Research Topics
| H F KrousSummaryAffiliation: Children's Hospital and Health Center Country: USA Publications
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Detail Information
Publications
Laryngeal basement membrane thickening is not a reliable postmortem marker for SIDS: results from the Chicago Infant Mortality StudyH F Krous
Children s Hospital San Diego, California 92123, USA
Am J Forensic Med Pathol 20:221-7. 1999..Therefore, LBMT should not be used to diagnose SIDS...- Sudden death in toddlers with viral meningitis, massive cerebral edema, and neurogenic pulmonary edema and hemorrhage: report of two casesHenry F Krous
Department of Pathology, Rady Children s Hospital San Diego, San Diego, CA, USA
Pediatr Dev Pathol 10:463-9. 2007..They also underscore the importance of a comprehensive autopsy, including detailed neuropathologic examination and viral testing, in determining of the cause of unexpected death in toddlers... - Tumors associated with sudden infant and childhood deathHenry F Krous
Children s Hospital and Health Center, 3020 Children s Way, MC5007, San Diego, CA 92123, USA
Pediatr Dev Pathol 8:20-5. 2005..The diagnosis of these lesions can be established only after thorough postmortem examination... - Delayed infant death following catastrophic deterioration during breast-feedingHenry F Krous
Children's Hospital and Health Center, San Diego County, California 92123, USA
J Paediatr Child Health 41:215-7. 2005 - Sudden unexpected death in childhood: a report of 50 casesHenry F Krous
Department of Pathology, Children s Hospital and Health Center, San Diego, CA 92123, USA
Pediatr Dev Pathol 8:307-19. 2005..Legislation enabling research and formation of a multicenter research team is recommended to unravel the mystery of SUDC... - Sudden death in a neonate with idiopathic eosinophilic endomyocarditisHenry F Krous
Children s Hospital and Health Center, 3020 Children s Way, MC5007, San Diego, California 92123, USA
Pediatr Dev Pathol 8:587-92. 2005..The medical literature is reviewed... - Child Protective Services referrals in cases of sudden infant death: a 10-year, population-based analysis in San Diego County, CaliforniaHenry F Krous
Children s Hospital, San Diego, CA 92123, USA
Child Maltreat 11:247-56. 2006.... - Hemoglobin F in sudden infant death syndrome: a San Diego SIDS/SUDC Research Project reportHenry F Krous
Rady Children s Hospital and Health Center, 3020 Children s Way, MC5007, San Diego, CA 92123, USA
J Forensic Leg Med 14:456-60. 2007..Given that our results were obtained using optimal methods in well-defined SIDS and control cases, we concur with others that %HbF is not elevated in SIDS... - Nephrogenic systemic fibrosis with multiorgan involvement in a teenage male after lymphoma, Ewing's sarcoma, end-stage renal disease, and hemodialysisHenry F Krous
Pathology Department, Rady Children s Hospital San Diego, San Diego, CA, USA
Pediatr Dev Pathol 10:395-402. 2007..These previously unreported findings expand the spectrum of multiorgan involvement in NSF providing additional evidence that it is an emerging systemic disorder... - Pulmonary intra-alveolar siderophages in SIDS and suffocation: a San Diego SIDS/SUDC Research Project reportHenry F Krous
Department of Pathology, Children s Hospital and Health Center, 3020 Children s Way, MC5007, San Diego, CA 92123, USA
Pediatr Dev Pathol 9:103-14. 2006..The number of PS varies widely in cases of sudden infant death caused by SIDS and accidental or inflicted suffocation and cannot be used as an independent variable to ascertain past attempts at suffocation... - Aspiration of gastric contents in sudden infant death syndrome without cardiopulmonary resuscitationHenry F Krous
Department of Pathology, Rady Children s Hospital, San Diego, California 92123, USA
J Pediatr 150:241-6. 2007.... - Pulmonary intra-alveolar hemorrhage in SIDS and suffocationHenry F Krous
Department of Pathology, Rady Children s Hospital, San Diego, CA, USA
J Forensic Leg Med 14:461-70. 2007..We conclude that each case must be evaluated on its own merits after thorough review of the medical history, circumstances of death, and postmortem findings... - Congenital cerebellar malignant rhabdoid tumor in an infant with junctional epidermolysis bullosaHenry F Krous
Department of Pathology, Rady Children s Hospital and Health Center, San Diego, CA, USA
Pediatr Dev Pathol 10:481-6. 2007..Cytogenetic results from the infant and his tumor and both of his parents suggest the infant's EB and MRT were not genetically linked... - A comparison of pulmonary intra-alveolar hemorrhage in cases of sudden infant death due to SIDS in a safe sleep environment or to suffocationHenry F Krous
Department of Pathology, Rady Children s Hospital San Diego, 3020 Children s Way, MC5007, San Diego, CA 92123, USA
Forensic Sci Int 172:56-62. 2007..Each case must be evaluated on its own merits after thorough review of the medical history, circumstances of death, and postmortem findings... - Medial smooth muscle thickness in small pulmonary arteries in sudden infant death syndrome revisitedHenry F Krous
Department of Pathology, Children s Hospital San Diego, 3020 Children s Way, MC5007, San Diego, CA 92123, USA
Pediatr Dev Pathol 5:375-85. 2002.... - Pathology research into sudden infant death syndrome: where do we go from here?Henry F Krous
Children s Hospital and Health Center, 3020 Children s Way, M5007, San Diego, CA 92123, USA
Pediatrics 114:492-4. 2004 - A comparison of respiratory symptoms and inflammation in sudden infant death syndrome and in accidental or inflicted infant deathHenry F Krous
Department of Pathology, Children s Hospital San Diego, San Diego, CA 92123, USA
Am J Forensic Med Pathol 24:1-8. 2003..Among control cases, 89% were positive, with 94% being polymicrobial. This study confirms that microscopic inflammatory infiltrates in sudden infant death syndrome are not lethal... - Environmental hyperthermic infant and early childhood death: circumstances, pathologic changes, and manner of deathH F Krous
Children s Hospital San Diego, CA 92123, USA
Am J Forensic Med Pathol 22:374-82. 2001..The manner of death was either accident or homicide. Recommendations for the scene investigation are made... - Oronasal blood in sudden infant deathH F Krous
Children s Hospital San Diego, CA 92123, USA
Am J Forensic Med Pathol 22:346-51. 2001..Sanguineous secretions that are mucoid or frothy are likely of remote origin, such as lung alveoli. The use of an otoscope to establish the origin of oronasal blood in cases of sudden infant death is recommended... - Cystic fibrosis--another cause of nodular glomerulosclerosisHenry F Krous
Department of Pathology and Pediatrics, Children's Hospital and Health Center, University of California, San Diego School of Medicine, San Diego, Calif 92123, USA
Nephron Clin Pract 96:c67-9. 2004 - Sudden infant death syndrome and unclassified sudden infant deaths: a definitional and diagnostic approachHenry F Krous
Department of Pathology, Children s Hospital San Diego, University of California, San Diego, School of Medicine, San Diego, California 92123, USA
Pediatrics 114:234-8. 2004..It is anticipated that these new definitions will be modified in the future to accommodate new understanding of SIDS and sudden infant death... - Infanticide: is its incidence among postneonatal infant deaths increasing?: an 18-year population-based analysis in CaliforniaHenry F Krous
Department of Pathology, Children s Hospital San Diego, 92123, USA
Am J Forensic Med Pathol 23:127-31. 2002..2%. It is concluded that this increased percentage is due to a decrease in SIDS deaths and not to an actual increase in infanticide deaths... - Delayed death in sudden infant death syndrome: a San Diego SIDS/SUDC Research Project 15-year population-based reportHenry F Krous
Rady Children s Hospital and Health Center, San Diego, CA 92123, USA
Forensic Sci Int 176:209-16. 2008..We did not identify factors that would reliably predict which SIDS cases might be discovered soon enough to allow earlier and more effective CPR and survival without permanent brain injury... - Unclassified sudden infant death associated with pulmonary intra-alveolar hemosiderosis and hemorrhageHomeyra Masoumi
Department of Pathology, Rady Children s Hospital and Health Center, 3020 Children s Way, MC5007, San Diego, CA 92123, USA
J Forensic Leg Med 14:471-4. 2007.... 
Intrathoracic petechiae in SIDS: a retrospective population-based 15-year studyHenry F Krous
Rady Children s Hospital San Diego, 3020 Children s Way, M5007, San Diego, CA 92123, USA
Forensic Sci Med Pathol 4:234-9. 2008..Our data do not support a role for external UAO caused by face positioning directly into the sleep surface in SIDS, but are consistent with internal UAO associated with apnea or gasping before dying of SIDS...
Pulmonary arterial medial smooth muscle thickness in sudden infant death syndrome: an analysis of subsets of 73 casesHenry F Krous
Department of Pathology, Rady Children s Hospital San Diego, CA 92123, USA
Forensic Sci Med Pathol 5:261-8. 2009..Statistical differences should not necessarily be equated with clinical importance, however future research incorporating more quantified historical data is recommended...- Sudden infant death while awakeHenry F Krous
Department of Pathology, Rady Children s Hospital and Health Center, 3020 Children s Way, MC5007, San Diego, CA 92123, USA
Forensic Sci Med Pathol 4:40-6. 2008..Careful attention should be given to the awake or sleep state immediately prior to the sudden clinical collapse, and death of infants; those who were awake should be reported to enhance understanding of this phenomenon... - Brainstem serotonergic deficiency in sudden infant death syndromeJhodie R Duncan
Department of Pathology, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
JAMA 303:430-7. 2010..Abnormalities of serotonin (5-hydroxytryptamine [5-HT]) receptor binding in regions of the medulla oblongata involved in this control have been reported in infants dying from SIDS... - Sudden death in toddlers associated with developmental abnormalities of the hippocampus: a report of five casesHannah C Kinney
Department of Pathology, Children s Hospital and Harvard Medical School, Boston, MA, USA
Pediatr Dev Pathol 10:208-23. 2007..Future studies are needed to confirm these initial findings and to define the putative links between sudden death, hippocampal anomalies, and febrile seizures in toddlers... - Sudden, unexpected death associated with meningioangiomatosis: case reportChris Wixom
Children's Hospital and Health Center, 3020 Children's Way, MC5007, San Diego, CA 92123, USA
Pediatr Dev Pathol 8:240-4. 2005..Because no other cause of death was found, we postulate that he likely died as a result of a seizure secondary to meningioangiomatosis... - Myocardial inflammation, cellular death, and viral detection in sudden infant death caused by SIDS, suffocation, or myocarditisHenry F Krous
Department of Pathology, University of California San Diego, La Jolla, CA 92037, USA
Pediatr Res 66:17-21. 2009..Very mild myocardial lymphocyte and macrophage infiltration and scattered necrotic cardiomyocytes in SIDS are not pathologic, but may occur after the developing heart is exposed to environmental pathogens, including viruses... - Meadow, Southall, and the General Medical Council of the United kingdomDavid L Chadwick
Chadwick Center for Children and Families, Children s Hospital San Diego, CA 91941, USA
Pediatrics 117:2247-51. 2006..Licensing boards may have difficulty in competently regulating doctors' expert testimony, at least in cases involving child maltreatment... - Sudden death in a toddler with laryngotracheitis caused by human parainfluenza virus-1Jonathan R Lucas
Office of the Medical Examiner, San Diego, CA, USA
Pediatr Dev Pathol 12:165-8. 2009.... - Autoinfarcted wandering spleen and fatal pneumococcal sepsis in an infantEric A Breisch
Department of Pathology, Children s Hospital and Health Center, 3020 Children s Way, M5007, San Diego, CA 92123, USA
Pediatr Dev Pathol 8:132-5. 2005..The wandering spleen was autoinfarcted and adherent to the left hepatic lobe, with resultant functional hyposplenism... - The role of the pediatric pathologist as expert witness in a case of neonatal deathHenry F Krous
Rady Children s Hospital San Diego, San Diego, CA, USA
Pediatr Dev Pathol 11:200-5. 2008..We discuss U.S. Supreme Court rulings pertaining to medical expert testimony and identify remedies to increase just outcomes in cases of medical malpractice... - Sudden unexpected death in a toddler with Williams syndromeHenry F Krous
Rady Children s Hospital and Health Center, 3020 Children s Way, MC5007, San Diego, CA 92123, USA
Forensic Sci Med Pathol 4:240-5. 2008..The cardiovascular anomalies and their association with sudden death as well as the clinical neurological and neuropathologic abnormalities identified in WS are delineated and discussed... - Sudden unexpected death in childhood associated with cardiac rhabdomyoma, involuting adrenal ganglioneuroma, and megalencephaly: another expression of tuberous sclerosis?Homeyra Masoumi
Rady Children s Hospital and Health Center, San Diego, CA, USA
Pediatr Dev Pathol 10:129-33. 2007..The constellation of her autopsy findings suggested a diagnosis of tuberous sclerosis, for which there are gene defects that can be identified in surviving family members... - Serotonin-related FEV gene variant in the sudden infant death syndrome is a common polymorphism in the African-American populationKevin G Broadbelt
Department of Pathology, Enders Building Room 1111, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
Pediatr Res 66:631-5. 2009..128-(191_192)dupA). The polymorphism seems to be a common, likely nonpathogenic, variant in the African-American population... - Multiple serotonergic brainstem abnormalities in sudden infant death syndromeDavid S Paterson
Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, MA, USA
JAMA 296:2124-32. 2006..Previously, abnormalities in 5-HT receptor binding in the medullae of infants dying from sudden infant death syndrome (SIDS) were identified, suggesting that medullary 5-HT dysfunction may be responsible for a subset of SIDS cases... - Pediatric forensic pathology in crisisRoger W Byard
Pediatr Dev Pathol 7:212-3. 2004 - Infants and toddlers must not be thought of as "miniature adults" - a forensic perspectiveHenry F Krous
J Forensic Leg Med 14:451-2. 2007 - Pulmonary neuroendocrine cells and neuroepithelial bodies in sudden infant death syndrome: potential markers of airway chemoreceptor dysfunctionErnest Cutz
Division of Pathology, Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, M5G1X8, Canada
Pediatr Dev Pathol 10:106-16. 2007..Morphometric assessment and/or measurement of the secretory products of these cells (for example, CGA, bombesin) could provide a potential biological marker for SIDS... - Sudden infant death syndrome: overview and updateRoger W Byard
Division of Pathology, Forensic Science Centre, 21 Divett Place, Adelaide 5000, South Australia, Australia
Pediatr Dev Pathol 6:112-27. 2003.... - Vascular endothelial growth factor in the cerebrospinal fluid of infants who died of sudden infant death syndrome: evidence for antecedent hypoxiaKimberly L Jones
Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
Pediatrics 111:358-63. 2003..The vascular endothelial growth factor (VEGF) gene is highly sensitive to changes in tissue partial oxygen tension, and changes in genomic and protein expression occur even after changes in oxygenation within the physiologic range... - Reflections on redefining SIDSHenry F Krous
Arch Pediatr Adolesc Med 157:291-2. 2003 - Newborn hearing screens and SIDSHenry F Krous
Early Hum Dev 84:371. 2008 - Serum testosterone and estradiol in sudden infant deathMichael J Emery
Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, FL, USA
J Pediatr 147:586-91. 2005..To test the hypothesis that among infants who die unexpectedly, testosterone and/or estradiol levels are elevated in those diagnosed with SIDS versus those with known causes of death (controls)... - Sudden infant death syndrome (SIDS)--standardised investigations and classification: recommendationsThomas Bajanowski
Institute of Legal Medicine, University Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
Forensic Sci Int 165:129-43. 2007..Standardisation of infant death investigations with the application of uniform definitions and protocols will ensure optimal investigation of individual cases and enable international comparisons of trends... - Why is a postmortem examination important when an infant or child dies suddenly?Henry F Krous
Pediatr Dev Pathol 9:168-9. 2006 - Congenital mid ureteral stricturesAndrew H Hwang
Division of Urology, Childrens Hospital Los Angeles, Los Angeles, California 90027, USA
J Urol 174:1999-2002. 2005..Congenital mid ureteral stricture is rare. We report 7 cases, and discuss the differences in preoperative evaluation and surgical management compared to other obstructive entities... - Pneumocystis is not a direct cause of sudden infant death syndromeSergio L Vargas
Programa de Microbiología Instituto de Ciencias Biomédicas, Facultad de Medicina Universidad de Chile, Santiago, Chile
Pediatr Infect Dis J 26:81-3. 2007..Cysts were identified in 33% of SIDS cases and 29% of controls. We conclude that Pneumocystis is not a direct cause of SIDS...