Sookyong Koh

Summary

Affiliation: Children's Memorial Hospital
Country: USA

Publications

  1. pmc Role of brain inflammation in epileptogenesis
    Jieun Choi
    Department of Pediatrics, Division of Neurology, Northwestern University Children s Memorial Hospital, Chicago, IL 2300 Children s Plaza, Box 51, Children s Memorial Hospital, Chicago, IL 60614, USA
    Yonsei Med J 49:1-18. 2008
  2. ncbi request reprint Environmental enrichment reverses the impaired exploratory behavior and altered gene expression induced by early-life seizures
    Sookyong Koh
    Children s Memorial Hospital, Children s Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    J Child Neurol 20:796-802. 2005
  3. pmc Depressive behavior and selective down-regulation of serotonin receptor expression after early-life seizures: reversal by environmental enrichment
    Sookyong Koh
    Pediatrics, Children s Memorial Hospital, Northwestern University Feinburg School of Medicine Chicago, IL 60614, USA
    Epilepsy Behav 10:26-31. 2007
  4. pmc Cellular injury and neuroinflammation in children with chronic intractable epilepsy
    Jieun Choi
    Department of Pediatrics, Northwestern University Children s Memorial Hospital, Chicago, IL, USA
    J Neuroinflammation 6:38. 2009
  5. pmc Early-life experience alters response of developing brain to seizures
    Cassandra Kazl
    Department of Neurology, Children s Memorial Hospital, Children s Memorial Research Center, Northwestern University, Feinberg School of Medicine, Chicago, IL 60614, USA
    Brain Res 1285:174-81. 2009
  6. ncbi request reprint Microarray analysis of postictal transcriptional regulation of neuropeptides
    Dawn N Wilson
    Division of Neurology, Children s Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, IL 60614, USA
    J Mol Neurosci 25:285-98. 2005
  7. pmc Maturation-dependent behavioral deficits and cell injury in developing animals during the subacute postictal period
    Lauren M Mlsna
    Neurobiology Program, Ann and Robert H Lurie Children s Hospital of Chicago Research Center, Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Chicago, IL 60614, USA
    Epilepsy Behav 29:190-7. 2013
  8. pmc Child Neurology: Dravet syndrome: when to suspect the diagnosis
    John J Millichap
    Division of Neurology, Children s Memorial Hospital, Northwestern University Medical School, Chicago, IL 60614, USA
    Neurology 73:e59-62. 2009
  9. ncbi request reprint Glial activation links early-life seizures and long-term neurologic dysfunction: evidence using a small molecule inhibitor of proinflammatory cytokine upregulation
    Kathleen C Somera-Molina
    Integrated Graduate Program, Department of Pediatrics, Division of Neurology, Center for Drug Discovery and Chemical Biology, Northwestern Univrsity, Chicago, Illinois, USA
    Epilepsia 48:1785-800. 2007
  10. pmc Temperature-sensitive Cav1.2 calcium channels support intrinsic firing of pyramidal neurons and provide a target for the treatment of febrile seizures
    Daniel Radzicki
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Neurosci 33:9920-31. 2013

Research Grants

Collaborators

Detail Information

Publications17

  1. pmc Role of brain inflammation in epileptogenesis
    Jieun Choi
    Department of Pediatrics, Division of Neurology, Northwestern University Children s Memorial Hospital, Chicago, IL 2300 Children s Plaza, Box 51, Children s Memorial Hospital, Chicago, IL 60614, USA
    Yonsei Med J 49:1-18. 2008
    ..We provide an overview of the current knowledge that implicates brain inflammation as a common predisposing factor in epilepsy, particularly childhood epilepsy...
  2. ncbi request reprint Environmental enrichment reverses the impaired exploratory behavior and altered gene expression induced by early-life seizures
    Sookyong Koh
    Children s Memorial Hospital, Children s Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    J Child Neurol 20:796-802. 2005
    ..Real-time quantitative reverse transcriptase-polymerase chain reaction confirmed our microarray data on select genes. Our results provide an experimental basis for promoting enriching education programs for children with epilepsy...
  3. pmc Depressive behavior and selective down-regulation of serotonin receptor expression after early-life seizures: reversal by environmental enrichment
    Sookyong Koh
    Pediatrics, Children s Memorial Hospital, Northwestern University Feinburg School of Medicine Chicago, IL 60614, USA
    Epilepsy Behav 10:26-31. 2007
    ..Our results suggest that seizures lead to increased susceptibility to depression through transcriptional regulation while environment, in turn, can interact with gene expression to influence the behavioral outcome of epilepsy...
  4. pmc Cellular injury and neuroinflammation in children with chronic intractable epilepsy
    Jieun Choi
    Department of Pediatrics, Northwestern University Children s Memorial Hospital, Chicago, IL, USA
    J Neuroinflammation 6:38. 2009
    ....
  5. pmc Early-life experience alters response of developing brain to seizures
    Cassandra Kazl
    Department of Neurology, Children s Memorial Hospital, Children s Memorial Research Center, Northwestern University, Feinberg School of Medicine, Chicago, IL 60614, USA
    Brain Res 1285:174-81. 2009
    ....
  6. ncbi request reprint Microarray analysis of postictal transcriptional regulation of neuropeptides
    Dawn N Wilson
    Division of Neurology, Children s Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, IL 60614, USA
    J Mol Neurosci 25:285-98. 2005
    ..Also, suppression of tachykinin and corticotropin-releasing hormone might be effective in alleviating seizure-induced neuronal damage...
  7. pmc Maturation-dependent behavioral deficits and cell injury in developing animals during the subacute postictal period
    Lauren M Mlsna
    Neurobiology Program, Ann and Robert H Lurie Children s Hospital of Chicago Research Center, Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Chicago, IL 60614, USA
    Epilepsy Behav 29:190-7. 2013
    ....
  8. pmc Child Neurology: Dravet syndrome: when to suspect the diagnosis
    John J Millichap
    Division of Neurology, Children s Memorial Hospital, Northwestern University Medical School, Chicago, IL 60614, USA
    Neurology 73:e59-62. 2009
    ..Early recognition and diagnosis of DS and management with appropriate anticonvulsants and treatment plan may reduce the seizure burden and improve long-term developmental outcome...
  9. ncbi request reprint Glial activation links early-life seizures and long-term neurologic dysfunction: evidence using a small molecule inhibitor of proinflammatory cytokine upregulation
    Kathleen C Somera-Molina
    Integrated Graduate Program, Department of Pediatrics, Division of Neurology, Center for Drug Discovery and Chemical Biology, Northwestern Univrsity, Chicago, Illinois, USA
    Epilepsia 48:1785-800. 2007
    ....
  10. pmc Temperature-sensitive Cav1.2 calcium channels support intrinsic firing of pyramidal neurons and provide a target for the treatment of febrile seizures
    Daniel Radzicki
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Neurosci 33:9920-31. 2013
    ....
  11. pmc Minocycline attenuates microglia activation and blocks the long-term epileptogenic effects of early-life seizures
    Jayne Abraham
    Department of Pediatrics, Children s Memorial Hospital, Division of Neurobiology, Children s Memorial Research Center, IL, USA
    Neurobiol Dis 46:425-30. 2012
    ..Our results suggest that anti-inflammatory therapy after SE may be useful to block the epileptogenic process and mitigate the long-term damaging effects of early-life seizures...
  12. pmc Characterization of a commonly used mouse model of SMA reveals increased seizure susceptibility and heightened fear response in FVB/N mice
    Rocky G Gogliotti
    Human Molecular Genetics Program, Children s Memorial Hospital Chicago, IL 60614, USA
    Neurobiol Dis 43:142-51. 2011
    ..This should be taken into account in pre-clinical studies that utilize this transgene, especially in therapy-treated SMA mice that have extended survival...
  13. ncbi request reprint Dravet syndrome (severe myoclonic epilepsy in infancy): a retrospective study of 16 patients
    Christian Korff
    Epilepsy Center, Children s Memorial Hospital, Chicago, Illinois 60614 3394, USA
    J Child Neurol 22:185-94. 2007
    ..Despite its reputation for seizure intractability, several treatment options may be particularly helpful, whereas others need to be avoided...
  14. ncbi request reprint Susceptibility to seizure-induced injury and acquired microencephaly following intraventricular injection of saporin-conjugated 192 IgG in developing rat brain
    Sookyong Koh
    MGH Epilepsy Service, Epilepsy Research Laboratory, Massachusetts General Hospital and Harvard Medical School, VBK 830, 55 Fruit Street, Boston, MA 02114, USA
    Exp Neurol 194:457-66. 2005
    ....
  15. ncbi request reprint NBQX or topiramate treatment after perinatal hypoxia-induced seizures prevents later increases in seizure-induced neuronal injury
    Sookyong Koh
    Department of Neurology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Epilepsia 45:569-75. 2004
    ....
  16. ncbi request reprint Are seizures harmful: what can we learn from animal models?
    Andrew J Cole
    Epilepsy Research Laboratory, Massachusetts General Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02114, USA
    Prog Brain Res 135:13-23. 2002
    ..In the future, we can anticipate that animal models will continue to be useful, especially when whole-animal preparations are used to generate material for detailed in vitro examination...
  17. ncbi request reprint Cryptogenic late-onset epileptic spasms or late infantile epileptogenic encephalopathy?
    Douglas R Nordli
    Epilepsia 48:206-8. 2007

Research Grants3

  1. MOLECULAR & CELLULAR CONSEQUENCES OF EARLY LIFE SEIZURE
    Sookyong Koh; Fiscal Year: 2003
    ..abstract not available ..
  2. Brain Inflammation in Childhood Epilepsy
    Sookyong Koh; Fiscal Year: 2007
    ..Together these Aims are designed to test the central hypothesis that the epileptogenic effect of early life seizures is mediated by brain inflammation. ..