Henry Klassen

Summary

Affiliation: Children's Hospital of Orange County
Country: USA

Publications

  1. ncbi request reprint Isolation of retinal progenitor cells from post-mortem human tissue and comparison with autologous brain progenitors
    Henry Klassen
    Stem Cell Research, Children s Hospital of Orange County Research Institute, Orange, California 92868 3874, USA
    J Neurosci Res 77:334-43. 2004
  2. ncbi request reprint Surface markers expressed by multipotent human and mouse neural progenitor cells include tetraspanins and non-protein epitopes
    H Klassen
    Stem Cell Research, Children s Hospital of Orange County, 455 South Main Street, Orange, CA 92868, USA
    Neurosci Lett 312:180-2. 2001
  3. ncbi request reprint The immunological properties of adult hippocampal progenitor cells
    Henry Klassen
    Stem Cell Research, Children s Hospital of Orange County, 455 South Main Street, Orange, CA 92868, USA
    Vision Res 43:947-56. 2003
  4. ncbi request reprint Expression of cytokines by multipotent neural progenitor cells
    Henry J Klassen
    Stem Cell Research, Children s Hospital of Orange County, 455 South Main Street, Orange, CA 92868 3874, USA
    Cytokine 22:101-6. 2003
  5. pmc Isolation of progenitor cells from GFP-transgenic pigs and transplantation to the retina of allorecipients
    Henry Klassen
    Department of Ophthalmology, School of Medicine, University of California, Irvine, Orange, California 92868 4380, USA
    Cloning Stem Cells 10:391-402. 2008
  6. ncbi request reprint Expression of neurodevelopmental markers by cultured porcine neural precursor cells
    Philip H Schwartz
    National Human Neural Stem Cell Resource, Children s Hospital of Orange County, Research Institute, 455 South Main Street, Orange, California 92868 3874, USA
    Stem Cells 23:1286-94. 2005
  7. ncbi request reprint Neural precursors isolated from the developing cat brain show retinal integration following transplantation to the retina of the dystrophic cat
    Henry Klassen
    Stem Cell Research, Children s Hospital of Orange County Research Institute, Orange, CA, USA
    Vet Ophthalmol 10:245-53. 2007
  8. ncbi request reprint Progenitor cells from the porcine neural retina express photoreceptor markers after transplantation to the subretinal space of allorecipients
    Henry Klassen
    Stem Cell Research, Children s Hospital of Orange County, Orange, California, USA
    Stem Cells 25:1222-30. 2007
  9. pmc Sequential changes in the gene expression profile of murine retinal progenitor cells during the induction of differentiation
    Ping Gu
    Gavin Herbert Eye Institute, Department of Ophthalmology, School of Medicine, University of California, Irvine, Orange, CA 92868, USA
    Mol Vis 15:2111-22. 2009
  10. ncbi request reprint Stem cells and retinal repair
    Henry Klassen
    Stem Cell Research, Children s Hospital of Orange County, Orange, CA 92868, USA
    Prog Retin Eye Res 23:149-81. 2004

Research Grants

  1. Characterization of transgenic neural stem cells
    Henry Klassen; Fiscal Year: 2002

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Isolation of retinal progenitor cells from post-mortem human tissue and comparison with autologous brain progenitors
    Henry Klassen
    Stem Cell Research, Children s Hospital of Orange County Research Institute, Orange, California 92868 3874, USA
    J Neurosci Res 77:334-43. 2004
    ..hRPCs can be distinguished from hBPC cultures by the expression of retinal specification genes and recoverin...
  2. ncbi request reprint Surface markers expressed by multipotent human and mouse neural progenitor cells include tetraspanins and non-protein epitopes
    H Klassen
    Stem Cell Research, Children s Hospital of Orange County, 455 South Main Street, Orange, CA 92868, USA
    Neurosci Lett 312:180-2. 2001
    ..The markers reported here have been implicated in a wide range of cellular functions including proliferation, migration, differentiation, apoptosis, and immune recognition...
  3. ncbi request reprint The immunological properties of adult hippocampal progenitor cells
    Henry Klassen
    Stem Cell Research, Children s Hospital of Orange County, 455 South Main Street, Orange, CA 92868, USA
    Vision Res 43:947-56. 2003
    ..Taken together, these results indicate that AHPCs are non-immunogenic in vitro. This is consistent with their pattern of MHC expression and does not require an active immunosuppressive mechanism...
  4. ncbi request reprint Expression of cytokines by multipotent neural progenitor cells
    Henry J Klassen
    Stem Cell Research, Children s Hospital of Orange County, 455 South Main Street, Orange, CA 92868 3874, USA
    Cytokine 22:101-6. 2003
    ....
  5. pmc Isolation of progenitor cells from GFP-transgenic pigs and transplantation to the retina of allorecipients
    Henry Klassen
    Department of Ophthalmology, School of Medicine, University of California, Irvine, Orange, California 92868 4380, USA
    Cloning Stem Cells 10:391-402. 2008
    ..These findings demonstrate the feasibility of allogeneic progenitor transplantation in a large mammal and the utility of the pig in ocular regeneration studies...
  6. ncbi request reprint Expression of neurodevelopmental markers by cultured porcine neural precursor cells
    Philip H Schwartz
    National Human Neural Stem Cell Resource, Children s Hospital of Orange County, Research Institute, 455 South Main Street, Orange, California 92868 3874, USA
    Stem Cells 23:1286-94. 2005
    ....
  7. ncbi request reprint Neural precursors isolated from the developing cat brain show retinal integration following transplantation to the retina of the dystrophic cat
    Henry Klassen
    Stem Cell Research, Children s Hospital of Orange County Research Institute, Orange, CA, USA
    Vet Ophthalmol 10:245-53. 2007
    ..The feasibility of deriving and transplanting feline neural precursor cells, combined with the availability of the dystrophic Abyssinian cat, provide a new feline model system for the study of retinal repair...
  8. ncbi request reprint Progenitor cells from the porcine neural retina express photoreceptor markers after transplantation to the subretinal space of allorecipients
    Henry Klassen
    Stem Cell Research, Children s Hospital of Orange County, Orange, California, USA
    Stem Cells 25:1222-30. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  9. pmc Sequential changes in the gene expression profile of murine retinal progenitor cells during the induction of differentiation
    Ping Gu
    Gavin Herbert Eye Institute, Department of Ophthalmology, School of Medicine, University of California, Irvine, Orange, CA 92868, USA
    Mol Vis 15:2111-22. 2009
    ..In vitro analysis of cultured RPCs allows detailed examination of marker gene expression during the initial phase of differentiation and can provide insight into the variables influencing this process...
  10. ncbi request reprint Stem cells and retinal repair
    Henry Klassen
    Stem Cell Research, Children s Hospital of Orange County, Orange, CA 92868, USA
    Prog Retin Eye Res 23:149-81. 2004
    ....
  11. ncbi request reprint Isolation and characterization of neural progenitor cells from post-mortem human cortex
    Philip H Schwartz
    National Human Neural Stem Cell Resource, Children s Hospital of Orange County Research Institute, Orange, California 92868 3874, USA
    J Neurosci Res 74:838-51. 2003
    ..These data suggest that post-mortem human brain tissue is an important source of neural progenitor cells that will be useful for analysis of neural differentiation and for transplantation studies...
  12. ncbi request reprint Recruitment of endogenous neural progenitor cells by malignant neoplasms of the central nervous system
    Henry Klassen
    Stem Cell and Retinal Regeneration Program, University of California, Irvine, Department of Ophthalmology, 101 The City Dr, Bldg 55, Rm 204, Orange, CA 92868 4380, USA
    Curr Stem Cell Res Ther 2:113-9. 2007
    ..Finally, it is worth noting that the situation described in the current hypothesis might apply to a variety of other stem and precursor cell-containing systems throughout the body...
  13. ncbi request reprint Multipotent retinal progenitors express developmental markers, differentiate into retinal neurons, and preserve light-mediated behavior
    Henry J Klassen
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 45:4167-73. 2004
    ..To use progenitor cells isolated from the neural retina for transplantation studies in mice with retinal degeneration...
  14. ncbi request reprint Retinal transplantation
    Tat Fong Ng
    Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
    Chem Immunol Allergy 92:300-16. 2007
    ..This information will allow for the development of strategies to improve graft outcome and lead to successful repair of the diseased eye...
  15. ncbi request reprint CNS progenitor cells promote a permissive environment for neurite outgrowth via a matrix metalloproteinase-2-dependent mechanism
    Yiqin Zhang
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 27:4499-506. 2007
    ..This suggests a novel therapeutic role for progenitor cells in the treatment of CNS degenerative diseases...
  16. ncbi request reprint Retinal progenitor cell xenografts to the pig retina: morphologic integration and cytochemical differentiation
    Karin Warfvinge
    Department of Ophthalmology, Lund University Hospital, Lund, Sweden
    Arch Ophthalmol 123:1385-93. 2005
    ..To investigate the survival, integration, and differentiation of mouse retinal progenitor cells after transplantation to the subretinal space of adult pigs...

Research Grants1

  1. Characterization of transgenic neural stem cells
    Henry Klassen; Fiscal Year: 2002
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