SoJung Lee

Summary

Affiliation: Children's Hospital of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Waist circumference is an independent predictor of insulin resistance in black and white youths
    SoJung Lee
    Children s Hospital of Pittsburgh, Division of Pediatric Endocrinology, Metabolism, and Diabetes Mellitus, Weight Management and Wellness Center, 3705 Fifth Avenue at DeSoto Street, Pittsburgh, PA 15213, USA
    J Pediatr 148:188-94. 2006
  2. ncbi request reprint Insulin resistance: link to the components of the metabolic syndrome and biomarkers of endothelial dysfunction in youth
    SoJung Lee
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, PA 15213, USA
    Diabetes Care 30:2091-7. 2007
  3. doi request reprint Effects of acute exercise on postprandial triglyceride response after a high-fat meal in overweight black and white adolescents
    S Lee
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Int J Obes (Lond) 37:966-71. 2013
  4. pmc Relationships between insulin sensitivity, skeletal muscle mass and muscle quality in obese adolescent boys
    S Lee
    Division of Weight Management and Wellness, University of Pittsburgh School of Medicine, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA
    Eur J Clin Nutr 66:1366-8. 2012
  5. pmc Effects of aerobic versus resistance exercise without caloric restriction on abdominal fat, intrahepatic lipid, and insulin sensitivity in obese adolescent boys: a randomized, controlled trial
    SoJung Lee
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Diabetes 61:2787-95. 2012
  6. pmc Skeletal muscle lipid content and insulin sensitivity in black versus white obese adolescents: is there a race differential?
    SoJung Lee
    Division of Weight Management and Wellness, Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15201, USA
    J Clin Endocrinol Metab 95:2426-32. 2010
  7. pmc Measurement site of visceral adipose tissue and prediction of metabolic syndrome in youth
    SoJung Lee
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Pediatr Diabetes 12:250-7. 2011
  8. pmc β-Cell lipotoxicity in response to free fatty acid elevation in prepubertal youth: African American versus Caucasian contrast
    Sara F Michaliszyn
    Division of Weight Management, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Diabetes 62:2917-22. 2013
  9. pmc In vivo insulin sensitivity and secretion in obese youth: what are the differences between normal glucose tolerance, impaired glucose tolerance, and type 2 diabetes?
    Fida Bacha
    Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes Care 32:100-5. 2009
  10. pmc β-Cell lipotoxicity after an overnight intravenous lipid challenge and free fatty acid elevation in African American versus American white overweight/obese adolescents
    Kara S Hughan
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15224, USA
    J Clin Endocrinol Metab 98:2062-9. 2013

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Waist circumference is an independent predictor of insulin resistance in black and white youths
    SoJung Lee
    Children s Hospital of Pittsburgh, Division of Pediatric Endocrinology, Metabolism, and Diabetes Mellitus, Weight Management and Wellness Center, 3705 Fifth Avenue at DeSoto Street, Pittsburgh, PA 15213, USA
    J Pediatr 148:188-94. 2006
    ..We examined how well waist circumference (WC) reflects total and abdominal fat and whether WC predicts insulin resistance independent of body mass index (BMI) percentile in youths...
  2. ncbi request reprint Insulin resistance: link to the components of the metabolic syndrome and biomarkers of endothelial dysfunction in youth
    SoJung Lee
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, PA 15213, USA
    Diabetes Care 30:2091-7. 2007
    ..We examined the relationship of in vivo insulin sensitivity to the components of the metabolic syndrome and biomarkers of endothelial dysfunction in youth...
  3. doi request reprint Effects of acute exercise on postprandial triglyceride response after a high-fat meal in overweight black and white adolescents
    S Lee
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Int J Obes (Lond) 37:966-71. 2013
    ..We examined the effects of acute exercise on postprandial triglyceride (TG) metabolism following a high-fat meal in overweight black vs white adolescents...
  4. pmc Relationships between insulin sensitivity, skeletal muscle mass and muscle quality in obese adolescent boys
    S Lee
    Division of Weight Management and Wellness, University of Pittsburgh School of Medicine, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA
    Eur J Clin Nutr 66:1366-8. 2012
    ..Our findings suggest that SM quality, but not SM mass, is associated with IS in obese adolescent boys...
  5. pmc Effects of aerobic versus resistance exercise without caloric restriction on abdominal fat, intrahepatic lipid, and insulin sensitivity in obese adolescent boys: a randomized, controlled trial
    SoJung Lee
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Diabetes 61:2787-95. 2012
    ..72) and insulin sensitivity (r = -0.47). Both AE and RE alone are effective for reducing abdominal fat and intrahepatic lipid in obese adolescent boys. RE but not AE is also associated with significant improvements in insulin sensitivity...
  6. pmc Skeletal muscle lipid content and insulin sensitivity in black versus white obese adolescents: is there a race differential?
    SoJung Lee
    Division of Weight Management and Wellness, Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15201, USA
    J Clin Endocrinol Metab 95:2426-32. 2010
    ..We tested the hypothesis that skeletal muscle lipid content (SMLC) is higher in obese black adolescents compared with their white peers and assessed the relationship between SMLC and insulin sensitivity (IS)...
  7. pmc Measurement site of visceral adipose tissue and prediction of metabolic syndrome in youth
    SoJung Lee
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Pediatr Diabetes 12:250-7. 2011
    ..We examined the influence of the measurement site of VAT on the relationships between VAT and metabolic syndrome (MetS) in African-American (AA) and American-White (AW) youth...
  8. pmc β-Cell lipotoxicity in response to free fatty acid elevation in prepubertal youth: African American versus Caucasian contrast
    Sara F Michaliszyn
    Division of Weight Management, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Diabetes 62:2917-22. 2013
    ....
  9. pmc In vivo insulin sensitivity and secretion in obese youth: what are the differences between normal glucose tolerance, impaired glucose tolerance, and type 2 diabetes?
    Fida Bacha
    Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes Care 32:100-5. 2009
    ..The aim of this study was to investigate the differences in insulin sensitivity (IS) and secretion in obese adolescents with IGT compared with those with normal glucose tolerance (NGT) and type 2 diabetes...
  10. pmc β-Cell lipotoxicity after an overnight intravenous lipid challenge and free fatty acid elevation in African American versus American white overweight/obese adolescents
    Kara S Hughan
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15224, USA
    J Clin Endocrinol Metab 98:2062-9. 2013
    ..The present study investigated β-cell lipotoxicity to test whether increased free fatty acid (FFA) levels result in greater β-cell dysfunction in AA vs AW OW/OB adolescents...
  11. pmc Metabolomic profiling of amino acids and β-cell function relative to insulin sensitivity in youth
    Sara F Michaliszyn
    Children s Hospital of Pittsburgh, 4401 Penn Avenue, Pittsburgh, Pennsylvania 15224, USA
    J Clin Endocrinol Metab 97:E2119-24. 2012
    ..In longitudinal studies of adults, elevated amino acid (AA) concentrations predicted future type 2 diabetes mellitus (T2DM)...
  12. pmc 25-hydroxyvitamin D concentrations and in vivo insulin sensitivity and β-cell function relative to insulin sensitivity in black and white youth
    Kumaravel Rajakumar
    Department of Pediatrics, Division of General Academic Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Diabetes Care 35:627-33. 2012
    ..To examine the relationships between plasma 25-hydroxyvitamin D [25(OH)D] and in vivo insulin sensitivity and β-cell function relative to insulin sensitivity, disposition index (DI), in black and white youth...
  13. pmc Surrogate estimates of insulin sensitivity in obese youth along the spectrum of glucose tolerance from normal to prediabetes to diabetes
    Lindsey George
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15224, USA
    J Clin Endocrinol Metab 96:2136-45. 2011
    ..In epidemiological studies of childhood obesity, simple and reliable surrogate estimates of insulin sensitivity are needed because the gold standard, the hyperinsulinemic-euglycemic clamp, is not feasible on a large scale...
  14. pmc Effects of an overnight intravenous lipid infusion on intramyocellular lipid content and insulin sensitivity in African-American versus Caucasian adolescents
    SoJung Lee
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15224, USA
    Metabolism 62:417-23. 2013
    ....
  15. pmc HbA(1c) diagnostic categories and β-cell function relative to insulin sensitivity in overweight/obese adolescents
    Lindsey A Sjaarda
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Diabetes Care 35:2559-63. 2012
    ..We hypothesized that alterations in the pathophysiologic mechanisms of type 2 diabetes may be evident in the American Diabetes Association recommended at-risk/prediabetes category (HbA(1c) 5.7 to <6.5%)...
  16. pmc Type 2 diabetes in youth: are there racial differences in β-cell responsiveness relative to insulin sensitivity?
    Fida Bacha
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh, Pittsburgh, PA, USA
    Pediatr Diabetes 13:259-65. 2012
    ..Non-diabetic African American (AA) youth have an upregulated insulin secretion relative to insulin sensitivity (IS) compared with their American White (AW) peers. We investigated if similar racial differences exist in youth with T2DM...
  17. pmc From pre-diabetes to type 2 diabetes in obese youth: pathophysiological characteristics along the spectrum of glucose dysregulation
    Fida Bacha
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes Care 33:2225-31. 2010
    ..We investigated differences in insulin sensitivity and secretion among youth with IFG, IGT, and coexistent IFG/IGT compared with those with normal glucose tolerance (NGT) and type 2 diabetes...
  18. ncbi request reprint Cardiorespiratory fitness in youth: relationship to insulin sensitivity and beta-cell function
    SoJung Lee
    Children s Hospital of Pittsburgh, Division of Pediatric Endocrinology, Metabolism, and Diabetes Mellitus, Weight Management and Wellness Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Obesity (Silver Spring) 14:1579-85. 2006
    ..We examined whether the relationship between cardiorespiratory fitness (CRF) and insulin sensitivity (IS)/secretion is independent of adiposity in healthy African-American (n = 65) and white (n = 57) youth...
  19. pmc In vivo insulin sensitivity and lipoprotein particle size and concentration in black and white children
    Stephen F Burns
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Diabetes Care 32:2087-93. 2009
    ..To examine sex-specific black/white differences in lipoprotein profile and the role of visceral adiposity and to assess the relationship between insulin sensitivity and lipoprotein profiles in each group...
  20. pmc Polycystic ovary syndrome and nonalcoholic fatty liver in obese adolescents: association with metabolic risk profile
    Sara F Michaliszyn
    Division of Weight Management, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
    Fertil Steril 100:1745-51. 2013
    ..To investigate the relationship between liver fat and in vivo insulin sensitivity, body composition, abdominal adiposity, and lipid metabolism in obese adolescent girls with polycystic ovary syndrome (PCOS)...
  21. pmc Progressive deterioration of β-cell function in obese youth with type 2 diabetes
    Fida Bacha
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA
    Pediatr Diabetes 14:106-11. 2013
    ..In adults, type 2 diabetes (T2DM) is characterized with progressive deterioration in insulin secretion. Data are scanty in youth. We investigated prospectively the change in β-cell function and in insulin sensitivity in youth with T2DM...
  22. pmc Indices of insulin secretion during a liquid mixed-meal test in obese youth with diabetes
    Fida Bacha
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    J Pediatr 162:924-9. 2013
    ....
  23. ncbi request reprint Racial differences in adiponectin in youth: relationship to visceral fat and insulin sensitivity
    SoJung Lee
    Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Weight Management and Wellness Center, Children s Hospital of Pittsburgh, 3705 Fifth Avenue at DeSoto St, Pittsburgh, Pennsylvania 15213, USA
    Diabetes Care 29:51-6. 2006
    ....
  24. doi request reprint Race and gender differences in the relationships between anthropometrics and abdominal fat in youth
    SoJung Lee
    Children s Hospital of Pittsburgh, Division of Weight Management and Wellness, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Obesity (Silver Spring) 16:1066-71. 2008
    ..We examined the influence of race and gender on abdominal adipose tissue (AT) distribution for a given anthropometric measure including waist circumference (WC), waist-to-hip ratio (WHR) and waist-to-height (W/Ht) in youth...
  25. pmc Vitamin D status, adiposity, and lipids in black American and Caucasian children
    Kumaravel Rajakumar
    Department of Pediatrics, Division of General Academic Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224, USA
    J Clin Endocrinol Metab 96:1560-7. 2011
    ..The aim of the study was to examine the relationship between vitamin D status, total and abdominal adiposity, and lipids in black and white children...
  26. pmc Fat oxidation in black and white youth: a metabolic phenotype potentially predisposing black girls to obesity
    SoJung Lee
    University of Pittsburgh, School of Medicine, Weight Management and Wellness Center, Pediatric Clinical and Translational Research Center, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 93:4547-51. 2008
    ..Thus, we examined the relationships between race, pubertal development, and postabsorptive fat oxidation in youth...
  27. pmc Oral disposition index in obese youth from normal to prediabetes to diabetes: relationship to clamp disposition index
    Lindsey George Sjaarda
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA
    J Pediatr 161:51-7. 2012
    ....
  28. doi request reprint Comparison of different definitions of pediatric metabolic syndrome: relation to abdominal adiposity, insulin resistance, adiponectin, and inflammatory biomarkers
    SoJung Lee
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Pediatr 152:177-84. 2008
    ....
  29. pmc Drospirenone/ethinyl estradiol versus rosiglitazone treatment in overweight adolescents with polycystic ovary syndrome: comparison of metabolic, hormonal, and cardiovascular risk factors
    Hala Tfayli
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15224, USA
    J Clin Endocrinol Metab 96:1311-9. 2011
    ..Adolescents with polycystic ovary syndrome (PCOS) have insulin resistance and higher rates of the metabolic syndrome...
  30. pmc Declining beta-cell function relative to insulin sensitivity with increasing fasting glucose levels in the nondiabetic range in children
    Hala Tfayli
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Diabetes Care 33:2024-30. 2010
    ..This investigation tested the hypothesis that beta-cell function relative to insulin sensitivity decreases with increasing FPG in youth...
  31. pmc Measuring β-cell function relative to insulin sensitivity in youth: does the hyperglycemic clamp suffice?
    Lindsey Sjaarda
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Diabetes Care 36:1607-12. 2013
    ....
  32. pmc Metabolomic profiling of fatty acid and amino acid metabolism in youth with obesity and type 2 diabetes: evidence for enhanced mitochondrial oxidation
    Stephanie J Mihalik
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Diabetes Care 35:605-11. 2012
    ..We compared acylcarnitine (AcylCN) species, common amino acid and fat oxidation (FOX) byproducts, and plasma amino acids in normal weight (NW; n = 39), obese (OB; n = 64), and type 2 diabetic (n = 17) adolescents...
  33. ncbi request reprint Waist circumference, blood pressure, and lipid components of the metabolic syndrome
    SoJung Lee
    Weight Management and Wellness Center and Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Pediatr 149:809-16. 2006
    ..To examine whether waist circumference (WC) predicts blood pressure (BP) and lipid components of the metabolic syndrome independent of body mass index (BMI) percentile in youths...
  34. pmc Sleep-disordered breathing in obese adolescents is associated with visceral adiposity and markers of insulin resistance
    Tamara S Hannon
    Division of Weight Management and Wellness, Department of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Int J Pediatr Obes 6:157-60. 2011
    ..Further study to allow for critical assessment of the relationships between sleep-disordered breathing and cardiometabolic risk factors in obese youth remains necessary...
  35. doi request reprint Physical activity and abdominal obesity in youth
    YoonMyung Kim
    Department of Health and Physical Activity, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Appl Physiol Nutr Metab 34:571-81. 2009
    ..However, evidence regarding the effect of resistance training alone as a strategy for the treatment of abdominal obesity is lacking and warrants further investigation...
  36. pmc Whole-body MRI and ethnic differences in adipose tissue and skeletal muscle distribution in overweight black and white adolescent boys
    SoJung Lee
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Faculty Pavilion Sixth Floor 6102, 400 45th Street, Pittsburgh, PA 15224, USA
    J Obes 2011:159373. 2011
    ..For a given amount of total SM, black boys had more (P < .05) SM in the thigh. Compared with overweight white boys, overweight black boys have less visceral fat, more subcutaneous fat, and more thigh skeletal muscle...
  37. pmc Changes in fat and skeletal muscle with exercise training in obese adolescents: comparison of whole-body MRI and dual energy X-ray absorptiometry
    SoJung Lee
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Obesity (Silver Spring) 21:2063-71. 2013
    ..We examined skeletal muscle (SM) and fat distribution using whole-body MRI in response to aerobic (AE) versus resistance exercise (RE) training in obese adolescents and whether DXA provides similar estimates of fat and SM change as MRI...