Ronald M Krauss

Summary

Affiliation: Children's Hospital Oakland Research Institute
Country: USA

Publications

  1. pmc Multivariate methods and software for association mapping in dose-response genome-wide association studies
    Chad C Brown
    Department of Statistics, North Carolina State University, Raleigh, NC, USA
    BioData Min 5:21. 2012
  2. pmc Changes in lipoprotein subfraction concentration and composition in healthy individuals treated with the CETP inhibitor anacetrapib
    Ronald M Krauss
    Children s Hospital Oakland Research Institute, Oakland, CA, USA
    J Lipid Res 53:540-7. 2012
  3. ncbi request reprint Separate effects of reduced carbohydrate intake and weight loss on atherogenic dyslipidemia
    Ronald M Krauss
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Am J Clin Nutr 83:1025-31; quiz 1205. 2006
  4. doi request reprint Lipoprotein subfractions and cardiovascular disease risk
    Ronald M Krauss
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Curr Opin Lipidol 21:305-11. 2010
  5. doi request reprint Variation in the 3-hydroxyl-3-methylglutaryl coenzyme a reductase gene is associated with racial differences in low-density lipoprotein cholesterol response to simvastatin treatment
    Ronald M Krauss
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Circulation 117:1537-44. 2008
  6. ncbi request reprint What can the genome tell us about LDL cholesterol?
    Ronald M Krauss
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Lancet 371:450-2. 2008
  7. ncbi request reprint Dietary and genetic probes of atherogenic dyslipidemia
    Ronald M Krauss
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Arterioscler Thromb Vasc Biol 25:2265-72. 2005
  8. pmc Combined influence of LDLR and HMGCR sequence variation on lipid-lowering response to simvastatin
    Lara M Mangravite
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Arterioscler Thromb Vasc Biol 30:1485-92. 2010
  9. pmc Changes in atherogenic dyslipidemia induced by carbohydrate restriction in men are dependent on dietary protein source
    Lara M Mangravite
    Children s Hospital Oakland Research Institute, Oakland, CA, USA
    J Nutr 141:2180-5. 2011
  10. pmc Saturated fat, carbohydrate, and cardiovascular disease
    Patty W Siri-Tarino
    Department of Atherosclerosis Research Children s Hospital Oakland Research Institute Oakland, CA, USA
    Am J Clin Nutr 91:502-9. 2010

Research Grants

Detail Information

Publications76

  1. pmc Multivariate methods and software for association mapping in dose-response genome-wide association studies
    Chad C Brown
    Department of Statistics, North Carolina State University, Raleigh, NC, USA
    BioData Min 5:21. 2012
    ..However, previous studies may have over-simplified the complex differences in dose-response profiles between genotypes, resulting in a loss of power...
  2. pmc Changes in lipoprotein subfraction concentration and composition in healthy individuals treated with the CETP inhibitor anacetrapib
    Ronald M Krauss
    Children s Hospital Oakland Research Institute, Oakland, CA, USA
    J Lipid Res 53:540-7. 2012
    ..The impact of these changes on cardiovascular risk remains to be determined...
  3. ncbi request reprint Separate effects of reduced carbohydrate intake and weight loss on atherogenic dyslipidemia
    Ronald M Krauss
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Am J Clin Nutr 83:1025-31; quiz 1205. 2006
    ..Low-carbohydrate diets have been used to manage obesity and its metabolic consequences...
  4. doi request reprint Lipoprotein subfractions and cardiovascular disease risk
    Ronald M Krauss
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Curr Opin Lipidol 21:305-11. 2010
    ..This review summarizes the properties of the major LDL and HDL particle subclasses, and recent evidence linking their measurement with risk of atherosclerosis and CVD...
  5. doi request reprint Variation in the 3-hydroxyl-3-methylglutaryl coenzyme a reductase gene is associated with racial differences in low-density lipoprotein cholesterol response to simvastatin treatment
    Ronald M Krauss
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Circulation 117:1537-44. 2008
    ..We hypothesized that single nucleotide polymorphisms in the gene encoding HMGCR, a rate-limiting enzyme in cholesterol synthesis and the direct enzymatic target of statins, contribute to variation in statin response...
  6. ncbi request reprint What can the genome tell us about LDL cholesterol?
    Ronald M Krauss
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Lancet 371:450-2. 2008
  7. ncbi request reprint Dietary and genetic probes of atherogenic dyslipidemia
    Ronald M Krauss
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Arterioscler Thromb Vasc Biol 25:2265-72. 2005
    ..This information may also ultimately help in identifying those individuals who are most likely to achieve cardiovascular risk benefit from specific dietary interventions...
  8. pmc Combined influence of LDLR and HMGCR sequence variation on lipid-lowering response to simvastatin
    Lara M Mangravite
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Arterioscler Thromb Vasc Biol 30:1485-92. 2010
    ..We tested the extent to which combined effects of common alleles of LDLR and HMGCR can contribute to this variability...
  9. pmc Changes in atherogenic dyslipidemia induced by carbohydrate restriction in men are dependent on dietary protein source
    Lara M Mangravite
    Children s Hospital Oakland Research Institute, Oakland, CA, USA
    J Nutr 141:2180-5. 2011
    ..Given our previous observations with mixed protein diets, the present findings raise the possibility that dietary protein source may modify the effects of saturated fat on atherogenic lipoproteins...
  10. pmc Saturated fat, carbohydrate, and cardiovascular disease
    Patty W Siri-Tarino
    Department of Atherosclerosis Research Children s Hospital Oakland Research Institute Oakland, CA, USA
    Am J Clin Nutr 91:502-9. 2010
    ....
  11. pmc Reversal of small, dense LDL subclass phenotype by normalization of adiposity
    Patty W Siri-Tarino
    Atherosclerosis Research, Children s Hospital Oakland Research Institute, Oakland, California, USA
    Obesity (Silver Spring) 17:1768-75. 2009
    ..Conversion of LDL subclass pattern B to pattern A and reversal of ALP can be achieved in a high proportion of overweight men by normalization of adiposity...
  12. ncbi request reprint Increased plasma concentrations of lipoprotein(a) during a low-fat, high-carbohydrate diet are associated with increased plasma concentrations of apolipoprotein C-III bound to apolipoprotein B-containing lipoproteins
    Min Jeong Shin
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Am J Clin Nutr 85:1527-32. 2007
    ..Low-fat, high-carbohydrate (LFHC) diets have been shown to increase plasma concentrations of lipoprotein(a) [Lp(a)] and of triacylglycerol- rich lipoproteins (TRLs)...
  13. pmc Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin
    Marisa Wong Medina
    Children s Hospital Oakland Research Institute, CA 94609, USA
    Circulation 118:355-62. 2008
    ..We hypothesized that HMGCR alternative splicing might be related to the interindividual variation in plasma low-density lipoprotein cholesterol response to statin treatment...
  14. pmc A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function
    Feng Gao
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Hum Mol Genet 22:1424-31. 2013
    ....
  15. pmc RHOA is a modulator of the cholesterol-lowering effects of statin
    Marisa W Medina
    Children s Hospital Oakland Research Institute, Oakland, California, United States of America
    PLoS Genet 8:e1003058. 2012
    ....
  16. doi request reprint Apolipoprotein CIII bound to apoB-containing lipoproteins is associated with small, dense LDL independent of plasma triglyceride levels in healthy men
    Min Jeong Shin
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King, Jr Way, Oakland, CA 94609, USA
    Atherosclerosis 211:337-41. 2010
    ..We tested whether there is an association of apoCIII with small, dense LDL levels that is independent of plasma TG level...
  17. pmc VLDL hydrolysis by LPL activates PPAR-alpha through generation of unbound fatty acids
    Maxwell A Ruby
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    J Lipid Res 51:2275-81. 2010
    ..These data suggest that the PPAR-alpha response is generated by unbound fatty acids released locally by lipase activity and not by circulating plasma fatty acids...
  18. pmc Acute overactive endocannabinoid signaling induces glucose intolerance, hepatic steatosis, and novel cannabinoid receptor 1 responsive genes
    Maxwell A Ruby
    Department of Atherosclerosis Research, Children s Hospital Oakland Research Institute, Oakland, California, United States of America
    PLoS ONE 6:e26415. 2011
    ..Overall, we show that acute IDFP treatment induces hepatic TG accumulation and insulin resistance, at least in part through the CB1 receptor, and identify novel cannabinoid responsive genes...
  19. ncbi request reprint Fatty acid desaturase regulation in adipose tissue by dietary composition is independent of weight loss and is correlated with the plasma triacylglycerol response
    Lara M Mangravite
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Am J Clin Nutr 86:759-67. 2007
    ..Atherogenic dyslipidemia associated with elevated plasma triacylglycerol concentrations and reduced HDL is improved by both caloric restriction and reduced carbohydrate consumption...
  20. pmc Coordinately regulated alternative splicing of genes involved in cholesterol biosynthesis and uptake
    Marisa Wong Medina
    Department of Atherosclerosis Research, Children s Hospital Oakland Research Institute, Oakland, California, United States of America
    PLoS ONE 6:e19420. 2011
    ..Thus coordinated regulation of alternative splicing may contribute to cellular cholesterol homeostasis as well as plasma LDL levels...
  21. pmc Saturated fatty acids and risk of coronary heart disease: modulation by replacement nutrients
    Patty W Siri-Tarino
    Atherosclerosis Research, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Curr Atheroscler Rep 12:384-90. 2010
    ..Therefore, dietary recommendations should emphasize substitution of polyunsaturated fat and minimally processed grains for saturated fat...
  22. pmc Overactive endocannabinoid signaling impairs apolipoprotein E-mediated clearance of triglyceride-rich lipoproteins
    Maxwell A Ruby
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Proc Natl Acad Sci U S A 105:14561-6. 2008
    ..These findings suggest a role of CB1 activation in the pathogenesis of obesity-related hypertriglyceridemia and underscore the potential efficacy of CB1 antagonists in treating metabolic disease...
  23. pmc The role of HMGCR alternative splicing in statin efficacy
    Marisa Wong Medina
    Children s Hospital Oakland Research Institute, CA 94609, USA
    Trends Cardiovasc Med 19:173-7. 2009
    ....
  24. ncbi request reprint Plasma clearance of human low-density lipoprotein in human apolipoprotein B transgenic mice is related to particle diameter
    Kaspar Berneis
    Donner Laboratory, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA, USA
    Metabolism 53:483-7. 2004
    ..This might be due to compositional or structural features of smaller LDL that lead to retarded clearance...
  25. ncbi request reprint Pharmacogenomics of statin response
    Lara M Mangravite
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Curr Opin Mol Ther 10:555-61. 2008
    ..Initial observations must be replicated across multiple statin clinical trials and in multiple population groups of differing race and ethnicity before they can be assessed for clinical utility...
  26. pmc Polymorphisms in the peroxisome proliferator activated receptor alpha gene are associated with levels of apolipoprotein CIII and triglyceride in African-Americans but not Caucasians
    Min Jeong Shin
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Atherosclerosis 198:313-9. 2008
    ....
  27. pmc Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease
    Patty W Siri-Tarino
    Children s Hospital, Oakland Research Institute Oakland, CA, USA
    Am J Clin Nutr 91:535-46. 2010
    ..A reduction in dietary saturated fat has generally been thought to improve cardiovascular health...
  28. pmc Changes in lipoprotein(a), oxidized phospholipids, and LDL subclasses with a low-fat high-carbohydrate diet
    Nastaran Faghihnia
    Department of Atherosclerosis Research, Children s Hospital Oakland Research Institute, Oakland, CA, USA
    J Lipid Res 51:3324-30. 2010
    ..05). These results demonstrate that induction of increased levels of Lp(a) by an LFHC diet is associated with increases in OxPLs and with changes in LDL subclass distribution that may reflect altered metabolism of Lp(a) particles...
  29. pmc Reversal of small, dense LDL subclass phenotype by weight loss is associated with impaired fat oxidation
    Patty W Siri-Tarino
    Atherosclerosis Research, Children s Hospital Oakland Research Institute, Oakland, California, USA
    Obesity (Silver Spring) 19:61-8. 2011
    ..Pattern B men who converted to pattern A with weight loss may have an underlying impairment in fat oxidation that predisposes to both dyslipidemia and an impaired ability to achieve weight loss by energy restriction...
  30. ncbi request reprint Metabolic abnormalities: triglyceride and low-density lipoprotein
    Ronald M Krauss
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King, Jr Way, Oakland, CA 94609, USA
    Endocrinol Metab Clin North Am 33:405-15. 2004
    ..The role of reduced high-density lipoprotein in the metabolic syndrome is discussed elsewhere in this issue...
  31. pmc A reappraisal of the impact of dairy foods and milk fat on cardiovascular disease risk
    J Bruce German
    Department of Food Science and Technology, University of California, Davis, CA, 95616, USA
    Eur J Nutr 48:191-203. 2009
    ..A conference of scientists from different perspectives of dietary fat and health was convened in order to consider the scientific basis for these recommendations...
  32. ncbi request reprint Lipids and lipoproteins in patients with type 2 diabetes
    Ronald M Krauss
    Children s Hospital Oakland Research Center, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Diabetes Care 27:1496-504. 2004
    ..Clinical trials have shown significant improvement in coronary artery disease after diabetic dyslipidemia treatment...
  33. ncbi request reprint Properties of triglyceride-rich and cholesterol-rich lipoproteins in the remnant-like particle fraction of human blood plasma
    Elisa Campos
    Cardiovascular Research Institute, University of California San Francisco, 505 Parnassus Avenue, Rm L 1337, San Francisco, CA, USA
    J Lipid Res 43:365-74. 2002
    ..RLP-cholesterol concentrations in individuals with low plasma TG may not have the same clinical significance as they do in those with hypertriglyceridemia...
  34. ncbi request reprint Pharmacogenomics of statin response
    Lara M Mangravite
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Curr Opin Lipidol 18:409-14. 2007
    ....
  35. ncbi request reprint Dyslipidemia in type 2 diabetes
    Ronald M Krauss
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Med Clin North Am 88:897-909, x. 2004
    ..Clinical trials demonstrate that the use of such pharmaceutics to treat diabetic dyslipidemia concomitantly reduces the risk of coronary artery disease...
  36. ncbi request reprint Influence of dietary carbohydrate and fat on LDL and HDL particle distributions
    Patty W Siri
    Department of Atherosclerosis Research, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Curr Atheroscler Rep 7:455-9. 2005
    ..Low-carbohydrate diets may have the opposite effects. Diets with differing fatty acid composition can also influence LDL and HDL particle distributions...
  37. pmc A genome-wide association analysis of temozolomide response using lymphoblastoid cell lines shows a clinically relevant association with MGMT
    Chad C Brown
    Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695 7566, USA
    Pharmacogenet Genomics 22:796-802. 2012
    ..Recently, lymphoblastoid cell lines (LCLs) have emerged as an innovative model system for mapping gene variants that predict the dose response to chemotherapy drugs...
  38. pmc A nutrient-dense, high-fiber, fruit-based supplement bar increases HDL cholesterol, particularly large HDL, lowers homocysteine, and raises glutathione in a 2-wk trial
    Michele L Mietus-Snyder
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, Oakland, California, 94609, USA
    FASEB J 26:3515-27. 2012
    ..These results lay the groundwork for mechanistic/deconstruction experiments to identify critical bar components and putative synergistic combinations responsible for observed effects...
  39. pmc Hold the antioxidants and improve plasma lipids?
    Ronald M Krauss
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    J Clin Invest 113:1253-5. 2004
    ..Conversely, PERPP is suppressed by antioxidants and by saturated fatty acids, which are not susceptible to lipid peroxidation. Hence reduction of oxidative stress may have the unexpected side effect of increasing plasma lipid levels...
  40. pmc Alternative splicing in the regulation of cholesterol homeostasis
    Marisa W Medina
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Curr Opin Lipidol 24:147-52. 2013
    ..In this review, we highlight recent studies examining alternative splicing as a modulator of cellular cholesterol homeostasis and as an underlying mechanism of dyslipidemia...
  41. ncbi request reprint Insulin resistance syndrome and dyslipidemia
    Ronald M Krauss
    Endocr Pract 9:67-72. 2003
  42. ncbi request reprint Low-density lipoprotein particle size loci in familial combined hyperlipidemia: evidence for multiple loci from a genome scan
    Michael D Badzioch
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, USA
    Arterioscler Thromb Vasc Biol 24:1942-50. 2004
    ..Low-density lipoprotein (LDL) size is associated with vascular disease and with familial combined hyperlipidemia (FCHL)...
  43. pmc Tracing sub-structure in the European American population with PCA-informative markers
    Peristera Paschou
    Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupoli, Greece
    PLoS Genet 4:e1000114. 2008
    ..Furthermore, our redundancy removal algorithm can be applied on sets of ancestry informative markers selected with any method in order to select the most uncorrelated SNPs, and significantly decreases genotyping costs...
  44. ncbi request reprint Analysis of polymorphisms in the 3' untranslated region of the LDL receptor gene and their effect on plasma cholesterol levels and drug response
    Wei Chen
    VA Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Int J Mol Med 21:345-53. 2008
    ....
  45. ncbi request reprint Is the size of low-density lipoprotein particles related to the risk of coronary heart disease?
    Ronald M Krauss
    JAMA 287:712-3. 2002
  46. ncbi request reprint Haplotypes in the APOA1-C3-A4-A5 gene cluster affect plasma lipids in both humans and baboons
    Qian Fei Wang
    Genome Sciences Department, Lawrence Berkeley National Laboratory, CA 94720, USA
    Hum Mol Genet 13:1049-56. 2004
    ....
  47. ncbi request reprint Association of the APOLIPOPROTEIN A1/C3/A4/A5 gene cluster with triglyceride levels and LDL particle size in familial combined hyperlipidemia
    Rebecca Mar
    Department of Human Genetics, University of California, Los Angeles, USA
    Circ Res 94:993-9. 2004
    ....
  48. ncbi request reprint Effects on lipoprotein subclasses of combined expression of human hepatic lipase and human apoB in transgenic rabbits
    Manfredi Rizzo
    Department of Genome Sciences, Lawrence Berkeley National Laboratory, University of California, Berkeley, USA
    Arterioscler Thromb Vasc Biol 24:141-6. 2004
    ..The effects of combined expression of human hepatic lipase (HL) and human apolipoprotein B (apoB) on low-density lipoprotein (LDL) subclasses were examined in rabbits, a species naturally deficient in HL activity...
  49. ncbi request reprint Effects of simvastatin, an HMG-CoA reductase inhibitor, in patients with hypertriglyceridemia
    Jonathan Isaacsohn
    Metabolic and Atherosclerosis Research Center, Cincinnati, Ohio, USA
    Clin Cardiol 26:18-24. 2003
    ....
  50. ncbi request reprint ApoC-III content of apoB-containing lipoproteins is associated with binding to the vascular proteoglycan biglycan
    Katherine Olin-Lewis
    Department of Medicine, University of Washington, Seattle, WA, USA
    J Lipid Res 43:1969-77. 2002
    ..ApoC-III content may thus be a marker for lipoproteins characterized as having an increased ability to bind proteoglycans...
  51. ncbi request reprint Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels
    Len A Pennacchio
    Genome Sciences Department, MS 84 171, Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, CA 94720, USA
    Hum Mol Genet 11:3031-8. 2002
    ..Together, the APOA5*2 and APOA5*3 haplotypes are found in 25-50% of African-Americans, Hispanics and Caucasians and support the contribution of common human variation to quantitative phenotypes in the general population...
  52. ncbi request reprint Phenotypic predictors of response to simvastatin therapy among African-Americans and Caucasians: the Cholesterol and Pharmacogenetics (CAP) Study
    Joel A Simon
    General Internal Medicine Section, Medical Service, Veterans Affairs Medical Center, San Francisco, California, USA
    Am J Cardiol 97:843-50. 2006
    ..The magnitude of the lipid and lipoprotein responses, however, differed among participants according to a number of phenotypic and demographic characteristics...
  53. ncbi request reprint Metabolic effects of nandrolone decanoate and resistance training in men with HIV
    Fred R Sattler
    Departments of Medicine, Biokinesiology and Physical Therapy, and of Biometry, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
    Am J Physiol Endocrinol Metab 283:E1214-22. 2002
    ..05). These metabolic effects were favorable (other than for HDL), but changes were generally transient (except for HDL in group 2), with measurements returning to baseline 2 mo after the interventions were completed...
  54. ncbi request reprint American College of Endocrinology position statement on the insulin resistance syndrome
    Daniel Einhorn
    American College of Endocrinology
    Endocr Pract 9:237-52. 2003
  55. pmc Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein
    Alexander P Reiner
    University of Washington, Department of Epidemiology, Seattle, WA 98195, USA
    Am J Hum Genet 82:1193-201. 2008
    ....
  56. pmc Consumption of fructose-sweetened beverages for 10 weeks increases postprandial triacylglycerol and apolipoprotein-B concentrations in overweight and obese women
    Michael M Swarbrick
    Department of Nutrition, University of California, Davis, CA 95616, USA
    Br J Nutr 100:947-52. 2008
    ....
  57. ncbi request reprint Determination and use of haplotypes: ethnic comparison and association of the lipoprotein lipase gene and coronary artery disease in Mexican-Americans
    Mark O Goodarzi
    Division of Medical Genetics, Department of Medicine, Cedars Sinai Medical Center and UCLA, Los Angeles, California, USA
    Genet Med 5:322-7. 2003
    ..To illustrate an approach of deriving haplotypes for genetic association studies, using the lipoprotein lipase (LPL) gene and coronary artery disease...
  58. ncbi request reprint Smallest LDL particles are most strongly related to coronary disease progression in men
    Paul T Williams
    Life Sciences Division, E O Lawrence Berkeley National Laboratory, University of California, Berkeley, USA
    Arterioscler Thromb Vasc Biol 23:314-21. 2003
    ..2 to 24.7 nm), LDL-IVa (23.3 to 24.2 nm), and LDL-IVb (22.0 to 23.3 nm in diameter). We hypothesized that the association between smaller LDL particles and coronary artery disease (CAD) risk might involve specific LDL subclasses...
  59. ncbi request reprint Individualized hormone-replacement therapy?
    Ronald M Krauss
    N Engl J Med 346:1017-8. 2002
  60. ncbi request reprint Analysis and quantitation of biotinylated apoB-containing lipoproteins with streptavidin-Cy3
    Kaspar Berneis
    Donner Laboratory, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    J Lipid Res 43:1155-9. 2002
    ..54 A, P = 0.3). Biotinylation and prestaining of lipoprotein particle with streptavidin-Cy3 provides a new fluorescence-based method for detection and quantitative analysis of lipoprotein subspecies by gradient gel electrophoresis...
  61. ncbi request reprint Metabolic origins and clinical significance of LDL heterogeneity
    Kaspar K Berneis
    Donner Laboratory, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    J Lipid Res 43:1363-79. 2002
    ..Future delineation of the determinants of heterogeneity of LDL and other apoB-containing lipoproteins may contribute to improved identification and management of patients at high risk for atherosclerotic disease...
  62. ncbi request reprint Differential effects of ramipril on ambulatory blood pressure in African Americans and Caucasians
    Andrew Moran
    Department of Medicine, University of California at San Francisco, and San Francisco General Hospital, California, USA
    Am J Hypertens 20:884-91. 2007
    ..Past studies did not compare daytime and nighttime ambulatory blood-pressure responses to angiotensin-converting enzyme inhibitors in African Americans and Caucasians...
  63. ncbi request reprint Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia
    Alan D Attie
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI, USA
    J Lipid Res 43:1899-907. 2002
    ..We propose that many of the factors that influence plasma triglyceride levels do so by converging upon the regulation of SCD activity...
  64. ncbi request reprint Behavioral versus genetic correlates of lipoproteins and adiposity in identical twins discordant for exercise
    Paul T Williams
    Lawrence Berkeley National Laboratory, Donner Laboratory, One Cyclotron Rd, Berkeley, CA 94720, USA
    Circulation 112:350-6. 2005
    ....
  65. ncbi request reprint Association between angiotensinogen, angiotensin II receptor genes, and blood pressure response to an angiotensin-converting enzyme inhibitor
    Xiaowen Su
    Medical Genetics Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    Circulation 115:725-32. 2007
    ....
  66. ncbi request reprint Endurance training has little effect on active muscle free fatty acid, lipoprotein cholesterol, or triglyceride net balances
    Kevin A Jacobs
    University of California, Berkeley, CA 94720 3140, USA
    Am J Physiol Endocrinol Metab 291:E656-65. 2006
    ..Therefore, the favorable effects of physical activity on the lipid profiles of young, healthy normolipidemic men in the postprandial state are not attributable to changes in HDL-C or LDL-C exchange across active skeletal muscle...
  67. ncbi request reprint Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute scientific statement
    Scott M Grundy
    Curr Opin Cardiol 21:1-6. 2006
  68. pmc Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges
    Russell A Wilke
    Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Nat Rev Drug Discov 6:904-16. 2007
    ..Key challenges for the discovery of predictive risk alleles for these SADRs are also considered...
  69. ncbi request reprint Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement
    Scott M Grundy
    Circulation 112:2735-52. 2005
  70. ncbi request reprint Diagnosis and management of the metabolic syndrome. An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Executive summary
    Scott M Grundy
    Cardiol Rev 13:322-7. 2005
  71. ncbi request reprint Is there a simple way to identify insulin-resistant individuals at increased risk of cardiovascular disease?
    Tracey McLaughlin
    Stanford University School of Medicine, Stanford, California, USA
    Am J Cardiol 96:399-404. 2005
    ..5 provides a simple means of identifying insulin-resistant, dyslipidemic patients who are likely to be at increased risk of cardiovascular disease...
  72. ncbi request reprint Protein in optimal health: heart disease and type 2 diabetes
    Donald K Layman
    Department of Food Science and Human Nutrition, University of Illinois, Urbana, IL 61801, USA
    Am J Clin Nutr 87:1571S-1575S. 2008
    ..Additional research is needed to determine specific levels of protein, carbohydrate, and fat for optimum health of individuals who differ in age, physical activity, and metabolic phenotypes...
  73. doi request reprint Direct determination of lipoprotein particle sizes and concentrations by ion mobility analysis
    Michael P Caulfield
    Quest Diagnostics Nichols Institute, San Juan Capistrano, CA 92675, USA
    Clin Chem 54:1307-16. 2008
    ....
  74. pmc Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults
    Julio Licinio
    Center for Pharmacogenomics, Neuropsychiatric Institute, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1761, USA
    Proc Natl Acad Sci U S A 101:4531-6. 2004
    ..These results highlight the role of the leptin pathway in adults with key effects on the regulation of body weight, gonadal function, and behavior...
  75. ncbi request reprint Obesity in BSB mice is correlated with expression of genes for iron homeostasis and leptin
    Poupak Farahani
    Rowe Program in Genetics, University of California, Davis, California 95616, USA
    Obes Res 12:191-204. 2004
    ..We searched for genes whose alleles cause obesity and novel pathways correlated with obesity...
  76. ncbi request reprint Pharmacogenomics: challenges and opportunities
    Dan M Roden
    Vanderbilt University, Nashville, Tennessee, USA
    Ann Intern Med 145:749-57. 2006
    ..Overcoming these challenges holds the promise of improving new drug development and ultimately individualizing the selection of appropriate drugs and dosages for individual patients...

Research Grants3

  1. COMPARATIVE GENOMIC ANALYSIS OF CARDIOVASCULAR GENE REGU
    Ronald Krauss; Fiscal Year: 2003
    ..6) The establishment of an educational program for cardiovascular researchers in the use of genomic databases and tools. ..
  2. Pharmacogenomics and Risk of Cardiovascular Disease
    Ronald Krauss; Fiscal Year: 2007
    ..This program presents a comprehensive approach for determining effects of specific genotypes on clinically meaningful variations in responsiveness to a class of drugs widely used to prevent cardiovascular disease. ..