaceted. Identifying the immune mechanisms that lead to control of initial infection and prevent reactivation of latent infection is crucial to combating this disease...
  17. pmc Comparison of the effects of pathogenic simian human immunodeficiency virus strains SHIV-89.6P and SHIV-KU2 in cynomolgus macaques
    Santosh N Pawar
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    AIDS Res Hum Retroviruses 24:643-54. 2008
    ..SHIV-89.6P induced more IFN-gamma expression than SHIV-KU2. These results indicate SHIV-89.6P and SHIV-KU2 infect cynomolgus macaques and may be used to accurately model effects of HIV infection on latent TB...
  18. ncbi request reprint Incidence of invasive pneumococcal disease in children 3 to 36 months of age at a tertiary care pediatric center 2 years after licensure of the pneumococcal conjugate vaccine
    Philana Ling Lin
    Division of Pediatric Infectious Diseases, Children s Hospital of Pittsburgh, PA 15213, USA
    Pediatrics 111:896-9. 2003
  19. doi request reprint Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing
    Philana Ling Lin
    1 Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA 2
    Nat Med 20:75-9. 2014
    ..Defining the local factors that dictate outcome will be useful in developing effective interventions to prevent active TB. ..
  20. doi request reprint Chronic granulomatous disease in an adolescent with recurrent impetigo and cholecystectomy
    Ellen T Scholnicoff
    Division of Pulmonary Medicine, Allergy, and Immunology, Children s Hospital of Pittsburgh, Pittsburgh, PA, USA
    Pediatr Infect Dis J 28:255-7. 2009
    ..We report the case of a 12-year-old girl with recurrent impetigo whose history of cholecystitis triggered an evaluation that revealed chronic granulomatous disease...
  21. pmc Differences in reactivation of tuberculosis induced from anti-TNF treatments are based on bioavailability in granulomatous tissue
    Simeone Marino
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    PLoS Comput Biol 3:1909-24. 2007
    ..Alternatively, the dose and timing of anti-TNF therapy could be modified. Anti-TNF therapy will likely lead to numerous incidents of primary TB if used in areas where exposure is likely...

Research Grants2

  1. TNF and Granuloma Formation in Tuberculosis
    PHILANA LIN; Fiscal Year: 2007
    ..These changes will be analyzed the context of granuloma structure and host response to infection. The University of Pittsburgh provides an ideal research environment to support this training program. ..