Chia Yi Kuan

Summary

Affiliation: Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi Targeting the JNK signaling pathway for stroke and Parkinson's diseases therapy
    Chia Yi Kuan
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Curr Drug Targets CNS Neurol Disord 4:63-7. 2005
  2. pmc A critical role of neural-specific JNK3 for ischemic apoptosis
    Chia Yi Kuan
    Department of Pediatrics, Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 100:15184-9. 2003
  3. pmc Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain
    Chia Yi Kuan
    Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Neurosci 24:10763-72. 2004
  4. ncbi Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons
    Lei Chen
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Neurosci 27:3884-93. 2007
  5. pmc Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation
    Kei Ichi Katayama
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 108:7607-12. 2011
  6. pmc Plasminogen activator inhibitor-1 mitigates brain injury in a rat model of infection-sensitized neonatal hypoxia-ischemia
    Dianer Yang
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Cereb Cortex 23:1218-29. 2013
  7. pmc Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly
    Lei Chen
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 103:16520-5. 2006
  8. pmc Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy
    Faisal Adhami
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Room 3464, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Am J Pathol 169:566-83. 2006
  9. ncbi Nestin-CreER mice reveal DNA synthesis by nonapoptotic neurons following cerebral ischemia hypoxia
    Kevin A Burns
    Divisions of Developmental Biology and Pediatric Neurology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Cereb Cortex 17:2585-92. 2007
  10. pmc Deleterious effects of plasminogen activators in neonatal cerebral hypoxia-ischemia
    Faisal Adhami
    Division of Developmental Biology and Division of Neurology, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Am J Pathol 172:1704-16. 2008

Collaborators

Detail Information

Publications33

  1. ncbi Targeting the JNK signaling pathway for stroke and Parkinson's diseases therapy
    Chia Yi Kuan
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Curr Drug Targets CNS Neurol Disord 4:63-7. 2005
    ..The mechanisms by which JNK signaling induces apoptosis and evidence of cytoprotective effects of these JNK inhibitors are summarized in the present review...
  2. pmc A critical role of neural-specific JNK3 for ischemic apoptosis
    Chia Yi Kuan
    Department of Pediatrics, Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 100:15184-9. 2003
    ..The downstream mechanism of JNK3-mediated apoptosis may include the induction of Bim and Fas and the mitochondrial release of cytochrome c. These results suggest that JNK3 is a potential target for neuroprotection therapies in stroke...
  3. pmc Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain
    Chia Yi Kuan
    Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Neurosci 24:10763-72. 2004
    ..Manipulating the aberrant apoptosis-associated DNA synthesis that occurs with hypoxia-ischemia and perhaps neurodegenerative diseases could promote neuronal survival and neurogenesis...
  4. ncbi Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons
    Lei Chen
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Neurosci 27:3884-93. 2007
    ..Moreover, they indicate that Rac1 has a critical role in axon guidance and in acquisition of migratory competency during differentiation of the progenitors for the ventral telencephalon-derived interneurons...
  5. pmc Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation
    Kei Ichi Katayama
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 108:7607-12. 2011
    ..These results demonstrate a critical role of RhoA in the maintenance of apical adherens junctions and the regulation of neural progenitor proliferation in the developing mammalian brain...
  6. pmc Plasminogen activator inhibitor-1 mitigates brain injury in a rat model of infection-sensitized neonatal hypoxia-ischemia
    Dianer Yang
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Cereb Cortex 23:1218-29. 2013
    ..Together, because CPAI blocks both proteolytic and nonproteolytic tPA neurotoxicity, it is a promising therapeutics of neonatal HI injury either with or without infection...
  7. pmc Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly
    Lei Chen
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 103:16520-5. 2006
    ..Taken together, these results indicate that Cdc42 has an essential role in establishing the apical-basal polarity of the telencephalic NE, which is needed for the expansion and bifurcation of cerebral hemispheres...
  8. pmc Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy
    Faisal Adhami
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Room 3464, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Am J Pathol 169:566-83. 2006
    ..Together, these results suggest that ischemia-hypoxia is a powerful stimulus for spontaneous coagulation leading to reperfusion deficits and autophagic/lysosomal cell death in brain...
  9. ncbi Nestin-CreER mice reveal DNA synthesis by nonapoptotic neurons following cerebral ischemia hypoxia
    Kevin A Burns
    Divisions of Developmental Biology and Pediatric Neurology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Cereb Cortex 17:2585-92. 2007
    ..These results suggest that the nestin-CreER system is a useful tool for detecting embryonic and adult neurogensis. They also confirm the existence of nonproliferative DNA synthesis by old neurons after experimental brain injury...
  10. pmc Deleterious effects of plasminogen activators in neonatal cerebral hypoxia-ischemia
    Faisal Adhami
    Division of Developmental Biology and Division of Neurology, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Am J Pathol 172:1704-16. 2008
    ....
  11. pmc Ex vivo diffusion tensor imaging and neuropathological correlation in a murine model of hypoxia-ischemia-induced thrombotic stroke
    Ahmed Shereen
    Department of Radiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Cereb Blood Flow Metab 31:1155-69. 2011
    ..Taken together, these results suggest that cross-evaluation of multiple DTI parameters may provide a fuller picture of axonal and dendritic injury in acute ischemic stroke...
  12. doi Intranasal delivery of cell-penetrating anti-NF-κB peptides (Tat-NBD) alleviates infection-sensitized hypoxic-ischemic brain injury
    Dianer Yang
    Division of Developmental Biology, Department of Pediatrics, Cincinnati s Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Exp Neurol 247:447-55. 2013
    ..Together, these results suggest a novel therapy of infection-sensitized HI brain injury in newborns...
  13. doi Taming neonatal hypoxic-ischemic brain injury by intranasal delivery of plasminogen activator inhibitor-1
    Dianer Yang
    Department of Pediatrics, Cincinnati s Children s Hospital Medical Center, Cincinnati, OH, USA
    Stroke 44:2623-7. 2013
    ..Thus, we tested whether intranasal administration of PAI-1 can bypass blood-brain barrier and mitigate neonatal HI brain injury...
  14. ncbi Midgestational lethality in mice lacking the parathyroid hormone (PTH)/PTH-related peptide receptor is associated with abrupt cardiomyocyte death
    Jin Qian
    Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Endocrinology 144:1053-61. 2003
    ..Taken together, these findings indicate that the PTH1R is required for the development of normal cardiomyocyte function...
  15. pmc c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling
    Qiangrong Liang
    Department of Pediatrics, University of Cincinnati, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    EMBO J 22:5079-89. 2003
    ..These results also suggest that myocardial JNK activation is primarily dedicated to modulating calcineurin-NFAT signaling in the regulation of differentiated heart growth...
  16. pmc Gsx2 controls region-specific activation of neural stem cells and injury-induced neurogenesis in the adult subventricular zone
    Alejandro López-Juárez
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    Genes Dev 27:1272-87. 2013
    ..These results demonstrate that mobilization of adult NSCs is controlled in a region-specific manner and that distinct mechanisms operate in continuous and injury-induced neurogenesis in the adult brain...
  17. pmc Jun NH2-terminal kinase (JNK) prevents nuclear beta-catenin accumulation and regulates axis formation in Xenopus embryos
    Guanghong Liao
    Department of Pediatrics, Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 103:16313-8. 2006
    ..Thus, the high level of sustained maternal JNK activity in early Xenopus embryos may provide a timing mechanism for controlling the dorsal axis formation...
  18. pmc Cdc42GAP regulates c-Jun N-terminal kinase (JNK)-mediated apoptosis and cell number during mammalian perinatal growth
    Lei Wang
    Division of Experimental Hematology, Children s Hospital Medical Center, Molecular Developmental Biology Graduate Program, University of Cincinnati, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 102:13484-9. 2005
    ..These results reveal a role of Cdc42GAP in mammalian perinatal growth and implicate the c-Jun N-terminal kinase-mediated apoptosis machinery as a Cdc42 effector pathway in vivo...
  19. ncbi Low doses of bromo- and iododeoxyuridine produce near-saturation labeling of adult proliferative populations in the dentate gyrus
    Kevin A Burns
    Department of Pediatrics, Division of Developmental Biology, Room 3464, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Eur J Neurosci 21:803-7. 2005
    ..These results suggest that the standard dose of BrdU is sufficient to label the majority of proliferative populations in the S-phase in pulse labeling experiments...
  20. pmc Promiscuous recombination of LoxP alleles during gametogenesis in cornea Cre driver mice
    Daniel Y Weng
    Department of Ophthalmology, University of Cincinnati, Cincinnati, OH 45267 0838, USA
    Mol Vis 14:562-71. 2008
    ..To examine whether promiscuous Cre/LoxP recombination happens during gametogenesis in double transgenic mice carrying LoxP modified alleles and Cre transgene driven by tissue-specific promoter outside the gonads of adult mice...
  21. ncbi Retinoic acid induces CDK inhibitors and growth arrest specific (Gas) genes in neural crest cells
    Linping Wang
    Division of Molecular Cardiovascular Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Dev Growth Differ 47:119-30. 2005
    ..This heterogeneity contributes to the pleiotropic effects of RA, specifically those affecting proliferation and cell death...
  22. pmc Rac1 deficiency in the forebrain results in neural progenitor reduction and microcephaly
    Lei Chen
    Divisios of Experimental Hematology, University of Cincinnati, Cincinnati, OH 45229, USA
    Dev Biol 325:162-70. 2009
    ..Together, these results suggest that Rac1 regulates self-renewal, survival, and differentiation of telencephalic neural progenitors, and that dysfunctions of Rac1 may lead to primary microcephaly...
  23. pmc Coordinated control of self-renewal and differentiation of neural stem cells by Myc and the p19ARF-p53 pathway
    Motoshi Nagao
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    J Cell Biol 183:1243-57. 2008
    ..We propose that opposing actions of Myc and the p19(ARF)-p53 pathway have important functions in coordinated developmental control of self-renewal and cell fate choices in NSCs...
  24. ncbi Modulation of germ cell apoptosis with a nitric oxide synthase inhibitor in a murine model of congenital cryptorchidism
    William R DeFoor
    Division of Pediatric Urology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Urol 172:1731-5; discussion 1735. 2004
    ..The Hoxa 11 knockout mouse has congenital bilateral cryptorchidism and is uniformly sterile. We examined the time course of apoptosis in this model and attempted to attenuate this response in vivo by inhibition of NOS...
  25. ncbi The roles of autophagy in cerebral ischemia
    Faisal Adhami
    Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Autophagy 3:42-4. 2007
    ..Finally, we suggest autophagy is an important modifier of cell death and survival, interacting with necrosis and apoptosis in determining the outcomes and final morphology of deceased neurons...
  26. doi Overexpression of vascular endothelial growth factor in the germinal matrix induces neurovascular proteases and intraventricular hemorrhage
    Dianer Yang
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Sci Transl Med 5:193ra90. 2013
    ..Collectively, these results support a causative role of VEGF in perinatal cerebral hemorrhage and implicate its downstream proteases as potential therapeutic targets. ..
  27. pmc Mannitol-facilitated perfusion staining with 2,3,5-triphenyltetrazolium chloride (TTC) for detection of experimental cerebral infarction and biochemical analysis
    Yu Yo Sun
    Division of Developmental Biology, Division of Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, United States
    J Neurosci Methods 203:122-9. 2012
    ..These results demonstrate a fast and inexpensive method that simplifies the task of quantifying cerebral infarction in small or severely injured brains and assists biochemical analysis of experimental cerebral ischemia...
  28. pmc Engineering a lysosomal enzyme with a derivative of receptor-binding domain of apoE enables delivery across the blood-brain barrier
    Daren Wang
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 110:2999-3004. 2013
    ..These findings provide a noninvasive and BBB-targeted procedure for the delivery of large-molecule therapeutic agents to treat neurological lysosomal storage disorders and potentially other diseases that involve the brain...
  29. doi Developmental and post-injury cortical gliogenesis: a genetic fate-mapping study with Nestin-CreER mice
    Kevin A Burns
    Division of Developmental Biology, Division of Neurology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Glia 57:1115-29. 2009
    ..8% after stab-wound injury. Together, these results suggest NG2+ progenitors, rather than GFAP+ astrocytes, are the primary source of proliferative gliosis after adult brain injury...
  30. pmc Therapeutic administration of plasminogen activator inhibitor-1 prevents hypoxic-ischemic brain injury in newborns
    Dianer Yang
    Division of Developmental Biology and Division of Neurology, Department of Radiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Neurosci 29:8669-74. 2009
    ..Together, these results suggest that the brain PA system plays a pivotal role in neonatal cerebral HI and may be a promising therapeutic target in infants suffering hypoxic-ischemic encephalopathy...
  31. ncbi Mixed lineage kinase-c-jun N-terminal kinase signaling pathway: a new therapeutic target in Parkinson's disease
    Robert M Silva
    Department of Neurology, The College of Physicians and Surgeons, Columbia University, 650 West 168th Street, New York, NY 10032, USA
    Mov Disord 20:653-64. 2005
    ..These studies suggest important future directions for the development of therapies that will target this important cell death pathway...
  32. ncbi Specific pathophysiological functions of JNK isoforms in the brain
    Stephan Brecht
    Institute of Pharmacology, University Hospital of Schleswig Holstein, Campus Kiel, Hospitalstrasse 4, 24105 Kiel, Germany
    Eur J Neurosci 21:363-77. 2005
    ..This comprehensive study provides novel insights into the context-dependent physiological and pathological functions of JNK isoforms...
  33. pmc Requirement of JIP scaffold proteins for NMDA-mediated signal transduction
    Norman J Kennedy
    Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Genes Dev 21:2336-46. 2007
    ..JIP complexes interact with the SH2 domain of cFyn and may therefore promote tyrosine phosphorylation and activity of the NMDA receptor. We conclude that JIP scaffold proteins are critically required for normal NMDA receptor function...