Ashutosh Lal

Summary

Affiliation: Children's Hospital and Research Center
Country: USA

Publications

  1. pmc Combined chelation therapy with deferasirox and deferoxamine in thalassemia
    Ashutosh Lal
    Hematology Oncology, Children s Hospital and Research Center, Oakland, CA 94609, USA
    Blood Cells Mol Dis 50:99-104. 2013
  2. ncbi request reprint Bone mineral density in children with sickle cell anemia
    Ashutosh Lal
    Children s Hospital and Research Center at Oakland, Oakland, California 94609, USA
    Pediatr Blood Cancer 47:901-6. 2006
  3. doi request reprint Lipoic acid and acetyl-carnitine reverse iron-induced oxidative stress in human fibroblasts
    Ashutosh Lal
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, Oakland, California, USA
    Redox Rep 13:2-10. 2008
  4. pmc Association of chromosome damage detected as micronuclei with hematological diseases and micronutrient status
    Ashutosh Lal
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Mutagenesis 26:57-62. 2011
  5. doi request reprint Heterogeneity of hemoglobin H disease in childhood
    Ashutosh Lal
    Hematology Oncology, Children s Hospital and Research Center Oakland, Oakland, CA 94609, USA
    N Engl J Med 364:710-8. 2011
  6. ncbi request reprint Measuring chromosome breaks in patients with thalassemia
    Tal Offer
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Ann N Y Acad Sci 1054:439-44. 2005
  7. pmc A nutrient-dense, high-fiber, fruit-based supplement bar increases HDL cholesterol, particularly large HDL, lowers homocysteine, and raises glutathione in a 2-wk trial
    Michele L Mietus-Snyder
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, Oakland, California, 94609, USA
    FASEB J 26:3515-27. 2012
  8. pmc Clinical assay of four thiol amino acid redox couples by LC-MS/MS: utility in thalassemia
    Jung H Suh
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 877:3418-27. 2009
  9. ncbi request reprint The role of fetal hemoglobin-enhancing agents in thalassemia
    Ashutosh Lal
    Department of Hematology Oncology, Children s Hospital and Research Center at Oakland, Oakland, CA 94609, USA
    Semin Hematol 41:17-22. 2004

Collaborators

Detail Information

Publications9

  1. pmc Combined chelation therapy with deferasirox and deferoxamine in thalassemia
    Ashutosh Lal
    Hematology Oncology, Children s Hospital and Research Center, Oakland, CA 94609, USA
    Blood Cells Mol Dis 50:99-104. 2013
    ..03±0.01 μM, p=0.006). The simultaneous administration of DFO and DFX rapidly reduced systemic and myocardial iron, and provided an excellent control of the toxic labile plasma iron species without an increase in toxicity...
  2. ncbi request reprint Bone mineral density in children with sickle cell anemia
    Ashutosh Lal
    Children s Hospital and Research Center at Oakland, Oakland, California 94609, USA
    Pediatr Blood Cancer 47:901-6. 2006
    ..We evaluated bone mineral density (BMD) and risk factors for poor bone mineralization in children with sickle cell anemia (SCA)...
  3. doi request reprint Lipoic acid and acetyl-carnitine reverse iron-induced oxidative stress in human fibroblasts
    Ashutosh Lal
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, Oakland, California, USA
    Redox Rep 13:2-10. 2008
    ..We conclude that LA is highly effective in reversing oxidative stress arising from iron overload and that its antioxidant efficacy is further enhanced in combination with ALCAR...
  4. pmc Association of chromosome damage detected as micronuclei with hematological diseases and micronutrient status
    Ashutosh Lal
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Mutagenesis 26:57-62. 2011
    ..Understanding the link between micronutrient status and MN frequency will contribute towards determining optimal micronutrient intake to preserve long-term health...
  5. doi request reprint Heterogeneity of hemoglobin H disease in childhood
    Ashutosh Lal
    Hematology Oncology, Children s Hospital and Research Center Oakland, Oakland, CA 94609, USA
    N Engl J Med 364:710-8. 2011
    ..Early diagnosis during newborn screening or infancy has enabled the observation of the natural history of hemoglobin H disease, a subtype of α-thalassemia...
  6. ncbi request reprint Measuring chromosome breaks in patients with thalassemia
    Tal Offer
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Ann N Y Acad Sci 1054:439-44. 2005
    ..Our findings indicate that higher levels of micronuclei frequencies are present in thalassemic RBCs...
  7. pmc A nutrient-dense, high-fiber, fruit-based supplement bar increases HDL cholesterol, particularly large HDL, lowers homocysteine, and raises glutathione in a 2-wk trial
    Michele L Mietus-Snyder
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, Oakland, California, 94609, USA
    FASEB J 26:3515-27. 2012
    ..These results lay the groundwork for mechanistic/deconstruction experiments to identify critical bar components and putative synergistic combinations responsible for observed effects...
  8. pmc Clinical assay of four thiol amino acid redox couples by LC-MS/MS: utility in thalassemia
    Jung H Suh
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 877:3418-27. 2009
    ..The method was used to assess thiol redox states in plasma and erythrocytes isolated from healthy subjects and thalassemia patients...
  9. ncbi request reprint The role of fetal hemoglobin-enhancing agents in thalassemia
    Ashutosh Lal
    Department of Hematology Oncology, Children s Hospital and Research Center at Oakland, Oakland, CA 94609, USA
    Semin Hematol 41:17-22. 2004
    ..The clinical trials of decitabine in thalassemia must carefully evaluate the dose and route of administration, and address concerns about long-term side effects...