Research Topics
Genomes and Genes | Ronald M KraussSummaryAffiliation: Children's Hospital Oakland Research Institute Country: USA Publications
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Publications
Changes in lipoprotein subfraction concentration and composition in healthy individuals treated with the CETP inhibitor anacetrapibRonald M Krauss
Children s Hospital Oakland Research Institute, Oakland, CA, USA
J Lipid Res 53:540-7. 2012..The impact of these changes on cardiovascular risk remains to be determined...
Dietary and genetic probes of atherogenic dyslipidemiaRonald M Krauss
Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
Arterioscler Thromb Vasc Biol 25:2265-72. 2005..This information may also ultimately help in identifying those individuals who are most likely to achieve cardiovascular risk benefit from specific dietary interventions...
Variation in the 3-hydroxyl-3-methylglutaryl coenzyme a reductase gene is associated with racial differences in low-density lipoprotein cholesterol response to simvastatin treatmentRonald M Krauss
Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
Circulation 117:1537-44. 2008..We hypothesized that single nucleotide polymorphisms in the gene encoding HMGCR, a rate-limiting enzyme in cholesterol synthesis and the direct enzymatic target of statins, contribute to variation in statin response...- Separate effects of reduced carbohydrate intake and weight loss on atherogenic dyslipidemiaRonald M Krauss
Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
Am J Clin Nutr 83:1025-31; quiz 1205. 2006..Low-carbohydrate diets have been used to manage obesity and its metabolic consequences... - What can the genome tell us about LDL cholesterol?Ronald M Krauss
Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
Lancet 371:450-2. 2008 - Lipoprotein subfractions and cardiovascular disease riskRonald M Krauss
Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
Curr Opin Lipidol 21:305-11. 2010..This review summarizes the properties of the major LDL and HDL particle subclasses, and recent evidence linking their measurement with risk of atherosclerosis and CVD... - Combined influence of LDLR and HMGCR sequence variation on lipid-lowering response to simvastatinLara M Mangravite
Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
Arterioscler Thromb Vasc Biol 30:1485-92. 2010..We tested the extent to which combined effects of common alleles of LDLR and HMGCR can contribute to this variability... - Changes in atherogenic dyslipidemia induced by carbohydrate restriction in men are dependent on dietary protein sourceLara M Mangravite
Children s Hospital Oakland Research Institute, Oakland, CA, USA
J Nutr 141:2180-5. 2011..Given our previous observations with mixed protein diets, the present findings raise the possibility that dietary protein source may modify the effects of saturated fat on atherogenic lipoproteins... - Saturated fat, carbohydrate, and cardiovascular diseasePatty W Siri-Tarino
Department of Atherosclerosis Research Children s Hospital Oakland Research Institute Oakland, CA, USA
Am J Clin Nutr 91:502-9. 2010.... - Reversal of small, dense LDL subclass phenotype by normalization of adiposityPatty W Siri-Tarino
Atherosclerosis Research, Children s Hospital Oakland Research Institute, Oakland, California, USA
Obesity (Silver Spring) 17:1768-75. 2009..Conversion of LDL subclass pattern B to pattern A and reversal of ALP can be achieved in a high proportion of overweight men by normalization of adiposity... - Increased plasma concentrations of lipoprotein(a) during a low-fat, high-carbohydrate diet are associated with increased plasma concentrations of apolipoprotein C-III bound to apolipoprotein B-containing lipoproteinsMin Jeong Shin
Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
Am J Clin Nutr 85:1527-32. 2007..Low-fat, high-carbohydrate (LFHC) diets have been shown to increase plasma concentrations of lipoprotein(a) [Lp(a)] and of triacylglycerol- rich lipoproteins (TRLs)... - Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatinMarisa Wong Medina
Children s Hospital Oakland Research Institute, CA 94609, USA
Circulation 118:355-62. 2008..We hypothesized that HMGCR alternative splicing might be related to the interindividual variation in plasma low-density lipoprotein cholesterol response to statin treatment... - RHOA is a modulator of the cholesterol-lowering effects of statinMarisa W Medina
Children s Hospital Oakland Research Institute, Oakland, California, United States of America
PLoS Genet 8:e1003058. 2012.... - Apolipoprotein CIII bound to apoB-containing lipoproteins is associated with small, dense LDL independent of plasma triglyceride levels in healthy menMin Jeong Shin
Children s Hospital Oakland Research Institute, 5700 Martin Luther King, Jr Way, Oakland, CA 94609, USA
Atherosclerosis 211:337-41. 2010..We tested whether there is an association of apoCIII with small, dense LDL levels that is independent of plasma TG level... - VLDL hydrolysis by LPL activates PPAR-alpha through generation of unbound fatty acidsMaxwell A Ruby
Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
J Lipid Res 51:2275-81. 2010..These data suggest that the PPAR-alpha response is generated by unbound fatty acids released locally by lipase activity and not by circulating plasma fatty acids... - Acute overactive endocannabinoid signaling induces glucose intolerance, hepatic steatosis, and novel cannabinoid receptor 1 responsive genesMaxwell A Ruby
Department of Atherosclerosis Research, Children s Hospital Oakland Research Institute, Oakland, California, United States of America
PLoS ONE 6:e26415. 2011..Overall, we show that acute IDFP treatment induces hepatic TG accumulation and insulin resistance, at least in part through the CB1 receptor, and identify novel cannabinoid responsive genes... - Fatty acid desaturase regulation in adipose tissue by dietary composition is independent of weight loss and is correlated with the plasma triacylglycerol responseLara M Mangravite
Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
Am J Clin Nutr 86:759-67. 2007..Atherogenic dyslipidemia associated with elevated plasma triacylglycerol concentrations and reduced HDL is improved by both caloric restriction and reduced carbohydrate consumption... - Coordinately regulated alternative splicing of genes involved in cholesterol biosynthesis and uptakeMarisa Wong Medina
Department of Atherosclerosis Research, Children s Hospital Oakland Research Institute, Oakland, California, United States of America
PLoS ONE 6:e19420. 2011..Thus coordinated regulation of alternative splicing may contribute to cellular cholesterol homeostasis as well as plasma LDL levels... - Overactive endocannabinoid signaling impairs apolipoprotein E-mediated clearance of triglyceride-rich lipoproteinsMaxwell A Ruby
Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
Proc Natl Acad Sci U S A 105:14561-6. 2008..These findings suggest a role of CB1 activation in the pathogenesis of obesity-related hypertriglyceridemia and underscore the potential efficacy of CB1 antagonists in treating metabolic disease... - Saturated fatty acids and risk of coronary heart disease: modulation by replacement nutrientsPatty W Siri-Tarino
Atherosclerosis Research, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
Curr Atheroscler Rep 12:384-90. 2010..Therefore, dietary recommendations should emphasize substitution of polyunsaturated fat and minimally processed grains for saturated fat... - The role of HMGCR alternative splicing in statin efficacyMarisa Wong Medina
Children s Hospital Oakland Research Institute, CA 94609, USA
Trends Cardiovasc Med 19:173-7. 2009.... - Plasma clearance of human low-density lipoprotein in human apolipoprotein B transgenic mice is related to particle diameterKaspar Berneis
Donner Laboratory, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA, USA
Metabolism 53:483-7. 2004..This might be due to compositional or structural features of smaller LDL that lead to retarded clearance... - Polymorphisms in the peroxisome proliferator activated receptor alpha gene are associated with levels of apolipoprotein CIII and triglyceride in African-Americans but not CaucasiansMin Jeong Shin
Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
Atherosclerosis 198:313-9. 2008.... - Pharmacogenomics of statin responseLara M Mangravite
Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
Curr Opin Mol Ther 10:555-61. 2008..Initial observations must be replicated across multiple statin clinical trials and in multiple population groups of differing race and ethnicity before they can be assessed for clinical utility... - Changes in lipoprotein(a), oxidized phospholipids, and LDL subclasses with a low-fat high-carbohydrate dietNastaran Faghihnia
Department of Atherosclerosis Research, Children s Hospital Oakland Research Institute, Oakland, CA, USA
J Lipid Res 51:3324-30. 2010..05). These results demonstrate that induction of increased levels of Lp(a) by an LFHC diet is associated with increases in OxPLs and with changes in LDL subclass distribution that may reflect altered metabolism of Lp(a) particles... - Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular diseasePatty W Siri-Tarino
Children s Hospital, Oakland Research Institute Oakland, CA, USA
Am J Clin Nutr 91:535-46. 2010..A reduction in dietary saturated fat has generally been thought to improve cardiovascular health... - Reversal of small, dense LDL subclass phenotype by weight loss is associated with impaired fat oxidationPatty W Siri-Tarino
Atherosclerosis Research, Children s Hospital Oakland Research Institute, Oakland, California, USA
Obesity (Silver Spring) 19:61-8. 2011..Pattern B men who converted to pattern A with weight loss may have an underlying impairment in fat oxidation that predisposes to both dyslipidemia and an impaired ability to achieve weight loss by energy restriction... - A reappraisal of the impact of dairy foods and milk fat on cardiovascular disease riskJ Bruce German
Department of Food Science and Technology, University of California, Davis, CA, 95616, USA
Eur J Nutr 48:191-203. 2009..A conference of scientists from different perspectives of dietary fat and health was convened in order to consider the scientific basis for these recommendations... - Properties of triglyceride-rich and cholesterol-rich lipoproteins in the remnant-like particle fraction of human blood plasmaElisa Campos
Cardiovascular Research Institute, University of California San Francisco, 505 Parnassus Avenue, Rm L-1337, San Francisco, CA, USA
J Lipid Res 43:365-74. 2002..RLP-cholesterol concentrations in individuals with low plasma TG may not have the same clinical significance as they do in those with hypertriglyceridemia... - Metabolic abnormalities: triglyceride and low-density lipoproteinRonald M Krauss
Children s Hospital Oakland Research Institute, 5700 Martin Luther King, Jr Way, Oakland, CA 94609, USA
Endocrinol Metab Clin North Am 33:405-15. 2004..The role of reduced high-density lipoprotein in the metabolic syndrome is discussed elsewhere in this issue... - Lipids and lipoproteins in patients with type 2 diabetesRonald M Krauss
Children s Hospital Oakland Research Center, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
Diabetes Care 27:1496-504. 2004..Clinical trials have shown significant improvement in coronary artery disease after diabetic dyslipidemia treatment... - Pharmacogenomics of statin responseLara M Mangravite
Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
Curr Opin Lipidol 18:409-14. 2007.... - Dyslipidemia in type 2 diabetesRonald M Krauss
Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
Med Clin North Am 88:897-909, x. 2004..Clinical trials demonstrate that the use of such pharmaceutics to treat diabetic dyslipidemia concomitantly reduces the risk of coronary artery disease... - Influence of dietary carbohydrate and fat on LDL and HDL particle distributionsPatty W Siri
Department of Atherosclerosis Research, Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA
Curr Atheroscler Rep 7:455-9. 2005..Low-carbohydrate diets may have the opposite effects. Diets with differing fatty acid composition can also influence LDL and HDL particle distributions... - A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor functionFeng Gao
Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
Hum Mol Genet 22:1424-31. 2013.... - A genome-wide association analysis of temozolomide response using lymphoblastoid cell lines shows a clinically relevant association with MGMTChad C Brown
Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695 7566, USA
Pharmacogenet Genomics 22:796-802. 2012..Recently, lymphoblastoid cell lines (LCLs) have emerged as an innovative model system for mapping gene variants that predict the dose response to chemotherapy drugs... - A nutrient-dense, high-fiber, fruit-based supplement bar increases HDL cholesterol, particularly large HDL, lowers homocysteine, and raises glutathione in a 2-wk trialMichele L Mietus-Snyder
Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, Oakland, California, 94609, USA
FASEB J 26:3515-27. 2012..These results lay the groundwork for mechanistic/deconstruction experiments to identify critical bar components and putative synergistic combinations responsible for observed effects... - Hold the antioxidants and improve plasma lipids?Ronald M Krauss
Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
J Clin Invest 113:1253-5. 2004..Conversely, PERPP is suppressed by antioxidants and by saturated fatty acids, which are not susceptible to lipid peroxidation. Hence reduction of oxidative stress may have the unexpected side effect of increasing plasma lipid levels... - Alternative splicing in the regulation of cholesterol homeostasisMarisa W Medina
Children s Hospital Oakland Research Institute, Oakland, California, USA
Curr Opin Lipidol 24:147-52. 2013..In this review, we highlight recent studies examining alternative splicing as a modulator of cellular cholesterol homeostasis and as an underlying mechanism of dyslipidemia... - Association of the APOLIPOPROTEIN A1/C3/A4/A5 gene cluster with triglyceride levels and LDL particle size in familial combined hyperlipidemiaRebecca Mar
Department of Human Genetics, University of California, Los Angeles, USA
Circ Res 94:993-9. 2004.... - Tracing sub-structure in the European American population with PCA-informative markersPeristera Paschou
Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupoli, Greece
PLoS Genet 4:e1000114. 2008..Furthermore, our redundancy removal algorithm can be applied on sets of ancestry informative markers selected with any method in order to select the most uncorrelated SNPs, and significantly decreases genotyping costs... - Haplotypes in the APOA1-C3-A4-A5 gene cluster affect plasma lipids in both humans and baboonsQian-fei Wang
Genome Sciences Department, Lawrence Berkeley National Laboratory, CA 94720, USA
Hum Mol Genet 13:1049-56. 2004.... - Effects of simvastatin, an HMG-CoA reductase inhibitor, in patients with hypertriglyceridemiaJonathan Isaacsohn
Metabolic and Atherosclerosis Research Center, Cincinnati, Ohio, USA
Clin Cardiol 26:18-24. 2003..05 - < 0.001). CONCLUSION: The results of this study demonstrate the beneficial effects of simvastatin in patients with hypertriglyceridemia... - Insulin resistance syndrome and dyslipidemiaRonald M Krauss
Endocr Pract 9:67-72. 2003 - Effects on lipoprotein subclasses of combined expression of human hepatic lipase and human apoB in transgenic rabbitsManfredi Rizzo
Department of Genome Sciences, Lawrence Berkeley National Laboratory, University of California, Berkeley, USA
Arterioscler Thromb Vasc Biol 24:141-6. 2004..The effects of combined expression of human hepatic lipase (HL) and human apolipoprotein B (apoB) on low-density lipoprotein (LDL) subclasses were examined in rabbits, a species naturally deficient in HL activity... - American College of Endocrinology position statement on the insulin resistance syndromeDaniel Einhorn
American College of Endocrinology
Endocr Pract 9:237-52. 2003 - Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levelsLen A Pennacchio
Genome Sciences Department, MS 84 171, Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, CA 94720, USA
Hum Mol Genet 11:3031-8. 2002..Together, the APOA5*2 and APOA5*3 haplotypes are found in 25-50% of African-Americans, Hispanics and Caucasians and support the contribution of common human variation to quantitative phenotypes in the general population... - Metabolic effects of nandrolone decanoate and resistance training in men with HIVFred R Sattler
Departments of Medicine, Biokinesiology and Physical Therapy, and of Biometry, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
Am J Physiol Endocrinol Metab 283:E1214-22. 2002..05). These metabolic effects were favorable (other than for HDL), but changes were generally transient (except for HDL in group 2), with measurements returning to baseline 2 mo after the interventions were completed... - Is the size of low-density lipoprotein particles related to the risk of coronary heart disease?Ronald M Krauss
JAMA 287:712-3. 2002 - Phenotypic predictors of response to simvastatin therapy among African-Americans and Caucasians: the Cholesterol and Pharmacogenetics (CAP) StudyJoel A Simon
General Internal Medicine Section, Medical Service, Veterans Affairs Medical Center, San Francisco, California, USA
Am J Cardiol 97:843-50. 2006..The magnitude of the lipid and lipoprotein responses, however, differed among participants according to a number of phenotypic and demographic characteristics... - Low-density lipoprotein particle size loci in familial combined hyperlipidemia: evidence for multiple loci from a genome scanMichael D Badzioch
Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, USA
Arterioscler Thromb Vasc Biol 24:1942-50. 2004.... - Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive proteinAlexander P Reiner
University of Washington, Department of Epidemiology, Seattle, WA 98195, USA
Am J Hum Genet 82:1193-201. 2008.... - Consumption of fructose-sweetened beverages for 10 weeks increases postprandial triacylglycerol and apolipoprotein-B concentrations in overweight and obese womenMichael M Swarbrick
Department of Nutrition, University of California, Davis, CA 95616, USA
Br J Nutr 100:947-52. 2008.... - ApoC-III content of apoB-containing lipoproteins is associated with binding to the vascular proteoglycan biglycanKatherine Olin-Lewis
Department of Medicine, University of Washington, Seattle, WA, USA
J Lipid Res 43:1969-77. 2002..ApoC-III content may thus be a marker for lipoproteins characterized as having an increased ability to bind proteoglycans... - Analysis of polymorphisms in the 3' untranslated region of the LDL receptor gene and their effect on plasma cholesterol levels and drug responseWei Chen
VA Palo Alto Health Care System, Palo Alto, CA 94304, USA
Int J Mol Med 21:345-53. 2008.... - Metabolic origins and clinical significance of LDL heterogeneityKaspar K Berneis
Donner Laboratory, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
J Lipid Res 43:1363-79. 2002..Future delineation of the determinants of heterogeneity of LDL and other apoB-containing lipoproteins may contribute to improved identification and management of patients at high risk for atherosclerotic disease... - Endurance training has little effect on active muscle free fatty acid, lipoprotein cholesterol, or triglyceride net balancesKevin A Jacobs
University of California, Berkeley, CA 94720-3140, USA
Am J Physiol Endocrinol Metab 291:E656-65. 2006..Therefore, the favorable effects of physical activity on the lipid profiles of young, healthy normolipidemic men in the postprandial state are not attributable to changes in HDL-C or LDL-C exchange across active skeletal muscle... - Individualized hormone-replacement therapy?Ronald M Krauss
N Engl J Med 346:1017-8. 2002 - Direct determination of lipoprotein particle sizes and concentrations by ion mobility analysisMichael P Caulfield
Quest Diagnostics Nichols Institute, San Juan Capistrano, CA 92675, USA
Clin Chem 54:1307-16. 2008.... - Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute scientific statementScott M Grundy
Curr Opin Cardiol 21:1-6. 2006 - Behavioral versus genetic correlates of lipoproteins and adiposity in identical twins discordant for exercisePaul T Williams
Lawrence Berkeley National Laboratory, Donner Laboratory, One Cyclotron Rd, Berkeley, CA 94720, USA
Circulation 112:350-6. 2005.... - Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific StatementScott M Grundy
Circulation 112:2735-52. 2005 - Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemiaAlan D Attie
Department of Biochemistry, University of Wisconsin Madison, Madison, WI, USA
J Lipid Res 43:1899-907. 2002..We propose that many of the factors that influence plasma triglyceride levels do so by converging upon the regulation of SCD activity... - Diagnosis and management of the metabolic syndrome. An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Executive summaryScott M Grundy
Cardiol Rev 13:322-7. 2005 - Pharmacogenomics: challenges and opportunitiesDan M Roden
Vanderbilt University, Nashville, Tennessee, USA
Ann Intern Med 145:749-57. 2006..Overcoming these challenges holds the promise of improving new drug development and ultimately individualizing the selection of appropriate drugs and dosages for individual patients... - Protein in optimal health: heart disease and type 2 diabetesDonald K Layman
Department of Food Science and Human Nutrition, University of Illinois, Urbana, IL 61801, USA
Am J Clin Nutr 87:1571S-1575S. 2008..Additional research is needed to determine specific levels of protein, carbohydrate, and fat for optimum health of individuals who differ in age, physical activity, and metabolic phenotypes... - Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adultsJulio Licinio
Center for Pharmacogenomics, Neuropsychiatric Institute, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1761, USA
Proc Natl Acad Sci U S A 101:4531-6. 2004..These results highlight the role of the leptin pathway in adults with key effects on the regulation of body weight, gonadal function, and behavior... - Obesity in BSB mice is correlated with expression of genes for iron homeostasis and leptinPoupak Farahani
Rowe Program in Genetics, University of California, Davis, California 95616, USA
Obes Res 12:191-204. 2004..Lep alleles derived from outbred, but not inbred, SPRET are a positional candidate for the chromosome 6 quantitative trait locus in BSB mice... - Identifying genetic risk factors for serious adverse drug reactions: current progress and challengesRussell A Wilke
Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
Nat Rev Drug Discov 6:904-16. 2007..Key challenges for the discovery of predictive risk alleles for these SADRs are also considered... - Differential effects of ramipril on ambulatory blood pressure in African Americans and CaucasiansAndrew Moran
Department of Medicine, University of California at San Francisco, and San Francisco General Hospital, California, USA
Am J Hypertens 20:884-91. 2007..Past studies did not compare daytime and nighttime ambulatory blood-pressure responses to angiotensin-converting enzyme inhibitors in African Americans and Caucasians... - Is there a simple way to identify insulin-resistant individuals at increased risk of cardiovascular disease?Tracey McLaughlin
Stanford University School of Medicine, Stanford, California, USA
Am J Cardiol 96:399-404. 2005..5 provides a simple means of identifying insulin-resistant, dyslipidemic patients who are likely to be at increased risk of cardiovascular disease... - Determination and use of haplotypes: ethnic comparison and association of the lipoprotein lipase gene and coronary artery disease in Mexican-AmericansMark O Goodarzi
Division of Medical Genetics, Department of Medicine, Cedars Sinai Medical Center and UCLA, Los Angeles, California, USA
Genet Med 5:322-7. 2003..To illustrate an approach of deriving haplotypes for genetic association studies, using the lipoprotein lipase (LPL) gene and coronary artery disease... - Smallest LDL particles are most strongly related to coronary disease progression in menPaul T Williams
Life Sciences Division, E.O. Lawrence Berkeley National Laboratory, University of California, Berkeley, USA
Arterioscler Thromb Vasc Biol 23:314-21. 2003..CONCLUSIONS: LDL-IVb was the single best lipoprotein predictor of increased stenosis, an unexpected result, given that LDL-IVb represents only a minor fraction of total LDL... - Association between angiotensinogen, angiotensin II receptor genes, and blood pressure response to an angiotensin-converting enzyme inhibitorXiaowen Su
Medical Genetics Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
Circulation 115:725-32. 2007.... - Analysis and quantitation of biotinylated apoB-containing lipoproteins with streptavidin-Cy3Kaspar Berneis
Donner Laboratory, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
J Lipid Res 43:1155-9. 2002..54 A, P = 0.3). Biotinylation and prestaining of lipoprotein particle with streptavidin-Cy3 provides a new fluorescence-based method for detection and quantitative analysis of lipoprotein subspecies by gradient gel electrophoresis...
Research Grants
- COMPARATIVE GENOMIC ANALYSIS OF CARDIOVASCULAR GENE REGURonald Krauss; Fiscal Year: 2003..6) The establishment of an educational program for cardiovascular researchers in the use of genomic databases and tools. ..
- Pharmacogenomics and Risk of Cardiovascular DiseaseRonald Krauss; Fiscal Year: 2007..This program presents a comprehensive approach for determining effects of specific genotypes on clinically meaningful variations in responsiveness to a class of drugs widely used to prevent cardiovascular disease. ..